2lpn - Revision history

OCA at 11:12, 15 February 2023

OCA — Wed, 15 Feb 2023 11:12:12 GMT

←Older revision		Revision as of 11:12, 15 February 2023
Line 1:		Line 1:

	==Solution Structure of N-Terminal domain of human Conserved Dopamine Neurotrophic Factor (CDNF)==		==Solution Structure of N-Terminal domain of human Conserved Dopamine Neurotrophic Factor (CDNF)==
-	<StructureSection load='2lpn' size='340' side='right'caption='[[2lpn~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2lpn' size='340' side='right'caption='[[2lpn]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lpn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LPN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lpn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LPN FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2w50\|2w50]]</div></td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lpn OCA], [https://pdbe.org/2lpn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lpn RCSB], [https://www.ebi.ac.uk/pdbsum/2lpn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lpn ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CDNF, ARMETL1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lpn OCA], [https://pdbe.org/2lpn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lpn RCSB], [https://www.ebi.ac.uk/pdbsum/2lpn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lpn ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CDNF_HUMAN CDNF_HUMAN]] Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).	+	[https://www.uniprot.org/uniprot/CDNF_HUMAN CDNF_HUMAN] Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Almeida~~, M S~~]]	+	[[Category: Almeida MS]]
-	[[Category: Cabral~~, K M.S~~]]	+	[[Category: Cabral KMS]]
-	[[Category: Foguel, D]]	+	[[Category: Foguel D]]
-	[[Category: Latge, C]]	+	[[Category: Latge C]]
-	[[Category: Pires~~, J R.M]]~~	+	[[Category: Pires JRM]]
-	~~[[Category: Hormone]]~~	+
-	~~[[Category: Intercellular signaling protein]]~~	+
-	~~[[Category: Nerve growth factor]]~~	+
-	~~[[Category: Nerve tissue protein]]~~	+
-	~~[[Category: Neuronal growth-associated]]~~	+
-	~~[[Category: Neurotrophic factor~~]]	+

OCA at 10:15, 12 May 2021

OCA — Wed, 12 May 2021 10:15:54 GMT

←Older revision		Revision as of 10:15, 12 May 2021
Line 1:		Line 1:

	==Solution Structure of N-Terminal domain of human Conserved Dopamine Neurotrophic Factor (CDNF)==		==Solution Structure of N-Terminal domain of human Conserved Dopamine Neurotrophic Factor (CDNF)==
-	<StructureSection load='2lpn' size='340' side='right' caption='[[2lpn]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2lpn' size='340' side='right'caption='[[2lpn]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lpn]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LPN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LPN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lpn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LPN FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w50\|2w50]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2w50\|2w50]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CDNF, ARMETL1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CDNF, ARMETL1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2lpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lpn OCA], [~~http~~://pdbe.org/2lpn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2lpn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2lpn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2lpn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lpn OCA], [https://pdbe.org/2lpn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lpn RCSB], [https://www.ebi.ac.uk/pdbsum/2lpn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lpn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CDNF_HUMAN CDNF_HUMAN]] Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).	+	[[https://www.uniprot.org/uniprot/CDNF_HUMAN CDNF_HUMAN]] Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Almeida, M S]]		[[Category: Almeida, M S]]
	[[Category: Cabral, K M.S]]		[[Category: Cabral, K M.S]]

OCA at 20:02, 1 August 2018

OCA — Wed, 01 Aug 2018 20:02:16 GMT

←Older revision		Revision as of 20:02, 1 August 2018
Line 1:		Line 1:
		+
	==Solution Structure of N-Terminal domain of human Conserved Dopamine Neurotrophic Factor (CDNF)==		==Solution Structure of N-Terminal domain of human Conserved Dopamine Neurotrophic Factor (CDNF)==
	<StructureSection load='2lpn' size='340' side='right' caption='[[2lpn]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lpn' size='340' side='right' caption='[[2lpn]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w50\|2w50]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w50\|2w50]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CDNF, ARMETL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CDNF, ARMETL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lpn OCA], [http://pdbe.org/2lpn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lpn RCSB], [http://www.ebi.ac.uk/pdbsum/2lpn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lpn OCA], [http://pdbe.org/2lpn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lpn RCSB], [http://www.ebi.ac.uk/pdbsum/2lpn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lpn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:54, 10 September 2015

