2lu2 - Revision history

OCA at 05:52, 15 May 2024

OCA — Wed, 15 May 2024 05:52:06 GMT

←Older revision		Revision as of 05:52, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lu2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LU2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lu2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LU2 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lu2 OCA], [https://pdbe.org/2lu2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lu2 RCSB], [https://www.ebi.ac.uk/pdbsum/2lu2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lu2 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lu2 OCA], [https://pdbe.org/2lu2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lu2 RCSB], [https://www.ebi.ac.uk/pdbsum/2lu2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lu2 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:10, 22 February 2023

OCA — Wed, 22 Feb 2023 13:10:36 GMT

←Older revision		Revision as of 13:10, 22 February 2023
Line 1:		Line 1:

	==MIC5 regulates the activity of Toxoplasma subtilisin 1 by mimicking a subtilisin prodomain==		==MIC5 regulates the activity of Toxoplasma subtilisin 1 by mimicking a subtilisin prodomain==
-	<StructureSection load='2lu2' size='340' side='right'caption='[[2lu2~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='2lu2' size='340' side='right'caption='[[2lu2]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lu2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Toxgo Toxgo~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LU2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lu2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LU2 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TGME49_077080, TGVEG_027740 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5811 TOXGO])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lu2 OCA], [https://pdbe.org/2lu2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lu2 RCSB], [https://www.ebi.ac.uk/pdbsum/2lu2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lu2 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lu2 OCA], [https://pdbe.org/2lu2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lu2 RCSB], [https://www.ebi.ac.uk/pdbsum/2lu2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lu2 ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Toxgo~~]]	+	[[Category: Toxoplasma gondii]]
-	[[Category: Carruthers~~, V B~~]]	+	[[Category: Carruthers VB]]
-	[[Category: Dou, Z]]	+	[[Category: Dou Z]]
-	[[Category: Henry, M]]	+	[[Category: Henry M]]
-	[[Category: Marchant, J]]	+	[[Category: Marchant J]]
-	[[Category: Matthews, S]]	+	[[Category: Matthews S]]
-	[[Category: Saouros, S]]	+	[[Category: Saouros S]]
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Invasion]]~~	+
-	~~[[Category: Micronemal protein 5]]~~	+
-	~~[[Category: Pathogenesis~~]]	+

OCA at 10:53, 19 May 2021

OCA — Wed, 19 May 2021 10:53:25 GMT

←Older revision		Revision as of 10:53, 19 May 2021
Line 1:		Line 1:

	==MIC5 regulates the activity of Toxoplasma subtilisin 1 by mimicking a subtilisin prodomain==		==MIC5 regulates the activity of Toxoplasma subtilisin 1 by mimicking a subtilisin prodomain==
-	<StructureSection load='2lu2' size='340' side='right' caption='[[2lu2]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='2lu2' size='340' side='right'caption='[[2lu2]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lu2]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Toxgo Toxgo]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LU2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LU2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lu2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxgo Toxgo]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LU2 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TGME49_077080, TGVEG_027740 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5811 TOXGO])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TGME49_077080, TGVEG_027740 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5811 TOXGO])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2lu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lu2 OCA], [~~http~~://pdbe.org/2lu2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2lu2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2lu2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2lu2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lu2 OCA], [https://pdbe.org/2lu2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lu2 RCSB], [https://www.ebi.ac.uk/pdbsum/2lu2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lu2 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Toxgo]]		[[Category: Toxgo]]
	[[Category: Carruthers, V B]]		[[Category: Carruthers, V B]]

OCA at 23:16, 9 August 2018

OCA — Thu, 09 Aug 2018 23:16:37 GMT

←Older revision		Revision as of 23:16, 9 August 2018
Line 1:		Line 1:
		+
	==MIC5 regulates the activity of Toxoplasma subtilisin 1 by mimicking a subtilisin prodomain==		==MIC5 regulates the activity of Toxoplasma subtilisin 1 by mimicking a subtilisin prodomain==
	<StructureSection load='2lu2' size='340' side='right' caption='[[2lu2]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2lu2' size='340' side='right' caption='[[2lu2]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2lu2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LU2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LU2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lu2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LU2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LU2 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TGME49_077080, TGVEG_027740 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5811 TOXGO])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TGME49_077080, TGVEG_027740 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5811 TOXGO])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lu2 OCA], [http://pdbe.org/2lu2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lu2 RCSB], [http://www.ebi.ac.uk/pdbsum/2lu2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lu2 OCA], [http://pdbe.org/2lu2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lu2 RCSB], [http://www.ebi.ac.uk/pdbsum/2lu2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lu2 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 14:55, 11 September 2015

