2mkj - Revision history

OCA at 06:06, 15 May 2024

OCA — Wed, 15 May 2024 06:06:51 GMT

←Older revision		Revision as of 06:06, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mkj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MKJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mkj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MKJ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkj OCA], [https://pdbe.org/2mkj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mkj RCSB], [https://www.ebi.ac.uk/pdbsum/2mkj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mkj ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkj OCA], [https://pdbe.org/2mkj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mkj RCSB], [https://www.ebi.ac.uk/pdbsum/2mkj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mkj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:00, 8 March 2023

OCA — Wed, 08 Mar 2023 08:00:15 GMT

←Older revision		Revision as of 08:00, 8 March 2023
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	==Solution structure of tandem RRM domains of cytoplasmic polyadenylation element binding protein 4 (CPEB4) in free state==		==Solution structure of tandem RRM domains of cytoplasmic polyadenylation element binding protein 4 (CPEB4) in free state==
-	<StructureSection load='2mkj' size='340' side='right'caption='[[2mkj~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2mkj' size='340' side='right'caption='[[2mkj]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mkj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MKJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mkj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MKJ FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2mke\|2mke]], [[2mkh\|2mkh]], [[2mki\|2mki]], [[2mkk\|2mkk]]</div></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkj OCA], [https://pdbe.org/2mkj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mkj RCSB], [https://www.ebi.ac.uk/pdbsum/2mkj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mkj ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CPEB4, KIAA1673 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkj OCA], [https://pdbe.org/2mkj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mkj RCSB], [https://www.ebi.ac.uk/pdbsum/2mkj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mkj ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CPEB4_HUMAN CPEB4_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Afroz, T]]	+	[[Category: Afroz T]]
-	[[Category: Allain~~, F H.~~T]]	+	[[Category: Allain FH-T]]
-	[[Category: Belloc, E]]	+	[[Category: Belloc E]]
-	[[Category: Boixet~~, J G~~]]	+	[[Category: Boixet JG]]
-	[[Category: Mendez, R]]	+	[[Category: Mendez R]]
-	[[Category: Skrisovska, L]]	+	[[Category: Skrisovska L]]
-	~~[[Category: Cpeb4]]~~	+
-	~~[[Category: Cytoplasmic polyadenylation]]~~	+
-	~~[[Category: Translation regulator]]~~	+
-	~~[[Category: Translational regulation~~]]	+

OCA at 15:16, 2 June 2021

OCA — Wed, 02 Jun 2021 15:16:20 GMT

←Older revision		Revision as of 15:16, 2 June 2021
Line 1:		Line 1:

	==Solution structure of tandem RRM domains of cytoplasmic polyadenylation element binding protein 4 (CPEB4) in free state==		==Solution structure of tandem RRM domains of cytoplasmic polyadenylation element binding protein 4 (CPEB4) in free state==
-	<StructureSection load='2mkj' size='340' side='right' caption='[[2mkj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2mkj' size='340' side='right'caption='[[2mkj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mkj]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2MKJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mkj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MKJ FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mke\|2mke]], [[2mkh\|2mkh]], [[2mki\|2mki]], [[2mkk\|2mkk]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2mke\|2mke]], [[2mkh\|2mkh]], [[2mki\|2mki]], [[2mkk\|2mkk]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CPEB4, KIAA1673 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CPEB4, KIAA1673 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2mkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkj OCA], [~~http~~://pdbe.org/2mkj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2mkj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2mkj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2mkj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkj OCA], [https://pdbe.org/2mkj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mkj RCSB], [https://www.ebi.ac.uk/pdbsum/2mkj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mkj ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Afroz, T]]		[[Category: Afroz, T]]
	[[Category: Allain, F H.T]]		[[Category: Allain, F H.T]]

OCA at 22:43, 9 August 2018

OCA — Thu, 09 Aug 2018 22:43:49 GMT

←Older revision		Revision as of 22:43, 9 August 2018
Line 3:		Line 3:
	<StructureSection load='2mkj' size='340' side='right' caption='[[2mkj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2mkj' size='340' side='right' caption='[[2mkj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mkj]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MKJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mkj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MKJ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mke\|2mke]], [[2mkh\|2mkh]], [[2mki\|2mki]], [[2mkk\|2mkk]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mke\|2mke]], [[2mkh\|2mkh]], [[2mki\|2mki]], [[2mkk\|2mkk]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkj OCA], [http://pdbe.org/2mkj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mkj RCSB], [http://www.ebi.ac.uk/pdbsum/2mkj PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CPEB4, KIAA1673 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkj OCA], [http://pdbe.org/2mkj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mkj RCSB], [http://www.ebi.ac.uk/pdbsum/2mkj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mkj ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Afroz, T]]		[[Category: Afroz, T]]
	[[Category: Allain, F H.T]]		[[Category: Allain, F H.T]]

OCA at 16:24, 10 May 2016

OCA — Tue, 10 May 2016 16:24:27 GMT

←Older revision		Revision as of 16:24, 10 May 2016
Line 1:		Line 1:
		+
	==Solution structure of tandem RRM domains of cytoplasmic polyadenylation element binding protein 4 (CPEB4) in free state==		==Solution structure of tandem RRM domains of cytoplasmic polyadenylation element binding protein 4 (CPEB4) in free state==
	<StructureSection load='2mkj' size='340' side='right' caption='[[2mkj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2mkj' size='340' side='right' caption='[[2mkj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>

