2lox - Revision history

OCA at 05:48, 15 May 2024

OCA — Wed, 15 May 2024 05:48:13 GMT

←Older revision		Revision as of 05:48, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lox]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LOX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lox]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LOX FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lox OCA], [https://pdbe.org/2lox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lox RCSB], [https://www.ebi.ac.uk/pdbsum/2lox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lox ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lox OCA], [https://pdbe.org/2lox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lox RCSB], [https://www.ebi.ac.uk/pdbsum/2lox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lox ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 11:11, 15 February 2023

OCA — Wed, 15 Feb 2023 11:11:14 GMT

←Older revision		Revision as of 11:11, 15 February 2023
Line 1:		Line 1:

	==NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and Rad2==		==NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and Rad2==
-	<StructureSection load='2lox' size='340' side='right'caption='[[2lox~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2lox' size='340' side='right'caption='[[2lox]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lox]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Baker's_yeast Baker's yeast~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LOX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lox]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LOX FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2gs0\|2gs0]], [[2l2i\|2l2i]], [[1y5o\|1y5o]], [[2k2u\|2k2u]]</div></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lox OCA], [https://pdbe.org/2lox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lox RCSB], [https://www.ebi.ac.uk/pdbsum/2lox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lox ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">D9740.3, TFB1, YDR311W ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), RAD2, YGR258C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lox OCA], [https://pdbe.org/2lox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lox RCSB], [https://www.ebi.ac.uk/pdbsum/2lox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lox ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TFB1_YEAST TFB1_YEAST]] Acts as component of the general transcription and DNA repair factor IIH (TFIIH) core, which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro.<ref>PMID:7961739</ref> <ref>PMID:8631896</ref> [[https://www.uniprot.org/uniprot/RAD2_YEAST RAD2_YEAST]] Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair.<ref>PMID:8247134</ref>	+	[https://www.uniprot.org/uniprot/TFB1_YEAST TFB1_YEAST] Acts as component of the general transcription and DNA repair factor IIH (TFIIH) core, which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro.<ref>PMID:7961739</ref> <ref>PMID:8631896</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Baker's yeast]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lafrance-Vanasse, J]]	+	[[Category: Saccharomyces cerevisiae S288C]]
-	[[Category: Legault, P]]	+	[[Category: Lafrance-Vanasse J]]
-	[[Category: Omichinski, J]]	+	[[Category: Legault P]]
-	~~[[Category: Transcription-hydrolase complex~~]]	+	[[Category: Omichinski J]]

OCA at 10:15, 12 May 2021

OCA — Wed, 12 May 2021 10:15:22 GMT

←Older revision		Revision as of 10:15, 12 May 2021
Line 1:		Line 1:

	==NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and Rad2==		==NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and Rad2==
-	<StructureSection load='2lox' size='340' side='right' caption='[[2lox]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2lox' size='340' side='right'caption='[[2lox]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lox]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LOX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LOX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lox]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LOX FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gs0\|2gs0]], [[2l2i\|2l2i]], [[1y5o\|1y5o]], [[2k2u\|2k2u]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2gs0\|2gs0]], [[2l2i\|2l2i]], [[1y5o\|1y5o]], [[2k2u\|2k2u]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">D9740.3, TFB1, YDR311W ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), RAD2, YGR258C ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">D9740.3, TFB1, YDR311W ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), RAD2, YGR258C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2lox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lox OCA], [~~http~~://pdbe.org/2lox PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2lox RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2lox PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2lox ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lox OCA], [https://pdbe.org/2lox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lox RCSB], [https://www.ebi.ac.uk/pdbsum/2lox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lox ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TFB1_YEAST TFB1_YEAST]] Acts as component of the general transcription and DNA repair factor IIH (TFIIH) core, which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro.<ref>PMID:7961739</ref> <ref>PMID:8631896</ref> [[~~http~~://www.uniprot.org/uniprot/RAD2_YEAST RAD2_YEAST]] Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair.<ref>PMID:8247134</ref>	+	[[https://www.uniprot.org/uniprot/TFB1_YEAST TFB1_YEAST]] Acts as component of the general transcription and DNA repair factor IIH (TFIIH) core, which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro.<ref>PMID:7961739</ref> <ref>PMID:8631896</ref> [[https://www.uniprot.org/uniprot/RAD2_YEAST RAD2_YEAST]] Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair.<ref>PMID:8247134</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Baker's yeast]]		[[Category: Baker's yeast]]
		+	[[Category: Large Structures]]
	[[Category: Lafrance-Vanasse, J]]		[[Category: Lafrance-Vanasse, J]]
	[[Category: Legault, P]]		[[Category: Legault, P]]
	[[Category: Omichinski, J]]		[[Category: Omichinski, J]]
	[[Category: Transcription-hydrolase complex]]		[[Category: Transcription-hydrolase complex]]

