2mhf - Revision history

OCA at 06:05, 15 May 2024

OCA — Wed, 15 May 2024 06:05:38 GMT

←Older revision		Revision as of 06:05, 15 May 2024
Line 3:		Line 3:
	<StructureSection load='2mhf' size='340' side='right'caption='[[2mhf]]' scene=''>		<StructureSection load='2mhf' size='340' side='right'caption='[[2mhf]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MHF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mhf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MHF FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhf OCA], [https://pdbe.org/2mhf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mhf RCSB], [https://www.ebi.ac.uk/pdbsum/2mhf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mhf ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhf OCA], [https://pdbe.org/2mhf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mhf RCSB], [https://www.ebi.ac.uk/pdbsum/2mhf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mhf ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A8WHX9_DANRE A8WHX9_DANRE]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The carboxy-terminal region of the KCNH family of potassium channels contains a cyclic-nucleotide binding homology domain (CNBHD) that is important for channel gating and trafficking. The solution structure of the CNBHD of the KCNH potassium of zebrafish was determined using solution NMR spectroscopy. This domain exists as a monomer under solution conditions and adopts a similar fold to that determined by X-ray crystallography. The CNBHD does not bind cAMP because residue Y740 blocks the entry of cyclic-nucleotide to the binding pocket. Relaxation results show that the CNBHD is rigid except that some residues in the loop between beta6 and beta7 are flexible. Our results will be useful to understand the gating mechanism of KCNH family members through the CNBHD.
		+
		+	Solution structure of the cyclic-nucleotide binding homology domain of a KCNH channel.,Li Q, Ng HQ, Yoon HS, Kang C J Struct Biol. 2014 Mar 14. pii: S1047-8477(14)00061-6. doi:, 10.1016/j.jsb.2014.03.008. PMID:24632450<ref>PMID:24632450</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 2mhf" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Danio rerio]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Li Q]]		[[Category: Li Q]]
	[[Category: Ng H]]		[[Category: Ng H]]

OCA at 10:21, 31 August 2022

OCA — Wed, 31 Aug 2022 10:21:25 GMT

←Older revision		Revision as of 10:21, 31 August 2022
Line 1:		Line 1:

	==Solution structure of the cyclic-nucleotide binding homology domain of a KCNH channel==		==Solution structure of the cyclic-nucleotide binding homology domain of a KCNH channel==
-	<StructureSection load='2mhf' size='340' side='right'caption='[[2mhf~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2mhf' size='340' side='right'caption='[[2mhf]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>~~[[2mhf]] is a 1 chain structure.~~ Full ~~experimental~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MHF FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MHF FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhf OCA], [https://pdbe.org/2mhf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mhf RCSB], [https://www.ebi.ac.uk/pdbsum/2mhf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mhf ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhf OCA], [https://pdbe.org/2mhf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mhf RCSB], [https://www.ebi.ac.uk/pdbsum/2mhf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mhf ProSAT]</span></td></tr>
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The carboxy-terminal region of the KCNH family of potassium channels contains a cyclic-nucleotide binding homology domain (CNBHD) that is important for channel gating and trafficking. The solution structure of the CNBHD of the KCNH potassium of zebrafish was determined using solution NMR spectroscopy. This domain exists as a monomer under solution conditions and adopts a similar fold to that determined by X-ray crystallography. The CNBHD does not bind cAMP because residue Y740 blocks the entry of cyclic-nucleotide to the binding pocket. Relaxation results show that the CNBHD is rigid except that some residues in the loop between beta6 and beta7 are flexible. Our results will be useful to understand the gating mechanism of KCNH family members through the CNBHD.
-
-	Solution structure of the cyclic-nucleotide binding homology domain of a KCNH channel.,Li Q, Ng HQ, Yoon HS, Kang C J Struct Biol. 2014 Mar 14. pii: S1047-8477(14)00061-6. doi:, 10.1016/j.jsb.2014.03.008. PMID:24632450<ref>PMID:24632450</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2mhf" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Li, Q]]	+	[[Category: Li Q]]
-	[[Category: Ng, H]]	+	[[Category: Ng H]]
-	~~[[Category: Dynamic]]~~	+
-	~~[[Category: Ion channel]]~~	+
-	~~[[Category: Kcnh]]~~	+
-	~~[[Category: Nucleotide binding domain]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 04:54, 25 August 2022

