2mc3 - Revision history

OCA at 06:03, 15 May 2024

OCA — Wed, 15 May 2024 06:03:48 GMT

←Older revision		Revision as of 06:03, 15 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mc3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MC3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mc3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MC3 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mc3 OCA], [https://pdbe.org/2mc3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mc3 RCSB], [https://www.ebi.ac.uk/pdbsum/2mc3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mc3 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mc3 OCA], [https://pdbe.org/2mc3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mc3 RCSB], [https://www.ebi.ac.uk/pdbsum/2mc3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mc3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 06:31, 2 March 2023

OCA — Thu, 02 Mar 2023 06:31:10 GMT

←Older revision		Revision as of 06:31, 2 March 2023
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	==NMR solution structure of the winged-helix domain from MUS81 structure-specific endonuclease==		==NMR solution structure of the winged-helix domain from MUS81 structure-specific endonuclease==
-	<StructureSection load='2mc3' size='340' side='right'caption='[[2mc3~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2mc3' size='340' side='right'caption='[[2mc3]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mc3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MC3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mc3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MC3 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hCG_23303, MUS81 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mc3 OCA], [https://pdbe.org/2mc3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mc3 RCSB], [https://www.ebi.ac.uk/pdbsum/2mc3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mc3 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mc3 OCA], [https://pdbe.org/2mc3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mc3 RCSB], [https://www.ebi.ac.uk/pdbsum/2mc3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mc3 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/MUS81_HUMAN MUS81_HUMAN] Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.<ref>PMID:11741546</ref> <ref>PMID:12374758</ref> <ref>PMID:12686547</ref> <ref>PMID:12721304</ref> <ref>PMID:14617801</ref> <ref>PMID:15805243</ref> <ref>PMID:17289582</ref> <ref>PMID:19595721</ref> <ref>PMID:19596235</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 2mc3" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2mc3" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Endonuclease 3D structures\|Endonuclease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fadden, A]]	+	[[Category: Fadden A]]
-	[[Category: Harris, R]]	+	[[Category: Harris R]]
-	[[Category: Mcdonald~~, N Q]]~~	+	[[Category: Mcdonald NQ]]
-	~~[[Category: Alpha beta]]~~	+
-	~~[[Category: Dna binding]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Winged-helix~~]]	+

OCA at 10:07, 26 May 2021

OCA — Wed, 26 May 2021 10:07:19 GMT

←Older revision		Revision as of 10:07, 26 May 2021
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	==NMR solution structure of the winged-helix domain from MUS81 structure-specific endonuclease==		==NMR solution structure of the winged-helix domain from MUS81 structure-specific endonuclease==
-	<StructureSection load='2mc3' size='340' side='right' caption='[[2mc3]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2mc3' size='340' side='right'caption='[[2mc3]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mc3]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MC3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2MC3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mc3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MC3 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hCG_23303, MUS81 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hCG_23303, MUS81 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2mc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mc3 OCA], [~~http~~://pdbe.org/2mc3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2mc3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2mc3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2mc3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mc3 OCA], [https://pdbe.org/2mc3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mc3 RCSB], [https://www.ebi.ac.uk/pdbsum/2mc3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mc3 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Fadden, A]]		[[Category: Fadden, A]]
	[[Category: Harris, R]]		[[Category: Harris, R]]

OCA at 08:11, 12 September 2018

OCA — Wed, 12 Sep 2018 08:11:42 GMT

←Older revision		Revision as of 08:11, 12 September 2018
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	<StructureSection load='2mc3' size='340' side='right' caption='[[2mc3]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2mc3' size='340' side='right' caption='[[2mc3]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mc3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MC3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MC3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mc3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MC3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MC3 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mc3 OCA], [http://pdbe.org/2mc3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mc3 RCSB], [http://www.ebi.ac.uk/pdbsum/2mc3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mc3 ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hCG_23303, MUS81 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mc3 OCA], [http://pdbe.org/2mc3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mc3 RCSB], [http://www.ebi.ac.uk/pdbsum/2mc3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mc3 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Fadden, A]]		[[Category: Fadden, A]]
	[[Category: Harris, R]]		[[Category: Harris, R]]

OCA at 02:21, 11 December 2016

OCA — Sun, 11 Dec 2016 02:21:31 GMT

←Older revision		Revision as of 02:21, 11 December 2016
Line 1:		Line 1:
		+
	==NMR solution structure of the winged-helix domain from MUS81 structure-specific endonuclease==		==NMR solution structure of the winged-helix domain from MUS81 structure-specific endonuclease==
	<StructureSection load='2mc3' size='340' side='right' caption='[[2mc3]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2mc3' size='340' side='right' caption='[[2mc3]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mc3]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MC3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MC3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mc3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MC3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MC3 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hCG_23303, MUS81 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mc3 OCA], [http://pdbe.org/2mc3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mc3 RCSB], [http://www.ebi.ac.uk/pdbsum/2mc3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mc3 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mc3 OCA], [http://pdbe.org/2mc3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mc3 RCSB], [http://www.ebi.ac.uk/pdbsum/2mc3 PDBsum]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]
	[[Category: Fadden, A]]		[[Category: Fadden, A]]
	[[Category: Harris, R]]		[[Category: Harris, R]]

