2lwx - Revision history

OCA at 05:54, 15 May 2024

OCA — Wed, 15 May 2024 05:54:23 GMT

←Older revision		Revision as of 05:54, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lwx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LWX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lwx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LWX FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwx OCA], [https://pdbe.org/2lwx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lwx RCSB], [https://www.ebi.ac.uk/pdbsum/2lwx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lwx ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwx OCA], [https://pdbe.org/2lwx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lwx RCSB], [https://www.ebi.ac.uk/pdbsum/2lwx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lwx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 13:15, 22 February 2023

OCA — Wed, 22 Feb 2023 13:15:19 GMT

←Older revision		Revision as of 13:15, 22 February 2023
Line 1:		Line 1:

	==Solution structure of the C-terminal Pdr1-activating domain of the J-protein Zuo1==		==Solution structure of the C-terminal Pdr1-activating domain of the J-protein Zuo1==
-	<StructureSection load='2lwx' size='340' side='right'caption='[[2lwx~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2lwx' size='340' side='right'caption='[[2lwx]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lwx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Baker's_yeast Baker's yeast~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LWX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lwx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LWX FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YGR285C, ZUO1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwx OCA], [https://pdbe.org/2lwx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lwx RCSB], [https://www.ebi.ac.uk/pdbsum/2lwx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lwx ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwx OCA], [https://pdbe.org/2lwx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lwx RCSB], [https://www.ebi.ac.uk/pdbsum/2lwx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lwx ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ZUO1_YEAST ZUO1_YEAST]] Component of the ribosome-associated complex (RAC), a heterodimeric chaperone complex involved in regulation of accurate translation termination and in folding or maintaining nascent polypeptides in a folding-competent state. RAC stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones SSB1/SSB2 that bind to the nascent polypeptide chain. ZUO1 can act as a J-protein for SSB1/SSB2 only when associated with SSZ1.<ref>PMID:15456889</ref> <ref>PMID:15908962</ref>	+	[https://www.uniprot.org/uniprot/ZUO1_YEAST ZUO1_YEAST] Component of the ribosome-associated complex (RAC), a heterodimeric chaperone complex involved in regulation of accurate translation termination and in folding or maintaining nascent polypeptides in a folding-competent state. RAC stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones SSB1/SSB2 that bind to the nascent polypeptide chain. ZUO1 can act as a J-protein for SSB1/SSB2 only when associated with SSZ1.<ref>PMID:15456889</ref> <ref>PMID:15908962</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Baker's yeast]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Craig, E A~~]]	+	[[Category: Saccharomyces cerevisiae S288C]]
-	[[Category: ~~Ducett, J K~~]]	+	[[Category: Craig EA]]
-	[[Category: ~~Peterson, F C~~]]	+	[[Category: Ducett JK]]
-	[[Category: ~~Volkman, B F~~]]	+	[[Category: Peterson FC]]
-	[[Category: ~~Chaperone]]~~	+	[[Category: Volkman BF]]
-	~~[[Category: J-protein]]~~	+
-	~~[[Category: Molecular chaperone]]~~	+
-	~~[[Category: Pleiotropic drug resistance~~]]	+

OCA at 10:55, 19 May 2021

OCA — Wed, 19 May 2021 10:55:16 GMT

←Older revision		Revision as of 10:55, 19 May 2021
Line 1:		Line 1:

	==Solution structure of the C-terminal Pdr1-activating domain of the J-protein Zuo1==		==Solution structure of the C-terminal Pdr1-activating domain of the J-protein Zuo1==
-	<StructureSection load='2lwx' size='340' side='right' caption='[[2lwx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2lwx' size='340' side='right'caption='[[2lwx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lwx]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LWX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lwx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LWX FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YGR285C, ZUO1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YGR285C, ZUO1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2lwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwx OCA], [~~http~~://pdbe.org/2lwx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2lwx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2lwx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2lwx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwx OCA], [https://pdbe.org/2lwx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lwx RCSB], [https://www.ebi.ac.uk/pdbsum/2lwx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lwx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ZUO1_YEAST ZUO1_YEAST]] Component of the ribosome-associated complex (RAC), a heterodimeric chaperone complex involved in regulation of accurate translation termination and in folding or maintaining nascent polypeptides in a folding-competent state. RAC stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones SSB1/SSB2 that bind to the nascent polypeptide chain. ZUO1 can act as a J-protein for SSB1/SSB2 only when associated with SSZ1.<ref>PMID:15456889</ref> <ref>PMID:15908962</ref>	+	[[https://www.uniprot.org/uniprot/ZUO1_YEAST ZUO1_YEAST]] Component of the ribosome-associated complex (RAC), a heterodimeric chaperone complex involved in regulation of accurate translation termination and in folding or maintaining nascent polypeptides in a folding-competent state. RAC stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones SSB1/SSB2 that bind to the nascent polypeptide chain. ZUO1 can act as a J-protein for SSB1/SSB2 only when associated with SSZ1.<ref>PMID:15456889</ref> <ref>PMID:15908962</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Baker's yeast]]		[[Category: Baker's yeast]]
		+	[[Category: Large Structures]]
	[[Category: Craig, E A]]		[[Category: Craig, E A]]
	[[Category: Ducett, J K]]		[[Category: Ducett, J K]]