OCA — Thu, 25 Aug 2022 04:54:42 GMT

←Older revision		Revision as of 04:54, 25 August 2022
Line 3:		Line 3:
	<StructureSection load='2mhf' size='340' side='right'caption='[[2mhf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2mhf' size='340' side='right'caption='[[2mhf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mhf]] is a 1 chain structure ~~with sequence from [https://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]~~. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MHF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mhf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MHF FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">kcnh3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhf OCA], [https://pdbe.org/2mhf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mhf RCSB], [https://www.ebi.ac.uk/pdbsum/2mhf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mhf ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhf OCA], [https://pdbe.org/2mhf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mhf RCSB], [https://www.ebi.ac.uk/pdbsum/2mhf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mhf ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Brachidanio rerio]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Li, Q]]		[[Category: Li, Q]]

OCA at 15:14, 2 June 2021

OCA — Wed, 02 Jun 2021 15:14:43 GMT

←Older revision		Revision as of 15:14, 2 June 2021
Line 1:		Line 1:

	==Solution structure of the cyclic-nucleotide binding homology domain of a KCNH channel==		==Solution structure of the cyclic-nucleotide binding homology domain of a KCNH channel==
-	<StructureSection load='2mhf' size='340' side='right' caption='[[2mhf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2mhf' size='340' side='right'caption='[[2mhf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mhf]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2MHF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mhf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MHF FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">kcnh3 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">kcnh3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2mhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhf OCA], [~~http~~://pdbe.org/2mhf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2mhf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2mhf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2mhf ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhf OCA], [https://pdbe.org/2mhf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mhf RCSB], [https://www.ebi.ac.uk/pdbsum/2mhf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mhf ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Brachidanio rerio]]		[[Category: Brachidanio rerio]]
		+	[[Category: Large Structures]]
	[[Category: Li, Q]]		[[Category: Li, Q]]
	[[Category: Ng, H]]		[[Category: Ng, H]]

OCA at 23:11, 9 August 2018

OCA — Thu, 09 Aug 2018 23:11:26 GMT

←Older revision		Revision as of 23:11, 9 August 2018
Line 1:		Line 1:
		+
	==Solution structure of the cyclic-nucleotide binding homology domain of a KCNH channel==		==Solution structure of the cyclic-nucleotide binding homology domain of a KCNH channel==
	<StructureSection load='2mhf' size='340' side='right' caption='[[2mhf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2mhf' size='340' side='right' caption='[[2mhf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2mhf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MHF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mhf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MHF FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">kcnh3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">kcnh3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhf OCA], [http://pdbe.org/2mhf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mhf RCSB], [http://www.ebi.ac.uk/pdbsum/2mhf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhf OCA], [http://pdbe.org/2mhf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mhf RCSB], [http://www.ebi.ac.uk/pdbsum/2mhf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mhf ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:11, 10 September 2015

OCA — Thu, 10 Sep 2015 12:11:16 GMT

←Older revision		Revision as of 12:11, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2mhf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MHF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mhf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MHF FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">kcnh3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">kcnh3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mhf RCSB], [http://www.ebi.ac.uk/pdbsum/2mhf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhf OCA], [http://pdbe.org/2mhf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mhf RCSB], [http://www.ebi.ac.uk/pdbsum/2mhf PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2mhf" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:08, 3 January 2015

