2lnk - Revision history

OCA at 05:47, 15 May 2024

OCA — Wed, 15 May 2024 05:47:07 GMT

←Older revision		Revision as of 05:47, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lnk]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LNK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lnk]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LNK FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lnk OCA], [https://pdbe.org/2lnk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lnk RCSB], [https://www.ebi.ac.uk/pdbsum/2lnk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lnk ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lnk OCA], [https://pdbe.org/2lnk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lnk RCSB], [https://www.ebi.ac.uk/pdbsum/2lnk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lnk ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 11:09, 15 February 2023

OCA — Wed, 15 Feb 2023 11:09:16 GMT

←Older revision		Revision as of 11:09, 15 February 2023
Line 1:		Line 1:

	==Solution structure of Ca-bound S100A4 in complex with non-muscle myosin IIA==		==Solution structure of Ca-bound S100A4 in complex with non-muscle myosin IIA==
-	<StructureSection load='2lnk' size='340' side='right'caption='[[2lnk~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2lnk' size='340' side='right'caption='[[2lnk]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lnk]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LNK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lnk]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LNK FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S100A4, CAPL, MTS1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lnk OCA], [https://pdbe.org/2lnk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lnk RCSB], [https://www.ebi.ac.uk/pdbsum/2lnk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lnk ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lnk OCA], [https://pdbe.org/2lnk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lnk RCSB], [https://www.ebi.ac.uk/pdbsum/2lnk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lnk ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/MYH9_HUMAN MYH9_HUMAN]] MYH9-related thrombocytopenia;Autosomal dominant nonsyndromic sensorineural deafness type DFNA. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Subjects with mutations in the motor domain of MYH9 present with severe thrombocytopenia and develop nephritis and deafness before the age of 40 years, while those with mutations in the tail domain have a much lower risk of noncongenital complications and significantly higher platelet counts. The clinical course of patients with mutations in the four most frequently affected residues of MYH9 (responsible for 70% of MYH9-related cases) were evaluated. Mutations at residue 1933 do not induce kidney damage or cataracts and cause deafness only in the elderly, those in position 702 result in severe thrombocytopenia and produce nephritis and deafness at a juvenile age, while alterations at residue 1424 or 1841 result in intermediate clinical pictures. Genetic variations in MYH9 are associated with non-diabetic end stage renal disease (ESRD).	+	[https://www.uniprot.org/uniprot/MYH9_HUMAN MYH9_HUMAN] MYH9-related thrombocytopenia;Autosomal dominant nonsyndromic sensorineural deafness type DFNA. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Subjects with mutations in the motor domain of MYH9 present with severe thrombocytopenia and develop nephritis and deafness before the age of 40 years, while those with mutations in the tail domain have a much lower risk of noncongenital complications and significantly higher platelet counts. The clinical course of patients with mutations in the four most frequently affected residues of MYH9 (responsible for 70% of MYH9-related cases) were evaluated. Mutations at residue 1933 do not induce kidney damage or cataracts and cause deafness only in the elderly, those in position 702 result in severe thrombocytopenia and produce nephritis and deafness at a juvenile age, while alterations at residue 1424 or 1841 result in intermediate clinical pictures. Genetic variations in MYH9 are associated with non-diabetic end stage renal disease (ESRD).
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MYH9_HUMAN MYH9_HUMAN]] Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10.<ref>PMID:20052411</ref>	+	[https://www.uniprot.org/uniprot/MYH9_HUMAN MYH9_HUMAN] Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10.<ref>PMID:20052411</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Barsukov~~, I L~~]]	+	[[Category: Barsukov IL]]
-	[[Category: Elliott~~, P R]]~~	+	[[Category: Elliott PR]]
-	~~[[Category: All alpha]]~~	+
-	~~[[Category: Calcium binding]]~~	+
-	~~[[Category: Calcium binding protein]]~~	+
-	~~[[Category: Ef-hand]]~~	+
-	~~[[Category: Metal binding protein~~]]	+

