2lwa - Revision history

OCA at 05:54, 15 May 2024

OCA — Wed, 15 May 2024 05:54:06 GMT

←Older revision		Revision as of 05:54, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lwa]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Hong_Kong/1035/1998(H1N1)) Influenza A virus (A/Hong Kong/1035/1998(H1N1))]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LWA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lwa]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Hong_Kong/1035/1998(H1N1)) Influenza A virus (A/Hong Kong/1035/1998(H1N1))]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LWA FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwa OCA], [https://pdbe.org/2lwa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lwa RCSB], [https://www.ebi.ac.uk/pdbsum/2lwa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lwa ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwa OCA], [https://pdbe.org/2lwa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lwa RCSB], [https://www.ebi.ac.uk/pdbsum/2lwa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lwa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 09:18, 14 June 2023

OCA — Wed, 14 Jun 2023 09:18:23 GMT

←Older revision		Revision as of 09:18, 14 June 2023
Line 1:		Line 1:

	==Conformational ensemble for the G8A mutant of the influenza hemagglutinin fusion peptide==		==Conformational ensemble for the G8A mutant of the influenza hemagglutinin fusion peptide==
-	<StructureSection load='2lwa' size='340' side='right'caption='[[2lwa~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2lwa' size='340' side='right'caption='[[2lwa]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lwa]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Influenza_a_virus_~~(a/~~hong_kong~~/1035/1998(~~h1n1~~)) Influenza a virus (a/~~hong kong~~/1035/1998(~~h1n1~~))]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LWA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lwa]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Hong_Kong/1035/1998(H1N1)) Influenza A virus (A/Hong Kong/1035/1998(H1N1))]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LWA FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2kxa\|2kxa]]</div></td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwa OCA], [https://pdbe.org/2lwa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lwa RCSB], [https://www.ebi.ac.uk/pdbsum/2lwa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lwa ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwa OCA], [https://pdbe.org/2lwa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lwa RCSB], [https://www.ebi.ac.uk/pdbsum/2lwa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lwa ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q91IJ0_9INFA Q91IJ0_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643]	+	[https://www.uniprot.org/uniprot/Q91IJ0_9INFA Q91IJ0_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bax, A]]	+	[[Category: Bax A]]
-	[[Category: Lorieau~~, J L~~]]	+	[[Category: Lorieau JL]]
-	[[Category: Louis~~, J M~~]]	+	[[Category: Louis JM]]
-	[[Category: Schwieters~~, C D]]~~	+	[[Category: Schwieters CD]]
-	~~[[Category: Fusion peptide]]~~	+
-	~~[[Category: G8a mutant]]~~	+
-	~~[[Category: Hemagglutinin]]~~	+
-	~~[[Category: Influenza virus]]~~	+
-	~~[[Category: Membrane protein~~]]	+

OCA at 11:30, 16 February 2022

OCA — Wed, 16 Feb 2022 11:30:08 GMT

←Older revision		Revision as of 11:30, 16 February 2022
Line 3:		Line 3:
	<StructureSection load='2lwa' size='340' side='right'caption='[[2lwa]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lwa' size='340' side='right'caption='[[2lwa]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lwa]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Influenza_a_virus_(a/hong_kong/1035/1998(h1n1)) Influenza a virus (a/hong kong/1035/1998(h1n1))]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2LWA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lwa]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_a_virus_(a/hong_kong/1035/1998(h1n1)) Influenza a virus (a/hong kong/1035/1998(h1n1))]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LWA FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kxa\|2kxa]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2kxa\|2kxa]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2lwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwa OCA], [~~http~~://pdbe.org/2lwa PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2lwa RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2lwa PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2lwa ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwa OCA], [https://pdbe.org/2lwa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lwa RCSB], [https://www.ebi.ac.uk/pdbsum/2lwa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lwa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/Q91IJ0_9INFA Q91IJ0_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643]	+	[[https://www.uniprot.org/uniprot/Q91IJ0_9INFA Q91IJ0_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:15, 13 May 2020

OCA — Wed, 13 May 2020 06:15:50 GMT

←Older revision		Revision as of 06:15, 13 May 2020
Line 1:		Line 1:

