2mkk - Revision history

OCA at 07:00, 1 May 2024

OCA — Wed, 01 May 2024 07:00:49 GMT

←Older revision		Revision as of 07:00, 1 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mkk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MKK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mkk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MKK FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkk OCA], [https://pdbe.org/2mkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mkk RCSB], [https://www.ebi.ac.uk/pdbsum/2mkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mkk ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkk OCA], [https://pdbe.org/2mkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mkk RCSB], [https://www.ebi.ac.uk/pdbsum/2mkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mkk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/CPEB1_HUMAN CPEB1_HUMAN] Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress.<ref>PMID:15966895</ref> <ref>PMID:15731006</ref>		[https://www.uniprot.org/uniprot/CPEB1_HUMAN CPEB1_HUMAN] Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress.<ref>PMID:15966895</ref> <ref>PMID:15731006</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Cytoplasmic changes in polyA tail length is a key mechanism of translational control and is implicated in germline development, synaptic plasticity, cellular proliferation, senescence, and cancer progression. The presence of a U-rich cytoplasmic polyadenylation element (CPE) in the 3' untranslated regions (UTRs) of the responding mRNAs gives them the selectivity to be regulated by the CPE-binding (CPEB) family of proteins, which recognizes RNA via the tandem RNA recognition motifs (RRMs). Here we report the solution structures of the tandem RRMs of two human paralogs (CPEB1 and CPEB4) in their free and RNA-bound states. The structures reveal an unprecedented arrangement of RRMs in the free state that undergo an original closure motion upon RNA binding that ensures high fidelity. Structural and functional characterization of the ZZ domain (zinc-binding domain) of CPEB1 suggests a role in both protein-protein and protein-RNA interactions. Together with functional studies, the structures reveal how RNA binding by CPEB proteins leads to an optimal positioning of the N-terminal and ZZ domains at the 3' UTR, which favors the nucleation of the functional ribonucleoprotein complexes for translation regulation.
-
-	A fly trap mechanism provides sequence-specific RNA recognition by CPEB proteins.,Afroz T, Skrisovska L, Belloc E, Guillen-Boixet J, Mendez R, Allain FH Genes Dev. 2014 Jul 1;28(13):1498-514. doi: 10.1101/gad.241133.114. PMID:24990967<ref>PMID:24990967</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2mkk" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:00, 8 March 2023

OCA — Wed, 08 Mar 2023 08:00:15 GMT

←Older revision		Revision as of 08:00, 8 March 2023
Line 1:		Line 1:

	==Structural model of tandem RRM domains of cytoplasmic polyadenylation element binding protein 1 (CPEB1) in complex with RNA==		==Structural model of tandem RRM domains of cytoplasmic polyadenylation element binding protein 1 (CPEB1) in complex with RNA==
-	<StructureSection load='2mkk' size='340' side='right'caption='[[2mkk~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='2mkk' size='340' side='right'caption='[[2mkk]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mkk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MKK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mkk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MKK FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2mke\|2mke]], [[2mkh\|2mkh]], [[2mki\|2mki]], [[2mkj\|2mkj]]</div></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkk OCA], [https://pdbe.org/2mkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mkk RCSB], [https://www.ebi.ac.uk/pdbsum/2mkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mkk ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CPEB1, CPEB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkk OCA], [https://pdbe.org/2mkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mkk RCSB], [https://www.ebi.ac.uk/pdbsum/2mkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mkk ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CPEB1_HUMAN CPEB1_HUMAN]] Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress.<ref>PMID:15966895</ref> <ref>PMID:15731006</ref>	+	[https://www.uniprot.org/uniprot/CPEB1_HUMAN CPEB1_HUMAN] Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress.<ref>PMID:15966895</ref> <ref>PMID:15731006</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Afroz, T]]	+	[[Category: Afroz T]]
-	[[Category: Allain~~, F H.~~T]]	+	[[Category: Allain FH-T]]
-	[[Category: Belloc, E]]	+	[[Category: Belloc E]]
-	[[Category: Boixet~~, J G~~]]	+	[[Category: Boixet JG]]
-	[[Category: Mendez, R]]	+	[[Category: Mendez R]]
-	[[Category: Skrisovska, L]]	+	[[Category: Skrisovska L]]
-	~~[[Category: Cpeb1]]~~	+
-	~~[[Category: Cytoplasmic polyadenylation]]~~	+
-	~~[[Category: Protein-rna interaction]]~~	+
-	~~[[Category: Translation regulation]]~~	+
-	~~[[Category: Translation regulator-rna complex~~]]	+

OCA at 15:16, 2 June 2021

OCA — Wed, 02 Jun 2021 15:16:21 GMT

←Older revision		Revision as of 15:16, 2 June 2021
Line 1:		Line 1:

