2m65 - Revision history

OCA at 06:00, 15 May 2024

OCA — Wed, 15 May 2024 06:00:42 GMT

←Older revision		Revision as of 06:00, 15 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2m65]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M65 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M65 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2m65]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M65 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M65 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m65 OCA], [https://pdbe.org/2m65 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m65 RCSB], [https://www.ebi.ac.uk/pdbsum/2m65 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m65 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m65 OCA], [https://pdbe.org/2m65 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m65 RCSB], [https://www.ebi.ac.uk/pdbsum/2m65 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m65 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 13:31, 22 February 2023

OCA — Wed, 22 Feb 2023 13:31:14 GMT

←Older revision		Revision as of 13:31, 22 February 2023
Line 1:		Line 1:

	==NMR structure of human restriction factor APOBEC3A==		==NMR structure of human restriction factor APOBEC3A==
-	<StructureSection load='2m65' size='340' side='right'caption='[[2m65~~]], [[NMR_Ensembles_of_Models \| 30 NMR models~~]]' scene=''>	+	<StructureSection load='2m65' size='340' side='right'caption='[[2m65]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2m65]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M65 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M65 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2m65]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M65 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M65 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APOBEC3A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m65 OCA], [https://pdbe.org/2m65 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m65 RCSB], [https://www.ebi.ac.uk/pdbsum/2m65 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m65 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m65 OCA], [https://pdbe.org/2m65 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m65 RCSB], [https://www.ebi.ac.uk/pdbsum/2m65 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m65 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ABC3A_HUMAN ABC3A_HUMAN]] DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.<ref>PMID:10469298</ref> <ref>PMID:12859895</ref> <ref>PMID:16527742</ref> <ref>PMID:19461882</ref> <ref>PMID:20615867</ref> <ref>PMID:20062055</ref> <ref>PMID:21496894</ref> <ref>PMID:21460793</ref> <ref>PMID:21123384</ref> <ref>PMID:21368204</ref> <ref>PMID:22896697</ref> <ref>PMID:22457529</ref>	+	[https://www.uniprot.org/uniprot/ABC3A_HUMAN ABC3A_HUMAN] DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.<ref>PMID:10469298</ref> <ref>PMID:12859895</ref> <ref>PMID:16527742</ref> <ref>PMID:19461882</ref> <ref>PMID:20615867</ref> <ref>PMID:20062055</ref> <ref>PMID:21496894</ref> <ref>PMID:21460793</ref> <ref>PMID:21123384</ref> <ref>PMID:21368204</ref> <ref>PMID:22896697</ref> <ref>PMID:22457529</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ahn, J]]	+	[[Category: Ahn J]]
-	[[Category: Byeon, C]]	+	[[Category: Byeon C]]
-	[[Category: Byeon~~, I L~~]]	+	[[Category: Byeon IL]]
-	[[Category: Gronenborn~~, A M]]~~	+	[[Category: Gronenborn AM]]
-	~~[[Category: Antiviral defense]]~~	+
-	~~[[Category: Apobec3a]]~~	+
-	~~[[Category: Cytidine deaminase]]~~	+
-	~~[[Category: Host-virus interaction]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Zinc-binding~~]]	+

