2lxb - Revision history

OCA at 05:54, 15 May 2024

OCA — Wed, 15 May 2024 05:54:40 GMT

←Older revision		Revision as of 05:54, 15 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lxb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LXB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lxb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LXB FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lxb OCA], [https://pdbe.org/2lxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lxb RCSB], [https://www.ebi.ac.uk/pdbsum/2lxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lxb ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lxb OCA], [https://pdbe.org/2lxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lxb RCSB], [https://www.ebi.ac.uk/pdbsum/2lxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lxb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 13:17, 22 February 2023

OCA — Wed, 22 Feb 2023 13:17:29 GMT

←Older revision		Revision as of 13:17, 22 February 2023
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	==Solution structure of the Sgt2 homodimerization domain==		==Solution structure of the Sgt2 homodimerization domain==
-	<StructureSection load='2lxb' size='340' side='right'caption='[[2lxb~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='2lxb' size='340' side='right'caption='[[2lxb]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lxb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Baker's_yeast Baker's yeast~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LXB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lxb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LXB FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4goc\|4goc]], [[2lxa\|2lxa]], [[2lxc\|2lxc]], [[4god\|4god]], [[4goe\|4goe]], [[4gof\|4gof]]</div></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lxb OCA], [https://pdbe.org/2lxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lxb RCSB], [https://www.ebi.ac.uk/pdbsum/2lxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lxb ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SGT2, UNF346, YOR007C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lxb OCA], [https://pdbe.org/2lxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lxb RCSB], [https://www.ebi.ac.uk/pdbsum/2lxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lxb ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SGT2_YEAST SGT2_YEAST]] Co-chaperone that binds to the molecular chaperone Hsp70 (SSA1 and SSA2). Regulates Hsp70 ATPase activity (By similarity). Required for recovery from heat shock.<ref>PMID:12482202</ref>	+	[https://www.uniprot.org/uniprot/SGT2_YEAST SGT2_YEAST] Co-chaperone that binds to the molecular chaperone Hsp70 (SSA1 and SSA2). Regulates Hsp70 ATPase activity (By similarity). Required for recovery from heat shock.<ref>PMID:12482202</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Baker's yeast]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Chartron, J W~~]]	+	[[Category: Saccharomyces cerevisiae S288C]]
-	[[Category: ~~Clemons, W M~~]]	+	[[Category: Chartron JW]]
-	[[Category: ~~Vandervelde, D G~~]]	+	[[Category: Clemons Jr WM]]
-	[[Category: ~~Four-helix bundle]]~~	+	[[Category: Vandervelde DG]]
-	~~[[Category: Get pathway]]~~	+
-	~~[[Category: Get5 binding domain]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Protein-protein interaction~~]]	+

OCA at 10:55, 19 May 2021

OCA — Wed, 19 May 2021 10:55:27 GMT

←Older revision		Revision as of 10:55, 19 May 2021
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	==Solution structure of the Sgt2 homodimerization domain==		==Solution structure of the Sgt2 homodimerization domain==
-	<StructureSection load='2lxb' size='340' side='right' caption='[[2lxb]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='2lxb' size='340' side='right'caption='[[2lxb]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lxb]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LXB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LXB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lxb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LXB FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4goc\|4goc]], [[2lxa\|2lxa]], [[2lxc\|2lxc]], [[4god\|4god]], [[4goe\|4goe]], [[4gof\|4gof]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4goc\|4goc]], [[2lxa\|2lxa]], [[2lxc\|2lxc]], [[4god\|4god]], [[4goe\|4goe]], [[4gof\|4gof]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SGT2, UNF346, YOR007C ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SGT2, UNF346, YOR007C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2lxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lxb OCA], [~~http~~://pdbe.org/2lxb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2lxb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2lxb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2lxb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lxb OCA], [https://pdbe.org/2lxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lxb RCSB], [https://www.ebi.ac.uk/pdbsum/2lxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lxb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SGT2_YEAST SGT2_YEAST]] Co-chaperone that binds to the molecular chaperone Hsp70 (SSA1 and SSA2). Regulates Hsp70 ATPase activity (By similarity). Required for recovery from heat shock.<ref>PMID:12482202</ref>	+	[[https://www.uniprot.org/uniprot/SGT2_YEAST SGT2_YEAST]] Co-chaperone that binds to the molecular chaperone Hsp70 (SSA1 and SSA2). Regulates Hsp70 ATPase activity (By similarity). Required for recovery from heat shock.<ref>PMID:12482202</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 2lxb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2lxb" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Small glutamine-rich tetratricopeptide repeat containing protein alpha\|Small glutamine-rich tetratricopeptide repeat containing protein alpha]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Baker's yeast]]		[[Category: Baker's yeast]]
		+	[[Category: Large Structures]]
	[[Category: Chartron, J W]]		[[Category: Chartron, J W]]
	[[Category: Clemons, W M]]		[[Category: Clemons, W M]]