OCA at 11:46, 10 September 2015

OCA — Thu, 10 Sep 2015 11:46:42 GMT

←Older revision		Revision as of 11:46, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2mkj]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MKJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mkj]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MKJ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mke\|2mke]], [[2mkh\|2mkh]], [[2mki\|2mki]], [[2mkk\|2mkk]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mke\|2mke]], [[2mkh\|2mkh]], [[2mki\|2mki]], [[2mkk\|2mkk]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mkj RCSB], [http://www.ebi.ac.uk/pdbsum/2mkj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkj OCA], [http://pdbe.org/2mkj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mkj RCSB], [http://www.ebi.ac.uk/pdbsum/2mkj PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2mkj" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:37, 5 January 2015

OCA — Mon, 05 Jan 2015 12:37:48 GMT

←Older revision		Revision as of 12:37, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mkj]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MKJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mkj]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MKJ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mke\|2mke]], [[2mkh\|2mkh]], [[2mki\|2mki]], [[2mkk\|2mkk]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mke\|2mke]], [[2mkh\|2mkh]], [[2mki\|2mki]], [[2mkk\|2mkk]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mkj RCSB], [http://www.ebi.ac.uk/pdbsum/2mkj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mkj RCSB], [http://www.ebi.ac.uk/pdbsum/2mkj PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Afroz, T.]]	+	[[Category: Afroz, T]]
-	[[Category: Allain, F H.T.]]	+	[[Category: Allain, F H.T]]
-	[[Category: Belloc, E.]]	+	[[Category: Belloc, E]]
-	[[Category: Boixet, J G.]]	+	[[Category: Boixet, J G]]
-	[[Category: Mendez, R.]]	+	[[Category: Mendez, R]]
-	[[Category: Skrisovska, L.]]	+	[[Category: Skrisovska, L]]
	[[Category: Cpeb4]]		[[Category: Cpeb4]]
	[[Category: Cytoplasmic polyadenylation]]		[[Category: Cytoplasmic polyadenylation]]
	[[Category: Translation regulator]]		[[Category: Translation regulator]]
	[[Category: Translational regulation]]		[[Category: Translational regulation]]

OCA at 07:53, 23 July 2014

OCA — Wed, 23 Jul 2014 07:53:15 GMT

←Older revision		Revision as of 07:53, 23 July 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Solution structure of tandem RRM domains of cytoplasmic polyadenylation element binding protein 4 (CPEB4) in free state==
		+	<StructureSection load='2mkj' size='340' side='right' caption='[[2mkj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2mkj]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MKJ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mke\|2mke]], [[2mkh\|2mkh]], [[2mki\|2mki]], [[2mkk\|2mkk]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mkj RCSB], [http://www.ebi.ac.uk/pdbsum/2mkj PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cytoplasmic changes in polyA tail length is a key mechanism of translational control and is implicated in germline development, synaptic plasticity, cellular proliferation, senescence, and cancer progression. The presence of a U-rich cytoplasmic polyadenylation element (CPE) in the 3' untranslated regions (UTRs) of the responding mRNAs gives them the selectivity to be regulated by the CPE-binding (CPEB) family of proteins, which recognizes RNA via the tandem RNA recognition motifs (RRMs). Here we report the solution structures of the tandem RRMs of two human paralogs (CPEB1 and CPEB4) in their free and RNA-bound states. The structures reveal an unprecedented arrangement of RRMs in the free state that undergo an original closure motion upon RNA binding that ensures high fidelity. Structural and functional characterization of the ZZ domain (zinc-binding domain) of CPEB1 suggests a role in both protein-protein and protein-RNA interactions. Together with functional studies, the structures reveal how RNA binding by CPEB proteins leads to an optimal positioning of the N-terminal and ZZ domains at the 3' UTR, which favors the nucleation of the functional ribonucleoprotein complexes for translation regulation.

-	~~The entry 2mkj is ON HOLD until Paper Publication~~	+	A fly trap mechanism provides sequence-specific RNA recognition by CPEB proteins.,Afroz T, Skrisovska L, Belloc E, Guillen-Boixet J, Mendez R, Allain FH Genes Dev. 2014 Jul 1;28(13):1498-514. doi: 10.1101/gad.241133.114. PMID:24990967<ref>PMID:24990967</ref>

-	~~Authors~~: Afroz, T., ~~Skrisovska, L~~., Belloc, E., Boixet, J.G., Mendez, R., ~~Allain, F.H.-T~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Solution structure of tandem RRM domains of cytoplasmic~~ polyadenylation ~~element binding protein 4 (CPEB4) in free state~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Afroz, T.]]
		+	[[Category: Allain, F H.T.]]
		+	[[Category: Belloc, E.]]
		+	[[Category: Boixet, J G.]]
		+	[[Category: Mendez, R.]]
		+	[[Category: Skrisovska, L.]]
		+	[[Category: Cpeb4]]
		+	[[Category: Cytoplasmic polyadenylation]]
		+	[[Category: Translation regulator]]
		+	[[Category: Translational regulation]]

OCA at 16:03, 3 March 2014

OCA — Mon, 03 Mar 2014 16:03:45 GMT

←Older revision		Revision as of 16:03, 3 March 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2mkj is ON HOLD	+	The entry 2mkj is ON HOLD until Paper Publication

	Authors: Afroz, T., Skrisovska, L., Belloc, E., Boixet, J.G., Mendez, R., Allain, F.H.-T.		Authors: Afroz, T., Skrisovska, L., Belloc, E., Boixet, J.G., Mendez, R., Allain, F.H.-T.

	Description: Solution structure of tandem RRM domains of cytoplasmic polyadenylation element binding protein 4 (CPEB4) in free state		Description: Solution structure of tandem RRM domains of cytoplasmic polyadenylation element binding protein 4 (CPEB4) in free state

OCA: Protected "2mkj" [edit=sysop:move=sysop]

OCA — Wed, 19 Feb 2014 15:37:42 GMT

Protected "2mkj" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:37, 19 February 2014