2lj9 - Revision history

OCA at 11:02, 15 February 2023

OCA — Wed, 15 Feb 2023 11:02:47 GMT

←Older revision		Revision as of 11:02, 15 February 2023
Line 1:		Line 1:

	==Partial 3d structure of the c-terminal part of the free arabidopsis thaliana cp12-2 in its oxidized form==		==Partial 3d structure of the c-terminal part of the free arabidopsis thaliana cp12-2 in its oxidized form==
-	<StructureSection load='2lj9' size='340' side='right'caption='[[2lj9~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2lj9' size='340' side='right'caption='[[2lj9]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lj9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Arath Arath~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LJ9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lj9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LJ9 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At3g62410, CP12-2, T12C14_110 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lj9 OCA], [https://pdbe.org/2lj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lj9 RCSB], [https://www.ebi.ac.uk/pdbsum/2lj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lj9 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lj9 OCA], [https://pdbe.org/2lj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lj9 RCSB], [https://www.ebi.ac.uk/pdbsum/2lj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lj9 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CP122_ARATH CP122_ARATH]] Acts as a linker essential in the assembly of a core complex of PRK/GAPDH. Coordinates the reversible inactivation of chloroplast enzymes GAPDH and PRK during darkness in photosynthetic tissues.<ref>PMID:16258009</ref> <ref>PMID:20399532</ref>	+	[https://www.uniprot.org/uniprot/CP122_ARATH CP122_ARATH] Acts as a linker essential in the assembly of a core complex of PRK/GAPDH. Coordinates the reversible inactivation of chloroplast enzymes GAPDH and PRK during darkness in photosynthetic tissues.<ref>PMID:16258009</ref> <ref>PMID:20399532</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arath~~]]	+	[[Category: Arabidopsis thaliana]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Marri, L]]	+	[[Category: Marri L]]
-	[[Category: Sparla, F]]	+	[[Category: Sparla F]]
-	[[Category: Trivelli, X]]	+	[[Category: Trivelli X]]
-	[[Category: Trost, P]]	+	[[Category: Trost P]]
-	~~[[Category: Helix]]~~	+
-	~~[[Category: Intrinsically disordered protein]]~~	+
-	~~[[Category: Protein binding~~]]	+

OCA at 10:11, 12 May 2021

OCA — Wed, 12 May 2021 10:11:42 GMT

←Older revision		Revision as of 10:11, 12 May 2021
Line 1:		Line 1:

	==Partial 3d structure of the c-terminal part of the free arabidopsis thaliana cp12-2 in its oxidized form==		==Partial 3d structure of the c-terminal part of the free arabidopsis thaliana cp12-2 in its oxidized form==
-	<StructureSection load='2lj9' size='340' side='right' caption='[[2lj9]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2lj9' size='340' side='right'caption='[[2lj9]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lj9]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Arath Arath]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJ9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LJ9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lj9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arath Arath]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LJ9 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At3g62410, CP12-2, T12C14_110 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At3g62410, CP12-2, T12C14_110 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2lj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lj9 OCA], [~~http~~://pdbe.org/2lj9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2lj9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2lj9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2lj9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lj9 OCA], [https://pdbe.org/2lj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lj9 RCSB], [https://www.ebi.ac.uk/pdbsum/2lj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lj9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CP122_ARATH CP122_ARATH]] Acts as a linker essential in the assembly of a core complex of PRK/GAPDH. Coordinates the reversible inactivation of chloroplast enzymes GAPDH and PRK during darkness in photosynthetic tissues.<ref>PMID:16258009</ref> <ref>PMID:20399532</ref>	+	[[https://www.uniprot.org/uniprot/CP122_ARATH CP122_ARATH]] Acts as a linker essential in the assembly of a core complex of PRK/GAPDH. Coordinates the reversible inactivation of chloroplast enzymes GAPDH and PRK during darkness in photosynthetic tissues.<ref>PMID:16258009</ref> <ref>PMID:20399532</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Arath]]		[[Category: Arath]]
		+	[[Category: Large Structures]]
	[[Category: Marri, L]]		[[Category: Marri, L]]
	[[Category: Sparla, F]]		[[Category: Sparla, F]]

