2m18 - Revision history

OCA at 05:57, 15 May 2024

OCA — Wed, 15 May 2024 05:57:08 GMT

←Older revision		Revision as of 05:57, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2m18]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M18 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2m18]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M18 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m18 OCA], [https://pdbe.org/2m18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m18 RCSB], [https://www.ebi.ac.uk/pdbsum/2m18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m18 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m18 OCA], [https://pdbe.org/2m18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m18 RCSB], [https://www.ebi.ac.uk/pdbsum/2m18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m18 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:24, 14 June 2023

OCA — Wed, 14 Jun 2023 09:24:26 GMT

←Older revision		Revision as of 09:24, 14 June 2023
Line 1:		Line 1:

	==Structure of stacked G-quadruplex formed by human TERRA sequence in potassium solution==		==Structure of stacked G-quadruplex formed by human TERRA sequence in potassium solution==
-	<StructureSection load='2m18' size='340' side='right'caption='[[2m18~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='2m18' size='340' side='right'caption='[[2m18]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2m18]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M18 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2m18]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M18 FirstGlance]. <br>
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Martadinata, H]]	+	[[Category: Martadinata H]]
-	[[Category: Phan~~, A T]]~~	+	[[Category: Phan AT]]
-	~~[[Category: Human telomeric rna]]~~	+
-	~~[[Category: Rna]]~~	+
-	~~[[Category: Rna g-quadruplex]]~~	+
-	~~[[Category: Stacked g-quadruplex~~]]	+

OCA at 11:31, 16 February 2022

OCA — Wed, 16 Feb 2022 11:31:26 GMT

←Older revision		Revision as of 11:31, 16 February 2022
Line 3:		Line 3:
	<StructureSection load='2m18' size='340' side='right'caption='[[2m18]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2m18' size='340' side='right'caption='[[2m18]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2m18]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M18 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2M18 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2m18]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M18 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2m18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m18 OCA], [~~http~~://pdbe.org/2m18 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2m18 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2m18 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2m18 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m18 OCA], [https://pdbe.org/2m18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m18 RCSB], [https://www.ebi.ac.uk/pdbsum/2m18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m18 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:17, 13 May 2020

OCA — Wed, 13 May 2020 06:17:29 GMT

←Older revision		Revision as of 06:17, 13 May 2020
Line 1:		Line 1:

	==Structure of stacked G-quadruplex formed by human TERRA sequence in potassium solution==		==Structure of stacked G-quadruplex formed by human TERRA sequence in potassium solution==
-	<StructureSection load='2m18' size='340' side='right' caption='[[2m18]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='2m18' size='340' side='right'caption='[[2m18]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2m18]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M18 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2M18 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2m18]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M18 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2M18 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2m18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m18 OCA], [http://pdbe.org/2m18 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m18 RCSB], [http://www.ebi.ac.uk/pdbsum/2m18 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2m18 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2m18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m18 OCA], [http://pdbe.org/2m18 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m18 RCSB], [http://www.ebi.ac.uk/pdbsum/2m18 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2m18 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Martadinata, H]]		[[Category: Martadinata, H]]
	[[Category: Phan, A T]]		[[Category: Phan, A T]]

OCA at 23:00, 9 August 2018

OCA — Thu, 09 Aug 2018 23:00:13 GMT

←Older revision		Revision as of 23:00, 9 August 2018
Line 1:		Line 1:
		+
	==Structure of stacked G-quadruplex formed by human TERRA sequence in potassium solution==		==Structure of stacked G-quadruplex formed by human TERRA sequence in potassium solution==
	<StructureSection load='2m18' size='340' side='right' caption='[[2m18]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2m18' size='340' side='right' caption='[[2m18]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2m18]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M18 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M18 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2m18]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M18 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M18 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m18 OCA], [http://pdbe.org/2m18 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m18 RCSB], [http://www.ebi.ac.uk/pdbsum/2m18 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m18 OCA], [http://pdbe.org/2m18 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m18 RCSB], [http://www.ebi.ac.uk/pdbsum/2m18 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2m18 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:16, 10 September 2015

OCA — Thu, 10 Sep 2015 17:16:25 GMT

←Older revision		Revision as of 17:16, 10 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2m18]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M18 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M18 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2m18]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M18 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M18 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m18 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m18 RCSB], [http://www.ebi.ac.uk/pdbsum/2m18 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m18 OCA], [http://pdbe.org/2m18 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m18 RCSB], [http://www.ebi.ac.uk/pdbsum/2m18 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 13:		Line 13:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2m18" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:27, 18 December 2014

