2mlv - Revision history

OCA at 07:01, 1 May 2024

OCA — Wed, 01 May 2024 07:01:03 GMT

←Older revision		Revision as of 07:01, 1 May 2024
Line 9:		Line 9:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/Q7X2B5_LACLL Q7X2B5_LACLL]		[https://www.uniprot.org/uniprot/Q7X2B5_LACLL Q7X2B5_LACLL]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	LsbB is a class II leaderless lactococcal bacteriocin of 30 amino acids. In the present work, the structure and function relationship of LsbB was assessed. Structure determination by nuclear magnetic resonance (NMR) spectroscopy showed that LsbB has an N-terminal alpha-helix while the C-terminal of the molecule remains unstructured. To define the receptor binding domain of LsbB, a competition assay was performed in which a systematic collection of truncated peptides of various lengths covering different parts of LsbB was used to inhibit the antimicrobial activity of LsbB. The results indicate that the outmost eight amino acid sequence at the C-terminal end is likely to contain the receptor binding domain because only truncated fragments from this region could antagonize the antimicrobial activity of LsbB. Furthermore, alanine substitution revealed that the tryptophan in position 25 (W25) is crucial for the blocking activity of the truncated peptides as well as for the antimicrobial activity of the full-length bacteriocin. LsbB shares significant sequence homology with five other leaderless bacteriocins, especially at their C-terminal halves where all contain a conserved KxxxGxxPWE-motif, suggesting that they might recognize the same receptor as LsbB. This notion was supported by the fact that truncated peptides with sequences derived from the C-terminal regions of two LsbB-related bacteriocins inhibited the activity of LsbB, in the same manner as found with the truncated version of LsbB. Taken together these structure-function studies provide strong evidence that the receptor-binding parts of LsbB and sequence-related bacteriocins are located in their C-terminal halves.
-
-	Defining the structure and receptor binding domain of the leaderless bacteriocin LsbB.,Ovchinnikov KV, Kristiansen PE, Uzelac G, Topisirovic L, Kojic M, Nissen-Meyer J, Nes IF, Diep DB J Biol Chem. 2014 Jul 3. pii: jbc.M114.579698. PMID:24993828<ref>PMID:24993828</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2mlv" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:57, 22 November 2023

OCA — Wed, 22 Nov 2023 11:57:10 GMT

←Older revision		Revision as of 11:57, 22 November 2023
Line 1:		Line 1:

	==Structure of the antimicrobial peptide LsbB in TFE/water==		==Structure of the antimicrobial peptide LsbB in TFE/water==
-	<StructureSection load='2mlv' size='340' side='right'caption='[[2mlv~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2mlv' size='340' side='right'caption='[[2mlv]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mlv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MLV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MLV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mlv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_lactis_subsp._lactis Lactococcus lactis subsp. lactis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MLV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MLV FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'>[[2mlu\|2mlu]]</div~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mlv OCA], [https://pdbe.org/2mlv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mlv RCSB], [https://www.ebi.ac.uk/pdbsum/2mlv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mlv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mlv OCA], [https://pdbe.org/2mlv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mlv RCSB], [https://www.ebi.ac.uk/pdbsum/2mlv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mlv ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q7X2B5_LACLL Q7X2B5_LACLL]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Lactococcus lactis subsp. lactis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Diep, D]]	+	[[Category: Diep D]]
-	[[Category: Kristiansen, P]]	+	[[Category: Kristiansen P]]
-	[[Category: Ovchinnikov, K]]	+	[[Category: Ovchinnikov K]]
-	~~[[Category: Antimicrobial peptide]]~~	+
-	~~[[Category: Antimicrobial protein]]~~	+
-	~~[[Category: Bacteriocin]]~~	+
-	~~[[Category: Mode of killing]]~~	+
-	~~[[Category: Receptor binding domain]]~~	+
-	~~[[Category: Tfe~~]]	+