OCA at 19:48, 1 August 2018

OCA — Wed, 01 Aug 2018 19:48:26 GMT

←Older revision		Revision as of 19:48, 1 August 2018
Line 1:		Line 1:
		+
	==Partial 3d structure of the c-terminal part of the free arabidopsis thaliana cp12-2 in its oxidized form==		==Partial 3d structure of the c-terminal part of the free arabidopsis thaliana cp12-2 in its oxidized form==
	<StructureSection load='2lj9' size='340' side='right' caption='[[2lj9]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lj9' size='340' side='right' caption='[[2lj9]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2lj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LJ9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LJ9 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At3g62410, CP12-2, T12C14_110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At3g62410, CP12-2, T12C14_110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lj9 OCA], [http://pdbe.org/2lj9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lj9 RCSB], [http://www.ebi.ac.uk/pdbsum/2lj9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lj9 OCA], [http://pdbe.org/2lj9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lj9 RCSB], [http://www.ebi.ac.uk/pdbsum/2lj9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lj9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 23:56, 9 September 2015

OCA — Wed, 09 Sep 2015 23:56:25 GMT

←Older revision		Revision as of 23:56, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='2lj9' size='340' side='right' caption='[[2lj9]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lj9' size='340' side='right' caption='[[2lj9]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Arabidopsis_thaliana Arabidopsis thaliana~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LJ9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LJ9 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At3g62410, CP12-2, T12C14_110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ~~Arabidopsis thaliana~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At3g62410, CP12-2, T12C14_110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lj9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lj9 RCSB], [http://www.ebi.ac.uk/pdbsum/2lj9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lj9 OCA], [http://pdbe.org/2lj9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lj9 RCSB], [http://www.ebi.ac.uk/pdbsum/2lj9 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~Q9LZP9_ARATH Q9LZP9_ARATH~~]] Acts as a linker essential in the assembly of a core complex of PRK/GAPDH. Coordinates the reversible inactivation of chloroplast enzymes GAPDH and PRK during darkness in photosynthetic tissues.<ref>PMID:16258009</ref> <ref>PMID:20399532</ref>	+	[[http://www.uniprot.org/uniprot/CP122_ARATH CP122_ARATH]] Acts as a linker essential in the assembly of a core complex of PRK/GAPDH. Coordinates the reversible inactivation of chloroplast enzymes GAPDH and PRK during darkness in photosynthetic tissues.<ref>PMID:16258009</ref> <ref>PMID:20399532</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2lj9" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arabidopsis thaliana~~]]	+	[[Category: Arath]]
	[[Category: Marri, L]]		[[Category: Marri, L]]
	[[Category: Sparla, F]]		[[Category: Sparla, F]]

OCA at 13:57, 24 December 2014

OCA — Wed, 24 Dec 2014 13:57:14 GMT

←Older revision		Revision as of 13:57, 24 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lj9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lj9 RCSB], [http://www.ebi.ac.uk/pdbsum/2lj9 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lj9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lj9 RCSB], [http://www.ebi.ac.uk/pdbsum/2lj9 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q9LZP9_ARATH Q9LZP9_ARATH]] Acts as a linker essential in the assembly of a core complex of PRK/GAPDH. Coordinates the reversible inactivation of chloroplast enzymes GAPDH and PRK during darkness in photosynthetic tissues.<ref>PMID:16258009</ref> <ref>PMID:20399532</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:28, 22 December 2014

OCA — Mon, 22 Dec 2014 06:28:27 GMT

←Older revision		Revision as of 06:28, 22 December 2014
Line 2:		Line 2:
	<StructureSection load='2lj9' size='340' side='right' caption='[[2lj9]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lj9' size='340' side='right' caption='[[2lj9]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJ9 OCA]. <br>	+	<table><tr><td colspan='2'>[[2lj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LJ9 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At3g62410, CP12-2, T12C14_110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At3g62410, CP12-2, T12C14_110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr>
-	<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class~~='~~plainlinks~~'~~>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lj9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lj9 RCSB], [http://www.ebi.ac.uk/pdbsum/2lj9 PDBsum]</span></td></tr>
-	~~<tr~~><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lj9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lj9 RCSB], [http://www.ebi.ac.uk/pdbsum/2lj9 PDBsum]</span></td></tr>	+	</table>
-	<table>	+
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 12:
	Conformational Selection and Folding-upon-binding of Intrinsically Disordered Protein CP12 Regulate Photosynthetic Enzymes Assembly.,Fermani S, Trivelli X, Sparla F, Thumiger A, Calvaresi M, Marri L, Falini G, Zerbetto F, Trost P J Biol Chem. 2012 Jun 15;287(25):21372-83. Epub 2012 Apr 18. PMID:22514274<ref>PMID:22514274</ref>		Conformational Selection and Folding-upon-binding of Intrinsically Disordered Protein CP12 Regulate Photosynthetic Enzymes Assembly.,Fermani S, Trivelli X, Sparla F, Thumiger A, Calvaresi M, Marri L, Falini G, Zerbetto F, Trost P J Biol Chem. 2012 Jun 15;287(25):21372-83. Epub 2012 Apr 18. PMID:22514274<ref>PMID:22514274</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 20:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
-	[[Category: Marri, L.]]	+	[[Category: Marri, L]]
-	[[Category: Sparla, F.]]	+	[[Category: Sparla, F]]
-	[[Category: Trivelli, X.]]	+	[[Category: Trivelli, X]]
-	[[Category: Trost, P.]]	+	[[Category: Trost, P]]
	[[Category: Helix]]		[[Category: Helix]]
	[[Category: Intrinsically disordered protein]]		[[Category: Intrinsically disordered protein]]
	[[Category: Protein binding]]		[[Category: Protein binding]]