OCA at 05:21, 10 September 2015

OCA — Thu, 10 Sep 2015 05:21:35 GMT

←Older revision		Revision as of 05:21, 10 September 2015
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	<table><tr><td colspan='2'>[[2mc3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MC3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MC3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mc3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MC3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MC3 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hCG_23303, MUS81 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hCG_23303, MUS81 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mc3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mc3 RCSB], [http://www.ebi.ac.uk/pdbsum/2mc3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mc3 OCA], [http://pdbe.org/2mc3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mc3 RCSB], [http://www.ebi.ac.uk/pdbsum/2mc3 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2mc3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:16, 21 December 2014

OCA — Sun, 21 Dec 2014 16:16:49 GMT

←Older revision		Revision as of 16:16, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2mc3\| PDB=2mc3 \| SCENE= }}~~	+	==NMR solution structure of the winged-helix domain from MUS81 structure-specific endonuclease==
-	===NMR solution structure of the winged-helix domain from MUS81 structure-specific endonuclease===	+	<StructureSection load='2mc3' size='340' side='right' caption='[[2mc3]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_23982516}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2mc3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MC3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MC3 FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hCG_23303, MUS81 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mc3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mc3 RCSB], [http://www.ebi.ac.uk/pdbsum/2mc3 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The MUS81-EME1 endonuclease maintains metazoan genomic integrity by cleaving branched DNA structures that arise during the resolution of recombination intermediates. In humans, MUS81 also forms a poorly characterized complex with EME2. Here, we identify and determine the structure of a winged helix (WH) domain from human MUS81, which binds DNA. WH domain mutations greatly reduce binding of the isolated domain to DNA and impact on incision activity of MUS81-EME1/EME2 complexes. Deletion of the WH domain reduces the endonuclease activity of both MUS81-EME1 and MUS81-EME2 complexes, and incisions made by MUS81-EME2 are made closer to the junction on substrates containing a downstream duplex, such as fork structures and nicked Holliday junctions. WH domain mutation or deletion in Schizosaccharomyces pombe phenocopies the DNA-damage sensitivity of strains deleted for mus81. Our results indicate an important role for the WH domain in both yeast and human MUS81 complexes.

-	~~==About this Structure==~~	+	A winged helix domain in human MUS81 binds DNA and modulates the endonuclease activity of MUS81 complexes.,Fadden AJ, Schalbetter S, Bowles M, Harris R, Lally J, Carr AM, McDonald NQ Nucleic Acids Res. 2013 Aug 27. PMID:23982516<ref>PMID:23982516</ref>
-	~~[[2mc3]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Human Human]~~. ~~Full experimental information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2MC3 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023982516</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Fadden, A.]]	+	[[Category: Fadden, A]]
-	[[Category: Harris, R.]]	+	[[Category: Harris, R]]
-	[[Category: Mcdonald, N Q.]]	+	[[Category: Mcdonald, N Q]]
	[[Category: Alpha beta]]		[[Category: Alpha beta]]
	[[Category: Dna binding]]		[[Category: Dna binding]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Winged-helix]]		[[Category: Winged-helix]]

OCA at 05:58, 4 December 2013

OCA — Wed, 04 Dec 2013 05:58:16 GMT

←Older revision		Revision as of 05:58, 4 December 2013
Line 4:		Line 4:

	==About this Structure==		==About this Structure==
-	[[2mc3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MC3 OCA].	+	[[2mc3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MC3 OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:023982516</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:023982516</ref><references group="xtra"/><references/>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Fadden, A.]]		[[Category: Fadden, A.]]
	[[Category: Harris, R.]]		[[Category: Harris, R.]]

OCA at 04:08, 20 September 2013

OCA — Fri, 20 Sep 2013 04:08:50 GMT

←Older revision		Revision as of 04:08, 20 September 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_2mc3\| PDB=2mc3 \| SCENE= }}
		+	===NMR solution structure of the winged-helix domain from MUS81 structure-specific endonuclease===
		+	{{ABSTRACT_PUBMED_23982516}}

-	~~The entry~~ 2mc3 is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
		+	[[2mc3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MC3 OCA].

-	~~Authors~~: ~~Harris, R.,~~ Fadden, A., Mcdonald, N.Q.	+	==Reference==
-		+	<ref group="xtra">PMID:023982516</ref><references group="xtra"/><references/>
-	~~Description~~: ~~NMR solution structure of the winged~~-helix ~~domain from MUS81 structure-specific endonuclease~~	+	[[Category: Homo sapiens]]
		+	[[Category: Fadden, A.]]
		+	[[Category: Harris, R.]]
		+	[[Category: Mcdonald, N Q.]]
		+	[[Category: Alpha beta]]
		+	[[Category: Dna binding]]
		+	[[Category: Hydrolase]]
		+	[[Category: Winged-helix]]

OCA at 04:23, 12 September 2013

OCA — Thu, 12 Sep 2013 04:23:28 GMT

←Older revision		Revision as of 04:23, 12 September 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2mc3 is ON HOLD	+	The entry 2mc3 is ON HOLD until Paper Publication

	Authors: Harris, R., Fadden, A., Mcdonald, N.Q.		Authors: Harris, R., Fadden, A., Mcdonald, N.Q.

	Description: NMR solution structure of the winged-helix domain from MUS81 structure-specific endonuclease		Description: NMR solution structure of the winged-helix domain from MUS81 structure-specific endonuclease