OCA — Fri, 11 Sep 2015 14:55:56 GMT

←Older revision		Revision as of 14:55, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2lu2' size='340' side='right' caption='[[2lu2]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2lu2' size='340' side='right' caption='[[2lu2]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lu2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Toxoplasma_gondii Toxoplasma gondii~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LU2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LU2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lu2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LU2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LU2 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TGME49_077080, TGVEG_027740 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5811 ~~Toxoplasma gondii~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TGME49_077080, TGVEG_027740 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5811 TOXGO])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lu2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lu2 RCSB], [http://www.ebi.ac.uk/pdbsum/2lu2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lu2 OCA], [http://pdbe.org/2lu2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lu2 RCSB], [http://www.ebi.ac.uk/pdbsum/2lu2 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2lu2" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Toxoplasma gondii~~]]	+	[[Category: Toxgo]]
	[[Category: Carruthers, V B]]		[[Category: Carruthers, V B]]
	[[Category: Dou, Z]]		[[Category: Dou, Z]]

OCA at 16:03, 19 January 2015

OCA — Mon, 19 Jan 2015 16:03:27 GMT

←Older revision		Revision as of 16:03, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lu2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LU2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LU2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lu2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LU2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LU2 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TGME49_077080, TGVEG_027740 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5811 Toxoplasma gondii])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TGME49_077080, TGVEG_027740 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5811 Toxoplasma gondii])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lu2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lu2 RCSB], [http://www.ebi.ac.uk/pdbsum/2lu2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lu2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lu2 RCSB], [http://www.ebi.ac.uk/pdbsum/2lu2 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: Toxoplasma gondii]]		[[Category: Toxoplasma gondii]]
-	[[Category: Carruthers, V B.]]	+	[[Category: Carruthers, V B]]
-	[[Category: Dou, Z.]]	+	[[Category: Dou, Z]]
-	[[Category: Henry, M.]]	+	[[Category: Henry, M]]
-	[[Category: Marchant, J.]]	+	[[Category: Marchant, J]]
-	[[Category: Matthews, S.]]	+	[[Category: Matthews, S]]
-	[[Category: Saouros, S.]]	+	[[Category: Saouros, S]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Invasion]]		[[Category: Invasion]]
	[[Category: Micronemal protein 5]]		[[Category: Micronemal protein 5]]
	[[Category: Pathogenesis]]		[[Category: Pathogenesis]]

OCA at 05:26, 29 September 2014

OCA — Mon, 29 Sep 2014 05:26:25 GMT

←Older revision		Revision as of 05:26, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2lu2.~~png~~\|~~left\|200px~~]]	+	==MIC5 regulates the activity of Toxoplasma subtilisin 1 by mimicking a subtilisin prodomain==
		+	<StructureSection load='2lu2' size='340' side='right' caption='[[2lu2]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2lu2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LU2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LU2 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TGME49_077080, TGVEG_027740 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5811 Toxoplasma gondii])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lu2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lu2 RCSB], [http://www.ebi.ac.uk/pdbsum/2lu2 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Toxoplasma gondii is the model parasite of the phylum Apicomplexa, which contains obligate intracellular parasites of medical and veterinary importance. Apicomplexans invade host cells by a multistep process involving the secretion of adhesive microneme protein (MIC) complexes. The subtilisin protease TgSUB1 trims several MICs on the parasite surface to activate gliding motility and host invasion. Although a previous study showed that expression of the secretory protein TgMIC5 suppresses TgSUB1 activity, the mechanism was unknown. Here, we solve the three-dimensional structure of TgMIC5 by nuclear magnetic resonance (NMR), revealing that it mimics a subtilisin prodomain including a flexible C-terminal peptide that may insert into the subtilisin active site. We show that TgMIC5 is an almost 50-fold more potent inhibitor of TgSUB1 activity than the small molecule inhibitor N-[N-(N-acetyl-l-leucyl)-l-leucyl]-l-norleucine (ALLN). Moreover, we demonstrate that TgMIC5 is retained on the parasite plasma membrane via its physical interaction with the membrane-anchored TgSUB1.