OCA at 22:53, 9 August 2018

OCA — Thu, 09 Aug 2018 22:53:32 GMT

←Older revision		Revision as of 22:53, 9 August 2018
Line 1:		Line 1:
		+
	==Solution structure of the C-terminal Pdr1-activating domain of the J-protein Zuo1==		==Solution structure of the C-terminal Pdr1-activating domain of the J-protein Zuo1==
	<StructureSection load='2lwx' size='340' side='right' caption='[[2lwx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lwx' size='340' side='right' caption='[[2lwx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2lwx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LWX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lwx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LWX FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YGR285C, ZUO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YGR285C, ZUO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwx OCA], [http://pdbe.org/2lwx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lwx RCSB], [http://www.ebi.ac.uk/pdbsum/2lwx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwx OCA], [http://pdbe.org/2lwx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lwx RCSB], [http://www.ebi.ac.uk/pdbsum/2lwx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lwx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 03:27, 10 September 2015

OCA — Thu, 10 Sep 2015 03:27:35 GMT

←Older revision		Revision as of 03:27, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2lwx' size='340' side='right' caption='[[2lwx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lwx' size='340' side='right' caption='[[2lwx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lwx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LWX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lwx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LWX FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YGR285C, ZUO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 ~~Saccharomyces cerevisiae S288c~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YGR285C, ZUO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lwx RCSB], [http://www.ebi.ac.uk/pdbsum/2lwx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwx OCA], [http://pdbe.org/2lwx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lwx RCSB], [http://www.ebi.ac.uk/pdbsum/2lwx PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2lwx" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae s288c~~]]	+	[[Category: Baker's yeast]]
	[[Category: Craig, E A]]		[[Category: Craig, E A]]
	[[Category: Ducett, J K]]		[[Category: Ducett, J K]]

OCA at 16:52, 24 December 2014

OCA — Wed, 24 Dec 2014 16:52:47 GMT

←Older revision		Revision as of 16:52, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lwx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LWX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lwx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LWX FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YGR285C, ZUO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YGR285C, ZUO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lwx RCSB], [http://www.ebi.ac.uk/pdbsum/2lwx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lwx RCSB], [http://www.ebi.ac.uk/pdbsum/2lwx PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ZUO1_YEAST ZUO1_YEAST]] Component of the ribosome-associated complex (RAC), a heterodimeric chaperone complex involved in regulation of accurate translation termination and in folding or maintaining nascent polypeptides in a folding-competent state. RAC stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones SSB1/SSB2 that bind to the nascent polypeptide chain. ZUO1 can act as a J-protein for SSB1/SSB2 only when associated with SSZ1.<ref>PMID:15456889</ref> <ref>PMID:15908962</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae s288c]]		[[Category: Saccharomyces cerevisiae s288c]]
-	[[Category: Craig, E A.]]	+	[[Category: Craig, E A]]
-	[[Category: Ducett, J K.]]	+	[[Category: Ducett, J K]]
-	[[Category: Peterson, F C.]]	+	[[Category: Peterson, F C]]
-	[[Category: Volkman, B F.]]	+	[[Category: Volkman, B F]]
	[[Category: Chaperone]]		[[Category: Chaperone]]
	[[Category: J-protein]]		[[Category: J-protein]]
	[[Category: Molecular chaperone]]		[[Category: Molecular chaperone]]
	[[Category: Pleiotropic drug resistance]]		[[Category: Pleiotropic drug resistance]]