OCA at 10:14, 12 May 2021

OCA — Wed, 12 May 2021 10:14:28 GMT

←Older revision		Revision as of 10:14, 12 May 2021
Line 1:		Line 1:

	==Solution structure of Ca-bound S100A4 in complex with non-muscle myosin IIA==		==Solution structure of Ca-bound S100A4 in complex with non-muscle myosin IIA==
-	<StructureSection load='2lnk' size='340' side='right' caption='[[2lnk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2lnk' size='340' side='right'caption='[[2lnk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lnk]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LNK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lnk]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LNK FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S100A4, CAPL, MTS1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S100A4, CAPL, MTS1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2lnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lnk OCA], [~~http~~://pdbe.org/2lnk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2lnk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2lnk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2lnk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lnk OCA], [https://pdbe.org/2lnk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lnk RCSB], [https://www.ebi.ac.uk/pdbsum/2lnk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lnk ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/MYH9_HUMAN MYH9_HUMAN]] MYH9-related thrombocytopenia;Autosomal dominant nonsyndromic sensorineural deafness type DFNA. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Subjects with mutations in the motor domain of MYH9 present with severe thrombocytopenia and develop nephritis and deafness before the age of 40 years, while those with mutations in the tail domain have a much lower risk of noncongenital complications and significantly higher platelet counts. The clinical course of patients with mutations in the four most frequently affected residues of MYH9 (responsible for 70% of MYH9-related cases) were evaluated. Mutations at residue 1933 do not induce kidney damage or cataracts and cause deafness only in the elderly, those in position 702 result in severe thrombocytopenia and produce nephritis and deafness at a juvenile age, while alterations at residue 1424 or 1841 result in intermediate clinical pictures. Genetic variations in MYH9 are associated with non-diabetic end stage renal disease (ESRD).	+	[[https://www.uniprot.org/uniprot/MYH9_HUMAN MYH9_HUMAN]] MYH9-related thrombocytopenia;Autosomal dominant nonsyndromic sensorineural deafness type DFNA. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Subjects with mutations in the motor domain of MYH9 present with severe thrombocytopenia and develop nephritis and deafness before the age of 40 years, while those with mutations in the tail domain have a much lower risk of noncongenital complications and significantly higher platelet counts. The clinical course of patients with mutations in the four most frequently affected residues of MYH9 (responsible for 70% of MYH9-related cases) were evaluated. Mutations at residue 1933 do not induce kidney damage or cataracts and cause deafness only in the elderly, those in position 702 result in severe thrombocytopenia and produce nephritis and deafness at a juvenile age, while alterations at residue 1424 or 1841 result in intermediate clinical pictures. Genetic variations in MYH9 are associated with non-diabetic end stage renal disease (ESRD).
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MYH9_HUMAN MYH9_HUMAN]] Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10.<ref>PMID:20052411</ref>	+	[[https://www.uniprot.org/uniprot/MYH9_HUMAN MYH9_HUMAN]] Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10.<ref>PMID:20052411</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Myosin\|Myosin]]	+	*[[Myosin 3D Structures\|Myosin 3D Structures]]
-	*[[S100 ~~protein~~\|S100 ~~protein~~]]	+	*[[S100 proteins 3D structures\|S100 proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Barsukov, I L]]		[[Category: Barsukov, I L]]
	[[Category: Elliott, P R]]		[[Category: Elliott, P R]]

OCA at 19:32, 1 August 2018

OCA — Wed, 01 Aug 2018 19:32:16 GMT

←Older revision		Revision as of 19:32, 1 August 2018
Line 1:		Line 1:
		+
	==Solution structure of Ca-bound S100A4 in complex with non-muscle myosin IIA==		==Solution structure of Ca-bound S100A4 in complex with non-muscle myosin IIA==
	<StructureSection load='2lnk' size='340' side='right' caption='[[2lnk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lnk' size='340' side='right' caption='[[2lnk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2lnk]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LNK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lnk]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LNK FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S100A4, CAPL, MTS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S100A4, CAPL, MTS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lnk OCA], [http://pdbe.org/2lnk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lnk RCSB], [http://www.ebi.ac.uk/pdbsum/2lnk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lnk OCA], [http://pdbe.org/2lnk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lnk RCSB], [http://www.ebi.ac.uk/pdbsum/2lnk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lnk ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 14:27, 11 September 2015

