2lsy - Revision history

OCA at 05:51, 15 May 2024

OCA — Wed, 15 May 2024 05:51:34 GMT

←Older revision		Revision as of 05:51, 15 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lsy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LSY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lsy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LSY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsy OCA], [https://pdbe.org/2lsy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lsy RCSB], [https://www.ebi.ac.uk/pdbsum/2lsy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lsy ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsy OCA], [https://pdbe.org/2lsy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lsy RCSB], [https://www.ebi.ac.uk/pdbsum/2lsy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lsy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 09:10, 14 June 2023

OCA — Wed, 14 Jun 2023 09:10:44 GMT

←Older revision		Revision as of 09:10, 14 June 2023
Line 1:		Line 1:

	==Structure of the C-terminal domain from human REV1==		==Structure of the C-terminal domain from human REV1==
-	<StructureSection load='2lsy' size='340' side='right'caption='[[2lsy~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2lsy' size='340' side='right'caption='[[2lsy]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lsy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LSY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lsy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LSY FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2lsk\|2lsk]]</div></td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsy OCA], [https://pdbe.org/2lsy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lsy RCSB], [https://www.ebi.ac.uk/pdbsum/2lsy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lsy ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsy OCA], [https://pdbe.org/2lsy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lsy RCSB], [https://www.ebi.ac.uk/pdbsum/2lsy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lsy ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/REV1_HUMAN REV1_HUMAN]] Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.<ref>PMID:10536157</ref> <ref>PMID:10760286</ref> <ref>PMID:11278384</ref> <ref>PMID:11485998</ref> <ref>PMID:22266823</ref>	+	[https://www.uniprot.org/uniprot/REV1_HUMAN REV1_HUMAN] Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.<ref>PMID:10536157</ref> <ref>PMID:10760286</ref> <ref>PMID:11278384</ref> <ref>PMID:11485998</ref> <ref>PMID:22266823</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 2lsy" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2lsy" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[DNA polymerase 3D structures\|DNA polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bezsonova, I]]	+	[[Category: Bezsonova I]]
-	[[Category: Korzhnev, D]]	+	[[Category: Korzhnev D]]
-	[[Category: Pozhidaeva, A]]	+	[[Category: Pozhidaeva A]]
-	[[Category: Pustovalova, Y]]	+	[[Category: Pustovalova Y]]
-	~~[[Category: Dna polymerase]]~~	+
-	~~[[Category: Dna repair]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Translesion synthesis~~]]	+

OCA at 07:54, 9 February 2022

OCA — Wed, 09 Feb 2022 07:54:14 GMT

←Older revision		Revision as of 07:54, 9 February 2022
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	<StructureSection load='2lsy' size='340' side='right'caption='[[2lsy]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lsy' size='340' side='right'caption='[[2lsy]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lsy]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2LSY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lsy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LSY FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lsk\|2lsk]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2lsk\|2lsk]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2lsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsy OCA], [~~http~~://pdbe.org/2lsy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2lsy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2lsy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2lsy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsy OCA], [https://pdbe.org/2lsy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lsy RCSB], [https://www.ebi.ac.uk/pdbsum/2lsy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lsy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/REV1_HUMAN REV1_HUMAN]] Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.<ref>PMID:10536157</ref> <ref>PMID:10760286</ref> <ref>PMID:11278384</ref> <ref>PMID:11485998</ref> <ref>PMID:22266823</ref>	+	[[https://www.uniprot.org/uniprot/REV1_HUMAN REV1_HUMAN]] Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.<ref>PMID:10536157</ref> <ref>PMID:10760286</ref> <ref>PMID:11278384</ref> <ref>PMID:11485998</ref> <ref>PMID:22266823</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:07, 6 May 2020

OCA — Wed, 06 May 2020 07:07:56 GMT

←Older revision		Revision as of 07:07, 6 May 2020
Line 1:		Line 1:

	==Structure of the C-terminal domain from human REV1==		==Structure of the C-terminal domain from human REV1==
-	<StructureSection load='2lsy' size='340' side='right' caption='[[2lsy]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2lsy' size='340' side='right'caption='[[2lsy]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lsy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSY OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LSY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lsy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2LSY FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lsk\|2lsk]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lsk\|2lsk]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2lsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsy OCA], [http://pdbe.org/2lsy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lsy RCSB], [http://www.ebi.ac.uk/pdbsum/2lsy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lsy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2lsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsy OCA], [http://pdbe.org/2lsy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lsy RCSB], [http://www.ebi.ac.uk/pdbsum/2lsy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lsy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bezsonova, I]]		[[Category: Bezsonova, I]]
	[[Category: Korzhnev, D]]		[[Category: Korzhnev, D]]

