2mda - Revision history

OCA at 06:59, 1 May 2024

OCA — Wed, 01 May 2024 06:59:49 GMT

←Older revision		Revision as of 06:59, 1 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mda]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MDA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mda]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MDA FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mda OCA], [https://pdbe.org/2mda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mda RCSB], [https://www.ebi.ac.uk/pdbsum/2mda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mda ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mda OCA], [https://pdbe.org/2mda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mda RCSB], [https://www.ebi.ac.uk/pdbsum/2mda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mda ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/TY3H_RAT TY3H_RAT] Plays an important role in the physiology of adrenergic neurons.		[https://www.uniprot.org/uniprot/TY3H_RAT TY3H_RAT] Plays an important role in the physiology of adrenergic neurons.
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Tyrosine hydroxylase (TyrH) catalyzes the hydroxylation of tyrosine to form 3,4-dihydroxyphenylalanine in the biosynthesis of the catecholamine neurotransmitters. The activity of the enzyme is regulated by phosphorylation of serine residues in a regulatory domain and by binding of catecholamines to the active site. Available structures of TyrH lack the regulatory domain, limiting the understanding of the effect of regulation on structure. We report the use of NMR spectroscopy to analyze the solution structure of the isolated regulatory domain of rat TyrH. The protein is composed of a largely unstructured N-terminal region (residues 1-71) and a well-folded C-terminal portion (residues 72-159). The structure of a truncated version of the regulatory domain containing residues 65-159 has been determined and establishes that it is an ACT domain. The isolated domain is a homodimer in solution, with the structure of each monomer very similar to that of the core of the regulatory domain of phenylalanine hydroxylase. Two TyrH regulatory domain monomers form an ACT domain dimer composed of a sheet of eight strands with four alpha-helices on one side of the sheet. Backbone dynamic analyses were carried out to characterize the conformational flexibility of TyrH65-159. The results provide molecular details critical for understanding the regulatory mechanism of TyrH.
-
-	The Solution Structure of the Regulatory Domain of Tyrosine Hydroxylase.,Zhang S, Huang T, Ilangovan U, Hinck AP, Fitzpatrick PF J Mol Biol. 2013 Dec 17. pii: S0022-2836(13)00779-1. doi:, 10.1016/j.jmb.2013.12.015. PMID:24361276<ref>PMID:24361276</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2mda" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
		+	*[[Hydroxylases 3D structures\|Hydroxylases 3D structures]]
	*[[Monooxygenase 3D structures\|Monooxygenase 3D structures]]		*[[Monooxygenase 3D structures\|Monooxygenase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:31, 2 March 2023

OCA — Thu, 02 Mar 2023 06:31:46 GMT

←Older revision		Revision as of 06:31, 2 March 2023
Line 1:		Line 1:

	==The Solution Structure of the Regulatory Domain of Tyrosine Hydroxylase==		==The Solution Structure of the Regulatory Domain of Tyrosine Hydroxylase==
-	<StructureSection load='2mda' size='340' side='right'caption='[[2mda~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='2mda' size='340' side='right'caption='[[2mda]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mda]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MDA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mda]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MDA FirstGlance]. <br>
-	</td></tr>~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Th ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mda OCA], [https://pdbe.org/2mda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mda RCSB], [https://www.ebi.ac.uk/pdbsum/2mda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mda ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mda OCA], [https://pdbe.org/2mda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mda RCSB], [https://www.ebi.ac.uk/pdbsum/2mda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mda ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TY3H_RAT TY3H_RAT]] Plays an important role in the physiology of adrenergic neurons.	+	[https://www.uniprot.org/uniprot/TY3H_RAT TY3H_RAT] Plays an important role in the physiology of adrenergic neurons.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fitzpatrick, P]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Hinck, A]]	+	[[Category: Fitzpatrick P]]
-	[[Category: Huang, T]]	+	[[Category: Hinck A]]
-	[[Category: Zhang, S]]	+	[[Category: Huang T]]
-	~~[[Category: Act domain]]~~	+	[[Category: Zhang S]]
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Regulation]]~~	+
-	~~[[Category: Tyrosine hydroxylase~~]]	+

OCA at 10:07, 26 May 2021

OCA — Wed, 26 May 2021 10:07:49 GMT

←Older revision		Revision as of 10:07, 26 May 2021
Line 1:		Line 1:

	==The Solution Structure of the Regulatory Domain of Tyrosine Hydroxylase==		==The Solution Structure of the Regulatory Domain of Tyrosine Hydroxylase==
-	<StructureSection load='2mda' size='340' side='right' caption='[[2mda]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='2mda' size='340' side='right'caption='[[2mda]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mda]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MDA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2MDA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mda]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MDA FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Th ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Th ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2mda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mda OCA], [~~http~~://pdbe.org/2mda PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2mda RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2mda PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2mda ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mda OCA], [https://pdbe.org/2mda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mda RCSB], [https://www.ebi.ac.uk/pdbsum/2mda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mda ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TY3H_RAT TY3H_RAT]] Plays an important role in the physiology of adrenergic neurons.	+	[[https://www.uniprot.org/uniprot/TY3H_RAT TY3H_RAT]] Plays an important role in the physiology of adrenergic neurons.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Monooxygenase\|Monooxygenase]]	+	*[[Monooxygenase 3D structures\|Monooxygenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Fitzpatrick, P]]		[[Category: Fitzpatrick, P]]
	[[Category: Hinck, A]]		[[Category: Hinck, A]]

OCA at 22:57, 9 August 2018

OCA — Thu, 09 Aug 2018 22:57:45 GMT

←Older revision		Revision as of 22:57, 9 August 2018
Line 1:		Line 1:
		+
	==The Solution Structure of the Regulatory Domain of Tyrosine Hydroxylase==		==The Solution Structure of the Regulatory Domain of Tyrosine Hydroxylase==
	<StructureSection load='2mda' size='340' side='right' caption='[[2mda]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2mda' size='340' side='right' caption='[[2mda]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2mda]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MDA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mda]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MDA FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Th ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Th ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mda OCA], [http://pdbe.org/2mda PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mda RCSB], [http://www.ebi.ac.uk/pdbsum/2mda PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mda OCA], [http://pdbe.org/2mda PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mda RCSB], [http://www.ebi.ac.uk/pdbsum/2mda PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mda ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 2mda" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2mda" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Monooxygenase\|Monooxygenase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:37, 10 September 2015

OCA — Thu, 10 Sep 2015 13:37:37 GMT

←Older revision		Revision as of 13:37, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2mda]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MDA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mda]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MDA FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Th ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Th ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mda OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mda RCSB], [http://www.ebi.ac.uk/pdbsum/2mda PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mda OCA], [http://pdbe.org/2mda PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mda RCSB], [http://www.ebi.ac.uk/pdbsum/2mda PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2mda" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 00:51, 25 December 2014

OCA — Thu, 25 Dec 2014 00:51:17 GMT

←Older revision		Revision as of 00:51, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2mda\| PDB=2mda \| SCENE= }}~~	+	==The Solution Structure of the Regulatory Domain of Tyrosine Hydroxylase==
-	===The Solution Structure of the Regulatory Domain of Tyrosine Hydroxylase===	+	<StructureSection load='2mda' size='340' side='right' caption='[[2mda]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_24361276}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2mda]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MDA FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Th ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mda OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mda RCSB], [http://www.ebi.ac.uk/pdbsum/2mda PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/TY3H_RAT TY3H_RAT]] Plays an important role in the physiology of adrenergic neurons.		[[http://www.uniprot.org/uniprot/TY3H_RAT TY3H_RAT]] Plays an important role in the physiology of adrenergic neurons.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Tyrosine hydroxylase (TyrH) catalyzes the hydroxylation of tyrosine to form 3,4-dihydroxyphenylalanine in the biosynthesis of the catecholamine neurotransmitters. The activity of the enzyme is regulated by phosphorylation of serine residues in a regulatory domain and by binding of catecholamines to the active site. Available structures of TyrH lack the regulatory domain, limiting the understanding of the effect of regulation on structure. We report the use of NMR spectroscopy to analyze the solution structure of the isolated regulatory domain of rat TyrH. The protein is composed of a largely unstructured N-terminal region (residues 1-71) and a well-folded C-terminal portion (residues 72-159). The structure of a truncated version of the regulatory domain containing residues 65-159 has been determined and establishes that it is an ACT domain. The isolated domain is a homodimer in solution, with the structure of each monomer very similar to that of the core of the regulatory domain of phenylalanine hydroxylase. Two TyrH regulatory domain monomers form an ACT domain dimer composed of a sheet of eight strands with four alpha-helices on one side of the sheet. Backbone dynamic analyses were carried out to characterize the conformational flexibility of TyrH65-159. The results provide molecular details critical for understanding the regulatory mechanism of TyrH.

