2lkj - Revision history

OCA at 12:16, 15 November 2023

OCA — Wed, 15 Nov 2023 12:16:55 GMT

←Older revision		Revision as of 12:16, 15 November 2023
Line 1:		Line 1:

	==Structures and Interaction Analyses of the Integrin Alpha-M Beta-2 Cytoplasmic Tails==		==Structures and Interaction Analyses of the Integrin Alpha-M Beta-2 Cytoplasmic Tails==
-	<StructureSection load='2lkj' size='340' side='right'caption='[[2lkj~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2lkj' size='340' side='right'caption='[[2lkj]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lkj]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LKJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lkj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LKJ FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=SEP:PHOSPHOSERINE'>SEP</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2lke\|2lke]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lkj OCA], [https://pdbe.org/2lkj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lkj RCSB], [https://www.ebi.ac.uk/pdbsum/2lkj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lkj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lkj OCA], [https://pdbe.org/2lkj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lkj RCSB], [https://www.ebi.ac.uk/pdbsum/2lkj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lkj ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:[https://omim.org/entry/609939 609939]]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.	+	[https://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:[https://omim.org/entry/609939 609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.	+	[https://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Amalraj, M]]	+	[[Category: Amalraj M]]
-	[[Category: Bhattacharjya, S]]	+	[[Category: Bhattacharjya S]]
-	[[Category: Chua~~, G L~~]]	+	[[Category: Chua GL]]
-	[[Category: Tan~~, S M~~]]	+	[[Category: Tan SM]]
-	[[Category: Tang~~, X Y]]~~	+	[[Category: Tang XY]]
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Cytoplasmic]]~~	+
-	~~[[Category: Dpc micelle]]~~	+
-	~~[[Category: Mac-1 alpha]]~~	+
-	~~[[Category: Myristoylated]]~~	+
-	~~[[Category: Serine phosphorylated~~]]	+

OCA at 07:52, 9 February 2022

OCA — Wed, 09 Feb 2022 07:52:40 GMT

OCA at 07:05, 6 May 2020

OCA — Wed, 06 May 2020 07:05:59 GMT

←Older revision		Revision as of 07:05, 6 May 2020
Line 1:		Line 1:

	==Structures and Interaction Analyses of the Integrin Alpha-M Beta-2 Cytoplasmic Tails==		==Structures and Interaction Analyses of the Integrin Alpha-M Beta-2 Cytoplasmic Tails==
-	<StructureSection load='2lkj' size='340' side='right' caption='[[2lkj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2lkj' size='340' side='right'caption='[[2lkj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lkj]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKJ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LKJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lkj]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2LKJ FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lke\|2lke]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lke\|2lke]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2lkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lkj OCA], [http://pdbe.org/2lkj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lkj RCSB], [http://www.ebi.ac.uk/pdbsum/2lkj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lkj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2lkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lkj OCA], [http://pdbe.org/2lkj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lkj RCSB], [http://www.ebi.ac.uk/pdbsum/2lkj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lkj ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Integrin\|Integrin]]	+	*[[Integrin 3D structures\|Integrin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Amalraj, M]]		[[Category: Amalraj, M]]
	[[Category: Bhattacharjya, S]]		[[Category: Bhattacharjya, S]]

OCA at 20:05, 1 August 2018

OCA — Wed, 01 Aug 2018 20:05:16 GMT

←Older revision		Revision as of 20:05, 1 August 2018
Line 1:		Line 1:
		+
	==Structures and Interaction Analyses of the Integrin Alpha-M Beta-2 Cytoplasmic Tails==		==Structures and Interaction Analyses of the Integrin Alpha-M Beta-2 Cytoplasmic Tails==
	<StructureSection load='2lkj' size='340' side='right' caption='[[2lkj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lkj' size='340' side='right' caption='[[2lkj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lke\|2lke]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lke\|2lke]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lkj OCA], [http://pdbe.org/2lkj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lkj RCSB], [http://www.ebi.ac.uk/pdbsum/2lkj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lkj OCA], [http://pdbe.org/2lkj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lkj RCSB], [http://www.ebi.ac.uk/pdbsum/2lkj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lkj ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 04:27, 10 September 2015