OCA at 19:20, 1 August 2018

OCA — Wed, 01 Aug 2018 19:20:54 GMT

←Older revision		Revision as of 19:20, 1 August 2018
Line 1:		Line 1:
		+
	==NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and Rad2==		==NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and Rad2==
	<StructureSection load='2lox' size='340' side='right' caption='[[2lox]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lox' size='340' side='right' caption='[[2lox]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gs0\|2gs0]], [[2l2i\|2l2i]], [[1y5o\|1y5o]], [[2k2u\|2k2u]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gs0\|2gs0]], [[2l2i\|2l2i]], [[1y5o\|1y5o]], [[2k2u\|2k2u]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">D9740.3, TFB1, YDR311W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), RAD2, YGR258C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">D9740.3, TFB1, YDR311W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), RAD2, YGR258C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lox OCA], [http://pdbe.org/2lox PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lox RCSB], [http://www.ebi.ac.uk/pdbsum/2lox PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lox OCA], [http://pdbe.org/2lox PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lox RCSB], [http://www.ebi.ac.uk/pdbsum/2lox PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lox ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 23:06, 10 September 2015

OCA — Thu, 10 Sep 2015 23:06:35 GMT

←Older revision		Revision as of 23:06, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2lox' size='340' side='right' caption='[[2lox]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lox' size='340' side='right' caption='[[2lox]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lox]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LOX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LOX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lox]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LOX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LOX FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gs0\|2gs0]], [[2l2i\|2l2i]], [[1y5o\|1y5o]], [[2k2u\|2k2u]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gs0\|2gs0]], [[2l2i\|2l2i]], [[1y5o\|1y5o]], [[2k2u\|2k2u]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">D9740.3, TFB1, YDR311W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~4932 Saccharomyces cerevisiae~~]), RAD2, YGR258C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~4932 Saccharomyces cerevisiae~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">D9740.3, TFB1, YDR311W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), RAD2, YGR258C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lox OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lox RCSB], [http://www.ebi.ac.uk/pdbsum/2lox PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lox OCA], [http://pdbe.org/2lox PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lox RCSB], [http://www.ebi.ac.uk/pdbsum/2lox PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2lox" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Baker's yeast]]
	[[Category: Lafrance-Vanasse, J]]		[[Category: Lafrance-Vanasse, J]]
	[[Category: Legault, P]]		[[Category: Legault, P]]
	[[Category: Omichinski, J]]		[[Category: Omichinski, J]]
	[[Category: Transcription-hydrolase complex]]		[[Category: Transcription-hydrolase complex]]

OCA at 07:21, 25 December 2014

OCA — Thu, 25 Dec 2014 07:21:45 GMT

←Older revision		Revision as of 07:21, 25 December 2014
Line 2:		Line 2:
	<StructureSection load='2lox' size='340' side='right' caption='[[2lox]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lox' size='340' side='right' caption='[[2lox]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lox]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LOX OCA]. <br>	+	<table><tr><td colspan='2'>[[2lox]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LOX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LOX FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gs0\|2gs0]], [[2l2i\|2l2i]], [[1y5o\|1y5o]], [[2k2u\|2k2u]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gs0\|2gs0]], [[2l2i\|2l2i]], [[1y5o\|1y5o]], [[2k2u\|2k2u]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">D9740.3, TFB1, YDR311W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), RAD2, YGR258C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">D9740.3, TFB1, YDR311W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), RAD2, YGR258C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
-	<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class~~='~~plainlinks~~'~~>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lox OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lox RCSB], [http://www.ebi.ac.uk/pdbsum/2lox PDBsum]</span></td></tr>
-	~~<tr~~><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lox OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lox RCSB], [http://www.ebi.ac.uk/pdbsum/2lox PDBsum]</span></td></tr>	+	</table>
-	<table>	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TFB1_YEAST TFB1_YEAST]] Acts as component of the general transcription and DNA repair factor IIH (TFIIH) core, which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro.<ref>PMID:7961739</ref> <ref>PMID:8631896</ref> [[http://www.uniprot.org/uniprot/RAD2_YEAST RAD2_YEAST]] Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair.<ref>PMID:8247134</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 15:
	Structural and functional characterization of interactions involving the Tfb1 subunit of TFIIH and the NER factor Rad2.,Lafrance-Vanasse J, Arseneault G, Cappadocia L, Chen HT, Legault P, Omichinski JG Nucleic Acids Res. 2012 Feb 28. PMID:22373916<ref>PMID:22373916</ref>		Structural and functional characterization of interactions involving the Tfb1 subunit of TFIIH and the NER factor Rad2.,Lafrance-Vanasse J, Arseneault G, Cappadocia L, Chen HT, Legault P, Omichinski JG Nucleic Acids Res. 2012 Feb 28. PMID:22373916<ref>PMID:22373916</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 21:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Lafrance-Vanasse, J.]]	+	[[Category: Lafrance-Vanasse, J]]
-	[[Category: Legault, P.]]	+	[[Category: Legault, P]]
-	[[Category: Omichinski, J.]]	+	[[Category: Omichinski, J]]
	[[Category: Transcription-hydrolase complex]]		[[Category: Transcription-hydrolase complex]]

