2lsw - Revision history

OCA at 05:51, 15 May 2024

OCA — Wed, 15 May 2024 05:51:27 GMT

←Older revision		Revision as of 05:51, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lsw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LSW FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lsw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LSW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsw OCA], [https://pdbe.org/2lsw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lsw RCSB], [https://www.ebi.ac.uk/pdbsum/2lsw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lsw ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsw OCA], [https://pdbe.org/2lsw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lsw RCSB], [https://www.ebi.ac.uk/pdbsum/2lsw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lsw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 13:08, 22 February 2023

OCA — Wed, 22 Feb 2023 13:08:40 GMT

←Older revision		Revision as of 13:08, 22 February 2023
Line 1:		Line 1:

	==Structure, sulfatide-binding properties, and inhibition of platelet aggregation by a Disabled-2-derived peptide==		==Structure, sulfatide-binding properties, and inhibition of platelet aggregation by a Disabled-2-derived peptide==
-	<StructureSection load='2lsw' size='340' side='right'caption='[[2lsw~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2lsw' size='340' side='right'caption='[[2lsw]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lsw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LSW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lsw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LSW FirstGlance]. <br>
-	</td></tr>~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DAB2, DOC2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsw OCA], [https://pdbe.org/2lsw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lsw RCSB], [https://www.ebi.ac.uk/pdbsum/2lsw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lsw ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsw OCA], [https://pdbe.org/2lsw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lsw RCSB], [https://www.ebi.ac.uk/pdbsum/2lsw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lsw ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DAB2_HUMAN DAB2_HUMAN]] Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containg non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor.<ref>PMID:11387212</ref> <ref>PMID:12805222</ref> <ref>PMID:16267015</ref> <ref>PMID:16984970</ref> <ref>PMID:19306879</ref> <ref>PMID:21995445</ref> <ref>PMID:22491013</ref> <ref>PMID:22323290</ref>	+	[https://www.uniprot.org/uniprot/DAB2_HUMAN DAB2_HUMAN] Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containg non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor.<ref>PMID:11387212</ref> <ref>PMID:12805222</ref> <ref>PMID:16267015</ref> <ref>PMID:16984970</ref> <ref>PMID:19306879</ref> <ref>PMID:21995445</ref> <ref>PMID:22491013</ref> <ref>PMID:22323290</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Xiao, S]]	+	[[Category: Xiao S]]
-	~~[[Category: Blood clotting]]~~	+
-	~~[[Category: Dodecylphosphocholine]]~~	+
-	~~[[Category: Platelet aggregation inhibitor]]~~	+
-	~~[[Category: Sulfatide~~]]	+

OCA at 10:52, 19 May 2021

OCA — Wed, 19 May 2021 10:52:29 GMT

←Older revision		Revision as of 10:52, 19 May 2021
Line 1:		Line 1:

	==Structure, sulfatide-binding properties, and inhibition of platelet aggregation by a Disabled-2-derived peptide==		==Structure, sulfatide-binding properties, and inhibition of platelet aggregation by a Disabled-2-derived peptide==
-	<StructureSection load='2lsw' size='340' side='right' caption='[[2lsw]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2lsw' size='340' side='right'caption='[[2lsw]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lsw]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LSW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lsw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LSW FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DAB2, DOC2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DAB2, DOC2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2lsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsw OCA], [~~http~~://pdbe.org/2lsw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2lsw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2lsw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2lsw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsw OCA], [https://pdbe.org/2lsw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lsw RCSB], [https://www.ebi.ac.uk/pdbsum/2lsw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lsw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DAB2_HUMAN DAB2_HUMAN]] Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containg non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor.<ref>PMID:11387212</ref> <ref>PMID:12805222</ref> <ref>PMID:16267015</ref> <ref>PMID:16984970</ref> <ref>PMID:19306879</ref> <ref>PMID:21995445</ref> <ref>PMID:22491013</ref> <ref>PMID:22323290</ref>	+	[[https://www.uniprot.org/uniprot/DAB2_HUMAN DAB2_HUMAN]] Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containg non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor.<ref>PMID:11387212</ref> <ref>PMID:12805222</ref> <ref>PMID:16267015</ref> <ref>PMID:16984970</ref> <ref>PMID:19306879</ref> <ref>PMID:21995445</ref> <ref>PMID:22491013</ref> <ref>PMID:22323290</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Xiao, S]]		[[Category: Xiao, S]]
	[[Category: Blood clotting]]		[[Category: Blood clotting]]

