2ljc - Revision history

OCA at 06:55, 1 May 2024

OCA — Wed, 01 May 2024 06:55:54 GMT

←Older revision		Revision as of 06:55, 1 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ljc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_H3N2 Influenza A virus H3N2] and [https://en.wikipedia.org/wiki/Influenza_B_virus_(B/Taiwan/70061/2006) Influenza B virus (B/Taiwan/70061/2006)]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LJC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ljc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_H3N2 Influenza A virus H3N2] and [https://en.wikipedia.org/wiki/Influenza_B_virus_(B/Taiwan/70061/2006) Influenza B virus (B/Taiwan/70061/2006)]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LJC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RIM:RIMANTADINE'>RIM</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RIM:RIMANTADINE'>RIM</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ljc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljc OCA], [https://pdbe.org/2ljc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ljc RCSB], [https://www.ebi.ac.uk/pdbsum/2ljc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ljc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ljc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljc OCA], [https://pdbe.org/2ljc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ljc RCSB], [https://www.ebi.ac.uk/pdbsum/2ljc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ljc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/B4UQM4_9INFB B4UQM4_9INFB] [https://www.uniprot.org/uniprot/Q9YP62_9INFA Q9YP62_9INFA] Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation (By similarity).[SAAS:SAAS002089_004_400258]		[https://www.uniprot.org/uniprot/B4UQM4_9INFB B4UQM4_9INFB] [https://www.uniprot.org/uniprot/Q9YP62_9INFA Q9YP62_9INFA] Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation (By similarity).[SAAS:SAAS002089_004_400258]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The M2 channel of influenza A is a target of the adamantane family antiviral drugs. Two different drug-binding sites have been reported: one inside the pore, and the other is a lipid-facing pocket. A previous study showed that a chimera of M2 variants from influenza A and B that contains only the pore-binding site is sensitive to amantadine inhibition, suggesting that the primary site of inhibition is inside the pore. To obtain atomic details of channel-drug interaction, we determined the structures of the chimeric channel with and without rimantadine. Inside the channel and near the N-terminal end, methyl groups of Val27 and Ala30 from four subunits form a hydrophobic pocket around the adamantane, and the drug amino group appears to be in polar contact with the backbone oxygen of Ala30. The structures also reveal differences between the drug-bound and -unbound states of the channel that can explain drug resistance.
-
-	Structural investigation of rimantadine inhibition of the AM2-BM2 chimera channel of influenza viruses.,Pielak RM, Oxenoid K, Chou JJ Structure. 2011 Nov 9;19(11):1655-63. PMID:22078564<ref>PMID:22078564</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2ljc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[M2 protein\|M2 protein]]		*[[M2 protein\|M2 protein]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:03, 15 February 2023

OCA — Wed, 15 Feb 2023 11:03:07 GMT

←Older revision		Revision as of 11:03, 15 February 2023
Line 1:		Line 1:

	==Structure of the influenza AM2-BM2 chimeric channel bound to rimantadine==		==Structure of the influenza AM2-BM2 chimeric channel bound to rimantadine==
-	<StructureSection load='2ljc' size='340' side='right'caption='[[2ljc~~]], [[NMR_Ensembles_of_Models \| 15 NMR models~~]]' scene=''>	+	<StructureSection load='2ljc' size='340' side='right'caption='[[2ljc]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ljc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Influenza_a_virus_h3n2~~ Influenza a virus ~~h3n2~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LJC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ljc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_H3N2 Influenza A virus H3N2] and [https://en.wikipedia.org/wiki/Influenza_B_virus_(B/Taiwan/70061/2006) Influenza B virus (B/Taiwan/70061/2006)]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LJC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RIM:RIMANTADINE'>RIM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RIM:RIMANTADINE'>RIM</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2rlf\|2rlf]], [[2kix\|2kix]], [[2ljb\|2ljb]], [[2kwx\|2kwx]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BM2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=41857 Influenza A virus H3N2])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ljc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljc OCA], [https://pdbe.org/2ljc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ljc RCSB], [https://www.ebi.ac.uk/pdbsum/2ljc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ljc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ljc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljc OCA], [https://pdbe.org/2ljc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ljc RCSB], [https://www.ebi.ac.uk/pdbsum/2ljc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ljc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q9YP62_9INFA Q9YP62_9INFA]] Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation (By similarity).[SAAS:SAAS002089_004_400258]	+	[https://www.uniprot.org/uniprot/B4UQM4_9INFB B4UQM4_9INFB] [https://www.uniprot.org/uniprot/Q9YP62_9INFA Q9YP62_9INFA] Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation (By similarity).[SAAS:SAAS002089_004_400258]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Influenza a virus ~~h3n2~~]]	+	[[Category: Influenza A virus H3N2]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chou~~, J J~~]]	+	[[Category: Chou JJ]]
-	[[Category: Oxenoid, K]]	+	[[Category: Oxenoid K]]
-	[[Category: Pielak~~, R M]]~~	+	[[Category: Pielak RM]]
-	~~[[Category: Drug complex]]~~	+
-	~~[[Category: M2 channel]]~~	+
-	~~[[Category: Rimantadine binding]]~~	+
-	~~[[Category: Transport protein]]~~	+
-	~~[[Category: Transport protein-inhibitor complex~~]]	+