OCA at 11:37, 16 February 2022

OCA — Wed, 16 Feb 2022 11:37:11 GMT

←Older revision		Revision as of 11:37, 16 February 2022
Line 3:		Line 3:
	<StructureSection load='2mlv' size='340' side='right'caption='[[2mlv]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2mlv' size='340' side='right'caption='[[2mlv]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mlv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MLV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2MLV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mlv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MLV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MLV FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mlu\|2mlu]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2mlu\|2mlu]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2mlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mlv OCA], [~~http~~://pdbe.org/2mlv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2mlv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2mlv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2mlv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mlv OCA], [https://pdbe.org/2mlv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mlv RCSB], [https://www.ebi.ac.uk/pdbsum/2mlv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mlv ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:25, 13 May 2020

OCA — Wed, 13 May 2020 06:25:36 GMT

←Older revision		Revision as of 06:25, 13 May 2020
Line 1:		Line 1:

	==Structure of the antimicrobial peptide LsbB in TFE/water==		==Structure of the antimicrobial peptide LsbB in TFE/water==
-	<StructureSection load='2mlv' size='340' side='right' caption='[[2mlv]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2mlv' size='340' side='right'caption='[[2mlv]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mlv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MLV OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2MLV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mlv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MLV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2MLV FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mlu\|2mlu]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mlu\|2mlu]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2mlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mlv OCA], [http://pdbe.org/2mlv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mlv RCSB], [http://www.ebi.ac.uk/pdbsum/2mlv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mlv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2mlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mlv OCA], [http://pdbe.org/2mlv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mlv RCSB], [http://www.ebi.ac.uk/pdbsum/2mlv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mlv ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Diep, D]]		[[Category: Diep, D]]
	[[Category: Kristiansen, P]]		[[Category: Kristiansen, P]]

OCA at 22:53, 9 August 2018

OCA — Thu, 09 Aug 2018 22:53:08 GMT

←Older revision		Revision as of 22:53, 9 August 2018
Line 1:		Line 1:
		+
	==Structure of the antimicrobial peptide LsbB in TFE/water==		==Structure of the antimicrobial peptide LsbB in TFE/water==
	<StructureSection load='2mlv' size='340' side='right' caption='[[2mlv]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2mlv' size='340' side='right' caption='[[2mlv]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2mlv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MLV FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mlv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MLV FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mlu\|2mlu]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mlu\|2mlu]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mlv OCA], [http://pdbe.org/2mlv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mlv RCSB], [http://www.ebi.ac.uk/pdbsum/2mlv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mlv OCA], [http://pdbe.org/2mlv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mlv RCSB], [http://www.ebi.ac.uk/pdbsum/2mlv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mlv ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:01, 10 September 2015

OCA — Thu, 10 Sep 2015 15:01:25 GMT

←Older revision		Revision as of 15:01, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2mlv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MLV FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mlv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MLV FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mlu\|2mlu]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mlu\|2mlu]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mlv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mlv RCSB], [http://www.ebi.ac.uk/pdbsum/2mlv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mlv OCA], [http://pdbe.org/2mlv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mlv RCSB], [http://www.ebi.ac.uk/pdbsum/2mlv PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2mlv" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:45, 19 January 2015

OCA — Mon, 19 Jan 2015 16:45:43 GMT

←Older revision		Revision as of 16:45, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mlv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MLV FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mlv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MLV FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mlu\|2mlu]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mlu\|2mlu]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mlv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mlv RCSB], [http://www.ebi.ac.uk/pdbsum/2mlv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mlv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mlv RCSB], [http://www.ebi.ac.uk/pdbsum/2mlv PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Diep, D.]]	+	[[Category: Diep, D]]
-	[[Category: Kristiansen, P.]]	+	[[Category: Kristiansen, P]]
-	[[Category: Ovchinnikov, K.]]	+	[[Category: Ovchinnikov, K]]
	[[Category: Antimicrobial peptide]]		[[Category: Antimicrobial peptide]]
	[[Category: Antimicrobial protein]]		[[Category: Antimicrobial protein]]