OCA at 11:00, 19 May 2021

OCA — Wed, 19 May 2021 11:00:18 GMT

←Older revision		Revision as of 11:00, 19 May 2021
Line 1:		Line 1:
-	~~{{Large structure}}~~	+
	==NMR structure of human restriction factor APOBEC3A==		==NMR structure of human restriction factor APOBEC3A==
-	<StructureSection load='2m65' size='340' side='right' caption='[[2m65]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>	+	<StructureSection load='2m65' size='340' side='right'caption='[[2m65]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2m65]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M65 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2M65 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2m65]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M65 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M65 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APOBEC3A ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APOBEC3A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2m65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m65 OCA], [~~http~~://pdbe.org/2m65 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2m65 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2m65 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2m65 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m65 OCA], [https://pdbe.org/2m65 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m65 RCSB], [https://www.ebi.ac.uk/pdbsum/2m65 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m65 ProSAT]</span></td></tr>
	</table>		</table>
-	{{Large structure}}
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ABC3A_HUMAN ABC3A_HUMAN]] DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.<ref>PMID:10469298</ref> <ref>PMID:12859895</ref> <ref>PMID:16527742</ref> <ref>PMID:19461882</ref> <ref>PMID:20615867</ref> <ref>PMID:20062055</ref> <ref>PMID:21496894</ref> <ref>PMID:21460793</ref> <ref>PMID:21123384</ref> <ref>PMID:21368204</ref> <ref>PMID:22896697</ref> <ref>PMID:22457529</ref>	+	[[https://www.uniprot.org/uniprot/ABC3A_HUMAN ABC3A_HUMAN]] DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.<ref>PMID:10469298</ref> <ref>PMID:12859895</ref> <ref>PMID:16527742</ref> <ref>PMID:19461882</ref> <ref>PMID:20615867</ref> <ref>PMID:20062055</ref> <ref>PMID:21496894</ref> <ref>PMID:21460793</ref> <ref>PMID:21123384</ref> <ref>PMID:21368204</ref> <ref>PMID:22896697</ref> <ref>PMID:22457529</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ahn, J]]		[[Category: Ahn, J]]
	[[Category: Byeon, C]]		[[Category: Byeon, C]]

OCA at 22:38, 9 August 2018

OCA — Thu, 09 Aug 2018 22:38:08 GMT

←Older revision		Revision as of 22:38, 9 August 2018
Line 1:		Line 1:
		+	{{Large structure}}
	==NMR structure of human restriction factor APOBEC3A==		==NMR structure of human restriction factor APOBEC3A==
	<StructureSection load='2m65' size='340' side='right' caption='[[2m65]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>		<StructureSection load='2m65' size='340' side='right' caption='[[2m65]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APOBEC3A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APOBEC3A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m65 OCA], [http://pdbe.org/2m65 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m65 RCSB], [http://www.ebi.ac.uk/pdbsum/2m65 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m65 OCA], [http://pdbe.org/2m65 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m65 RCSB], [http://www.ebi.ac.uk/pdbsum/2m65 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2m65 ProSAT]</span></td></tr>
	</table>		</table>
	{{Large structure}}		{{Large structure}}

OCA at 22:24, 10 September 2015

OCA — Thu, 10 Sep 2015 22:24:02 GMT

←Older revision		Revision as of 22:24, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2m65' size='340' side='right' caption='[[2m65]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>		<StructureSection load='2m65' size='340' side='right' caption='[[2m65]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2m65]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M65 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M65 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2m65]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M65 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M65 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APOBEC3A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APOBEC3A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m65 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m65 RCSB], [http://www.ebi.ac.uk/pdbsum/2m65 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m65 OCA], [http://pdbe.org/2m65 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m65 RCSB], [http://www.ebi.ac.uk/pdbsum/2m65 PDBsum]</span></td></tr>
	</table>		</table>
		+	{{Large structure}}
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/ABC3A_HUMAN ABC3A_HUMAN]] DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.<ref>PMID:10469298</ref> <ref>PMID:12859895</ref> <ref>PMID:16527742</ref> <ref>PMID:19461882</ref> <ref>PMID:20615867</ref> <ref>PMID:20062055</ref> <ref>PMID:21496894</ref> <ref>PMID:21460793</ref> <ref>PMID:21123384</ref> <ref>PMID:21368204</ref> <ref>PMID:22896697</ref> <ref>PMID:22457529</ref>		[[http://www.uniprot.org/uniprot/ABC3A_HUMAN ABC3A_HUMAN]] DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.<ref>PMID:10469298</ref> <ref>PMID:12859895</ref> <ref>PMID:16527742</ref> <ref>PMID:19461882</ref> <ref>PMID:20615867</ref> <ref>PMID:20062055</ref> <ref>PMID:21496894</ref> <ref>PMID:21460793</ref> <ref>PMID:21123384</ref> <ref>PMID:21368204</ref> <ref>PMID:22896697</ref> <ref>PMID:22457529</ref>
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2m65" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Ahn, J]]		[[Category: Ahn, J]]
	[[Category: Byeon, C]]		[[Category: Byeon, C]]