OCA at 19:20, 1 August 2018

OCA — Wed, 01 Aug 2018 19:20:10 GMT

←Older revision		Revision as of 19:20, 1 August 2018
Line 1:		Line 1:
		+
	==Structure, sulfatide-binding properties, and inhibition of platelet aggregation by a Disabled-2-derived peptide==		==Structure, sulfatide-binding properties, and inhibition of platelet aggregation by a Disabled-2-derived peptide==
	<StructureSection load='2lsw' size='340' side='right' caption='[[2lsw]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lsw' size='340' side='right' caption='[[2lsw]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2lsw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LSW FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lsw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LSW FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DAB2, DOC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DAB2, DOC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsw OCA], [http://pdbe.org/2lsw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lsw RCSB], [http://www.ebi.ac.uk/pdbsum/2lsw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsw OCA], [http://pdbe.org/2lsw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lsw RCSB], [http://www.ebi.ac.uk/pdbsum/2lsw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lsw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 16:50, 10 September 2015

OCA — Thu, 10 Sep 2015 16:50:20 GMT

←Older revision		Revision as of 16:50, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2lsw' size='340' side='right' caption='[[2lsw]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lsw' size='340' side='right' caption='[[2lsw]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lsw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LSW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lsw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LSW FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DAB2, DOC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DAB2, DOC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lsw RCSB], [http://www.ebi.ac.uk/pdbsum/2lsw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsw OCA], [http://pdbe.org/2lsw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lsw RCSB], [http://www.ebi.ac.uk/pdbsum/2lsw PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2lsw" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Xiao, S]]		[[Category: Xiao, S]]
	[[Category: Blood clotting]]		[[Category: Blood clotting]]

OCA at 03:12, 25 December 2014

OCA — Thu, 25 Dec 2014 03:12:25 GMT

←Older revision		Revision as of 03:12, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lsw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LSW FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lsw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LSW FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DAB2, DOC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DAB2, DOC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lsw RCSB], [http://www.ebi.ac.uk/pdbsum/2lsw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lsw RCSB], [http://www.ebi.ac.uk/pdbsum/2lsw PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DAB2_HUMAN DAB2_HUMAN]] Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containg non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor.<ref>PMID:11387212</ref> <ref>PMID:12805222</ref> <ref>PMID:16267015</ref> <ref>PMID:16984970</ref> <ref>PMID:19306879</ref> <ref>PMID:21995445</ref> <ref>PMID:22491013</ref> <ref>PMID:22323290</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Xiao, S.]]	+	[[Category: Xiao, S]]
	[[Category: Blood clotting]]		[[Category: Blood clotting]]
	[[Category: Dodecylphosphocholine]]		[[Category: Dodecylphosphocholine]]
	[[Category: Platelet aggregation inhibitor]]		[[Category: Platelet aggregation inhibitor]]
	[[Category: Sulfatide]]		[[Category: Sulfatide]]