OCA at 06:31, 23 July 2014

OCA — Wed, 23 Jul 2014 06:31:44 GMT

←Older revision		Revision as of 06:31, 23 July 2014
Line 6:		Line 6:
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mlv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mlv RCSB], [http://www.ebi.ac.uk/pdbsum/2mlv PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mlv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mlv RCSB], [http://www.ebi.ac.uk/pdbsum/2mlv PDBsum]</span></td></tr>
	<table>		<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	LsbB is a class II leaderless lactococcal bacteriocin of 30 amino acids. In the present work, the structure and function relationship of LsbB was assessed. Structure determination by nuclear magnetic resonance (NMR) spectroscopy showed that LsbB has an N-terminal alpha-helix while the C-terminal of the molecule remains unstructured. To define the receptor binding domain of LsbB, a competition assay was performed in which a systematic collection of truncated peptides of various lengths covering different parts of LsbB was used to inhibit the antimicrobial activity of LsbB. The results indicate that the outmost eight amino acid sequence at the C-terminal end is likely to contain the receptor binding domain because only truncated fragments from this region could antagonize the antimicrobial activity of LsbB. Furthermore, alanine substitution revealed that the tryptophan in position 25 (W25) is crucial for the blocking activity of the truncated peptides as well as for the antimicrobial activity of the full-length bacteriocin. LsbB shares significant sequence homology with five other leaderless bacteriocins, especially at their C-terminal halves where all contain a conserved KxxxGxxPWE-motif, suggesting that they might recognize the same receptor as LsbB. This notion was supported by the fact that truncated peptides with sequences derived from the C-terminal regions of two LsbB-related bacteriocins inhibited the activity of LsbB, in the same manner as found with the truncated version of LsbB. Taken together these structure-function studies provide strong evidence that the receptor-binding parts of LsbB and sequence-related bacteriocins are located in their C-terminal halves.
		+
		+	Defining the structure and receptor binding domain of the leaderless bacteriocin LsbB.,Ovchinnikov KV, Kristiansen PE, Uzelac G, Topisirovic L, Kojic M, Nissen-Meyer J, Nes IF, Diep DB J Biol Chem. 2014 Jul 3. pii: jbc.M114.579698. PMID:24993828<ref>PMID:24993828</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 10:23, 16 July 2014

OCA — Wed, 16 Jul 2014 10:23:23 GMT

←Older revision		Revision as of 10:23, 16 July 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Structure of the antimicrobial peptide LsbB in TFE/water==
-		+	<StructureSection load='2mlv' size='340' side='right' caption='[[2mlv]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~The entry~~ 2mlv is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2mlv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MLV FirstGlance]. <br>
-	~~Authors~~: ~~Kristiansen~~, P., ~~Ovchinnikov, K~~., Diep, D.	+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mlu\|2mlu]]</td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mlv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mlv RCSB], [http://www.ebi.ac.uk/pdbsum/2mlv PDBsum]</span></td></tr>
-	~~Description~~: ~~Structure of the antimicrobial~~ peptide ~~LsbB in TFE/water~~	+	<table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Diep, D.]]
		+	[[Category: Kristiansen, P.]]
		+	[[Category: Ovchinnikov, K.]]
		+	[[Category: Antimicrobial peptide]]
		+	[[Category: Antimicrobial protein]]
		+	[[Category: Bacteriocin]]
		+	[[Category: Mode of killing]]
		+	[[Category: Receptor binding domain]]
		+	[[Category: Tfe]]

OCA at 05:30, 9 April 2014

OCA — Wed, 09 Apr 2014 05:30:03 GMT

←Older revision		Revision as of 05:30, 9 April 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2mlv is ON HOLD	+	The entry 2mlv is ON HOLD until Paper Publication

	Authors: Kristiansen, P., Ovchinnikov, K., Diep, D.		Authors: Kristiansen, P., Ovchinnikov, K., Diep, D.

	Description: Structure of the antimicrobial peptide LsbB in TFE/water		Description: Structure of the antimicrobial peptide LsbB in TFE/water