OCA at 10:11, 12 May 2021

OCA — Wed, 12 May 2021 10:11:45 GMT

←Older revision		Revision as of 10:11, 12 May 2021
Line 1:		Line 1:

	==Structure of the influenza AM2-BM2 chimeric channel bound to rimantadine==		==Structure of the influenza AM2-BM2 chimeric channel bound to rimantadine==
-	<StructureSection load='2ljc' size='340' side='right' caption='[[2ljc]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>	+	<StructureSection load='2ljc' size='340' side='right'caption='[[2ljc]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ljc]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Influenza_a_virus_h3n2 Influenza a virus h3n2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LJC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ljc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_a_virus_h3n2 Influenza a virus h3n2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LJC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RIM:RIMANTADINE'>RIM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RIM:RIMANTADINE'>RIM</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rlf\|2rlf]], [[2kix\|2kix]], [[2ljb\|2ljb]], [[2kwx\|2kwx]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2rlf\|2rlf]], [[2kix\|2kix]], [[2ljb\|2ljb]], [[2kwx\|2kwx]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BM2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=41857 Influenza A virus H3N2])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BM2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=41857 Influenza A virus H3N2])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ljc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljc OCA], [~~http~~://pdbe.org/2ljc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ljc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ljc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ljc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ljc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljc OCA], [https://pdbe.org/2ljc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ljc RCSB], [https://www.ebi.ac.uk/pdbsum/2ljc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ljc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/Q9YP62_9INFA Q9YP62_9INFA]] Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation (By similarity).[SAAS:SAAS002089_004_400258]	+	[[https://www.uniprot.org/uniprot/Q9YP62_9INFA Q9YP62_9INFA]] Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation (By similarity).[SAAS:SAAS002089_004_400258]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Influenza a virus h3n2]]		[[Category: Influenza a virus h3n2]]
		+	[[Category: Large Structures]]
	[[Category: Chou, J J]]		[[Category: Chou, J J]]
	[[Category: Oxenoid, K]]		[[Category: Oxenoid, K]]

OCA at 19:42, 1 August 2018

OCA — Wed, 01 Aug 2018 19:42:05 GMT

←Older revision		Revision as of 19:42, 1 August 2018
Line 1:		Line 1:
		+
	==Structure of the influenza AM2-BM2 chimeric channel bound to rimantadine==		==Structure of the influenza AM2-BM2 chimeric channel bound to rimantadine==
	<StructureSection load='2ljc' size='340' side='right' caption='[[2ljc]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='2ljc' size='340' side='right' caption='[[2ljc]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rlf\|2rlf]], [[2kix\|2kix]], [[2ljb\|2ljb]], [[2kwx\|2kwx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rlf\|2rlf]], [[2kix\|2kix]], [[2ljb\|2ljb]], [[2kwx\|2kwx]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=41857 Influenza A virus H3N2])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=41857 Influenza A virus H3N2])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ljc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljc OCA], [http://pdbe.org/2ljc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ljc RCSB], [http://www.ebi.ac.uk/pdbsum/2ljc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ljc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljc OCA], [http://pdbe.org/2ljc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ljc RCSB], [http://www.ebi.ac.uk/pdbsum/2ljc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ljc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 15:19, 11 September 2015