	==Structural model of tandem RRM domains of cytoplasmic polyadenylation element binding protein 1 (CPEB1) in complex with RNA==		==Structural model of tandem RRM domains of cytoplasmic polyadenylation element binding protein 1 (CPEB1) in complex with RNA==
-	<StructureSection load='2mkk' size='340' side='right' caption='[[2mkk]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='2mkk' size='340' side='right'caption='[[2mkk]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mkk]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2MKK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mkk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MKK FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mke\|2mke]], [[2mkh\|2mkh]], [[2mki\|2mki]], [[2mkj\|2mkj]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2mke\|2mke]], [[2mkh\|2mkh]], [[2mki\|2mki]], [[2mkj\|2mkj]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CPEB1, CPEB ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CPEB1, CPEB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2mkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkk OCA], [~~http~~://pdbe.org/2mkk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2mkk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2mkk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2mkk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkk OCA], [https://pdbe.org/2mkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mkk RCSB], [https://www.ebi.ac.uk/pdbsum/2mkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mkk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CPEB1_HUMAN CPEB1_HUMAN]] Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress.<ref>PMID:15966895</ref> <ref>PMID:15731006</ref>	+	[[https://www.uniprot.org/uniprot/CPEB1_HUMAN CPEB1_HUMAN]] Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress.<ref>PMID:15966895</ref> <ref>PMID:15731006</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Afroz, T]]		[[Category: Afroz, T]]
	[[Category: Allain, F H.T]]		[[Category: Allain, F H.T]]

OCA at 23:01, 9 August 2018

OCA — Thu, 09 Aug 2018 23:01:10 GMT

←Older revision		Revision as of 23:01, 9 August 2018
Line 1:		Line 1:
		+
	==Structural model of tandem RRM domains of cytoplasmic polyadenylation element binding protein 1 (CPEB1) in complex with RNA==		==Structural model of tandem RRM domains of cytoplasmic polyadenylation element binding protein 1 (CPEB1) in complex with RNA==
	<StructureSection load='2mkk' size='340' side='right' caption='[[2mkk]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2mkk' size='340' side='right' caption='[[2mkk]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mkk]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MKK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mkk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MKK FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mke\|2mke]], [[2mkh\|2mkh]], [[2mki\|2mki]], [[2mkj\|2mkj]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mke\|2mke]], [[2mkh\|2mkh]], [[2mki\|2mki]], [[2mkj\|2mkj]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkk OCA], [http://pdbe.org/2mkk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mkk RCSB], [http://www.ebi.ac.uk/pdbsum/2mkk PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CPEB1, CPEB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkk OCA], [http://pdbe.org/2mkk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mkk RCSB], [http://www.ebi.ac.uk/pdbsum/2mkk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mkk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Afroz, T]]		[[Category: Afroz, T]]
	[[Category: Allain, F H.T]]		[[Category: Allain, F H.T]]

OCA at 19:31, 10 September 2015

OCA — Thu, 10 Sep 2015 19:31:10 GMT

←Older revision		Revision as of 19:31, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2mkk]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MKK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mkk]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MKK FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mke\|2mke]], [[2mkh\|2mkh]], [[2mki\|2mki]], [[2mkj\|2mkj]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mke\|2mke]], [[2mkh\|2mkh]], [[2mki\|2mki]], [[2mkj\|2mkj]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mkk RCSB], [http://www.ebi.ac.uk/pdbsum/2mkk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkk OCA], [http://pdbe.org/2mkk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mkk RCSB], [http://www.ebi.ac.uk/pdbsum/2mkk PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2mkk" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:03, 25 December 2014

OCA — Thu, 25 Dec 2014 05:03:04 GMT

←Older revision		Revision as of 05:03, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mkk]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MKK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mkk]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MKK FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mke\|2mke]], [[2mkh\|2mkh]], [[2mki\|2mki]], [[2mkj\|2mkj]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mke\|2mke]], [[2mkh\|2mkh]], [[2mki\|2mki]], [[2mkj\|2mkj]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mkk RCSB], [http://www.ebi.ac.uk/pdbsum/2mkk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mkk RCSB], [http://www.ebi.ac.uk/pdbsum/2mkk PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CPEB1_HUMAN CPEB1_HUMAN]] Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress.<ref>PMID:15966895</ref> <ref>PMID:15731006</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Afroz, T.]]	+	[[Category: Afroz, T]]
-	[[Category: Allain, F H.T.]]	+	[[Category: Allain, F H.T]]
-	[[Category: Belloc, E.]]	+	[[Category: Belloc, E]]
-	[[Category: Boixet, J G.]]	+	[[Category: Boixet, J G]]
-	[[Category: Mendez, R.]]	+	[[Category: Mendez, R]]
-	[[Category: Skrisovska, L.]]	+	[[Category: Skrisovska, L]]
	[[Category: Cpeb1]]		[[Category: Cpeb1]]
	[[Category: Cytoplasmic polyadenylation]]		[[Category: Cytoplasmic polyadenylation]]