OCA — Thu, 18 Dec 2014 12:27:59 GMT

←Older revision		Revision as of 12:27, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2m18\| PDB~~=2m18 \| ~~SCENE~~= }}	+	==Structure of stacked G-quadruplex formed by human TERRA sequence in potassium solution==
-	===~~Structure~~ of stacked G-quadruplex formed by human TERRA sequence in potassium solution~~===~~	+	<StructureSection load='2m18' size='340' side='right' caption='[[2m18]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_23445442}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2m18]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M18 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M18 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m18 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m18 RCSB], [http://www.ebi.ac.uk/pdbsum/2m18 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Telomeric repeat-containing RNAs (TERRA) are transcription products of the telomeres. Human TERRA sequences containing UUAGGG repeats can form parallel-stranded G-quadruplexes. The stacking interaction of such structures was shown to be important for ligand targeting and higher-order arrangement of G-quadruplexes in long TERRA sequences. Here we report on the first high-resolution structure of a stacked G-quadruplex formed by the 10-nucleotide human TERRA sequence r(GGGUUAGGGU) in potassium solution. This structure comprises two dimeric three-layer parallel-stranded G-quadruplex blocks, which stack on each other at their 5'-ends. The adenine in each UUA loop is nearly coplanar with the 5'-end G-tetrad forming an A.(G.G.G.G).A hexad, thereby increasing the stacking contacts between the two blocks. Interestingly, this stacking and loop conformation is different from all structures previously reported for the free human TERRA but resembles the structure previously determined for a complex between a human TERRA sequence and an acridine ligand. This stacking conformation is a potential target for drugs that recognize or induce the stacking interface.

-	~~==About this~~ Structure==	+	Structure of Human Telomeric RNA (TERRA): Stacking of Two G-Quadruplex Blocks in K(+) Solution.,Martadinata H, Phan AT Biochemistry. 2013 Apr 2;52(13):2176-83. doi: 10.1021/bi301606u. Epub 2013 Mar, 19. PMID:23445442<ref>PMID:23445442</ref>
-	~~[[2m18]] is a 4 chain structure~~. ~~Full experimental information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id~~=~~2M18 OCA].~~	+
-	[[Category: Martadinata, H.]]	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: Phan, A T.]]	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Martadinata, H]]
		+	[[Category: Phan, A T]]
	[[Category: Human telomeric rna]]		[[Category: Human telomeric rna]]
	[[Category: Rna]]		[[Category: Rna]]
	[[Category: Rna g-quadruplex]]		[[Category: Rna g-quadruplex]]
	[[Category: Stacked g-quadruplex]]		[[Category: Stacked g-quadruplex]]

OCA at 20:26, 17 April 2013

OCA — Wed, 17 Apr 2013 20:26:11 GMT

←Older revision		Revision as of 20:26, 17 April 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_2m18\| PDB=2m18 \| SCENE= }}
		+	===Structure of stacked G-quadruplex formed by human TERRA sequence in potassium solution===
		+	{{ABSTRACT_PUBMED_23445442}}

-	~~The entry~~ 2m18 is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[2m18]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M18 OCA].
-	~~Authors~~: Martadinata, H., Phan, A.T.	+	[[Category: Martadinata, H.]]
-		+	[[Category: Phan, A T.]]
-	~~Description~~: ~~Structure of stacked G~~-quadruplex ~~formed by human TERRA sequence in potassium solution~~	+	[[Category: Human telomeric rna]]
		+	[[Category: Rna]]
		+	[[Category: Rna g-quadruplex]]
		+	[[Category: Stacked g-quadruplex]]

OCA at 07:57, 27 March 2013

OCA — Wed, 27 Mar 2013 07:57:54 GMT

←Older revision		Revision as of 07:57, 27 March 2013
Line 3:		Line 3:
	The entry 2m18 is ON HOLD until Paper Publication		The entry 2m18 is ON HOLD until Paper Publication

-	Authors: Martadinata, H., Phan, A.	+	Authors: Martadinata, H., Phan, A.T.

	Description: Structure of stacked G-quadruplex formed by human TERRA sequence in potassium solution		Description: Structure of stacked G-quadruplex formed by human TERRA sequence in potassium solution

OCA at 12:09, 6 February 2013

OCA — Wed, 06 Feb 2013 12:09:20 GMT

←Older revision		Revision as of 12:09, 6 February 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2m18 is ON HOLD	+	The entry 2m18 is ON HOLD until Paper Publication

	Authors: Martadinata, H., Phan, A.		Authors: Martadinata, H., Phan, A.

	Description: Structure of stacked G-quadruplex formed by human TERRA sequence in potassium solution		Description: Structure of stacked G-quadruplex formed by human TERRA sequence in potassium solution