OCA at 06:55, 25 December 2014

OCA — Thu, 25 Dec 2014 06:55:29 GMT

←Older revision		Revision as of 06:55, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m65 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m65 RCSB], [http://www.ebi.ac.uk/pdbsum/2m65 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m65 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m65 RCSB], [http://www.ebi.ac.uk/pdbsum/2m65 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ABC3A_HUMAN ABC3A_HUMAN]] DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.<ref>PMID:10469298</ref> <ref>PMID:12859895</ref> <ref>PMID:16527742</ref> <ref>PMID:19461882</ref> <ref>PMID:20615867</ref> <ref>PMID:20062055</ref> <ref>PMID:21496894</ref> <ref>PMID:21460793</ref> <ref>PMID:21123384</ref> <ref>PMID:21368204</ref> <ref>PMID:22896697</ref> <ref>PMID:22457529</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:42, 18 December 2014

OCA — Thu, 18 Dec 2014 11:42:00 GMT

←Older revision		Revision as of 11:42, 18 December 2014
Line 1:		Line 1:
-	~~{{Large~~ structure}}	+	==NMR structure of human restriction factor APOBEC3A==
-	~~{{STRUCTURE_2m65\| PDB~~=2m65 \| ~~SCENE~~= }}	+	<StructureSection load='2m65' size='340' side='right' caption='[[2m65]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
-	===~~NMR~~ structure ~~of human restriction factor~~ APOBEC3A===	+	== Structural highlights ==
-	~~{{ABSTRACT_PUBMED_23695684}}~~	+	<table><tr><td colspan='2'>[[2m65]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M65 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M65 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APOBEC3A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m65 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m65 RCSB], [http://www.ebi.ac.uk/pdbsum/2m65 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human APOBEC3A is a single-stranded DNA cytidine deaminase that restricts viral pathogens and endogenous retrotransposons, and has a role in the innate immune response. Furthermore, its potential to act as a genomic DNA mutator has implications for a role in carcinogenesis. A deeper understanding of APOBEC3A's deaminase and nucleic acid-binding properties, which is central to its biological activities, has been limited by the lack of structural information. Here we report the nuclear magnetic resonance solution structure of APOBEC3A and show that the critical interface for interaction with single-stranded DNA substrates includes residues extending beyond the catalytic centre. Importantly, by monitoring deaminase activity in real time, we find that A3A displays similar catalytic activity on APOBEC3A-specific TTCA- or A3G-specific CCCA-containing substrates, involving key determinants immediately 5' of the reactive C. Our results afford novel mechanistic insights into APOBEC3A-mediated deamination and provide the structural basis for further molecular studies.

-	~~==Function==~~	+	NMR structure of human restriction factor APOBEC3A reveals substrate binding and enzyme specificity.,Byeon IJ, Ahn J, Mitra M, Byeon CH, Hercik K, Hritz J, Charlton LM, Levin JG, Gronenborn AM Nat Commun. 2013;4:1890. doi: 10.1038/ncomms2883. PMID:23695684<ref>PMID:23695684</ref>
-	~~[[http://www.uniprot.org/uniprot/ABC3A_HUMAN ABC3A_HUMAN]] DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility~~ of ~~retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and~~ human ~~T-cell leukemia virus type 1 (HTLV-1)~~ and ~~may inhibit the mobility of LTR and non-LTR retrotransposons~~. ~~Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA~~. ~~Can induce somatic hypermutation in the nuclear and mitochondrial DNA~~. ~~May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation~~.~~<ref>PMID:10469298<~~/~~ref> <ref>~~PMID:12859895</ref> <ref>PMID:16527742</ref> <ref>PMID:19461882</ref> <ref>PMID:20615867</ref> <ref>PMID:20062055</ref> <ref>PMID:21496894</ref> <ref>PMID:21460793</ref> <ref>PMID:21123384</ref> <ref>PMID:21368204</ref> <ref>PMID:22896697</ref> <ref>PMID:~~22457529~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2m65]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2M65 OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023695684</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Ahn, J.]]	+	[[Category: Ahn, J]]
-	[[Category: Byeon, C.]]	+	[[Category: Byeon, C]]
-	[[Category: Byeon, I L.]]	+	[[Category: Byeon, I L]]
-	[[Category: Gronenborn, A M.]]	+	[[Category: Gronenborn, A M]]
	[[Category: Antiviral defense]]		[[Category: Antiviral defense]]
	[[Category: Apobec3a]]		[[Category: Apobec3a]]

