2m9i - Revision history

OCA at 06:02, 15 May 2024

OCA — Wed, 15 May 2024 06:02:45 GMT

←Older revision		Revision as of 06:02, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2m9i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M9I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M9I FirstGlance]. <br>		<table><tr><td colspan='2'>[[2m9i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M9I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M9I FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m9i OCA], [https://pdbe.org/2m9i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m9i RCSB], [https://www.ebi.ac.uk/pdbsum/2m9i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m9i ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m9i OCA], [https://pdbe.org/2m9i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m9i RCSB], [https://www.ebi.ac.uk/pdbsum/2m9i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m9i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 09:31, 14 June 2023

OCA — Wed, 14 Jun 2023 09:31:26 GMT

←Older revision		Revision as of 09:31, 14 June 2023
Line 1:		Line 1:

	==NMR solution structure of Pin1 WW domain variant 6-1==		==NMR solution structure of Pin1 WW domain variant 6-1==
-	<StructureSection load='2m9i' size='340' side='right'caption='[[2m9i~~]], [[NMR_Ensembles_of_Models \| 19 NMR models~~]]' scene=''>	+	<StructureSection load='2m9i' size='340' side='right'caption='[[2m9i]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2m9i]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M9I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M9I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2m9i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M9I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M9I FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2m9e\|2m9e]], [[2m9f\|2m9f]], [[2m9j\|2m9j]]</div></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m9i OCA], [https://pdbe.org/2m9i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m9i RCSB], [https://www.ebi.ac.uk/pdbsum/2m9i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m9i ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m9i OCA], [https://pdbe.org/2m9i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m9i RCSB], [https://www.ebi.ac.uk/pdbsum/2m9i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m9i ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN]] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>	+	[https://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, W]]	+	[[Category: Chen W]]
-	[[Category: Dyson~~, H J~~]]	+	[[Category: Dyson HJ]]
-	[[Category: Enck, S]]	+	[[Category: Enck S]]
-	[[Category: Kelly~~, J W~~]]	+	[[Category: Kelly JW]]
-	[[Category: Powers~~, E T~~]]	+	[[Category: Powers ET]]
-	[[Category: Price~~, J L~~]]	+	[[Category: Price JL]]
-	[[Category: Wong, C]]	+	[[Category: Wong C]]
-	~~[[Category: Ch-pi interaction]]~~	+
-	~~[[Category: Enhanced aromatic sequon]]~~	+
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: N-glycosylation]]~~	+
-	~~[[Category: Ww domain~~]]	+

OCA at 11:33, 16 February 2022

OCA — Wed, 16 Feb 2022 11:33:54 GMT

←Older revision		Revision as of 11:33, 16 February 2022
Line 3:		Line 3:
	<StructureSection load='2m9i' size='340' side='right'caption='[[2m9i]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>		<StructureSection load='2m9i' size='340' side='right'caption='[[2m9i]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2m9i]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M9I OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2M9I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2m9i]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M9I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M9I FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2m9e\|2m9e]], [[2m9f\|2m9f]], [[2m9j\|2m9j]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2m9e\|2m9e]], [[2m9f\|2m9f]], [[2m9j\|2m9j]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2m9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m9i OCA], [~~http~~://pdbe.org/2m9i PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2m9i RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2m9i PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2m9i ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m9i OCA], [https://pdbe.org/2m9i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m9i RCSB], [https://www.ebi.ac.uk/pdbsum/2m9i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m9i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN]] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>	+	[[https://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN]] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:20, 13 May 2020

OCA — Wed, 13 May 2020 06:20:45 GMT

←Older revision		Revision as of 06:20, 13 May 2020
Line 1:		Line 1:

	==NMR solution structure of Pin1 WW domain variant 6-1==		==NMR solution structure of Pin1 WW domain variant 6-1==
-	<StructureSection load='2m9i' size='340' side='right' caption='[[2m9i]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>	+	<StructureSection load='2m9i' size='340' side='right'caption='[[2m9i]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2m9i]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M9I OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2M9I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2m9i]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M9I OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2M9I FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2m9e\|2m9e]], [[2m9f\|2m9f]], [[2m9j\|2m9j]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2m9e\|2m9e]], [[2m9f\|2m9f]], [[2m9j\|2m9j]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2m9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m9i OCA], [http://pdbe.org/2m9i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m9i RCSB], [http://www.ebi.ac.uk/pdbsum/2m9i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2m9i ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2m9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m9i OCA], [http://pdbe.org/2m9i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m9i RCSB], [http://www.ebi.ac.uk/pdbsum/2m9i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2m9i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Peptidyl-prolyl cis-trans isomerase\|Peptidyl-prolyl cis-trans isomerase]]	+	*[[Peptidyl-prolyl cis-trans isomerase 3D structures\|Peptidyl-prolyl cis-trans isomerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Chen, W]]		[[Category: Chen, W]]
	[[Category: Dyson, H J]]		[[Category: Dyson, H J]]

OCA at 22:33, 9 August 2018

OCA — Thu, 09 Aug 2018 22:33:54 GMT

←Older revision		Revision as of 22:33, 9 August 2018
Line 1:		Line 1:
		+
	==NMR solution structure of Pin1 WW domain variant 6-1==		==NMR solution structure of Pin1 WW domain variant 6-1==
	<StructureSection load='2m9i' size='340' side='right' caption='[[2m9i]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>		<StructureSection load='2m9i' size='340' side='right' caption='[[2m9i]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2m9i]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M9I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M9I FirstGlance]. <br>		<table><tr><td colspan='2'>[[2m9i]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M9I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M9I FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2m9e\|2m9e]], [[2m9f\|2m9f]], [[2m9j\|2m9j]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2m9e\|2m9e]], [[2m9f\|2m9f]], [[2m9j\|2m9j]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m9i OCA], [http://pdbe.org/2m9i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m9i RCSB], [http://www.ebi.ac.uk/pdbsum/2m9i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m9i OCA], [http://pdbe.org/2m9i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m9i RCSB], [http://www.ebi.ac.uk/pdbsum/2m9i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2m9i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 17:19, 11 September 2015

OCA — Fri, 11 Sep 2015 17:19:55 GMT

←Older revision		Revision as of 17:19, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2m9i]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M9I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M9I FirstGlance]. <br>		<table><tr><td colspan='2'>[[2m9i]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M9I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M9I FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2m9e\|2m9e]], [[2m9f\|2m9f]], [[2m9j\|2m9j]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2m9e\|2m9e]], [[2m9f\|2m9f]], [[2m9j\|2m9j]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m9i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m9i RCSB], [http://www.ebi.ac.uk/pdbsum/2m9i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m9i OCA], [http://pdbe.org/2m9i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m9i RCSB], [http://www.ebi.ac.uk/pdbsum/2m9i PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2m9i" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Peptidyl-prolyl cis-trans isomerase\|Peptidyl-prolyl cis-trans isomerase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:32, 25 December 2014

OCA — Thu, 25 Dec 2014 19:32:29 GMT

←Older revision		Revision as of 19:32, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2m9i\| PDB=2m9i \| SCENE= }}~~	+	==NMR solution structure of Pin1 WW domain variant 6-1==
-	===NMR solution structure of Pin1 WW domain variant 6-1===	+	<StructureSection load='2m9i' size='340' side='right' caption='[[2m9i]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_23742246}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2m9i]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M9I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M9I FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2m9e\|2m9e]], [[2m9f\|2m9f]], [[2m9j\|2m9j]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m9i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m9i RCSB], [http://www.ebi.ac.uk/pdbsum/2m9i PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN]] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>		[[http://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN]] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Carbohydrate-aromatic interactions mediate many biological processes. However, the structure-energy relationships underpinning direct carbohydrate-aromatic packing in aqueous solution have been difficult to assess experimentally and remain elusive. Here, we determine the structures and folding energetics of chemically synthesized glycoproteins to quantify the contributions of the hydrophobic effect and CH-pi interactions to carbohydrate-aromatic packing interactions in proteins. We find that the hydrophobic effect contributes significantly to protein-carbohydrate interactions. Interactions between carbohydrates and aromatic amino acid side chains, however, are supplemented by CH-pi interactions. The strengths of experimentally determined carbohydrate-pi interactions do not correlate with the electrostatic properties of the involved aromatic residues, suggesting that the electrostatic component of CH-pi interactions in aqueous solution is small. Thus, tight binding of carbohydrates and aromatic residues is driven by the hydrophobic effect and CH-pi interactions featuring a dominating dispersive component.

