2lqn - Revision history

OCA at 05:49, 15 May 2024

OCA — Wed, 15 May 2024 05:49:34 GMT

←Older revision		Revision as of 05:49, 15 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lqn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LQN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lqn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LQN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqn OCA], [https://pdbe.org/2lqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lqn RCSB], [https://www.ebi.ac.uk/pdbsum/2lqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lqn ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqn OCA], [https://pdbe.org/2lqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lqn RCSB], [https://www.ebi.ac.uk/pdbsum/2lqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lqn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 11:13, 15 February 2023

OCA — Wed, 15 Feb 2023 11:13:06 GMT

←Older revision		Revision as of 11:13, 15 February 2023
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	==Solution structure of CRKL==		==Solution structure of CRKL==
-	<StructureSection load='2lqn' size='340' side='right'caption='[[2lqn~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2lqn' size='340' side='right'caption='[[2lqn]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lqn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LQN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lqn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LQN FirstGlance]. <br>
-	</td></tr>~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRKL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqn OCA], [https://pdbe.org/2lqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lqn RCSB], [https://www.ebi.ac.uk/pdbsum/2lqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lqn ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqn OCA], [https://pdbe.org/2lqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lqn RCSB], [https://www.ebi.ac.uk/pdbsum/2lqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lqn ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CRKL_HUMAN CRKL_HUMAN]] May mediate the transduction of intracellular signals.	+	[https://www.uniprot.org/uniprot/CRKL_HUMAN CRKL_HUMAN] May mediate the transduction of intracellular signals.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Jankowski, W]]	+	[[Category: Jankowski W]]
-	[[Category: Kalodimos, C]]	+	[[Category: Kalodimos C]]
-	[[Category: Saleh, T]]	+	[[Category: Saleh T]]
-	~~[[Category: Sh2]]~~	+
-	~~[[Category: Sh3]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 10:16, 12 May 2021

OCA — Wed, 12 May 2021 10:16:29 GMT

←Older revision		Revision as of 10:16, 12 May 2021
Line 1:		Line 1:
-	~~{{Large structure}}~~	+
	==Solution structure of CRKL==		==Solution structure of CRKL==
-	<StructureSection load='2lqn' size='340' side='right' caption='[[2lqn]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2lqn' size='340' side='right'caption='[[2lqn]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lqn]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LQN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lqn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LQN FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRKL ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRKL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2lqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqn OCA], [~~http~~://pdbe.org/2lqn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2lqn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2lqn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2lqn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqn OCA], [https://pdbe.org/2lqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lqn RCSB], [https://www.ebi.ac.uk/pdbsum/2lqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lqn ProSAT]</span></td></tr>
	</table>		</table>
-	{{Large structure}}
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CRKL_HUMAN CRKL_HUMAN]] May mediate the transduction of intracellular signals.	+	[[https://www.uniprot.org/uniprot/CRKL_HUMAN CRKL_HUMAN]] May mediate the transduction of intracellular signals.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Jankowski, W]]		[[Category: Jankowski, W]]
	[[Category: Kalodimos, C]]		[[Category: Kalodimos, C]]

OCA at 19:58, 1 August 2018

OCA — Wed, 01 Aug 2018 19:58:28 GMT

←Older revision		Revision as of 19:58, 1 August 2018
Line 1:		Line 1:
		+	{{Large structure}}
	==Solution structure of CRKL==		==Solution structure of CRKL==
	<StructureSection load='2lqn' size='340' side='right' caption='[[2lqn]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lqn' size='340' side='right' caption='[[2lqn]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2lqn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LQN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lqn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LQN FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqn OCA], [http://pdbe.org/2lqn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lqn RCSB], [http://www.ebi.ac.uk/pdbsum/2lqn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqn OCA], [http://pdbe.org/2lqn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lqn RCSB], [http://www.ebi.ac.uk/pdbsum/2lqn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lqn ProSAT]</span></td></tr>
	</table>		</table>
	{{Large structure}}		{{Large structure}}

OCA at 21:38, 15 October 2015

OCA — Thu, 15 Oct 2015 21:38:17 GMT

←Older revision		Revision as of 21:38, 15 October 2015
Line 1:		Line 1:
	==Solution structure of CRKL==		==Solution structure of CRKL==
-	<StructureSection load='2lqn' size='340' side='right' caption='[[2lqn]], [[NMR_Ensembles_of_Models \| 6 NMR models]]' scene=''>	+	<StructureSection load='2lqn' size='340' side='right' caption='[[2lqn]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lqn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LQN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lqn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LQN FirstGlance]. <br>
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqn OCA], [http://pdbe.org/2lqn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lqn RCSB], [http://www.ebi.ac.uk/pdbsum/2lqn PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqn OCA], [http://pdbe.org/2lqn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lqn RCSB], [http://www.ebi.ac.uk/pdbsum/2lqn PDBsum]</span></td></tr>
	</table>		</table>
		+	{{Large structure}}
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/CRKL_HUMAN CRKL_HUMAN]] May mediate the transduction of intracellular signals.		[[http://www.uniprot.org/uniprot/CRKL_HUMAN CRKL_HUMAN]] May mediate the transduction of intracellular signals.