OCA at 13:42, 19 June 2013

OCA — Wed, 19 Jun 2013 13:42:01 GMT

←Older revision		Revision as of 13:42, 19 June 2013
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-	~~'''Unreleased~~ structure~~'''~~	+	{{Large structure}}
		+	{{STRUCTURE_2m65\| PDB=2m65 \| SCENE= }}
		+	===NMR structure of human restriction factor APOBEC3A===
		+	{{ABSTRACT_PUBMED_23695684}}

-	~~The entry 2m65 is ON HOLD~~ ~~until Sep 21 2014~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/ABC3A_HUMAN ABC3A_HUMAN]] DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.<ref>PMID:10469298</ref> <ref>PMID:12859895</ref> <ref>PMID:16527742</ref> <ref>PMID:19461882</ref> <ref>PMID:20615867</ref> <ref>PMID:20062055</ref> <ref>PMID:21496894</ref> <ref>PMID:21460793</ref> <ref>PMID:21123384</ref> <ref>PMID:21368204</ref> <ref>PMID:22896697</ref> <ref>PMID:22457529</ref>

-	~~Authors~~: ~~Byeon, I~~.L.~~, Byeon, C~~.~~, Ahn, J~~.~~, Gronenborn, A~~.M.	+	==About this Structure==
		+	[[2m65]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M65 OCA].

-	~~Description~~: ~~NMR structure of human restriction factor APOBEC3A~~	+	==Reference==
		+	<ref group="xtra">PMID:023695684</ref><references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Ahn, J.]]
		+	[[Category: Byeon, C.]]
		+	[[Category: Byeon, I L.]]
		+	[[Category: Gronenborn, A M.]]
		+	[[Category: Antiviral defense]]
		+	[[Category: Apobec3a]]
		+	[[Category: Cytidine deaminase]]
		+	[[Category: Host-virus interaction]]
		+	[[Category: Hydrolase]]
		+	[[Category: Zinc-binding]]

OCA at 19:34, 17 April 2013

OCA — Wed, 17 Apr 2013 19:34:37 GMT

←Older revision		Revision as of 19:34, 17 April 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2m65 is ON HOLD	+	The entry 2m65 is ON HOLD until Sep 21 2014

	Authors: Byeon, I.L., Byeon, C., Ahn, J., Gronenborn, A.M.		Authors: Byeon, I.L., Byeon, C., Ahn, J., Gronenborn, A.M.

	Description: NMR structure of human restriction factor APOBEC3A		Description: NMR structure of human restriction factor APOBEC3A

OCA at 00:29, 4 April 2013

OCA — Thu, 04 Apr 2013 00:29:21 GMT

←Older revision		Revision as of 00:29, 4 April 2013
Line 3:		Line 3:
	The entry 2m65 is ON HOLD		The entry 2m65 is ON HOLD

-	Authors: Byeon, I.L., Byeon, C., Ahn, J.M., Gronenborn, A.M.	+	Authors: Byeon, I.L., Byeon, C., Ahn, J., Gronenborn, A.M.

	Description: NMR structure of human restriction factor APOBEC3A		Description: NMR structure of human restriction factor APOBEC3A