OCA — Thu, 10 Sep 2015 04:27:36 GMT

←Older revision		Revision as of 04:27, 10 September 2015
Line 5:		Line 5:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lke\|2lke]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lke\|2lke]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lkj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lkj RCSB], [http://www.ebi.ac.uk/pdbsum/2lkj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lkj OCA], [http://pdbe.org/2lkj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lkj RCSB], [http://www.ebi.ac.uk/pdbsum/2lkj PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2lkj" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 12:49, 18 December 2014

OCA — Thu, 18 Dec 2014 12:49:43 GMT

←Older revision		Revision as of 12:49, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2lkj\| PDB=2lkj \| SCENE= }}~~	+	==Structures and Interaction Analyses of the Integrin Alpha-M Beta-2 Cytoplasmic Tails==
-	===Structures and Interaction Analyses of the Integrin Alpha-M Beta-2 Cytoplasmic Tails===	+	<StructureSection load='2lkj' size='340' side='right' caption='[[2lkj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_22052909}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2lkj]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LKJ FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lke\|2lke]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lkj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lkj RCSB], [http://www.ebi.ac.uk/pdbsum/2lkj PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:[http://omim.org/entry/609939 609939]]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.		[[http://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:[http://omim.org/entry/609939 609939]]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Integrins are hetero-dimeric (alpha and beta subunits) signal transducer proteins involved in cell adhesions and migrations. The cytosolic tails of integrins are essential for transmitting bi-directional signaling and also implicated in maintaining the resting states of the receptors. In addition, cytosolic tails of integrin often undergo post-translation modification like phosphorylation. However, consequences of phosphorylation on the structures and interactions are not clear. The leukocyte-specific integrin alphaMbeta2 is essential for myeloid cell adhesion, phagocytosis and degranulation. In this work, we determine solution structures of myristoylated cytosolic tail of alphaM and a Ser phosphorylated variant in DPC micelles by NMR spectroscopy. Further, the interactions between alphaM tails, non phosphorylated and phosphorylated, with beta2 tail are investigated by NMR and fluorescence resonance energy transfer (FRET). The 3D structures of the 24-residue cytosolic tail of alphaM or phosphorylated alphaM are characterized by an N-terminal amphipathic helix and a loop at the C-terminus. The residues at the loop contain packing interactions with the hydrophobic face of the helix. 15N-1H HSQC experiments identify residues of alphaM and beta2 tails, those may be involved in formation of tail-tail hetero-complex. We have further examined interactions between myristoylated beta2 tail, in DPC micelles, with dansylated alphaM tail peptides by FRET. These studies reveal enhanced interactions between alphaM or phosphorylated alphaM tails with beta2 tail with Kd ~ 5.2+0.6 alphaM and Kd ~4.4+0.7 alphaM, respectively. Docked structures of tail/tail complexes delineated that alphaM/beta2 interface at the cytosolic region could be sustained by a network of polar interactions, ionic and/or hydrogen bonds.

-	~~==Function==~~	+	Structures and interaction analyses of the integrin alphaMbeta2 cytoplasmic tails.,Chua GL, Tang XY, Amalraj M, Tan SM, Bhattacharjya S J Biol Chem. 2011 Nov 3. PMID:22052909<ref>PMID:22052909</ref>
-	~~[[http://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Integrin alpha-M/beta-2 is implicated in various adhesive interactions~~ of ~~monocytes, macrophages and granulocytes as well as in mediating~~ the ~~uptake of complement-coated particles~~. ~~It is identical with CR-3~~, ~~the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-~~M~~/beta-2 is also a receptor for fibrinogen~~, ~~factor X and ICAM1~~. ~~It recognizes P1 and P2 peptides of fibrinogen gamma chain~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2lkj]] is~~ a ~~1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2LKJ OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:022052909</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Integrin\|Integrin]]
-	[[Category: Amalraj, M.]]	+	== References ==
-	[[Category: Bhattacharjya, S.]]	+	<references/>
-	[[Category: Chua, G L.]]	+	__TOC__
-	[[Category: Tan, S M.]]	+	</StructureSection>
-	[[Category: Tang, X Y.]]	+	[[Category: Amalraj, M]]
		+	[[Category: Bhattacharjya, S]]
		+	[[Category: Chua, G L]]
		+	[[Category: Tan, S M]]
		+	[[Category: Tang, X Y]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Cytoplasmic]]		[[Category: Cytoplasmic]]