	==Conformational ensemble for the G8A mutant of the influenza hemagglutinin fusion peptide==		==Conformational ensemble for the G8A mutant of the influenza hemagglutinin fusion peptide==
-	<StructureSection load='2lwa' size='340' side='right' caption='[[2lwa]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2lwa' size='340' side='right'caption='[[2lwa]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lwa]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/hong_kong/1035/1998(h1n1)) Influenza a virus (a/hong kong/1035/1998(h1n1))]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWA OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LWA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lwa]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/hong_kong/1035/1998(h1n1)) Influenza a virus (a/hong kong/1035/1998(h1n1))]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2LWA FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kxa\|2kxa]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kxa\|2kxa]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2lwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwa OCA], [http://pdbe.org/2lwa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lwa RCSB], [http://www.ebi.ac.uk/pdbsum/2lwa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lwa ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2lwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwa OCA], [http://pdbe.org/2lwa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lwa RCSB], [http://www.ebi.ac.uk/pdbsum/2lwa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lwa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Bax, A]]		[[Category: Bax, A]]
	[[Category: Lorieau, J L]]		[[Category: Lorieau, J L]]

OCA at 22:32, 9 August 2018

OCA — Thu, 09 Aug 2018 22:32:42 GMT

←Older revision		Revision as of 22:32, 9 August 2018
Line 1:		Line 1:
		+
	==Conformational ensemble for the G8A mutant of the influenza hemagglutinin fusion peptide==		==Conformational ensemble for the G8A mutant of the influenza hemagglutinin fusion peptide==
	<StructureSection load='2lwa' size='340' side='right' caption='[[2lwa]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lwa' size='340' side='right' caption='[[2lwa]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2lwa]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/hong_kong/1035/1998(h1n1)) Influenza a virus (a/hong kong/1035/1998(h1n1))]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LWA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lwa]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/hong_kong/1035/1998(h1n1)) Influenza a virus (a/hong kong/1035/1998(h1n1))]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LWA FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kxa\|2kxa]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kxa\|2kxa]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwa OCA], [http://pdbe.org/2lwa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lwa RCSB], [http://www.ebi.ac.uk/pdbsum/2lwa PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwa OCA], [http://pdbe.org/2lwa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lwa RCSB], [http://www.ebi.ac.uk/pdbsum/2lwa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lwa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 21:28, 10 September 2015

OCA — Thu, 10 Sep 2015 21:28:35 GMT

←Older revision		Revision as of 21:28, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2lwa]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/hong_kong/1035/1998(h1n1)) Influenza a virus (a/hong kong/1035/1998(h1n1))]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LWA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lwa]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/hong_kong/1035/1998(h1n1)) Influenza a virus (a/hong kong/1035/1998(h1n1))]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LWA FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kxa\|2kxa]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kxa\|2kxa]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lwa RCSB], [http://www.ebi.ac.uk/pdbsum/2lwa PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwa OCA], [http://pdbe.org/2lwa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lwa RCSB], [http://www.ebi.ac.uk/pdbsum/2lwa PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2lwa" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:19, 25 December 2014

OCA — Thu, 25 Dec 2014 06:19:43 GMT

←Older revision		Revision as of 06:19, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lwa RCSB], [http://www.ebi.ac.uk/pdbsum/2lwa PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lwa RCSB], [http://www.ebi.ac.uk/pdbsum/2lwa PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q91IJ0_9INFA Q91IJ0_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:26, 18 December 2014

