2lur - Revision history

OCA at 09:14, 14 June 2023

OCA — Wed, 14 Jun 2023 09:14:14 GMT

←Older revision		Revision as of 09:14, 14 June 2023
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	==NMR solution structure of Kb1[ghrw;23-28]==		==NMR solution structure of Kb1[ghrw;23-28]==
-	<StructureSection load='2lur' size='340' side='right'caption='[[2lur~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2lur' size='340' side='right'caption='[[2lur]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lur]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LUR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lur]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LUR FirstGlance]. <br>
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Craik~~, D J~~]]	+	[[Category: Craik DJ]]
-	[[Category: Daly~~, N L~~]]	+	[[Category: Daly NL]]
-	[[Category: Eliasen, R]]	+	[[Category: Eliasen R]]
-	~~[[Category: Beta hairpin]]~~	+
-	~~[[Category: Plant protein~~]]	+

OCA at 11:29, 16 February 2022

OCA — Wed, 16 Feb 2022 11:29:43 GMT

←Older revision		Revision as of 11:29, 16 February 2022
Line 3:		Line 3:
	<StructureSection load='2lur' size='340' side='right'caption='[[2lur]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lur' size='340' side='right'caption='[[2lur]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lur]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2LUR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lur]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LUR FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2lur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lur OCA], [~~http~~://pdbe.org/2lur PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2lur RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2lur PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2lur ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lur OCA], [https://pdbe.org/2lur PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lur RCSB], [https://www.ebi.ac.uk/pdbsum/2lur PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lur ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:15, 13 May 2020

OCA — Wed, 13 May 2020 06:15:24 GMT

←Older revision		Revision as of 06:15, 13 May 2020
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	==NMR solution structure of Kb1[ghrw;23-28]==		==NMR solution structure of Kb1[ghrw;23-28]==
-	<StructureSection load='2lur' size='340' side='right' caption='[[2lur]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2lur' size='340' side='right'caption='[[2lur]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lur]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUR OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LUR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lur]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2LUR FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2lur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lur OCA], [http://pdbe.org/2lur PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lur RCSB], [http://www.ebi.ac.uk/pdbsum/2lur PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lur ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2lur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lur OCA], [http://pdbe.org/2lur PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lur RCSB], [http://www.ebi.ac.uk/pdbsum/2lur PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lur ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Craik, D J]]		[[Category: Craik, D J]]
	[[Category: Daly, N L]]		[[Category: Daly, N L]]

OCA at 23:04, 9 August 2018

OCA — Thu, 09 Aug 2018 23:04:03 GMT

←Older revision		Revision as of 23:04, 9 August 2018
Line 1:		Line 1:
		+
	==NMR solution structure of Kb1[ghrw;23-28]==		==NMR solution structure of Kb1[ghrw;23-28]==
	<StructureSection load='2lur' size='340' side='right' caption='[[2lur]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lur' size='340' side='right' caption='[[2lur]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lur]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LUR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lur]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LUR FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lur OCA], [http://pdbe.org/2lur PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lur RCSB], [http://www.ebi.ac.uk/pdbsum/2lur PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lur OCA], [http://pdbe.org/2lur PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lur RCSB], [http://www.ebi.ac.uk/pdbsum/2lur PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lur ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:31, 11 September 2015

OCA — Fri, 11 Sep 2015 00:31:01 GMT

←Older revision		Revision as of 00:31, 11 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lur]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LUR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lur]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LUR FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lur OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lur RCSB], [http://www.ebi.ac.uk/pdbsum/2lur PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lur OCA], [http://pdbe.org/2lur PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lur RCSB], [http://www.ebi.ac.uk/pdbsum/2lur PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 13:		Line 13:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2lur" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:58, 19 January 2015

OCA — Mon, 19 Jan 2015 16:58:04 GMT

←Older revision		Revision as of 16:58, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lur]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LUR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lur]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LUR FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lur OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lur RCSB], [http://www.ebi.ac.uk/pdbsum/2lur PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lur OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lur RCSB], [http://www.ebi.ac.uk/pdbsum/2lur PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Craik, D J.]]	+	[[Category: Craik, D J]]
-	[[Category: Daly, N L.]]	+	[[Category: Daly, N L]]
-	[[Category: Eliasen, R.]]	+	[[Category: Eliasen, R]]
	[[Category: Beta hairpin]]		[[Category: Beta hairpin]]
	[[Category: Plant protein]]		[[Category: Plant protein]]