-	~~{{STRUCTURE_2lu2\| PDB=2lu2 \| SCENE= }}~~	+	Microneme protein 5 regulates the activity of toxoplasma subtilisin 1 by mimicking a subtilisin prodomain.,Saouros S, Dou Z, Henry M, Marchant J, Carruthers VB, Matthews S J Biol Chem. 2012 Oct 19;287(43):36029-40. doi: 10.1074/jbc.M112.389825. Epub, 2012 Aug 15. PMID:22896704<ref>PMID:22896704</ref>

-	~~===MIC5 regulates~~ the ~~activity~~ of ~~Toxoplasma subtilisin 1 by mimicking a subtilisin prodomain===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	==~~About this Structure~~==	+	<references/>
-	~~[[2lu2]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LU2 OCA].~~	+	__TOC__
		+	</StructureSection>
	[[Category: Toxoplasma gondii]]		[[Category: Toxoplasma gondii]]
	[[Category: Carruthers, V B.]]		[[Category: Carruthers, V B.]]

OCA at 06:46, 14 November 2012

OCA — Wed, 14 Nov 2012 06:46:46 GMT

←Older revision		Revision as of 06:46, 14 November 2012
Line 1:		Line 1:
-	[[Image:2lu2.~~jpg~~\|left\|200px]]	+	[[Image:2lu2.png\|left\|200px]]

	{{STRUCTURE_2lu2\| PDB=2lu2 \| SCENE= }}		{{STRUCTURE_2lu2\| PDB=2lu2 \| SCENE= }}

OCA at 06:00, 22 August 2012

OCA — Wed, 22 Aug 2012 06:00:08 GMT

←Older revision		Revision as of 06:00, 22 August 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2lu2.jpg\|left\|200px]]

-	~~The entry~~ 2lu2 ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_2lu2\| PDB=2lu2 \| SCENE= }}

-	~~Authors: Saouros, S., Dou, Z., Henry, M., Marchant, J., Carruthers, V.B., Matthews, S.~~	+	===MIC5 regulates the activity of Toxoplasma subtilisin 1 by mimicking a subtilisin prodomain===

-	~~Description~~: ~~MIC5 regulates the activity of~~ Toxoplasma ~~subtilisin 1 by mimicking a subtilisin prodomain~~	+
		+	==About this Structure==
		+	[[2lu2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LU2 OCA].
		+	[[Category: Toxoplasma gondii]]
		+	[[Category: Carruthers, V B.]]
		+	[[Category: Dou, Z.]]
		+	[[Category: Henry, M.]]
		+	[[Category: Marchant, J.]]
		+	[[Category: Matthews, S.]]
		+	[[Category: Saouros, S.]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Invasion]]
		+	[[Category: Micronemal protein 5]]
		+	[[Category: Pathogenesis]]

OCA at 04:38, 8 August 2012

OCA — Wed, 08 Aug 2012 04:38:30 GMT

←Older revision		Revision as of 04:38, 8 August 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2lu2 is ON HOLD	+	The entry 2lu2 is ON HOLD until Paper Publication

	Authors: Saouros, S., Dou, Z., Henry, M., Marchant, J., Carruthers, V.B., Matthews, S.		Authors: Saouros, S., Dou, Z., Henry, M., Marchant, J., Carruthers, V.B., Matthews, S.

	Description: MIC5 regulates the activity of Toxoplasma subtilisin 1 by mimicking a subtilisin prodomain		Description: MIC5 regulates the activity of Toxoplasma subtilisin 1 by mimicking a subtilisin prodomain