OCA at 07:41, 14 May 2014

OCA — Wed, 14 May 2014 07:41:20 GMT

←Older revision		Revision as of 07:41, 14 May 2014
Line 1:		Line 1:
-	[[~~Image:~~2lox.~~png~~\|~~left~~\|~~200px~~]]	+	==NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and Rad2==
		+	<StructureSection load='2lox' size='340' side='right' caption='[[2lox]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2lox]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LOX OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gs0\|2gs0]], [[2l2i\|2l2i]], [[1y5o\|1y5o]], [[2k2u\|2k2u]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">D9740.3, TFB1, YDR311W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), RAD2, YGR258C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lox OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lox RCSB], [http://www.ebi.ac.uk/pdbsum/2lox PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The general transcription factor IIH (TFIIH) plays crucial roles in transcription as part of the pre-initiation complex (PIC) and in DNA repair as part of the nucleotide excision repair (NER) machinery. During NER, TFIIH recruits the 3'-endonuclease Rad2 to damaged DNA. In this manuscript, we functionally and structurally characterized the interaction between the Tfb1 subunit of TFIIH and Rad2. We show that deletion of either the PH domain of Tfb1 (Tfb1PH) or several segments of the Rad2 spacer region yield yeast with enhanced sensitivity to UV irradiation. Isothermal titration calorimetry studies demonstrate that two acidic segments of the Rad2 spacer bind to Tfb1PH with nanomolar affinity. Structure determination of a Rad2-Tfb1PH complex indicates that Rad2 binds to TFIIH using a similar motif as TFIIEalpha uses to bind TFIIH in the PIC. Together, these results provide a mechanistic bridge between the role of TFIIH in transcription and DNA repair.

-	~~{{STRUCTURE_2lox\| PDB=2lox \| SCENE= }}~~	+	Structural and functional characterization of interactions involving the Tfb1 subunit of TFIIH and the NER factor Rad2.,Lafrance-Vanasse J, Arseneault G, Cappadocia L, Chen HT, Legault P, Omichinski JG Nucleic Acids Res. 2012 Feb 28. PMID:22373916<ref>PMID:22373916</ref>

-	~~===NMR structure~~ of the ~~complex between the PH domain of the Tfb1 subunit from TFIIH and Rad2===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22373916}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2lox]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2LOX OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022373916<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Lafrance-Vanasse, J.]]		[[Category: Lafrance-Vanasse, J.]]

OCA at 07:26, 11 July 2012

OCA — Wed, 11 Jul 2012 07:26:23 GMT

←Older revision		Revision as of 07:26, 11 July 2012
Line 1:		Line 1:
	[[Image:2lox.png\|left\|200px]]		[[Image:2lox.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2lox", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2lox\| PDB=2lox \| SCENE= }}		{{STRUCTURE_2lox\| PDB=2lox \| SCENE= }}

	===NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and Rad2===		===NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and Rad2===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22373916}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22373916 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_22373916}}		{{ABSTRACT_PUBMED_22373916}}

OCA at 06:16, 21 March 2012

OCA — Wed, 21 Mar 2012 06:16:00 GMT

←Older revision		Revision as of 06:16, 21 March 2012
Line 1:		Line 1:
-	[[Image:2lox.~~jpg~~\|left\|200px]]	+	[[Image:2lox.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and Rad2===		===NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and Rad2===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22373916}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22373916 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22373916}}

	==About this Structure==		==About this Structure==
	[[2lox]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LOX OCA].		[[2lox]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LOX OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022373916</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Lafrance-Vanasse, J.]]		[[Category: Lafrance-Vanasse, J.]]

OCA at 06:47, 15 February 2012

OCA — Wed, 15 Feb 2012 06:47:15 GMT

←Older revision		Revision as of 06:47, 15 February 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2lox.jpg\|left\|200px]]

-	The ~~entry 2lox~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2lox", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2lox\| PDB=2lox \| SCENE= }}

-	~~Authors: Lafrance-Vanasse, J., Legault, P., Omichinski, J.~~	+	===NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and Rad2===

-	~~Description: NMR~~ structure ~~of the complex between the PH domain of the Tfb1 subunit~~ from ~~TFIIH and Rad2~~	+
		+	==About this Structure==
		+	[[2lox]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LOX OCA].
		+	[[Category: Saccharomyces cerevisiae]]
		+	[[Category: Lafrance-Vanasse, J.]]
		+	[[Category: Legault, P.]]
		+	[[Category: Omichinski, J.]]
		+	[[Category: Transcription-hydrolase complex]]