OCA at 23:35, 24 March 2013

OCA — Sun, 24 Mar 2013 23:35:00 GMT

←Older revision		Revision as of 23:35, 24 March 2013
Line 1:		Line 1:
-	[[Image:2lkj.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_2lkj", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2lkj\| PDB=2lkj \| SCENE= }}		{{STRUCTURE_2lkj\| PDB=2lkj \| SCENE= }}
-
	===Structures and Interaction Analyses of the Integrin Alpha-M Beta-2 Cytoplasmic Tails===		===Structures and Interaction Analyses of the Integrin Alpha-M Beta-2 Cytoplasmic Tails===
		+	{{ABSTRACT_PUBMED_22052909}}

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:[http://omim.org/entry/609939 609939]]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.

-	~~<!--~~	+	==Function==
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22052909}}, adds the Publication Abstract to the page~~	+	[[http://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov)~~, ~~where 22052909~~ is the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_22052909}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:022052909</ref><references group="xtra"/>	+	<ref group="xtra">PMID:022052909</ref><references group="xtra"/><references/>
	[[Category: Amalraj, M.]]		[[Category: Amalraj, M.]]
	[[Category: Bhattacharjya, S.]]		[[Category: Bhattacharjya, S.]]

OCA at 11:19, 16 November 2011

OCA — Wed, 16 Nov 2011 11:19:59 GMT

←Older revision		Revision as of 11:19, 16 November 2011
Line 1:		Line 1:
-	[[Image:2lkj.~~jpg~~\|left\|200px]]	+	[[Image:2lkj.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===Structures and Interaction Analyses of the Integrin Alpha-M Beta-2 Cytoplasmic Tails===		===Structures and Interaction Analyses of the Integrin Alpha-M Beta-2 Cytoplasmic Tails===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22052909}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22052909 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22052909}}

	==About this Structure==		==About this Structure==
	[[2lkj]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKJ OCA].		[[2lkj]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKJ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022052909</ref><references group="xtra"/>
	[[Category: Amalraj, M.]]		[[Category: Amalraj, M.]]
	[[Category: Bhattacharjya, S.]]		[[Category: Bhattacharjya, S.]]

OCA at 08:27, 2 November 2011

OCA — Wed, 02 Nov 2011 08:27:33 GMT

←Older revision		Revision as of 08:27, 2 November 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2lkj.jpg\|left\|200px]]

-	The ~~entry 2lkj~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2lkj", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2lkj\| PDB=2lkj \| SCENE= }}

-	~~Authors: Chua, G.L., Tang, X.Y., Amalraj,~~ M~~., Tan, S.M., Bhattacharjya, S.~~	+	===Structures and Interaction Analyses of the Integrin Alpha-M Beta-2 Cytoplasmic Tails===

-	~~Description: Solution~~ structure ~~of myristoylated alpha~~ M ~~S14~~-phosphorylated	+
		+	==About this Structure==
		+	[[2lkj]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKJ OCA].
		+	[[Category: Amalraj, M.]]
		+	[[Category: Bhattacharjya, S.]]
		+	[[Category: Chua, G L.]]
		+	[[Category: Tan, S M.]]
		+	[[Category: Tang, X Y.]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Cytoplasmic]]
		+	[[Category: Dpc micelle]]
		+	[[Category: Mac-1 alpha]]
		+	[[Category: Myristoylated]]
		+	[[Category: Serine phosphorylated]]

OCA: Protected "2lkj" [edit=sysop:move=sysop]

OCA — Sun, 30 Oct 2011 08:28:25 GMT

Protected "2lkj" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:28, 30 October 2011

←Older revision		Revision as of 07:52, 9 February 2022
Line 3:		Line 3:
	<StructureSection load='2lkj' size='340' side='right'caption='[[2lkj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lkj' size='340' side='right'caption='[[2lkj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lkj]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2LKJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lkj]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LKJ FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lke\|2lke]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2lke\|2lke]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2lkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lkj OCA], [~~http~~://pdbe.org/2lkj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2lkj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2lkj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2lkj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lkj OCA], [https://pdbe.org/2lkj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lkj RCSB], [https://www.ebi.ac.uk/pdbsum/2lkj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lkj ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:[~~http~~://omim.org/entry/609939 609939]]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.	+	[[https://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:[https://omim.org/entry/609939 609939]]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.	+	[[https://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==