OCA at 09:42, 1 May 2014

OCA — Thu, 01 May 2014 09:42:17 GMT

←Older revision		Revision as of 09:42, 1 May 2014
Line 2:		Line 2:
	<StructureSection load='2lj9' size='340' side='right' caption='[[2lj9]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lj9' size='340' side='right' caption='[[2lj9]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	[[2lj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJ9 OCA]. <br>	+	<table><tr><td colspan='2'>[[2lj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJ9 OCA]. <br>
-	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>	+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At3g62410, CP12-2, T12C14_110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr>
-	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lj9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lj9 RCSB], [http://www.ebi.ac.uk/pdbsum/2lj9 PDBsum]</span><br>	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lj9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lj9 RCSB], [http://www.ebi.ac.uk/pdbsum/2lj9 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
	Carbon assimilation in plants is regulated by the reduction of specific protein disulfides by light and their re-oxidation in the dark. The redox switch CP12 is an intrinsically disordered protein that can form two disulfide bridges. In the dark oxidized CP12 forms an inactive supramolecular complex with glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and phosphoribulokinase, two enzymes of the carbon assimilation cycle. Here we show that binding of CP12 to GAPDH, the first step of ternary complex formation, follows an integrated mechanism that combines conformational selection with induced folding steps. Initially, a CP12 conformation characterized by a circular structural motif including the C-terminal disulfide is selected by GAPDH. Subsequently, the induced folding of the flexible C-terminal tail of CP12 in the active site of GAPDH stabilizes the binary complex. Formation of several hydrogen bonds compensates the entropic cost of CP12 fixation and terminates the interaction mechanism that contributes to carbon assimilation control.		Carbon assimilation in plants is regulated by the reduction of specific protein disulfides by light and their re-oxidation in the dark. The redox switch CP12 is an intrinsically disordered protein that can form two disulfide bridges. In the dark oxidized CP12 forms an inactive supramolecular complex with glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and phosphoribulokinase, two enzymes of the carbon assimilation cycle. Here we show that binding of CP12 to GAPDH, the first step of ternary complex formation, follows an integrated mechanism that combines conformational selection with induced folding steps. Initially, a CP12 conformation characterized by a circular structural motif including the C-terminal disulfide is selected by GAPDH. Subsequently, the induced folding of the flexible C-terminal tail of CP12 in the active site of GAPDH stabilizes the binary complex. Formation of several hydrogen bonds compensates the entropic cost of CP12 fixation and terminates the interaction mechanism that contributes to carbon assimilation control.
Line 11:		Line 14:

	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:03, 30 April 2014

OCA — Wed, 30 Apr 2014 10:03:38 GMT

←Older revision		Revision as of 10:03, 30 April 2014
Line 4:		Line 4:
	[[2lj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJ9 OCA]. <br>		[[2lj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJ9 OCA]. <br>
	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>		<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
		+	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lj9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lj9 RCSB], [http://www.ebi.ac.uk/pdbsum/2lj9 PDBsum]</span><br>
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
	Carbon assimilation in plants is regulated by the reduction of specific protein disulfides by light and their re-oxidation in the dark. The redox switch CP12 is an intrinsically disordered protein that can form two disulfide bridges. In the dark oxidized CP12 forms an inactive supramolecular complex with glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and phosphoribulokinase, two enzymes of the carbon assimilation cycle. Here we show that binding of CP12 to GAPDH, the first step of ternary complex formation, follows an integrated mechanism that combines conformational selection with induced folding steps. Initially, a CP12 conformation characterized by a circular structural motif including the C-terminal disulfide is selected by GAPDH. Subsequently, the induced folding of the flexible C-terminal tail of CP12 in the active site of GAPDH stabilizes the binary complex. Formation of several hydrogen bonds compensates the entropic cost of CP12 fixation and terminates the interaction mechanism that contributes to carbon assimilation control.		Carbon assimilation in plants is regulated by the reduction of specific protein disulfides by light and their re-oxidation in the dark. The redox switch CP12 is an intrinsically disordered protein that can form two disulfide bridges. In the dark oxidized CP12 forms an inactive supramolecular complex with glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and phosphoribulokinase, two enzymes of the carbon assimilation cycle. Here we show that binding of CP12 to GAPDH, the first step of ternary complex formation, follows an integrated mechanism that combines conformational selection with induced folding steps. Initially, a CP12 conformation characterized by a circular structural motif including the C-terminal disulfide is selected by GAPDH. Subsequently, the induced folding of the flexible C-terminal tail of CP12 in the active site of GAPDH stabilizes the binary complex. Formation of several hydrogen bonds compensates the entropic cost of CP12 fixation and terminates the interaction mechanism that contributes to carbon assimilation control.

OCA at 08:25, 30 April 2014

OCA — Wed, 30 Apr 2014 08:25:52 GMT

←Older revision		Revision as of 08:25, 30 April 2014
Line 1:		Line 1:
-	[[~~Image:~~2lj9~~.png~~\|~~left\|200px~~]]	+	==Partial 3d structure of the c-terminal part of the free arabidopsis thaliana cp12-2 in its oxidized form==
		+	<StructureSection load='2lj9' size='340' side='right' caption='[[2lj9]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	[[2lj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJ9 OCA]. <br>
		+	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
		+	== Publication Abstract from PubMed ==
		+	Carbon assimilation in plants is regulated by the reduction of specific protein disulfides by light and their re-oxidation in the dark. The redox switch CP12 is an intrinsically disordered protein that can form two disulfide bridges. In the dark oxidized CP12 forms an inactive supramolecular complex with glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and phosphoribulokinase, two enzymes of the carbon assimilation cycle. Here we show that binding of CP12 to GAPDH, the first step of ternary complex formation, follows an integrated mechanism that combines conformational selection with induced folding steps. Initially, a CP12 conformation characterized by a circular structural motif including the C-terminal disulfide is selected by GAPDH. Subsequently, the induced folding of the flexible C-terminal tail of CP12 in the active site of GAPDH stabilizes the binary complex. Formation of several hydrogen bonds compensates the entropic cost of CP12 fixation and terminates the interaction mechanism that contributes to carbon assimilation control.

-	~~{{STRUCTURE_2lj9\| PDB=2lj9 \| SCENE= }}~~	+	Conformational Selection and Folding-upon-binding of Intrinsically Disordered Protein CP12 Regulate Photosynthetic Enzymes Assembly.,Fermani S, Trivelli X, Sparla F, Thumiger A, Calvaresi M, Marri L, Falini G, Zerbetto F, Trost P J Biol Chem. 2012 Jun 15;287(25):21372-83. Epub 2012 Apr 18. PMID:22514274<ref>PMID:22514274</ref>

-	~~===Partial 3d structure~~ of the ~~c-terminal part of the free arabidopsis thaliana cp12-2 in its oxidized form===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	== References ==
-	~~{{ABSTRACT_PUBMED_22514274}}~~	+	<references/>
-		+	__TOC__
-	~~==About this Structure==~~	+	</StructureSection>
-	~~[[2lj9]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]~~. ~~Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJ9 OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022514274<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Marri, L.]]		[[Category: Marri, L.]]

OCA at 04:38, 27 June 2012

OCA — Wed, 27 Jun 2012 04:38:47 GMT

←Older revision		Revision as of 04:38, 27 June 2012
Line 1:		Line 1:
-	[[Image:2lj9.~~jpg~~\|left\|200px]]	+	[[Image:2lj9.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2lj9", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_2lj9\| PDB=2lj9 \| SCENE= }}		{{STRUCTURE_2lj9\| PDB=2lj9 \| SCENE= }}

	===Partial 3d structure of the c-terminal part of the free arabidopsis thaliana cp12-2 in its oxidized form===		===Partial 3d structure of the c-terminal part of the free arabidopsis thaliana cp12-2 in its oxidized form===

		+	{{ABSTRACT_PUBMED_22514274}}

	==About this Structure==		==About this Structure==
	[[2lj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJ9 OCA].		[[2lj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJ9 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022514274</ref><references group="xtra"/>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Marri, L.]]		[[Category: Marri, L.]]