OCA at 19:54, 1 August 2018

OCA — Wed, 01 Aug 2018 19:54:01 GMT

←Older revision		Revision as of 19:54, 1 August 2018
Line 1:		Line 1:
		+
	==Structure of the C-terminal domain from human REV1==		==Structure of the C-terminal domain from human REV1==
	<StructureSection load='2lsy' size='340' side='right' caption='[[2lsy]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lsy' size='340' side='right' caption='[[2lsy]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2lsy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LSY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lsy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LSY FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lsk\|2lsk]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lsk\|2lsk]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsy OCA], [http://pdbe.org/2lsy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lsy RCSB], [http://www.ebi.ac.uk/pdbsum/2lsy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsy OCA], [http://pdbe.org/2lsy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lsy RCSB], [http://www.ebi.ac.uk/pdbsum/2lsy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lsy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 22:00, 10 September 2015

OCA — Thu, 10 Sep 2015 22:00:50 GMT

←Older revision		Revision as of 22:00, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2lsy' size='340' side='right' caption='[[2lsy]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lsy' size='340' side='right' caption='[[2lsy]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lsy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LSY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lsy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LSY FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lsk\|2lsk]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lsk\|2lsk]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lsy RCSB], [http://www.ebi.ac.uk/pdbsum/2lsy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsy OCA], [http://pdbe.org/2lsy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lsy RCSB], [http://www.ebi.ac.uk/pdbsum/2lsy PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2lsy" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bezsonova, I]]		[[Category: Bezsonova, I]]
	[[Category: Korzhnev, D]]		[[Category: Korzhnev, D]]

OCA at 06:39, 25 December 2014

OCA — Thu, 25 Dec 2014 06:39:54 GMT

←Older revision		Revision as of 06:39, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lsy RCSB], [http://www.ebi.ac.uk/pdbsum/2lsy PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lsy RCSB], [http://www.ebi.ac.uk/pdbsum/2lsy PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/REV1_HUMAN REV1_HUMAN]] Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.<ref>PMID:10536157</ref> <ref>PMID:10760286</ref> <ref>PMID:11278384</ref> <ref>PMID:11485998</ref> <ref>PMID:22266823</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:32, 18 December 2014

OCA — Thu, 18 Dec 2014 12:32:40 GMT

←Older revision		Revision as of 12:32, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2lsy~~\| ~~PDB~~=2lsy \| ~~SCENE~~= }}	+	==Structure of the C-terminal domain from human REV1==
-	===~~Structure~~ of the C-terminal domain from human ~~REV1===~~	+	<StructureSection load='2lsy' size='340' side='right' caption='[[2lsy]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_22691049}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2lsy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LSY FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lsk\|2lsk]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lsy RCSB], [http://www.ebi.ac.uk/pdbsum/2lsy PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Rev1 is a translesion synthesis (TLS) DNA polymerase essential for DNA damage tolerance in eukaryotes. In the process of TLS stalled high-fidelity replicative DNA polymerases are temporarily replaced by specialized TLS enzymes that can bypass sites of DNA damage (lesions), thus allowing replication to continue or postreplicational gaps to be filled. Despite its limited catalytic activity, human Rev1 plays a key role in TLS by serving as a scaffold that provides an access of Y-family TLS polymerases poleta, iota, and kappa to their cognate DNA lesions and facilitates their subsequent exchange to polzeta that extends the distorted DNA primer-template. Rev1 interaction with the other major human TLS polymerases, poleta, iota, kappa and the regulatory subunit Rev7 of polzeta, is mediated by Rev1 C-terminal domain (Rev1-CT). We used NMR spectroscopy to determine the spatial structure of the Rev1-CT domain (residues 1157-1251) and its complex with Rev1 interacting region (RIR) from poleta (residues 524-539). The domain forms a four-helix bundle with a well-structured N-terminal beta-hairpin docking against helices 1 and 2, creating a binding pocket for the two conserved Phe residues of the RIR motif that upon binding folds into an alpha-helix. NMR spin-relaxation and NMR relaxation dispersion measurements suggest that free Rev1-CT and Rev1-CT/poleta-RIR complex exhibit mus-ms conformational dynamics encompassing the RIR binding site, which might facilitate selection of the molecular configuration optimal for binding. These results offer new insights into the control of TLS in human cells by providing a structural basis for understanding the recognition of the Rev1-CT by Y-family DNA polymerases.

