2miz - Revision history

OCA at 07:58, 8 March 2023

OCA — Wed, 08 Mar 2023 07:58:39 GMT

←Older revision		Revision as of 07:58, 8 March 2023
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	==Structure of the m04/gp34 mouse Cytomegalovirus Immunoevasin core domain==		==Structure of the m04/gp34 mouse Cytomegalovirus Immunoevasin core domain==
-	<StructureSection load='2miz' size='340' side='right'caption='[[2miz~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='2miz' size='340' side='right'caption='[[2miz]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2miz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Muhvk Muhvk~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MIZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2miz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Murine_cytomegalovirus_(strain_K181) Murine cytomegalovirus (strain K181)]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MIZ FirstGlance]. <br>
-	</td></tr>~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">m04 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=69156 MUHVK])</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2miz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2miz OCA], [https://pdbe.org/2miz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2miz RCSB], [https://www.ebi.ac.uk/pdbsum/2miz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2miz ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2miz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2miz OCA], [https://pdbe.org/2miz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2miz RCSB], [https://www.ebi.ac.uk/pdbsum/2miz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2miz ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A2Q6L0_MUHVK A2Q6L0_MUHVK]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Muhvk]]~~	+	[[Category: Bax A]]
-	[[Category: Bax, A]]	+	[[Category: Margulies DH]]
-	[[Category: Margulies~~, D H~~]]	+	[[Category: Natarajan K]]
-	[[Category: Natarajan, K]]	+	[[Category: Sgourakis NG]]
-	[[Category: Sgourakis~~, N G]]~~	+
-	~~[[Category: Ilv labelling]]~~	+
-	~~[[Category: Immunoglobulin-like fold]]~~	+
-	~~[[Category: Mhc class-i regulation]]~~	+
-	~~[[Category: Missing-self]]~~	+
-	~~[[Category: Natural killer decoy]]~~	+
-	~~[[Category: Residual dipolar coupling]]~~	+
-	~~[[Category: Rosetta modelling]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 15:15, 2 June 2021

OCA — Wed, 02 Jun 2021 15:15:27 GMT

←Older revision		Revision as of 15:15, 2 June 2021
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	==Structure of the m04/gp34 mouse Cytomegalovirus Immunoevasin core domain==		==Structure of the m04/gp34 mouse Cytomegalovirus Immunoevasin core domain==
-	<StructureSection load='2miz' size='340' side='right' caption='[[2miz]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='2miz' size='340' side='right'caption='[[2miz]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2miz]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Muhvk Muhvk]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2MIZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2miz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Muhvk Muhvk]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MIZ FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">m04 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=69156 MUHVK])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">m04 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=69156 MUHVK])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2miz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2miz OCA], [~~http~~://pdbe.org/2miz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2miz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2miz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2miz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2miz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2miz OCA], [https://pdbe.org/2miz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2miz RCSB], [https://www.ebi.ac.uk/pdbsum/2miz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2miz ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Muhvk]]		[[Category: Muhvk]]
	[[Category: Bax, A]]		[[Category: Bax, A]]

OCA at 23:05, 9 August 2018

OCA — Thu, 09 Aug 2018 23:05:11 GMT

←Older revision		Revision as of 23:05, 9 August 2018
Line 1:		Line 1:
		+
	==Structure of the m04/gp34 mouse Cytomegalovirus Immunoevasin core domain==		==Structure of the m04/gp34 mouse Cytomegalovirus Immunoevasin core domain==
	<StructureSection load='2miz' size='340' side='right' caption='[[2miz]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2miz' size='340' side='right' caption='[[2miz]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2miz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MIZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2miz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Muhvk Muhvk]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MIZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2miz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2miz OCA], [http://pdbe.org/2miz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2miz RCSB], [http://www.ebi.ac.uk/pdbsum/2miz PDBsum]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">m04 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=69156 MUHVK])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2miz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2miz OCA], [http://pdbe.org/2miz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2miz RCSB], [http://www.ebi.ac.uk/pdbsum/2miz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2miz ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 18:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Muhvk]]
	[[Category: Bax, A]]		[[Category: Bax, A]]
	[[Category: Margulies, D H]]		[[Category: Margulies, D H]]

OCA at 13:44, 10 September 2015

OCA — Thu, 10 Sep 2015 13:44:49 GMT

←Older revision		Revision as of 13:44, 10 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2miz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MIZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2miz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MIZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2miz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2miz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2miz RCSB], [http://www.ebi.ac.uk/pdbsum/2miz PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2miz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2miz OCA], [http://pdbe.org/2miz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2miz RCSB], [http://www.ebi.ac.uk/pdbsum/2miz PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 13:		Line 13:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2miz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:08, 25 January 2015

OCA — Sun, 25 Jan 2015 08:08:09 GMT

←Older revision		Revision as of 08:08, 25 January 2015
Line 17:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bax, A.]]	+	[[Category: Bax, A]]
-	[[Category: Margulies, D H.]]	+	[[Category: Margulies, D H]]
-	[[Category: Natarajan, K.]]	+	[[Category: Natarajan, K]]
-	[[Category: Sgourakis, N G.]]	+	[[Category: Sgourakis, N G]]
	[[Category: Ilv labelling]]		[[Category: Ilv labelling]]
	[[Category: Immunoglobulin-like fold]]		[[Category: Immunoglobulin-like fold]]