OCA — Thu, 10 Sep 2015 08:54:34 GMT

←Older revision		Revision as of 08:54, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2lpn' size='340' side='right' caption='[[2lpn]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lpn' size='340' side='right' caption='[[2lpn]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lpn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LPN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LPN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lpn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LPN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LPN FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w50\|2w50]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w50\|2w50]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CDNF, ARMETL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CDNF, ARMETL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lpn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lpn RCSB], [http://www.ebi.ac.uk/pdbsum/2lpn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lpn OCA], [http://pdbe.org/2lpn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lpn RCSB], [http://www.ebi.ac.uk/pdbsum/2lpn PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2lpn" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Almeida, M S]]		[[Category: Almeida, M S]]
	[[Category: Cabral, K M.S]]		[[Category: Cabral, K M.S]]

OCA at 21:23, 24 December 2014

OCA — Wed, 24 Dec 2014 21:23:11 GMT

←Older revision		Revision as of 21:23, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lpn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lpn RCSB], [http://www.ebi.ac.uk/pdbsum/2lpn PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lpn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lpn RCSB], [http://www.ebi.ac.uk/pdbsum/2lpn PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CDNF_HUMAN CDNF_HUMAN]] Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:45, 18 December 2014

OCA — Thu, 18 Dec 2014 12:45:57 GMT

←Older revision		Revision as of 12:45, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2lpn\| PDB=2lpn \| SCENE= }}~~	+	==Solution Structure of N-Terminal domain of human Conserved Dopamine Neurotrophic Factor (CDNF)==
-	===Solution Structure of N-Terminal domain of human Conserved Dopamine Neurotrophic Factor (CDNF)===	+	<StructureSection load='2lpn' size='340' side='right' caption='[[2lpn]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_22528768}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2lpn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LPN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LPN FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w50\|2w50]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CDNF, ARMETL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lpn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lpn RCSB], [http://www.ebi.ac.uk/pdbsum/2lpn PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Parkinson's disease (PD) is a neurodegenerative disorder that is caused by the death of midbrain dopaminergic neurons. Current therapies for PD do not halt the neurodegeneration nor repair the affected neurons. Therefore, search for novel neurotrophic factors (NTF) for midbrain dopaminergic neurons, which could be used in novel therapeutic approaches, is highly wanted. In 2007, a potent NTF for dopaminergic neurons was described as the conserved dopamine neurotrophic factor (CDNF). Single doses of this protein protect and restore dopaminergic neurons in experimental models of PD. CDNF has two domains; an N-terminal saposin-like domain, which may bind to membranes; and a presumably intrinsically unstructured C-terminal which contains an internal cysteine bridge in a CXXC motif similar to that of thiol/disulphide oxidoreductases and isomerases, and may thus reduce the endoplasmic reticulum stress caused by incorrectly folded proteins. We show for the first time the nuclear magnetic resonance assignment of N-terminal domain of recombinant CDNF (residues 1-105) by solution 2D and 3D NMR spectroscopy. We were able to obtain a nearly complete resonance assignment, which is the first step toward the solution structure determination of this neurotrophic factor.

-	~~==Function==~~	+	(1)H-, (13)C- and (15)N-NMR assignment of the N-terminal domain of human cerebral dopamine neurotrophic factor (CDNF).,Latge C, Cabral KM, Almeida MS, Foguel D Biomol NMR Assign. 2012 Apr 18. PMID:22528768<ref>PMID:22528768</ref>
-	~~[[http://www.uniprot.org/uniprot/CDNF_HUMAN CDNF_HUMAN]] Trophic factor for dopamine neurons. Prevents the 6~~-~~hydroxydopamine~~ (6-~~OHDA~~)-~~induced degeneration~~ of ~~dopaminergic neurons. When administered after 6-OHDA-lesioning, restores~~ the ~~dopaminergic function and prevents the degeneration~~ of ~~dopaminergic neurons in substantia nigra~~ (~~By similarity~~).	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2lpn]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2LPN OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:022528768</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Almeida, M S.]]	+	[[Category: Almeida, M S]]
-	[[Category: Cabral, K M.S.]]	+	[[Category: Cabral, K M.S]]
-	[[Category: Foguel, D.]]	+	[[Category: Foguel, D]]
-	[[Category: Latge, C.]]	+	[[Category: Latge, C]]
-	[[Category: Pires, J R.M.]]	+	[[Category: Pires, J R.M]]
	[[Category: Hormone]]		[[Category: Hormone]]
	[[Category: Intercellular signaling protein]]		[[Category: Intercellular signaling protein]]