OCA at 00:52, 2 October 2014

OCA — Thu, 02 Oct 2014 00:52:00 GMT

←Older revision		Revision as of 00:52, 2 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2lwx.~~png~~\|~~left\|200px~~]]	+	==Solution structure of the C-terminal Pdr1-activating domain of the J-protein Zuo1==
		+	<StructureSection load='2lwx' size='340' side='right' caption='[[2lwx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2lwx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LWX FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YGR285C, ZUO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lwx RCSB], [http://www.ebi.ac.uk/pdbsum/2lwx PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The C-terminal 69 residues of the J-protein Zuo1 are sufficient to activate Pdr1, a transcription factor involved in both pleiotropic drug resistance and growth control. Little is understood about the pathway of activation by this primarily ribosome associated Hsp40 co-chaperone. Here, we report that only the C-terminal 13 residues of Zuo1 are required for activation of Pdr1, with hydrophobic residues being critical for activity. Two-hybrid interaction experiments suggest that the interaction between this 13-residue Zuo1 peptide and Pdr1 is direct, analogous to the activation of Pdr1 by xenobiotics. However, simply dissociation of Zuo1 from the ribosome is not sufficient for induction of Pdr1 transcriptional activity, as the C-terminal 86 residues of Zuo1 fold into an autoinhibitory left-handed four-helix bundle. Hydrophobic residues critical for interaction with Pdr1 are sequestered within the structure of this C-terminal domain (CTD), necessitating unfolding for activation. Thus, although expression of the CTD does not result in activation, alterations that destabilize the structure cause induction of pleiotropic drug resistance. These destabilizing alterations also result in dissociation of the full-length protein from the ribosome. Thus, our results are consistent with an activation pathway in which unfolding of Zuo1's C-terminal helical bundle domain results in ribosome dissociation followed by activation of Pdr1 via a direct interaction.

-	~~{{STRUCTURE_2lwx\| PDB=2lwx \| SCENE= }}~~	+	Unfolding of the C-Terminal Domain of the J-Protein Zuo1 Releases Autoinhibition and Activates Pdr1-Dependent Transcription.,Ducett JK, Peterson FC, Hoover LA, Prunuske AJ, Volkman BF, Craig EA J Mol Biol. 2012 Oct 2. pii: S0022-2836(12)00785-1. doi:, 10.1016/j.jmb.2012.09.020. PMID:23036859<ref>PMID:23036859</ref>

-	~~===Solution structure~~ of the ~~C-terminal Pdr1-activating domain~~ of ~~the J-protein Zuo1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23036859}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[2lwx]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWX OCA].~~	+	</StructureSection>
	[[Category: Saccharomyces cerevisiae s288c]]		[[Category: Saccharomyces cerevisiae s288c]]
	[[Category: Craig, E A.]]		[[Category: Craig, E A.]]

OCA at 05:50, 17 October 2012

OCA — Wed, 17 Oct 2012 05:50:28 GMT

←Older revision		Revision as of 05:50, 17 October 2012
Line 1:		Line 1:
-	[[Image:2lwx.~~jpg~~\|left\|200px]]	+	[[Image:2lwx.png\|left\|200px]]

	{{STRUCTURE_2lwx\| PDB=2lwx \| SCENE= }}		{{STRUCTURE_2lwx\| PDB=2lwx \| SCENE= }}
Line 5:		Line 5:
	===Solution structure of the C-terminal Pdr1-activating domain of the J-protein Zuo1===		===Solution structure of the C-terminal Pdr1-activating domain of the J-protein Zuo1===

		+	{{ABSTRACT_PUBMED_23036859}}

	==About this Structure==		==About this Structure==
-	[[2lwx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae~~ Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWX OCA].	+	[[2lwx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWX OCA].
-	[[Category: Saccharomyces cerevisiae]]	+	[[Category: Saccharomyces cerevisiae s288c]]
	[[Category: Craig, E A.]]		[[Category: Craig, E A.]]
	[[Category: Ducett, J K.]]		[[Category: Ducett, J K.]]

OCA at 06:18, 3 October 2012

OCA — Wed, 03 Oct 2012 06:18:57 GMT

←Older revision		Revision as of 06:18, 3 October 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2lwx.jpg\|left\|200px]]

-	~~The entry~~ 2lwx ~~is ON HOLD~~	+	{{STRUCTURE_2lwx\| PDB=2lwx \| SCENE= }}

-	~~Authors: Volkman, B.F., Ducett, J.K., Peterson, F.~~C~~., Craig, E.A.~~	+	===Solution structure of the C-terminal Pdr1-activating domain of the J-protein Zuo1===

-	~~Description: Solution~~ structure ~~of the c~~-~~terminal PDR1 activating domain~~	+
		+	==About this Structure==
		+	[[2lwx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWX OCA].
		+	[[Category: Saccharomyces cerevisiae]]
		+	[[Category: Craig, E A.]]
		+	[[Category: Ducett, J K.]]
		+	[[Category: Peterson, F C.]]
		+	[[Category: Volkman, B F.]]
		+	[[Category: Chaperone]]
		+	[[Category: J-protein]]
		+	[[Category: Molecular chaperone]]
		+	[[Category: Pleiotropic drug resistance]]

OCA: Protected "2lwx" [edit=sysop:move=sysop]

OCA — Wed, 15 Aug 2012 05:05:11 GMT

Protected "2lwx" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:05, 15 August 2012