OCA — Thu, 18 Dec 2014 11:26:36 GMT

←Older revision		Revision as of 11:26, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2lwa\| PDB=2lwa \| SCENE= }}~~	+	==Conformational ensemble for the G8A mutant of the influenza hemagglutinin fusion peptide==
-	===Conformational ensemble for the G8A mutant of the influenza hemagglutinin fusion peptide===	+	<StructureSection load='2lwa' size='340' side='right' caption='[[2lwa]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_23169643}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2lwa]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/hong_kong/1035/1998(h1n1)) Influenza a virus (a/hong kong/1035/1998(h1n1))]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LWA FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kxa\|2kxa]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lwa RCSB], [http://www.ebi.ac.uk/pdbsum/2lwa PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The highly conserved first 23 residues of the influenza hemagglutinin HA2 subunit constitute the fusion domain, which plays a pivotal role in fusing viral and host-cell membranes. At neutral pH, this peptide adopts a tight helical hairpin wedge structure, stabilized by aliphatic hydrogen bonding and charge-dipole interactions. We demonstrate that at low pH, where the fusion process is triggered, the native peptide transiently visits activated states that are very similar to those sampled by a G8A mutant. This mutant retains a small fraction of helical hairpin conformation, in rapid equilibrium with at least two open structures. The exchange rate between the closed and open conformations of the wild-type fusion peptide is approximately 40 kHz, with a total open-state population of approximately 20%. Transitions to these activated states are likely to play a crucial role in formation of the fusion pore, an essential structure required in the final stage of membrane fusion.

-	~~==Function==~~	+	pH-triggered, activated-state conformations of the influenza hemagglutinin fusion peptide revealed by NMR.,Lorieau JL, Louis JM, Schwieters CD, Bax A Proc Natl Acad Sci U S A. 2012 Nov 19. PMID:23169643<ref>PMID:23169643</ref>
-	~~[[http://www.uniprot.org/uniprot/Q91IJ0_9INFA Q91IJ0_9INFA]] Binds to sialic acid~~-~~containing receptors on the cell surface~~, ~~bringing about the attachment~~ of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion ~~protein. Responsible for penetration of the virus into the cell cytoplasm~~ by ~~mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane~~. ~~Low pH in endosomes induces an irreversible conformational change in HA2~~, ~~releasing the fusion hydrophobic peptide~~. ~~Several trimers are required to form a competent fusion pore (By similarity)~~.~~[RuleBase~~:~~RU003324][SAAS~~:~~SAAS013829_004_327643]~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2lwa]] is a 3 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Influenza_a_virus_(~~a~~/hong_kong/1035/1998(h1n1)) Influenza a virus (a/hong kong/1035/1998(h1n1))]~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id~~=~~2LWA OCA].~~	+	</div>
-	[[Category: Bax, A.]]	+	== References ==
-	[[Category: Lorieau, J L.]]	+	<references/>
-	[[Category: Louis, J M.]]	+	__TOC__
-	[[Category: Schwieters, C D.]]	+	</StructureSection>
		+	[[Category: Bax, A]]
		+	[[Category: Lorieau, J L]]
		+	[[Category: Louis, J M]]
		+	[[Category: Schwieters, C D]]
	[[Category: Fusion peptide]]		[[Category: Fusion peptide]]
	[[Category: G8a mutant]]		[[Category: G8a mutant]]

OCA at 22:51, 3 April 2013

OCA — Wed, 03 Apr 2013 22:51:50 GMT

←Older revision		Revision as of 22:51, 3 April 2013
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-	[[Image:2lwa.png\|left\|200px]]
-
	{{STRUCTURE_2lwa\| PDB=2lwa \| SCENE= }}		{{STRUCTURE_2lwa\| PDB=2lwa \| SCENE= }}
-
	===Conformational ensemble for the G8A mutant of the influenza hemagglutinin fusion peptide===		===Conformational ensemble for the G8A mutant of the influenza hemagglutinin fusion peptide===
		+	{{ABSTRACT_PUBMED_23169643}}

-	~~{{ABSTRACT_PUBMED_23169643}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/Q91IJ0_9INFA Q91IJ0_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643]

	==About this Structure==		==About this Structure==

OCA at 10:31, 19 December 2012

OCA — Wed, 19 Dec 2012 10:31:00 GMT

←Older revision		Revision as of 10:31, 19 December 2012
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-	[[Image:2lwa.~~jpg~~\|left\|200px]]	+	[[Image:2lwa.png\|left\|200px]]

	{{STRUCTURE_2lwa\| PDB=2lwa \| SCENE= }}		{{STRUCTURE_2lwa\| PDB=2lwa \| SCENE= }}