-	~~==Function==~~	+	NMR Structure and Dynamics of the C-terminal Domain from Human Rev1 and its Complex with Rev1 Interacting Region of DNA Polymerase eta,Pozhidaeva A, Pustovalova Y, D'Souza S, Bezsonova I, Walker GC, Korzhnev DM Biochemistry. 2012 Jun 13. PMID:22691049<ref>PMID:22691049</ref>
-	~~[[http://www.uniprot.org/uniprot/REV1_HUMAN REV1_HUMAN]] Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to~~ the 3'-~~end~~ of a DNA ~~primer in a template-dependent reaction~~. ~~May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion~~. ~~Required for normal induction of mutations by physical and chemical agents.<ref>~~PMID:~~10536157</ref> <ref>PMID:10760286</ref> <ref>PMID:11278384</ref> <ref>PMID:11485998</ref>~~ <ref>PMID:~~22266823~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2lsy]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2LSY OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:022691049</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bezsonova, I.]]	+	[[Category: Bezsonova, I]]
-	[[Category: Korzhnev, D.]]	+	[[Category: Korzhnev, D]]
-	[[Category: Pozhidaeva, A.]]	+	[[Category: Pozhidaeva, A]]
-	[[Category: Pustovalova, Y.]]	+	[[Category: Pustovalova, Y]]
	[[Category: Dna polymerase]]		[[Category: Dna polymerase]]
	[[Category: Dna repair]]		[[Category: Dna repair]]
	[[Category: Protein binding]]		[[Category: Protein binding]]
	[[Category: Translesion synthesis]]		[[Category: Translesion synthesis]]

OCA at 08:39, 19 June 2013

OCA — Wed, 19 Jun 2013 08:39:54 GMT

←Older revision		Revision as of 08:39, 19 June 2013
Line 1:		Line 1:
-	[[Image:2lsy.jpg\|left\|200px]]
-
	{{STRUCTURE_2lsy\| PDB=2lsy \| SCENE= }}		{{STRUCTURE_2lsy\| PDB=2lsy \| SCENE= }}
-
	===Structure of the C-terminal domain from human REV1===		===Structure of the C-terminal domain from human REV1===
		+	{{ABSTRACT_PUBMED_22691049}}

-	~~{{ABSTRACT_PUBMED_22691049}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/REV1_HUMAN REV1_HUMAN]] Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.<ref>PMID:10536157</ref> <ref>PMID:10760286</ref> <ref>PMID:11278384</ref> <ref>PMID:11485998</ref> <ref>PMID:22266823</ref>

	==About this Structure==		==About this Structure==
Line 11:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:022691049</ref><references group="xtra"/>	+	<ref group="xtra">PMID:022691049</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bezsonova, I.]]		[[Category: Bezsonova, I.]]

OCA at 05:48, 27 June 2012

OCA — Wed, 27 Jun 2012 05:48:56 GMT

←Older revision		Revision as of 05:48, 27 June 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2lsy.jpg\|left\|200px]]

-	~~The entry~~ 2lsy ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_2lsy\| PDB=2lsy \| SCENE= }}

-	~~Authors: Pozhidaeva, A., Pustovalova, Y., Bezsonova, I., Korzhnev, D.~~	+	===Structure of the C-terminal domain from human REV1===

-	~~Description:~~ Structure ~~of the C-terminal domain~~ from ~~human REV1~~	+	{{ABSTRACT_PUBMED_22691049}}
		+
		+	==About this Structure==
		+	[[2lsy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSY OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022691049</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Bezsonova, I.]]
		+	[[Category: Korzhnev, D.]]
		+	[[Category: Pozhidaeva, A.]]
		+	[[Category: Pustovalova, Y.]]
		+	[[Category: Dna polymerase]]
		+	[[Category: Dna repair]]
		+	[[Category: Protein binding]]
		+	[[Category: Translesion synthesis]]