-	~~==About this~~ Structure==	+	The Solution Structure of the Regulatory Domain of Tyrosine Hydroxylase.,Zhang S, Huang T, Ilangovan U, Hinck AP, Fitzpatrick PF J Mol Biol. 2013 Dec 17. pii: S0022-2836(13)00779-1. doi:, 10.1016/j.jmb.2013.12.015. PMID:24361276<ref>PMID:24361276</ref>
-	~~[[2mda]] is a 2 chain structure~~. ~~Full experimental information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.~~il/oca-bin/ocashort?id=2MDA OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024361276</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Fitzpatrick, P.]]	+	== References ==
-	[[Category: Hinck, A.]]	+	<references/>
-	[[Category: Huang, T.]]	+	__TOC__
-	[[Category: Zhang, S.]]	+	</StructureSection>
		+	[[Category: Buffalo rat]]
		+	[[Category: Fitzpatrick, P]]
		+	[[Category: Hinck, A]]
		+	[[Category: Huang, T]]
		+	[[Category: Zhang, S]]
	[[Category: Act domain]]		[[Category: Act domain]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Regulation]]		[[Category: Regulation]]
	[[Category: Tyrosine hydroxylase]]		[[Category: Tyrosine hydroxylase]]

OCA at 06:47, 15 January 2014

OCA — Wed, 15 Jan 2014 06:47:12 GMT

←Older revision		Revision as of 06:47, 15 January 2014
Line 1:		Line 1:
	{{STRUCTURE_2mda\| PDB=2mda \| SCENE= }}		{{STRUCTURE_2mda\| PDB=2mda \| SCENE= }}
	===The Solution Structure of the Regulatory Domain of Tyrosine Hydroxylase===		===The Solution Structure of the Regulatory Domain of Tyrosine Hydroxylase===
		+	{{ABSTRACT_PUBMED_24361276}}

	==Function==		==Function==
Line 7:		Line 8:
	==About this Structure==		==About this Structure==
	[[2mda]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MDA OCA].		[[2mda]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MDA OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024361276</ref><references group="xtra"/><references/>
	[[Category: Fitzpatrick, P.]]		[[Category: Fitzpatrick, P.]]
	[[Category: Hinck, A.]]		[[Category: Hinck, A.]]

OCA at 12:10, 1 January 2014

OCA — Wed, 01 Jan 2014 12:10:21 GMT

←Older revision		Revision as of 12:10, 1 January 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_2mda\| PDB=2mda \| SCENE= }}
		+	===The Solution Structure of the Regulatory Domain of Tyrosine Hydroxylase===

-	~~The entry 2mda is ON HOLD until Jan 01 2015~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/TY3H_RAT TY3H_RAT]] Plays an important role in the physiology of adrenergic neurons.

-	~~Authors~~: ~~Zhang, S~~.~~, Huang, T~~., Hinck, A., ~~Fitzpatrick~~, P.	+	==About this Structure==
-		+	[[2mda]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MDA OCA].
-	~~Description~~: ~~The Solution Structure of the Regulatory Domain of~~ Tyrosine ~~Hydroxylase~~	+	[[Category: Fitzpatrick, P.]]
		+	[[Category: Hinck, A.]]
		+	[[Category: Huang, T.]]
		+	[[Category: Zhang, S.]]
		+	[[Category: Act domain]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Regulation]]
		+	[[Category: Tyrosine hydroxylase]]

OCA at 09:00, 25 December 2013

OCA — Wed, 25 Dec 2013 09:00:19 GMT

←Older revision		Revision as of 09:00, 25 December 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2mda is ON HOLD until ~~Dec 25 2014~~	+	The entry 2mda is ON HOLD until Jan 01 2015

	Authors: Zhang, S., Huang, T., Hinck, A., Fitzpatrick, P.		Authors: Zhang, S., Huang, T., Hinck, A., Fitzpatrick, P.

	Description: The Solution Structure of the Regulatory Domain of Tyrosine Hydroxylase		Description: The Solution Structure of the Regulatory Domain of Tyrosine Hydroxylase

OCA at 08:37, 18 December 2013

OCA — Wed, 18 Dec 2013 08:37:19 GMT

←Older revision		Revision as of 08:37, 18 December 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2mda is ON HOLD until ~~Paper Publication~~	+	The entry 2mda is ON HOLD until Dec 25 2014

	Authors: Zhang, S., Huang, T., Hinck, A., Fitzpatrick, P.		Authors: Zhang, S., Huang, T., Hinck, A., Fitzpatrick, P.

	Description: The Solution Structure of the Regulatory Domain of Tyrosine Hydroxylase		Description: The Solution Structure of the Regulatory Domain of Tyrosine Hydroxylase