OCA — Fri, 11 Sep 2015 15:19:51 GMT

←Older revision		Revision as of 15:19, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2ljc' size='340' side='right' caption='[[2ljc]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='2ljc' size='340' side='right' caption='[[2ljc]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ljc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Influenza_b_virus_(b/taiwan/70061/2006)~~ Influenza b virus ~~(b/taiwan/70061/2006)~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LJC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ljc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_h3n2 Influenza a virus h3n2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LJC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RIM:RIMANTADINE'>RIM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RIM:RIMANTADINE'>RIM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rlf\|2rlf]], [[2kix\|2kix]], [[2ljb\|2ljb]], [[2kwx\|2kwx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rlf\|2rlf]], [[2kix\|2kix]], [[2ljb\|2ljb]], [[2kwx\|2kwx]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~529646~~ Influenza B virus ~~(B/Taiwan/70061/2006)~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=41857 Influenza A virus H3N2])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ljc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ljc RCSB], [http://www.ebi.ac.uk/pdbsum/2ljc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ljc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljc OCA], [http://pdbe.org/2ljc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ljc RCSB], [http://www.ebi.ac.uk/pdbsum/2ljc PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2ljc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Influenza a virus h3n2]]
	[[Category: Chou, J J]]		[[Category: Chou, J J]]
	[[Category: Oxenoid, K]]		[[Category: Oxenoid, K]]

OCA at 18:18, 25 December 2014

OCA — Thu, 25 Dec 2014 18:18:10 GMT

←Older revision		Revision as of 18:18, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ljc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus_(b/taiwan/70061/2006) Influenza b virus (b/taiwan/70061/2006)]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LJC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ljc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus_(b/taiwan/70061/2006) Influenza b virus (b/taiwan/70061/2006)]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LJC FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RIM:RIMANTADINE'>RIM</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RIM:RIMANTADINE'>RIM</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rlf\|2rlf]], [[2kix\|2kix]], [[2ljb\|2ljb]], [[2kwx\|2kwx]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rlf\|2rlf]], [[2kix\|2kix]], [[2ljb\|2ljb]], [[2kwx\|2kwx]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=529646 Influenza B virus (B/Taiwan/70061/2006)])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=529646 Influenza B virus (B/Taiwan/70061/2006)])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ljc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ljc RCSB], [http://www.ebi.ac.uk/pdbsum/2ljc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ljc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ljc RCSB], [http://www.ebi.ac.uk/pdbsum/2ljc PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q9YP62_9INFA Q9YP62_9INFA]] Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation (By similarity).[SAAS:SAAS002089_004_400258]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Chou, J J.]]	+	[[Category: Chou, J J]]
-	[[Category: Oxenoid, K.]]	+	[[Category: Oxenoid, K]]
-	[[Category: Pielak, R M.]]	+	[[Category: Pielak, R M]]
	[[Category: Drug complex]]		[[Category: Drug complex]]
	[[Category: M2 channel]]		[[Category: M2 channel]]

OCA at 05:43, 29 September 2014

OCA — Mon, 29 Sep 2014 05:43:54 GMT

←Older revision		Revision as of 05:43, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2ljc.~~png~~\|~~left~~\|~~200px~~]]	+	==Structure of the influenza AM2-BM2 chimeric channel bound to rimantadine==
		+	<StructureSection load='2ljc' size='340' side='right' caption='[[2ljc]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2ljc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus_(b/taiwan/70061/2006) Influenza b virus (b/taiwan/70061/2006)]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LJC FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RIM:RIMANTADINE'>RIM</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rlf\|2rlf]], [[2kix\|2kix]], [[2ljb\|2ljb]], [[2kwx\|2kwx]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=529646 Influenza B virus (B/Taiwan/70061/2006)])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ljc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ljc RCSB], [http://www.ebi.ac.uk/pdbsum/2ljc PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The M2 channel of influenza A is a target of the adamantane family antiviral drugs. Two different drug-binding sites have been reported: one inside the pore, and the other is a lipid-facing pocket. A previous study showed that a chimera of M2 variants from influenza A and B that contains only the pore-binding site is sensitive to amantadine inhibition, suggesting that the primary site of inhibition is inside the pore. To obtain atomic details of channel-drug interaction, we determined the structures of the chimeric channel with and without rimantadine. Inside the channel and near the N-terminal end, methyl groups of Val27 and Ala30 from four subunits form a hydrophobic pocket around the adamantane, and the drug amino group appears to be in polar contact with the backbone oxygen of Ala30. The structures also reveal differences between the drug-bound and -unbound states of the channel that can explain drug resistance.