OCA at 10:29, 10 September 2015

OCA — Thu, 10 Sep 2015 10:29:16 GMT

←Older revision		Revision as of 10:29, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2lqn' size='340' side='right' caption='[[2lqn]], [[NMR_Ensembles_of_Models \| 6 NMR models]]' scene=''>		<StructureSection load='2lqn' size='340' side='right' caption='[[2lqn]], [[NMR_Ensembles_of_Models \| 6 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lqn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LQN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lqn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LQN FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lqn RCSB], [http://www.ebi.ac.uk/pdbsum/2lqn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqn OCA], [http://pdbe.org/2lqn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lqn RCSB], [http://www.ebi.ac.uk/pdbsum/2lqn PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2lqn" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Jankowski, W]]		[[Category: Jankowski, W]]
	[[Category: Kalodimos, C]]		[[Category: Kalodimos, C]]

OCA at 22:32, 24 December 2014

OCA — Wed, 24 Dec 2014 22:32:32 GMT

←Older revision		Revision as of 22:32, 24 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lqn RCSB], [http://www.ebi.ac.uk/pdbsum/2lqn PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lqn RCSB], [http://www.ebi.ac.uk/pdbsum/2lqn PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CRKL_HUMAN CRKL_HUMAN]] May mediate the transduction of intracellular signals.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 05:56, 22 December 2014

OCA — Mon, 22 Dec 2014 05:56:16 GMT

←Older revision		Revision as of 05:56, 22 December 2014
Line 2:		Line 2:
	<StructureSection load='2lqn' size='340' side='right' caption='[[2lqn]], [[NMR_Ensembles_of_Models \| 6 NMR models]]' scene=''>		<StructureSection load='2lqn' size='340' side='right' caption='[[2lqn]], [[NMR_Ensembles_of_Models \| 6 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lqn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQN OCA]. <br>	+	<table><tr><td colspan='2'>[[2lqn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LQN FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class~~='~~plainlinks~~'~~>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lqn RCSB], [http://www.ebi.ac.uk/pdbsum/2lqn PDBsum]</span></td></tr>
-	~~<tr~~><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lqn RCSB], [http://www.ebi.ac.uk/pdbsum/2lqn PDBsum]</span></td></tr>	+	</table>
-	<table>	+
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 12:
	Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII.,Jankowski W, Saleh T, Pai MT, Sriram G, Birge RB, Kalodimos CG Nat Chem Biol. 2012 May 13;8(6):590-6. doi: 10.1038/nchembio.954. PMID:22581121<ref>PMID:22581121</ref>		Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII.,Jankowski W, Saleh T, Pai MT, Sriram G, Birge RB, Kalodimos CG Nat Chem Biol. 2012 May 13;8(6):590-6. doi: 10.1038/nchembio.954. PMID:22581121<ref>PMID:22581121</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 20:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Jankowski, W.]]	+	[[Category: Jankowski, W]]
-	[[Category: Kalodimos, C.]]	+	[[Category: Kalodimos, C]]
-	[[Category: Saleh, T.]]	+	[[Category: Saleh, T]]
	[[Category: Sh2]]		[[Category: Sh2]]
	[[Category: Sh3]]		[[Category: Sh3]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 08:38, 7 May 2014

OCA — Wed, 07 May 2014 08:38:57 GMT

←Older revision		Revision as of 08:38, 7 May 2014
Line 1:		Line 1:
-	[[~~Image:~~2lqn.~~png~~\|~~left\|200px~~]]	+	==Solution structure of CRKL==
		+	<StructureSection load='2lqn' size='340' side='right' caption='[[2lqn]], [[NMR_Ensembles_of_Models \| 6 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2lqn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQN OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lqn RCSB], [http://www.ebi.ac.uk/pdbsum/2lqn PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	CrkL is a key signaling protein that mediates the leukemogenic activity of Bcr-Abl. CrkL is thought to adopt a structure that is similar to that of its CrkII homolog. The two proteins share high sequence identity and indistinguishable ligand binding preferences, yet they have distinct physiological roles. Here we show that the structures of CrkL and phosphorylated CrkL are markedly different than the corresponding structures of CrkII. As a result, the binding activities of the Src homology 2 and Src homology 3 domains in the two proteins are regulated in a distinct manner and to a different extent. The different structural architecture of CrkL and CrkII may account for their distinct functional roles. The data show that CrkL forms a constitutive complex with Abl, thus explaining the strong preference of Bcr-Abl for CrkL. The results also highlight how the structural organization of the modular domains in adaptor proteins can control signaling outcome.

-	<!--	+	Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII.,Jankowski W, Saleh T, Pai MT, Sriram G, Birge RB, Kalodimos CG Nat Chem Biol. 2012 May 13;8(6):590-6. doi: 10.1038/nchembio.954. PMID:22581121<ref>PMID:22581121</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_2lqn"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_2lqn\| PDB=2lqn \| SCENE= }}~~	+

-	~~===Solution structure~~ of ~~CRKL===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22581121}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22581121 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22581121}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2lqn]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQN OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022581121<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Jankowski, W.]]		[[Category: Jankowski, W.]]

OCA at 06:37, 6 June 2012

OCA — Wed, 06 Jun 2012 06:37:35 GMT

←Older revision		Revision as of 06:37, 6 June 2012
Line 1:		Line 1:
-	[[Image:2lqn.~~jpg~~\|left\|200px]]	+	[[Image:2lqn.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===Solution structure of CRKL===		===Solution structure of CRKL===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22581121}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22581121 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22581121}}

	==About this Structure==		==About this Structure==
	[[2lqn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQN OCA].		[[2lqn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQN OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022581121</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Jankowski, W.]]		[[Category: Jankowski, W.]]