OCA at 02:46, 29 September 2014

OCA — Mon, 29 Sep 2014 02:46:06 GMT

←Older revision		Revision as of 02:46, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2lsw.~~png~~\|~~left\|200px~~]]	+	==Structure, sulfatide-binding properties, and inhibition of platelet aggregation by a Disabled-2-derived peptide==
		+	<StructureSection load='2lsw' size='340' side='right' caption='[[2lsw]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2lsw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LSW FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DAB2, DOC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lsw RCSB], [http://www.ebi.ac.uk/pdbsum/2lsw PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Disabled-2 (Dab2) targets membranes and triggers a wide range of biological events, including endocytosis and platelet aggregation. Dab2, through its phosphotyrosine-binding (PTB) domain, inhibits platelet aggregation by competing with fibrinogen for alphaIIbbeta3 integrin receptor binding. We have recently shown that the N-terminal region, including the PTB domain (N-PTB), drives Dab2 to the platelet membrane surface by binding to sulfatides through two sulfatide-binding motifs, modulating the extent of platelet aggregation. The three-dimensional structure of a Dab2-derived peptide encompassing the sulfatide-binding motifs (SBM) has been determined in dodecylphosphocholine (DPC) micelles using NMR spectroscopy. Dab2 SBM contains two helices when embedded in micelles, reversibly binds to sulfatides with moderate affinity, lies parallel to the micelle surface, and, when added to a platelet mixture, reduces the number and size of sulfatide-induced aggregates. Overall, our findings identify and structurally characterize a minimal region in Dab2 that modulates platelet homotypic interactions, all of which provide the foundation for rational design of a new generation of anti-aggregatory low-molecular mass molecules for therapeutic purposes.

-	~~{{STRUCTURE_2lsw\| PDB=2lsw \| SCENE= }}~~	+	Structure, Sulfatide-binding Properties, and Inhibition of Platelet Aggregation by a Disabled-2-derived Peptide.,Xiao S, Charonko JJ, Fu X, Salmanzadeh A, Davalos RV, Vlachos PP, Finkielstein CV, Capelluto DG J Biol Chem. 2012 Sep 13. PMID:22977233<ref>PMID:22977233</ref>

-	~~===Structure~~, ~~sulfatide-binding properties, and inhibition~~ of ~~platelet aggregation by a Disabled-2-derived peptide===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22977233}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[2lsw]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSW OCA].~~	+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Xiao, S.]]		[[Category: Xiao, S.]]

OCA at 20:31, 26 September 2012

OCA — Wed, 26 Sep 2012 20:31:44 GMT

←Older revision		Revision as of 20:31, 26 September 2012
Line 1:		Line 1:
-	[[Image:2lsw.~~jpg~~\|left\|200px]]	+	[[Image:2lsw.png\|left\|200px]]

	{{STRUCTURE_2lsw\| PDB=2lsw \| SCENE= }}		{{STRUCTURE_2lsw\| PDB=2lsw \| SCENE= }}
Line 5:		Line 5:
	===Structure, sulfatide-binding properties, and inhibition of platelet aggregation by a Disabled-2-derived peptide===		===Structure, sulfatide-binding properties, and inhibition of platelet aggregation by a Disabled-2-derived peptide===

		+	{{ABSTRACT_PUBMED_22977233}}

	==About this Structure==		==About this Structure==

OCA at 07:17, 19 September 2012

OCA — Wed, 19 Sep 2012 07:17:18 GMT

←Older revision		Revision as of 07:17, 19 September 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2lsw.jpg\|left\|200px]]

-	~~The entry~~ 2lsw ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_2lsw\| PDB=2lsw \| SCENE= }}

-	~~Authors: Xiao~~, S.	+	===Structure, sulfatide-binding properties, and inhibition of platelet aggregation by a Disabled-2-derived peptide===

-	~~Description:~~ Structure~~, sulfatide~~-~~binding properties~~, ~~and inhibition of platelet~~ aggregation ~~by a Disabled-2-derived peptide~~	+
		+	==About this Structure==
		+	[[2lsw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSW OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Xiao, S.]]
		+	[[Category: Blood clotting]]
		+	[[Category: Dodecylphosphocholine]]
		+	[[Category: Platelet aggregation inhibitor]]
		+	[[Category: Sulfatide]]

OCA at 05:06, 27 June 2012

OCA — Wed, 27 Jun 2012 05:06:53 GMT

←Older revision		Revision as of 05:06, 27 June 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2lsw is ON HOLD	+	The entry 2lsw is ON HOLD until Paper Publication

	Authors: Xiao, S.		Authors: Xiao, S.

	Description: Structure, sulfatide-binding properties, and inhibition of platelet aggregation by a Disabled-2-derived peptide		Description: Structure, sulfatide-binding properties, and inhibition of platelet aggregation by a Disabled-2-derived peptide