OCA at 03:40, 29 September 2014

OCA — Mon, 29 Sep 2014 03:40:06 GMT

←Older revision		Revision as of 03:40, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2lur.~~png\|left\|200px~~]]	+	==NMR solution structure of Kb1[ghrw;23-28]==
		+	<StructureSection load='2lur' size='340' side='right' caption='[[2lur]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2lur]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LUR FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lur OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lur RCSB], [http://www.ebi.ac.uk/pdbsum/2lur PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Obesity is an increasingly important global health problem that lacks current treatment options. The melanocortin receptor 4 (MC4R) is a target for obesity therapies because its activation triggers appetite suppression and increases energy expenditure. Cyclotides have been suggested as scaffolds for the insertion and stabilization of pharmaceutically active peptides. In this study, we explored the development of appetite-reducing peptides by synthesizing MC4R agonists based on the insertion of the His-Phe-Arg-Trp sequence into the cyclotide kalata B1. The ability of the analogues to fold similarly to kalata B1 but display MC4R activity were investigated. Four peptides were synthesized using t-butoxycarbonyl peptide chemistry with a C-terminal thioester to facilitate backbone cyclization. The structures of the peptides were found to be similar to kalata B1, evaluated by Halpha NMR chemical shifts. KB1(GHFRWG;23-28) had a K(i) of 29 nm at the MC4R and was 107 or 314 times more selective over this receptor than MC1R or MC5R, respectively, and had no detectable binding to MC3R. The peptide had higher affinity for the MC4R than the endogenous agonist, alpha-melanocyte stimulation hormone, but it was less potent at the MC4R, with an EC(50) of 580 nm for activation of the MC4R. In conclusion, we synthesized melanocortin analogues of kalata B1 that preserve the structural scaffold and display receptor binding and functional activity. KB1(GHFRWG;23-28) is potent and selective for the MC4R. This compound validates the use of cyclotides as scaffolds and has the potential to be a new lead for the treatment of obesity.

-	~~{{STRUCTURE_2lur\| PDB=2lur \| SCENE= }}~~	+	Design, synthesis, structural and functional characterization of novel melanocortin agonists based on the cyclotide kalata b1.,Eliasen R, Daly NL, Wulff BS, Andresen TL, Conde-Frieboes KW, Craik DJ J Biol Chem. 2012 Nov 23;287(48):40493-501. doi: 10.1074/jbc.M112.395442. Epub, 2012 Sep 25. PMID:23012369<ref>PMID:23012369</ref>

-	~~===NMR solution structure~~ of ~~Kb1[ghrw;23-28]===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23012369}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[2lur]] is a 1 chain structure. Full experimental information is available from [http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=2LUR OCA].~~	+	</StructureSection>
	[[Category: Craik, D J.]]		[[Category: Craik, D J.]]
	[[Category: Daly, N L.]]		[[Category: Daly, N L.]]

OCA at 21:17, 12 December 2012

OCA — Wed, 12 Dec 2012 21:17:41 GMT

←Older revision		Revision as of 21:17, 12 December 2012
Line 1:		Line 1:
-	[[Image:2lur.~~jpg~~\|left\|200px]]	+	[[Image:2lur.png\|left\|200px]]

	{{STRUCTURE_2lur\| PDB=2lur \| SCENE= }}		{{STRUCTURE_2lur\| PDB=2lur \| SCENE= }}
Line 5:		Line 5:
	===NMR solution structure of Kb1[ghrw;23-28]===		===NMR solution structure of Kb1[ghrw;23-28]===

		+	{{ABSTRACT_PUBMED_23012369}}

	==About this Structure==		==About this Structure==

OCA at 05:15, 29 August 2012

OCA — Wed, 29 Aug 2012 05:15:59 GMT

←Older revision		Revision as of 05:15, 29 August 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2lur.jpg\|left\|200px]]

-	~~The entry~~ 2lur ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_2lur\| PDB=2lur \| SCENE= }}

-	~~Authors: Daly, N.L., Eliasen, R., Craik, D.J.~~	+	===NMR solution structure of Kb1[ghrw;23-28]===

-	~~Description: NMR solution~~ structure ~~of Kb1~~[~~ghrw;23~~-28]	+
		+	==About this Structure==
		+	[[2lur]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUR OCA].
		+	[[Category: Craik, D J.]]
		+	[[Category: Daly, N L.]]
		+	[[Category: Eliasen, R.]]
		+	[[Category: Beta hairpin]]
		+	[[Category: Plant protein]]

OCA at 07:01, 4 July 2012

OCA — Wed, 04 Jul 2012 07:01:01 GMT

←Older revision		Revision as of 07:01, 4 July 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2lur is ON HOLD	+	The entry 2lur is ON HOLD until Paper Publication

	Authors: Daly, N.L., Eliasen, R., Craik, D.J.		Authors: Daly, N.L., Eliasen, R., Craik, D.J.

-	Description: ~~KB1~~[~~GHRW~~;23-28]	+	Description: NMR solution structure of Kb1[ghrw;23-28]