OCA at 22:45, 9 August 2018

OCA — Thu, 09 Aug 2018 22:45:17 GMT

←Older revision		Revision as of 22:45, 9 August 2018
Line 1:		Line 1:
		+
	==Solution structure of the Sgt2 homodimerization domain==		==Solution structure of the Sgt2 homodimerization domain==
	<StructureSection load='2lxb' size='340' side='right' caption='[[2lxb]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2lxb' size='340' side='right' caption='[[2lxb]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4goc\|4goc]], [[2lxa\|2lxa]], [[2lxc\|2lxc]], [[4god\|4god]], [[4goe\|4goe]], [[4gof\|4gof]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4goc\|4goc]], [[2lxa\|2lxa]], [[2lxc\|2lxc]], [[4god\|4god]], [[4goe\|4goe]], [[4gof\|4gof]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SGT2, UNF346, YOR007C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SGT2, UNF346, YOR007C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lxb OCA], [http://pdbe.org/2lxb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lxb RCSB], [http://www.ebi.ac.uk/pdbsum/2lxb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lxb OCA], [http://pdbe.org/2lxb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lxb RCSB], [http://www.ebi.ac.uk/pdbsum/2lxb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lxb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 05:33, 10 September 2015

OCA — Thu, 10 Sep 2015 05:33:23 GMT

←Older revision		Revision as of 05:33, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2lxb' size='340' side='right' caption='[[2lxb]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2lxb' size='340' side='right' caption='[[2lxb]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lxb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LXB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lxb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LXB FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4goc\|4goc]], [[2lxa\|2lxa]], [[2lxc\|2lxc]], [[4god\|4god]], [[4goe\|4goe]], [[4gof\|4gof]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4goc\|4goc]], [[2lxa\|2lxa]], [[2lxc\|2lxc]], [[4god\|4god]], [[4goe\|4goe]], [[4gof\|4gof]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SGT2, UNF346, YOR007C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 ~~Saccharomyces cerevisiae S288c~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SGT2, UNF346, YOR007C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lxb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lxb RCSB], [http://www.ebi.ac.uk/pdbsum/2lxb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lxb OCA], [http://pdbe.org/2lxb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lxb RCSB], [http://www.ebi.ac.uk/pdbsum/2lxb PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SGT2_YEAST SGT2_YEAST]] Co-chaperone that binds to the molecular chaperone Hsp70 (SSA1 and SSA2). Regulates Hsp70 ATPase activity (By similarity). Required for recovery from heat shock.<ref>PMID:12482202</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2lxb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae s288c~~]]	+	[[Category: Baker's yeast]]
	[[Category: Chartron, J W]]		[[Category: Chartron, J W]]
	[[Category: Clemons, W M]]		[[Category: Clemons, W M]]

OCA at 05:13, 22 December 2014

OCA — Mon, 22 Dec 2014 05:13:19 GMT

←Older revision		Revision as of 05:13, 22 December 2014
Line 1:		Line 1:
-	[[~~Image:~~2lxb.~~png~~\|~~left~~\|~~200px~~]]	+	==Solution structure of the Sgt2 homodimerization domain==
		+	<StructureSection load='2lxb' size='340' side='right' caption='[[2lxb]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2lxb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LXB FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4goc\|4goc]], [[2lxa\|2lxa]], [[2lxc\|2lxc]], [[4god\|4god]], [[4goe\|4goe]], [[4gof\|4gof]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SGT2, UNF346, YOR007C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lxb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lxb RCSB], [http://www.ebi.ac.uk/pdbsum/2lxb PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In the cytoplasm, the correct delivery of membrane proteins is an essential and highly regulated process. The posttranslational targeting of the important tail-anchor membrane (TA) proteins has recently been under intense investigation. A specialized pathway, called the guided entry of TA proteins (GET) pathway in yeast and the transmembrane domain recognition complex (TRC) pathway in vertebrates, recognizes endoplasmic-reticulum-targeted TA proteins and delivers them through a complex series of handoffs. An early step is the formation of a complex between Sgt2/SGTA, a cochaperone with a presumed ubiquitin-like-binding domain (UBD), and Get5/UBL4A, a ubiquitin-like domain (UBL)-containing protein. We structurally characterize this UBD/UBL interaction for both yeast and human proteins. This characterization is supported by biophysical studies that demonstrate that complex formation is mediated by electrostatics, generating an interface that has high-affinity with rapid kinetics. In total, this work provides a refined model of the interplay of Sgt2 homologs in TA targeting.