OCA at 06:30, 20 June 2013

OCA — Thu, 20 Jun 2013 06:30:04 GMT

←Older revision		Revision as of 06:30, 20 June 2013
Line 1:		Line 1:
-	[[Image:2lpn.jpg\|left\|200px]]
-
	{{STRUCTURE_2lpn\| PDB=2lpn \| SCENE= }}		{{STRUCTURE_2lpn\| PDB=2lpn \| SCENE= }}
-
	===Solution Structure of N-Terminal domain of human Conserved Dopamine Neurotrophic Factor (CDNF)===		===Solution Structure of N-Terminal domain of human Conserved Dopamine Neurotrophic Factor (CDNF)===
-
	{{ABSTRACT_PUBMED_22528768}}		{{ABSTRACT_PUBMED_22528768}}
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/CDNF_HUMAN CDNF_HUMAN]] Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).

	==About this Structure==		==About this Structure==
	[[2lpn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LPN OCA].		[[2lpn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LPN OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022528768</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Almeida, M S.]]		[[Category: Almeida, M S.]]

OCA at 13:54, 20 February 2013

OCA — Wed, 20 Feb 2013 13:54:23 GMT

←Older revision		Revision as of 13:54, 20 February 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2lpn.jpg\|left\|200px]]

-	~~The entry~~ 2lpn ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_2lpn\| PDB=2lpn \| SCENE= }}

-	~~Authors: Latge, C., Cabral, K.M.S., Foguel, D., Pires, J.R.M., Almeida, M.S.~~	+	===Solution Structure of N-Terminal domain of human Conserved Dopamine Neurotrophic Factor (CDNF)===

-	~~Description: Solution~~ Structure ~~of N~~-~~Terminal domain of human Conserved Dopamine~~ Neurotrophic ~~Factor (CDNF)~~	+	{{ABSTRACT_PUBMED_22528768}}
		+
		+	==About this Structure==
		+	[[2lpn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LPN OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Almeida, M S.]]
		+	[[Category: Cabral, K M.S.]]
		+	[[Category: Foguel, D.]]
		+	[[Category: Latge, C.]]
		+	[[Category: Pires, J R.M.]]
		+	[[Category: Hormone]]
		+	[[Category: Intercellular signaling protein]]
		+	[[Category: Nerve growth factor]]
		+	[[Category: Nerve tissue protein]]
		+	[[Category: Neuronal growth-associated]]
		+	[[Category: Neurotrophic factor]]

OCA at 08:06, 29 February 2012

OCA — Wed, 29 Feb 2012 08:06:53 GMT

←Older revision		Revision as of 08:06, 29 February 2012
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2lpn is ON HOLD	+	The entry 2lpn is ON HOLD until Paper Publication

-	Authors: ~~Cristiane~~, L., ~~Katia~~, C.M.S., ~~Debora~~, F., Pires, J.M., Almeida, M.S.	+	Authors: Latge, C., Cabral, K.M.S., Foguel, D., Pires, J.R.M., Almeida, M.S.

	Description: Solution Structure of N-Terminal domain of human Conserved Dopamine Neurotrophic Factor (CDNF)		Description: Solution Structure of N-Terminal domain of human Conserved Dopamine Neurotrophic Factor (CDNF)

OCA: Protected "2lpn" [edit=sysop:move=sysop]

OCA — Wed, 22 Feb 2012 07:12:27 GMT

Protected "2lpn" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:12, 22 February 2012