OCA — Sat, 03 Jan 2015 22:08:01 GMT

←Older revision		Revision as of 22:08, 3 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_2mhf\| PDB=2mhf \| SCENE= }}~~	+	==Solution structure of the cyclic-nucleotide binding homology domain of a KCNH channel==
-	===Solution structure of the cyclic-nucleotide binding homology domain of a KCNH channel===	+	<StructureSection load='2mhf' size='340' side='right' caption='[[2mhf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_24632450}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2mhf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MHF FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">kcnh3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mhf RCSB], [http://www.ebi.ac.uk/pdbsum/2mhf PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The carboxy-terminal region of the KCNH family of potassium channels contains a cyclic-nucleotide binding homology domain (CNBHD) that is important for channel gating and trafficking. The solution structure of the CNBHD of the KCNH potassium of zebrafish was determined using solution NMR spectroscopy. This domain exists as a monomer under solution conditions and adopts a similar fold to that determined by X-ray crystallography. The CNBHD does not bind cAMP because residue Y740 blocks the entry of cyclic-nucleotide to the binding pocket. Relaxation results show that the CNBHD is rigid except that some residues in the loop between beta6 and beta7 are flexible. Our results will be useful to understand the gating mechanism of KCNH family members through the CNBHD.

-	~~==About this Structure==~~	+	Solution structure of the cyclic-nucleotide binding homology domain of a KCNH channel.,Li Q, Ng HQ, Yoon HS, Kang C J Struct Biol. 2014 Mar 14. pii: S1047-8477(14)00061-6. doi:, 10.1016/j.jsb.2014.03.008. PMID:24632450<ref>PMID:24632450</ref>
-	~~[[2mhf]] is a 1 chain~~ structure. ~~Full experimental information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.~~il/oca-bin/ocashort?id=2MHF OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024632450</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Li, Q.]]	+	== References ==
-	[[Category: Ng, H.]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Brachidanio rerio]]
		+	[[Category: Li, Q]]
		+	[[Category: Ng, H]]
	[[Category: Dynamic]]		[[Category: Dynamic]]
	[[Category: Ion channel]]		[[Category: Ion channel]]

OCA at 09:12, 2 April 2014

OCA — Wed, 02 Apr 2014 09:12:34 GMT

←Older revision		Revision as of 09:12, 2 April 2014
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_2mhf\| PDB=2mhf \| SCENE= }}
		+	===Solution structure of the cyclic-nucleotide binding homology domain of a KCNH channel===
		+	{{ABSTRACT_PUBMED_24632450}}

-	~~The entry~~ 2mhf is ~~ON HOLD~~	+	==About this Structure==
		+	[[2mhf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHF OCA].

-	~~Authors~~: Li, Q., Ng, H.	+	==Reference==
-		+	<ref group="xtra">PMID:024632450</ref><references group="xtra"/><references/>
-	~~Description~~: ~~Solution structure of the cyclic-nucleotide~~ binding ~~homology~~ domain ~~of a KCNH channel~~	+	[[Category: Li, Q.]]
		+	[[Category: Ng, H.]]
		+	[[Category: Dynamic]]
		+	[[Category: Ion channel]]
		+	[[Category: Kcnh]]
		+	[[Category: Nucleotide binding domain]]
		+	[[Category: Transport protein]]

OCA: Protected "2mhf" [edit=sysop:move=sysop]

OCA — Wed, 27 Nov 2013 09:08:37 GMT

Protected "2mhf" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:08, 27 November 2013

OCA: New page: '''Unreleased structure''' The entry 2mhf is ON HOLD Authors: Li, Q., Ng, H. Description: Solution structure of the cyclic-nucleotide binding homology domain of a KCNH channel

OCA — Wed, 27 Nov 2013 09:08:36 GMT

New page: '''Unreleased structure''' The entry 2mhf is ON HOLD Authors: Li, Q., Ng, H. Description: Solution structure of the cyclic-nucleotide binding homology domain of a KCNH channel

New page

'''Unreleased structure'''

The entry 2mhf is ON HOLD

Authors: Li, Q., Ng, H.

Description: Solution structure of the cyclic-nucleotide binding homology domain of a KCNH channel