-	~~{{STRUCTURE_2lxb\| PDB=2lxb \| SCENE= }}~~	+	Structures of the Sgt2/SGTA Dimerization Domain with the Get5/UBL4A UBL Domain Reveal an Interaction that Forms a Conserved Dynamic Interface.,Chartron JW, Vandervelde DG, Clemons WM Jr Cell Rep. 2012 Nov 7. pii: S2211-1247(12)00346-4. doi:, 10.1016/j.celrep.2012.10.010. PMID:23142665<ref>PMID:23142665</ref>

-	~~===Solution structure~~ of the ~~Sgt2 homodimerization domain===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23142665}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[2lxb]] is a 2 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LXB OCA].~~	+	</StructureSection>
	[[Category: Saccharomyces cerevisiae s288c]]		[[Category: Saccharomyces cerevisiae s288c]]
-	[[Category: Chartron, J W.]]	+	[[Category: Chartron, J W]]
-	[[Category: Clemons, W M.]]	+	[[Category: Clemons, W M]]
-	[[Category: Vandervelde, D G.]]	+	[[Category: Vandervelde, D G]]
	[[Category: Four-helix bundle]]		[[Category: Four-helix bundle]]
	[[Category: Get pathway]]		[[Category: Get pathway]]

OCA at 14:25, 28 November 2012

OCA — Wed, 28 Nov 2012 14:25:26 GMT

←Older revision		Revision as of 14:25, 28 November 2012
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-	[[Image:2lxb.~~jpg~~\|left\|200px]]	+	[[Image:2lxb.png\|left\|200px]]

	{{STRUCTURE_2lxb\| PDB=2lxb \| SCENE= }}		{{STRUCTURE_2lxb\| PDB=2lxb \| SCENE= }}
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	===Solution structure of the Sgt2 homodimerization domain===		===Solution structure of the Sgt2 homodimerization domain===

		+	{{ABSTRACT_PUBMED_23142665}}

	==About this Structure==		==About this Structure==

OCA at 09:41, 21 November 2012

OCA — Wed, 21 Nov 2012 09:41:36 GMT

←Older revision		Revision as of 09:41, 21 November 2012
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-	~~'''Unreleased structure'''~~	+	[[Image:2lxb.jpg\|left\|200px]]

-	~~The entry~~ 2lxb ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_2lxb\| PDB=2lxb \| SCENE= }}

-	~~Authors: Chartron, J.W., Vandervelde, D.G., Clemons Jr., W.M.~~	+	===Solution structure of the Sgt2 homodimerization domain===

-	~~Description: Solution~~ structure ~~of the Sgt2 homodimerization~~ domain	+
		+	==About this Structure==
		+	[[2lxb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LXB OCA].
		+	[[Category: Saccharomyces cerevisiae s288c]]
		+	[[Category: Chartron, J W.]]
		+	[[Category: Clemons, W M.]]
		+	[[Category: Vandervelde, D G.]]
		+	[[Category: Four-helix bundle]]
		+	[[Category: Get pathway]]
		+	[[Category: Get5 binding domain]]
		+	[[Category: Protein binding]]
		+	[[Category: Protein-protein interaction]]

OCA at 04:36, 12 September 2012

OCA — Wed, 12 Sep 2012 04:36:02 GMT

←Older revision		Revision as of 04:36, 12 September 2012
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2lxb is ON HOLD	+	The entry 2lxb is ON HOLD until Paper Publication

-	Authors: Chartron, J.W., ~~VanderVelde~~, D.G., Clemons, W.M~~., Jr~~.	+	Authors: Chartron, J.W., Vandervelde, D.G., Clemons Jr., W.M.

	Description: Solution structure of the Sgt2 homodimerization domain		Description: Solution structure of the Sgt2 homodimerization domain

OCA: Protected "2lxb" [edit=sysop:move=sysop]

OCA — Wed, 05 Sep 2012 04:36:58 GMT

Protected "2lxb" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:36, 5 September 2012