2lqg - Revision history

OCA at 05:49, 15 May 2024

OCA — Wed, 15 May 2024 05:49:18 GMT

←Older revision		Revision as of 05:49, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lqg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LQG FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lqg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LQG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqg OCA], [https://pdbe.org/2lqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lqg RCSB], [https://www.ebi.ac.uk/pdbsum/2lqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lqg ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqg OCA], [https://pdbe.org/2lqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lqg RCSB], [https://www.ebi.ac.uk/pdbsum/2lqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lqg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:

	==See Also==		==See Also==
-	*[[Talin\|Talin]]	+	*[[Talin 3D structures\|Talin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:12, 15 February 2023

OCA — Wed, 15 Feb 2023 11:12:47 GMT

←Older revision		Revision as of 11:12, 15 February 2023
Line 1:		Line 1:

	==Solution Structure of the R4 domain of talin==		==Solution Structure of the R4 domain of talin==
-	<StructureSection load='2lqg' size='340' side='right'caption='[[2lqg~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2lqg' size='340' side='right'caption='[[2lqg]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lqg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LQG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lqg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LQG FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tln1, Tln ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqg OCA], [https://pdbe.org/2lqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lqg RCSB], [https://www.ebi.ac.uk/pdbsum/2lqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lqg ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqg OCA], [https://pdbe.org/2lqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lqg RCSB], [https://www.ebi.ac.uk/pdbsum/2lqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lqg ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TLN1_MOUSE TLN1_MOUSE]] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.	+	[https://www.uniprot.org/uniprot/TLN1_MOUSE TLN1_MOUSE] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Barsukov~~, I L~~]]	+	[[Category: Barsukov IL]]
-	[[Category: Bate, N]]	+	[[Category: Bate N]]
-	[[Category: Critchley~~, D R~~]]	+	[[Category: Critchley DR]]
-	[[Category: Gingras~~, A R~~]]	+	[[Category: Gingras AR]]
-	[[Category: Goult~~, B T~~]]	+	[[Category: Goult BT]]
-	[[Category: Roberts~~, G C.K]]~~	+	[[Category: Roberts GCK]]
-	~~[[Category: Actin]]~~	+
-	~~[[Category: Adhesion]]~~	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Helical bundle]]~~	+
-	~~[[Category: Integrin]]~~	+
-	~~[[Category: Structural protein~~]]	+

OCA at 10:16, 12 May 2021

OCA — Wed, 12 May 2021 10:16:16 GMT

←Older revision		Revision as of 10:16, 12 May 2021
Line 1:		Line 1:

	==Solution Structure of the R4 domain of talin==		==Solution Structure of the R4 domain of talin==
-	<StructureSection load='2lqg' size='340' side='right' caption='[[2lqg]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2lqg' size='340' side='right'caption='[[2lqg]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lqg]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LQG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lqg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LQG FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tln1, Tln ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tln1, Tln ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2lqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqg OCA], [~~http~~://pdbe.org/2lqg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2lqg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2lqg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2lqg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqg OCA], [https://pdbe.org/2lqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lqg RCSB], [https://www.ebi.ac.uk/pdbsum/2lqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lqg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TLN1_MOUSE TLN1_MOUSE]] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.	+	[[https://www.uniprot.org/uniprot/TLN1_MOUSE TLN1_MOUSE]] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Barsukov, I L]]		[[Category: Barsukov, I L]]

OCA at 19:45, 1 August 2018

OCA — Wed, 01 Aug 2018 19:45:58 GMT

←Older revision		Revision as of 19:45, 1 August 2018
Line 1:		Line 1:
		+
	==Solution Structure of the R4 domain of talin==		==Solution Structure of the R4 domain of talin==
	<StructureSection load='2lqg' size='340' side='right' caption='[[2lqg]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lqg' size='340' side='right' caption='[[2lqg]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2lqg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LQG FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lqg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LQG FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tln1, Tln ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tln1, Tln ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqg OCA], [http://pdbe.org/2lqg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lqg RCSB], [http://www.ebi.ac.uk/pdbsum/2lqg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqg OCA], [http://pdbe.org/2lqg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lqg RCSB], [http://www.ebi.ac.uk/pdbsum/2lqg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lqg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 13:35, 10 September 2015

OCA — Thu, 10 Sep 2015 13:35:38 GMT

←Older revision		Revision as of 13:35, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2lqg' size='340' side='right' caption='[[2lqg]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lqg' size='340' side='right' caption='[[2lqg]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lqg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LQG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lqg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LQG FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tln1, Tln ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tln1, Tln ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lqg RCSB], [http://www.ebi.ac.uk/pdbsum/2lqg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqg OCA], [http://pdbe.org/2lqg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lqg RCSB], [http://www.ebi.ac.uk/pdbsum/2lqg PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2lqg" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Barsukov, I L]]		[[Category: Barsukov, I L]]
	[[Category: Bate, N]]		[[Category: Bate, N]]

OCA at 00:48, 25 December 2014

OCA — Thu, 25 Dec 2014 00:48:54 GMT

←Older revision		Revision as of 00:48, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lqg RCSB], [http://www.ebi.ac.uk/pdbsum/2lqg PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lqg RCSB], [http://www.ebi.ac.uk/pdbsum/2lqg PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TLN1_MOUSE TLN1_MOUSE]] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:18, 18 December 2014

