2mpo - Revision history

OCA at 18:56, 29 November 2023

OCA — Wed, 29 Nov 2023 18:56:48 GMT

←Older revision		Revision as of 18:56, 29 November 2023
Line 1:		Line 1:

	==Structural basis of Toxoplasma gondii MIC2-Associated Protein interaction with MIC2==		==Structural basis of Toxoplasma gondii MIC2-Associated Protein interaction with MIC2==
-	<StructureSection load='2mpo' size='340' side='right'caption='[[2mpo~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>	+	<StructureSection load='2mpo' size='340' side='right'caption='[[2mpo]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mpo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Toxgo Toxgo~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MPO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mpo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MPO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mpo OCA], [https://pdbe.org/2mpo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mpo RCSB], [https://www.ebi.ac.uk/pdbsum/2mpo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mpo ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mpo OCA], [https://pdbe.org/2mpo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mpo RCSB], [https://www.ebi.ac.uk/pdbsum/2mpo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mpo ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q967S9_TOXGO Q967S9_TOXGO]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Toxoplasma gondii parasites must actively invade host cells to propagate. Secretory microneme proteins have been shown to be important for both gliding motility and active invasion. MIC2-M2AP is a protein complex that is essential for productive motility and rapid invasion by binding to host cell surface receptors. To investigate the architecture of the MIC2 and M2AP complex, we identified the minimal domains sufficient for interaction and solved the NMR solution structure of the globular domain of M2AP. We found that M2AP adopts a modified galectin fold similar to the C-terminal domain of another microneme protein, MIC1. NMR and immunoprecipitation analyses implicated hydrophobic residues on one face of the M2AP galectin fold in binding to the membrane proximal sixth thrombospondin type I repeat domain of MIC2. Our findings provide a second example of a galectin fold adapted for microneme protein-protein interactions and suggest a conserved strategy for the assembly and folding of diverse protein complexes.
		+
		+	Structural basis of Toxoplasma gondii MIC2-associated protein interaction with MIC2.,Huynh MH, Liu B, Henry M, Liew L, Matthews SJ, Carruthers VB J Biol Chem. 2015 Jan 16;290(3):1432-41. doi: 10.1074/jbc.M114.613646. Epub 2014 , Nov 19. PMID:25411252<ref>PMID:25411252</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 2mpo" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Toxgo]]
-	[[Category: Liu, B]]
-	[[Category: Matthews, S]]
-	[[Category: Cell adhesion]]
-	[[Category: M2ap]]
-	[[Category: Mic2]]
-	[[Category: Microneme]]
-	[[Category: Plasmodium]]
	[[Category: Toxoplasma gondii]]		[[Category: Toxoplasma gondii]]
		+	[[Category: Liu B]]
		+	[[Category: Matthews S]]

OCA at 09:02, 23 February 2022

OCA — Wed, 23 Feb 2022 09:02:26 GMT

←Older revision		Revision as of 09:02, 23 February 2022
Line 3:		Line 3:
	<StructureSection load='2mpo' size='340' side='right'caption='[[2mpo]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='2mpo' size='340' side='right'caption='[[2mpo]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mpo]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Toxgo Toxgo]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MPO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2MPO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mpo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxgo Toxgo]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MPO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2mpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mpo OCA], [~~http~~://pdbe.org/2mpo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2mpo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2mpo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2mpo ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mpo OCA], [https://pdbe.org/2mpo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mpo RCSB], [https://www.ebi.ac.uk/pdbsum/2mpo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mpo ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 06:27, 20 May 2020

OCA — Wed, 20 May 2020 06:27:07 GMT

←Older revision		Revision as of 06:27, 20 May 2020
Line 1:		Line 1:

	==Structural basis of Toxoplasma gondii MIC2-Associated Protein interaction with MIC2==		==Structural basis of Toxoplasma gondii MIC2-Associated Protein interaction with MIC2==
-	<StructureSection load='2mpo' size='340' side='right' caption='[[2mpo]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>	+	<StructureSection load='2mpo' size='340' side='right'caption='[[2mpo]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mpo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MPO OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2MPO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mpo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MPO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2MPO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2mpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mpo OCA], [http://pdbe.org/2mpo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mpo RCSB], [http://www.ebi.ac.uk/pdbsum/2mpo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mpo ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2mpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mpo OCA], [http://pdbe.org/2mpo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mpo RCSB], [http://www.ebi.ac.uk/pdbsum/2mpo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mpo ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Toxgo]]		[[Category: Toxgo]]
	[[Category: Liu, B]]		[[Category: Liu, B]]

OCA at 16:58, 15 August 2018

OCA — Wed, 15 Aug 2018 16:58:38 GMT

←Older revision		Revision as of 16:58, 15 August 2018
Line 1:		Line 1:
		+
	==Structural basis of Toxoplasma gondii MIC2-Associated Protein interaction with MIC2==		==Structural basis of Toxoplasma gondii MIC2-Associated Protein interaction with MIC2==
	<StructureSection load='2mpo' size='340' side='right' caption='[[2mpo]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='2mpo' size='340' side='right' caption='[[2mpo]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mpo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MPO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MPO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mpo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MPO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MPO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mpo OCA], [http://pdbe.org/2mpo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mpo RCSB], [http://www.ebi.ac.uk/pdbsum/2mpo PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mpo OCA], [http://pdbe.org/2mpo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mpo RCSB], [http://www.ebi.ac.uk/pdbsum/2mpo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mpo ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Toxgo]]
	[[Category: Liu, B]]		[[Category: Liu, B]]
	[[Category: Matthews, S]]		[[Category: Matthews, S]]

OCA at 11:17, 11 September 2015

OCA — Fri, 11 Sep 2015 11:17:15 GMT

←Older revision		Revision as of 11:17, 11 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mpo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MPO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MPO FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mpo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MPO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MPO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mpo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mpo RCSB], [http://www.ebi.ac.uk/pdbsum/2mpo PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mpo OCA], [http://pdbe.org/2mpo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mpo RCSB], [http://www.ebi.ac.uk/pdbsum/2mpo PDBsum]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 08:03, 26 November 2014

OCA — Wed, 26 Nov 2014 08:03:40 GMT

←Older revision		Revision as of 08:03, 26 November 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Structural basis of Toxoplasma gondii MIC2-Associated Protein interaction with MIC2==
-		+	<StructureSection load='2mpo' size='340' side='right' caption='[[2mpo]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
-	~~The entry~~ 2mpo is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2mpo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MPO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MPO FirstGlance]. <br>
-	~~Authors~~: Liu, B., Matthews, S.	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mpo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mpo RCSB], [http://www.ebi.ac.uk/pdbsum/2mpo PDBsum]</span></td></tr>
-		+	</table>
-	~~Description~~: ~~Structural basis of~~ Toxoplasma gondii ~~MIC2-Associated Protein interaction with MIC2~~	+	__TOC__
		+	</StructureSection>
		+	[[Category: Liu, B]]
		+	[[Category: Matthews, S]]
		+	[[Category: Cell adhesion]]
		+	[[Category: M2ap]]
		+	[[Category: Mic2]]
		+	[[Category: Microneme]]
		+	[[Category: Plasmodium]]
		+	[[Category: Toxoplasma gondii]]

OCA: Protected "2mpo" [edit=sysop:move=sysop]

OCA — Wed, 04 Jun 2014 04:47:30 GMT

Protected "2mpo" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:47, 4 June 2014

OCA: New page: '''Unreleased structure''' The entry 2mpo is ON HOLD Authors: Liu, B., Matthews, S. Description: Structural basis of Toxoplasma gondii MIC2-Associated Protein interaction with MIC2

OCA — Wed, 04 Jun 2014 04:47:29 GMT

New page: '''Unreleased structure''' The entry 2mpo is ON HOLD Authors: Liu, B., Matthews, S. Description: Structural basis of Toxoplasma gondii MIC2-Associated Protein interaction with MIC2

New page

'''Unreleased structure'''

The entry 2mpo is ON HOLD

Authors: Liu, B., Matthews, S.

Description: Structural basis of Toxoplasma gondii MIC2-Associated Protein interaction with MIC2