-	~~{{STRUCTURE_2ljc\| PDB=2ljc \| SCENE= }}~~	+	Structural investigation of rimantadine inhibition of the AM2-BM2 chimera channel of influenza viruses.,Pielak RM, Oxenoid K, Chou JJ Structure. 2011 Nov 9;19(11):1655-63. PMID:22078564<ref>PMID:22078564</ref>

-	~~===Structure~~ of the ~~influenza AM2-BM2 chimeric channel bound to rimantadine===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22078564}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2ljc]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Influenza_b_virus_(b/taiwan/70061/2006) Influenza b virus (b/taiwan/70061/2006)]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2LJC OCA].~~	+

	==See Also==		==See Also==
	*[[M2 protein\|M2 protein]]		*[[M2 protein\|M2 protein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:022078564<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Chou, J J.]]		[[Category: Chou, J J.]]
	[[Category: Oxenoid, K.]]		[[Category: Oxenoid, K.]]

OCA at 19:53, 20 October 2012

OCA — Sat, 20 Oct 2012 19:53:30 GMT

←Older revision		Revision as of 19:53, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2ljc]] is a 4 chain structure ~~of [[M2 protein]]~~ with sequence from [http://en.wikipedia.org/wiki/~~Influenza_a_virus,_influenza_b_virus~~ Influenza ~~a virus, influenza~~ b virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJC OCA].	+	[[2ljc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus_(b/taiwan/70061/2006) Influenza b virus (b/taiwan/70061/2006)]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJC OCA].

	==See Also==		==See Also==
Line 15:		Line 15:
	==Reference==		==Reference==
	<ref group="xtra">PMID:022078564</ref><references group="xtra"/>		<ref group="xtra">PMID:022078564</ref><references group="xtra"/>
-	[[Category: Influenza a virus, influenza b virus]]
	[[Category: Chou, J J.]]		[[Category: Chou, J J.]]
	[[Category: Oxenoid, K.]]		[[Category: Oxenoid, K.]]

OCA at 08:48, 27 July 2012

OCA — Fri, 27 Jul 2012 08:48:14 GMT

←Older revision		Revision as of 08:48, 27 July 2012
Line 1:		Line 1:
	[[Image:2ljc.png\|left\|200px]]		[[Image:2ljc.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2ljc", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2ljc\| PDB=2ljc \| SCENE= }}		{{STRUCTURE_2ljc\| PDB=2ljc \| SCENE= }}

	===Structure of the influenza AM2-BM2 chimeric channel bound to rimantadine===		===Structure of the influenza AM2-BM2 chimeric channel bound to rimantadine===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22078564}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22078564 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_22078564}}		{{ABSTRACT_PUBMED_22078564}}

	==About this Structure==		==About this Structure==
-	[[2ljc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus,_influenza_b_virus Influenza a virus, influenza b virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJC OCA].	+	[[2ljc]] is a 4 chain structure of [[M2 protein]] with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus,_influenza_b_virus Influenza a virus, influenza b virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJC OCA].
		+
		+	==See Also==
		+	*[[M2 protein\|M2 protein]]

	==Reference==		==Reference==

OCA at 06:54, 21 March 2012

OCA — Wed, 21 Mar 2012 06:54:29 GMT

←Older revision		Revision as of 06:54, 21 March 2012
Line 11:		Line 11:
	===Structure of the influenza AM2-BM2 chimeric channel bound to rimantadine===		===Structure of the influenza AM2-BM2 chimeric channel bound to rimantadine===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22078564}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22078564 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22078564}}

	==About this Structure==		==About this Structure==
	[[2ljc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus,_influenza_b_virus Influenza a virus, influenza b virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJC OCA].		[[2ljc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus,_influenza_b_virus Influenza a virus, influenza b virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJC OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022078564</ref><references group="xtra"/>
	[[Category: Influenza a virus, influenza b virus]]		[[Category: Influenza a virus, influenza b virus]]
	[[Category: Chou, J J.]]		[[Category: Chou, J J.]]