OCA — Thu, 18 Dec 2014 12:18:03 GMT

←Older revision		Revision as of 12:18, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2lqg~~\| ~~PDB~~=2lqg \| ~~SCENE~~= }}	+	==Solution Structure of the R4 domain of talin==
-	===~~Solution Structure~~ of the R4 domain of talin~~===~~	+	<StructureSection load='2lqg' size='340' side='right' caption='[[2lqg]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_23389036}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2lqg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LQG FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tln1, Tln ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lqg RCSB], [http://www.ebi.ac.uk/pdbsum/2lqg PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Talin activates integrins, couples them to F-actin and recruits vinculin to focal adhesions (FAs). Here we report the structural characterization of the talin rod, 13 helical bundles (R1-R13) organized into a compact cluster of 4-helix bundles (R2-R4) within a linear chain of 5-helix bundles. Nine of the bundles contain vinculin-binding sites (VBSs) - R2R3 are atypical each containing two VBSs. Talin R2R3 also binds synergistically to RIAM, a Rap1 effector involved in integrin activation. Biochemical and structural data show that vinculin and RIAM binding to R2R3 is mutually exclusive. Moreover, vinculin binding requires domain unfolding while RIAM binds the folded R2R3 double domain. In cells, RIAM is enriched in nascent adhesions at the leading edge whereas vinculin is enriched in FAs, and expression of the talin-binding domain of vinculin displaces RIAM from FAs. We propose a model in which RIAM binding to R2R3 initially recruits talin to membranes where it activates integrins. As talin engages F-actin, force exerted on R2R3 disrupts RIAM binding and exposes the VBSs, which recruit vinculin to stabilize the complex.

-	~~==Function==~~	+	RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover.,Goult BT, Zacharchenko T, Bate N, Tsang R, Hey F, Gingras AR, Elliott PR, Roberts GC, Ballestrem C, Critchley DR, Barsukov IL J Biol Chem. 2013 Feb 6. PMID:23389036<ref>PMID:23389036</ref>
-	~~[[http://www.uniprot.org/uniprot/TLN1_MOUSE TLN1_MOUSE]] Probably involved in connections of major cytoskeletal structures~~ to ~~the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact~~ and, ~~in lymphocytes~~, ~~at cell-cell contacts~~.	+

-	==~~About this Structure~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[~~2lqg~~]] ~~is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQG OCA].~~	+	</div>
		+
		+	==See Also==
		+	*[[Talin\|Talin]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Barsukov, I L.]]	+	[[Category: Barsukov, I L]]
-	[[Category: Bate, N.]]	+	[[Category: Bate, N]]
-	[[Category: Critchley, D R.]]	+	[[Category: Critchley, D R]]
-	[[Category: Gingras, A R.]]	+	[[Category: Gingras, A R]]
-	[[Category: Goult, B T.]]	+	[[Category: Goult, B T]]
-	[[Category: Roberts, G C.K.]]	+	[[Category: Roberts, G C.K]]
	[[Category: Actin]]		[[Category: Actin]]
	[[Category: Adhesion]]		[[Category: Adhesion]]

OCA at 10:00, 24 April 2013

OCA — Wed, 24 Apr 2013 10:00:24 GMT

←Older revision		Revision as of 10:00, 24 April 2013
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-	[[Image:2lqg.png\|left\|200px]]
-
	{{STRUCTURE_2lqg\| PDB=2lqg \| SCENE= }}		{{STRUCTURE_2lqg\| PDB=2lqg \| SCENE= }}
-
	===Solution Structure of the R4 domain of talin===		===Solution Structure of the R4 domain of talin===
		+	{{ABSTRACT_PUBMED_23389036}}

-	~~{{ABSTRACT_PUBMED_23389036}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/TLN1_MOUSE TLN1_MOUSE]] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.

	==About this Structure==		==About this Structure==

OCA at 12:39, 20 February 2013

OCA — Wed, 20 Feb 2013 12:39:43 GMT

←Older revision		Revision as of 12:39, 20 February 2013
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-	[[Image:2lqg.~~jpg~~\|left\|200px]]	+	[[Image:2lqg.png\|left\|200px]]

	{{STRUCTURE_2lqg\| PDB=2lqg \| SCENE= }}		{{STRUCTURE_2lqg\| PDB=2lqg \| SCENE= }}
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	===Solution Structure of the R4 domain of talin===		===Solution Structure of the R4 domain of talin===

		+	{{ABSTRACT_PUBMED_23389036}}

	==About this Structure==		==About this Structure==

OCA at 10:35, 13 February 2013

OCA — Wed, 13 Feb 2013 10:35:40 GMT

←Older revision		Revision as of 10:35, 13 February 2013
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-	~~'''Unreleased structure'''~~	+	[[Image:2lqg.jpg\|left\|200px]]

-	~~The entry~~ 2lqg ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_2lqg\| PDB=2lqg \| SCENE= }}

-	~~Authors: Goult, B.T., Gingras, A.R., Bate, N., Roberts, G.C.K., Barsukov, I.L., Critchley, D.R.~~	+	===Solution Structure of the R4 domain of talin===

-	~~Description: Solution~~ Structure ~~of the~~ A ~~domain of talin~~	+
		+	==About this Structure==
		+	[[2lqg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQG OCA].
		+	[[Category: Mus musculus]]
		+	[[Category: Barsukov, I L.]]
		+	[[Category: Bate, N.]]
		+	[[Category: Critchley, D R.]]
		+	[[Category: Gingras, A R.]]
		+	[[Category: Goult, B T.]]
		+	[[Category: Roberts, G C.K.]]
		+	[[Category: Actin]]
		+	[[Category: Adhesion]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Helical bundle]]
		+	[[Category: Integrin]]
		+	[[Category: Structural protein]]