OCA at 08:55, 22 October 2014

OCA — Wed, 22 Oct 2014 08:55:13 GMT

←Older revision		Revision as of 08:55, 22 October 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2miz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MIZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2miz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MIZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2miz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2miz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2miz RCSB], [http://www.ebi.ac.uk/pdbsum/2miz PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2miz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2miz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2miz RCSB], [http://www.ebi.ac.uk/pdbsum/2miz PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Immunoevasins are key proteins used by viruses to subvert host immune responses. Determining their high-resolution structures is key to understanding virus-host interactions toward the design of vaccines and other antiviral therapies. Mouse cytomegalovirus encodes a unique set of immunoevasins, the m02-m06 family, that modulates major histocompatibility complex class I (MHC-I) antigen presentation to CD8+ T cells and natural killer cells. Notwithstanding the large number of genetic and functional studies, the structural biology of immunoevasins remains incompletely understood, largely because of crystallization bottlenecks. Here we implement a technology using sparse nuclear magnetic resonance data and integrative Rosetta modeling to determine the structure of the m04/gp34 immunoevasin extracellular domain. The structure reveals a beta fold that is representative of the m02-m06 family of viral proteins, several of which are known to bind MHC-I molecules and interfere with antigen presentation, suggesting its role as a diversified immune regulation module.
		+
		+	The structure of mouse cytomegalovirus m04 protein obtained from sparse NMR data reveals a conserved fold of the m02-m06 viral immune modulator family.,Sgourakis NG, Natarajan K, Ying J, Vogeli B, Boyd LF, Margulies DH, Bax A Structure. 2014 Sep 2;22(9):1263-73. doi: 10.1016/j.str.2014.05.018. Epub 2014, Aug 7. PMID:25126960<ref>PMID:25126960</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 10:23, 16 July 2014

OCA — Wed, 16 Jul 2014 10:23:14 GMT

←Older revision		Revision as of 10:23, 16 July 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Structure of the m04/gp34 mouse Cytomegalovirus Immunoevasin core domain==
-		+	<StructureSection load='2miz' size='340' side='right' caption='[[2miz]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
-	~~The entry~~ 2miz is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2miz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MIZ FirstGlance]. <br>
-	~~Authors~~: ~~Sgourakis~~, N.G., ~~Natarajan~~, K., Margulies, D.H., ~~Bax~~, A.	+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2miz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2miz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2miz RCSB], [http://www.ebi.ac.uk/pdbsum/2miz PDBsum]</span></td></tr>
-		+	<table>
-	~~Description~~: ~~Structure of the m04/gp34 mouse Cytomegalovirus Immunoevasin core domain~~	+	__TOC__
		+	</StructureSection>
		+	[[Category: Bax, A.]]
		+	[[Category: Margulies, D H.]]
		+	[[Category: Natarajan, K.]]
		+	[[Category: Sgourakis, N G.]]
		+	[[Category: Ilv labelling]]
		+	[[Category: Immunoglobulin-like fold]]
		+	[[Category: Mhc class-i regulation]]
		+	[[Category: Missing-self]]
		+	[[Category: Natural killer decoy]]
		+	[[Category: Residual dipolar coupling]]
		+	[[Category: Rosetta modelling]]
		+	[[Category: Viral protein]]

OCA at 07:11, 21 May 2014

OCA — Wed, 21 May 2014 07:11:07 GMT

←Older revision		Revision as of 07:11, 21 May 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2miz is ON HOLD	+	The entry 2miz is ON HOLD until Paper Publication

	Authors: Sgourakis, N.G., Natarajan, K., Margulies, D.H., Bax, A.		Authors: Sgourakis, N.G., Natarajan, K., Margulies, D.H., Bax, A.

	Description: Structure of the m04/gp34 mouse Cytomegalovirus Immunoevasin core domain		Description: Structure of the m04/gp34 mouse Cytomegalovirus Immunoevasin core domain

OCA: Protected "2miz" [edit=sysop:move=sysop]

OCA — Wed, 08 Jan 2014 08:35:33 GMT

Protected "2miz" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:35, 8 January 2014

OCA: New page: '''Unreleased structure''' The entry 2miz is ON HOLD Authors: Sgourakis, N.G., Natarajan, K., Margulies, D.H., Bax, A. Description: Structure of the m04/gp34 mouse Cytomegalovirus Immu...

OCA — Wed, 08 Jan 2014 08:35:32 GMT

New page: '''Unreleased structure''' The entry 2miz is ON HOLD Authors: Sgourakis, N.G., Natarajan, K., Margulies, D.H., Bax, A. Description: Structure of the m04/gp34 mouse Cytomegalovirus Immu...

New page

'''Unreleased structure'''

The entry 2miz is ON HOLD

Authors: Sgourakis, N.G., Natarajan, K., Margulies, D.H., Bax, A.

Description: Structure of the m04/gp34 mouse Cytomegalovirus Immunoevasin core domain