OCA — Fri, 11 Sep 2015 14:27:26 GMT

←Older revision		Revision as of 14:27, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2lnk' size='340' side='right' caption='[[2lnk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lnk' size='340' side='right' caption='[[2lnk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lnk]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LNK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lnk]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LNK FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S100A4, CAPL, MTS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S100A4, CAPL, MTS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lnk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lnk RCSB], [http://www.ebi.ac.uk/pdbsum/2lnk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lnk OCA], [http://pdbe.org/2lnk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lnk RCSB], [http://www.ebi.ac.uk/pdbsum/2lnk PDBsum]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/MYH9_HUMAN MYH9_HUMAN]] MYH9-related thrombocytopenia;Autosomal dominant nonsyndromic sensorineural deafness type DFNA. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Subjects with mutations in the motor domain of MYH9 present with severe thrombocytopenia and develop nephritis and deafness before the age of 40 years, while those with mutations in the tail domain have a much lower risk of noncongenital complications and significantly higher platelet counts. The clinical course of patients with mutations in the four most frequently affected residues of MYH9 (responsible for 70% of MYH9-related cases) were evaluated. Mutations at residue 1933 do not induce kidney damage or cataracts and cause deafness only in the elderly, those in position 702 result in severe thrombocytopenia and produce nephritis and deafness at a juvenile age, while alterations at residue 1424 or 1841 result in intermediate clinical pictures. Genetic variations in MYH9 are associated with non-diabetic end stage renal disease (ESRD).
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MYH9_HUMAN MYH9_HUMAN]] Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10.<ref>PMID:20052411</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2lnk" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 22:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Barsukov, I L]]		[[Category: Barsukov, I L]]
	[[Category: Elliott, P R]]		[[Category: Elliott, P R]]

OCA at 15:13, 19 January 2015

OCA — Mon, 19 Jan 2015 15:13:45 GMT

←Older revision		Revision as of 15:13, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lnk]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LNK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lnk]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LNK FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S100A4, CAPL, MTS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S100A4, CAPL, MTS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lnk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lnk RCSB], [http://www.ebi.ac.uk/pdbsum/2lnk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lnk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lnk RCSB], [http://www.ebi.ac.uk/pdbsum/2lnk PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Barsukov, I L.]]	+	[[Category: Barsukov, I L]]
-	[[Category: Elliott, P R.]]	+	[[Category: Elliott, P R]]
	[[Category: All alpha]]		[[Category: All alpha]]
	[[Category: Calcium binding]]		[[Category: Calcium binding]]

OCA at 05:05, 29 September 2014

OCA — Mon, 29 Sep 2014 05:05:26 GMT

←Older revision		Revision as of 05:05, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2lnk.~~png~~\|~~left\|200px~~]]	+	==Solution structure of Ca-bound S100A4 in complex with non-muscle myosin IIA==
		+	<StructureSection load='2lnk' size='340' side='right' caption='[[2lnk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2lnk]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LNK FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S100A4, CAPL, MTS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lnk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lnk RCSB], [http://www.ebi.ac.uk/pdbsum/2lnk PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Filament assembly of nonmuscle myosin IIA (NMIIA) is selectively regulated by the small Ca(2+)-binding protein, S100A4, which causes enhanced cell migration and metastasis in certain cancers. Our NMR structure shows that an S100A4 dimer binds to a single myosin heavy chain in an asymmetrical configuration. NMIIA in the complex forms a continuous helix that stretches across the surface of S100A4 and engages the Ca(2+)-dependent binding sites of each subunit in the dimer. Synergy between these sites leads to a very tight association (K(D) approximately 1 nM) that is unique in the S100 family. Single-residue mutations that remove this synergy weaken binding and ameliorate the effects of S100A4 on NMIIA filament assembly and cell spreading in A431 human epithelial carcinoma cells. We propose a model for NMIIA filament disassembly by S100A4 in which initial binding to the unstructured NMIIA tail initiates unzipping of the coiled coil and disruption of filament packing.