-	~~==About this Structure==~~	+	The Structural and Energetic Basis of Carbohydrate-Aromatic Packing Interactions in Proteins.,Chen W, Enck S, Price JL, Powers DL, Powers ET, Wong CH, Dyson HJ, Kelly JW J Am Chem Soc. 2013 Jun 7. PMID:23742246<ref>PMID:23742246</ref>
-	~~[[2m9i]] is a 1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2M9I OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023742246</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Chen, W.]]	+	== References ==
-	[[Category: Dyson, H J.]]	+	<references/>
-	[[Category: Enck, S.]]	+	__TOC__
-	[[Category: Kelly, J W.]]	+	</StructureSection>
-	[[Category: Powers, E T.]]	+	[[Category: Chen, W]]
-	[[Category: Price, J L.]]	+	[[Category: Dyson, H J]]
-	[[Category: Wong, C.]]	+	[[Category: Enck, S]]
		+	[[Category: Kelly, J W]]
		+	[[Category: Powers, E T]]
		+	[[Category: Price, J L]]
		+	[[Category: Wong, C]]
	[[Category: Ch-pi interaction]]		[[Category: Ch-pi interaction]]
	[[Category: Enhanced aromatic sequon]]		[[Category: Enhanced aromatic sequon]]

OCA at 10:27, 3 July 2013

OCA — Wed, 03 Jul 2013 10:27:10 GMT

←Older revision		Revision as of 10:27, 3 July 2013
Line 1:		Line 1:
	{{STRUCTURE_2m9i\| PDB=2m9i \| SCENE= }}		{{STRUCTURE_2m9i\| PDB=2m9i \| SCENE= }}
	===NMR solution structure of Pin1 WW domain variant 6-1===		===NMR solution structure of Pin1 WW domain variant 6-1===
		+	{{ABSTRACT_PUBMED_23742246}}

	==Function==		==Function==
Line 9:		Line 10:

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:023742246</ref><references group="xtra"/><references/>
	[[Category: Chen, W.]]		[[Category: Chen, W.]]
	[[Category: Dyson, H J.]]		[[Category: Dyson, H J.]]

OCA at 10:18, 30 June 2013

OCA — Sun, 30 Jun 2013 10:18:09 GMT

←Older revision		Revision as of 10:18, 30 June 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_2m9i\| PDB=2m9i \| SCENE= }}
		+	===NMR solution structure of Pin1 WW domain variant 6-1===

-	~~The entry 2m9i is ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN]] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>

-	~~Authors~~: ~~Enck, S., Chen, W., Price, J.L., Powers, E.T., Wong, C., Dyson, H~~.J.~~, Kelly, J~~.W.	+	==About this Structure==
		+	[[2m9i]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M9I OCA].

-	~~Description~~: ~~NMR solution structure of Pin1 WW domain variant 6~~-1	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Chen, W.]]
		+	[[Category: Dyson, H J.]]
		+	[[Category: Enck, S.]]
		+	[[Category: Kelly, J W.]]
		+	[[Category: Powers, E T.]]
		+	[[Category: Price, J L.]]
		+	[[Category: Wong, C.]]
		+	[[Category: Ch-pi interaction]]
		+	[[Category: Enhanced aromatic sequon]]
		+	[[Category: Isomerase]]
		+	[[Category: N-glycosylation]]
		+	[[Category: Ww domain]]

OCA: Protected "2m9i" [edit=sysop:move=sysop]

OCA — Wed, 19 Jun 2013 10:32:22 GMT

Protected "2m9i" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:32, 19 June 2013