OCA at 07:58, 23 July 2014

OCA — Wed, 23 Jul 2014 07:58:33 GMT

←Older revision		Revision as of 07:58, 23 July 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Structural model of tandem RRM domains of cytoplasmic polyadenylation element binding protein 1 (CPEB1) in complex with RNA==
		+	<StructureSection load='2mkk' size='340' side='right' caption='[[2mkk]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2mkk]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MKK FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mke\|2mke]], [[2mkh\|2mkh]], [[2mki\|2mki]], [[2mkj\|2mkj]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mkk RCSB], [http://www.ebi.ac.uk/pdbsum/2mkk PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cytoplasmic changes in polyA tail length is a key mechanism of translational control and is implicated in germline development, synaptic plasticity, cellular proliferation, senescence, and cancer progression. The presence of a U-rich cytoplasmic polyadenylation element (CPE) in the 3' untranslated regions (UTRs) of the responding mRNAs gives them the selectivity to be regulated by the CPE-binding (CPEB) family of proteins, which recognizes RNA via the tandem RNA recognition motifs (RRMs). Here we report the solution structures of the tandem RRMs of two human paralogs (CPEB1 and CPEB4) in their free and RNA-bound states. The structures reveal an unprecedented arrangement of RRMs in the free state that undergo an original closure motion upon RNA binding that ensures high fidelity. Structural and functional characterization of the ZZ domain (zinc-binding domain) of CPEB1 suggests a role in both protein-protein and protein-RNA interactions. Together with functional studies, the structures reveal how RNA binding by CPEB proteins leads to an optimal positioning of the N-terminal and ZZ domains at the 3' UTR, which favors the nucleation of the functional ribonucleoprotein complexes for translation regulation.

-	~~The entry 2mkk is ON HOLD until Paper Publication~~	+	A fly trap mechanism provides sequence-specific RNA recognition by CPEB proteins.,Afroz T, Skrisovska L, Belloc E, Guillen-Boixet J, Mendez R, Allain FH Genes Dev. 2014 Jul 1;28(13):1498-514. doi: 10.1101/gad.241133.114. PMID:24990967<ref>PMID:24990967</ref>

-	~~Authors~~: Afroz, T., ~~Skrisovska, L~~., Belloc, E., Boixet, J.G., Mendez, R., ~~Allain, F.H.-T~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Structural model of tandem RRM domains of cytoplasmic~~ polyadenylation ~~element binding protein 1 (CPEB1) in~~ complex ~~with RNA~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Afroz, T.]]
		+	[[Category: Allain, F H.T.]]
		+	[[Category: Belloc, E.]]
		+	[[Category: Boixet, J G.]]
		+	[[Category: Mendez, R.]]
		+	[[Category: Skrisovska, L.]]
		+	[[Category: Cpeb1]]
		+	[[Category: Cytoplasmic polyadenylation]]
		+	[[Category: Protein-rna interaction]]
		+	[[Category: Translation regulation]]
		+	[[Category: Translation regulator-rna complex]]

OCA at 16:03, 3 March 2014

OCA — Mon, 03 Mar 2014 16:03:48 GMT

←Older revision		Revision as of 16:03, 3 March 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2mkk is ON HOLD	+	The entry 2mkk is ON HOLD until Paper Publication

	Authors: Afroz, T., Skrisovska, L., Belloc, E., Boixet, J.G., Mendez, R., Allain, F.H.-T.		Authors: Afroz, T., Skrisovska, L., Belloc, E., Boixet, J.G., Mendez, R., Allain, F.H.-T.

	Description: Structural model of tandem RRM domains of cytoplasmic polyadenylation element binding protein 1 (CPEB1) in complex with RNA		Description: Structural model of tandem RRM domains of cytoplasmic polyadenylation element binding protein 1 (CPEB1) in complex with RNA

OCA: Protected "2mkk" [edit=sysop:move=sysop]

OCA — Wed, 19 Feb 2014 15:37:45 GMT

Protected "2mkk" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:37, 19 February 2014

OCA: New page: '''Unreleased structure''' The entry 2mkk is ON HOLD Authors: Afroz, T., Skrisovska, L., Belloc, E., Boixet, J.G., Mendez, R., Allain, F.H.-T. Description: Structural model of tandem R...

OCA — Wed, 19 Feb 2014 15:37:44 GMT

New page: '''Unreleased structure''' The entry 2mkk is ON HOLD Authors: Afroz, T., Skrisovska, L., Belloc, E., Boixet, J.G., Mendez, R., Allain, F.H.-T. Description: Structural model of tandem R...

New page

'''Unreleased structure'''

The entry 2mkk is ON HOLD

Authors: Afroz, T., Skrisovska, L., Belloc, E., Boixet, J.G., Mendez, R., Allain, F.H.-T.

Description: Structural model of tandem RRM domains of cytoplasmic polyadenylation element binding protein 1 (CPEB1) in complex with RNA