-	~~{{STRUCTURE_2lnk\| PDB=2lnk \| SCENE= }}~~	+	Asymmetric Mode of Ca(2+)-S100A4 Interaction with Nonmuscle Myosin IIA Generates Nanomolar Affinity Required for Filament Remodeling.,Elliott PR, Irvine AF, Jung HS, Tozawa K, Pastok MW, Picone R, Badyal SK, Basran J, Rudland PS, Barraclough R, Lian LY, Bagshaw CR, Kriajevska M, Barsukov IL Structure. 2012 Apr 4;20(4):654-66. Epub 2012 Apr 3. PMID:22483112<ref>PMID:22483112</ref>

-	~~===Solution structure~~ of ~~Ca-bound S100A4 in complex with non-muscle myosin IIA===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22483112}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2lnk]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2LNK OCA].~~	+

	==See Also==		==See Also==
	*[[Myosin\|Myosin]]		*[[Myosin\|Myosin]]
-		+	*[[S100 protein\|S100 protein]]
-	==~~Reference~~==	+	== References ==
-	<~~ref group="xtra">PMID:022483112<~~/~~ref~~><~~references group="xtra"~~/>	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Barsukov, I L.]]		[[Category: Barsukov, I L.]]

OCA at 19:35, 20 October 2012

OCA — Sat, 20 Oct 2012 19:35:09 GMT

←Older revision		Revision as of 19:35, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2lnk]] is a 3 chain structure ~~of [[Myosin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNK OCA].	+	[[2lnk]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNK OCA].

	==See Also==		==See Also==

OCA at 07:50, 27 July 2012

OCA — Fri, 27 Jul 2012 07:50:03 GMT

←Older revision		Revision as of 07:50, 27 July 2012
Line 1:		Line 1:
-	[[Image:2lnk.~~jpg~~\|left\|200px]]	+	[[Image:2lnk.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2lnk", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2lnk\| PDB=2lnk \| SCENE= }}		{{STRUCTURE_2lnk\| PDB=2lnk \| SCENE= }}

	===Solution structure of Ca-bound S100A4 in complex with non-muscle myosin IIA===		===Solution structure of Ca-bound S100A4 in complex with non-muscle myosin IIA===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22483112}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22483112 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_22483112}}		{{ABSTRACT_PUBMED_22483112}}

	==About this Structure==		==About this Structure==
-	[[2lnk]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNK OCA].	+	[[2lnk]] is a 3 chain structure of [[Myosin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNK OCA].
		+
		+	==See Also==
		+	*[[Myosin\|Myosin]]

	==Reference==		==Reference==

OCA at 09:15, 25 April 2012

OCA — Wed, 25 Apr 2012 09:15:25 GMT

←Older revision		Revision as of 09:15, 25 April 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2lnk.jpg\|left\|200px]]

-	The ~~entry 2lnk~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2lnk", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2lnk\| PDB=2lnk \| SCENE= }}

-	~~Authors: Barsukov, I.L., Elliott, P.R.~~	+	===Solution structure of Ca-bound S100A4 in complex with non-muscle myosin IIA===

-	~~Description~~: ~~Solution structure of Ca~~-~~bound S100A4 in complex~~ with ~~non~~-~~muscle myosin IIA~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22483112}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22483112 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22483112}}
		+
		+	==About this Structure==
		+	[[2lnk]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNK OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022483112</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Barsukov, I L.]]
		+	[[Category: Elliott, P R.]]
		+	[[Category: All alpha]]
		+	[[Category: Calcium binding]]
		+	[[Category: Calcium binding protein]]
		+	[[Category: Ef-hand]]
		+	[[Category: Metal binding protein]]