2mtv - Revision history

OCA at 07:02, 1 May 2024

OCA — Wed, 01 May 2024 07:02:17 GMT

←Older revision		Revision as of 07:02, 1 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mtv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MTV FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mtv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MTV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mtv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mtv OCA], [https://pdbe.org/2mtv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mtv RCSB], [https://www.ebi.ac.uk/pdbsum/2mtv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mtv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mtv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mtv OCA], [https://pdbe.org/2mtv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mtv RCSB], [https://www.ebi.ac.uk/pdbsum/2mtv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mtv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/YTDC1_RAT YTDC1_RAT] RNA-binding protein that regulates alternative splice site selection.<ref>PMID:10564280</ref> <ref>PMID:9473574</ref>		[https://www.uniprot.org/uniprot/YTDC1_RAT YTDC1_RAT] RNA-binding protein that regulates alternative splice site selection.<ref>PMID:10564280</ref> <ref>PMID:9473574</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	N6A methylation is the most abundant RNA modification occurring within messenger RNA. Impairment of methylase or demethylase functions are associated with severe phenotypes and diseases in several organisms. Beside writer and eraser enzymes of this dynamic RNA epigenetic modification, reader proteins that recognize this modification are involved in numerous cellular processes. Although the precise characterization of these reader proteins remains unknown, preliminary data showed that most potential reader proteins contained a conserved YT521-B homology (YTH) domain. Here we define the YTH domain of rat YT521-B as a N6-methylated adenosine reader domain and report its solution structure in complex with a N6-methylated RNA. The structure reveals a binding preference for NGANNN RNA hexamer and a deep hydrophobic cleft for m6A recognition. These findings establish a molecular function for YTH domains as m6A reader domains and should guide further studies into the biological functions of YTH-containing proteins in m6A recognition.
-
-	Solution structure of the YTH domain in complex with N6-methyladenosine RNA: a reader of methylated RNA.,Theler D, Dominguez C, Blatter M, Boudet J, Allain FH Nucleic Acids Res. 2014 Nov 11. pii: gku1116. PMID:25389274<ref>PMID:25389274</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2mtv" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:06, 8 March 2023

OCA — Wed, 08 Mar 2023 08:06:38 GMT

←Older revision		Revision as of 08:06, 8 March 2023
Line 1:		Line 1:

	==Solution Structure of the YTH Domain of YT521-B in complex with N6-Methyladenosine containing RNA==		==Solution Structure of the YTH Domain of YT521-B in complex with N6-Methyladenosine containing RNA==
-	<StructureSection load='2mtv' size='340' side='right'caption='[[2mtv~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2mtv' size='340' side='right'caption='[[2mtv]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mtv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MTV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mtv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MTV FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ythdc1, Yt521 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mtv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mtv OCA], [https://pdbe.org/2mtv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mtv RCSB], [https://www.ebi.ac.uk/pdbsum/2mtv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mtv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mtv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mtv OCA], [https://pdbe.org/2mtv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mtv RCSB], [https://www.ebi.ac.uk/pdbsum/2mtv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mtv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/YTDC1_RAT YTDC1_RAT]] RNA-binding protein that regulates alternative splice site selection.<ref>PMID:10564280</ref> <ref>PMID:9473574</ref>	+	[https://www.uniprot.org/uniprot/YTDC1_RAT YTDC1_RAT] RNA-binding protein that regulates alternative splice site selection.<ref>PMID:10564280</ref> <ref>PMID:9473574</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Allain, F H.T~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Blatter, M~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Boudet, J~~]]	+	[[Category: Allain FH-T]]
-	[[Category: ~~Dominguez, C~~]]	+	[[Category: Blatter M]]
-	[[Category: ~~Theler, D~~]]	+	[[Category: Boudet J]]
-	[[Category: ~~M6a~~]]	+	[[Category: Dominguez C]]
-	[[Category: ~~Rna binding protein-rna complex]]~~	+	[[Category: Theler D]]
-	~~[[Category: Yth~~]]	+

OCA at 15:20, 2 June 2021

OCA — Wed, 02 Jun 2021 15:20:55 GMT

←Older revision		Revision as of 15:20, 2 June 2021
Line 1:		Line 1:

	==Solution Structure of the YTH Domain of YT521-B in complex with N6-Methyladenosine containing RNA==		==Solution Structure of the YTH Domain of YT521-B in complex with N6-Methyladenosine containing RNA==
-	<StructureSection load='2mtv' size='340' side='right' caption='[[2mtv]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2mtv' size='340' side='right'caption='[[2mtv]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mtv]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2MTV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mtv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MTV FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ythdc1, Yt521 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ythdc1, Yt521 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2mtv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mtv OCA], [~~http~~://pdbe.org/2mtv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2mtv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2mtv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2mtv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mtv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mtv OCA], [https://pdbe.org/2mtv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mtv RCSB], [https://www.ebi.ac.uk/pdbsum/2mtv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mtv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/YTDC1_RAT YTDC1_RAT]] RNA-binding protein that regulates alternative splice site selection.<ref>PMID:10564280</ref> <ref>PMID:9473574</ref>	+	[[https://www.uniprot.org/uniprot/YTDC1_RAT YTDC1_RAT]] RNA-binding protein that regulates alternative splice site selection.<ref>PMID:10564280</ref> <ref>PMID:9473574</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Allain, F H.T]]		[[Category: Allain, F H.T]]
	[[Category: Blatter, M]]		[[Category: Blatter, M]]

OCA at 17:16, 15 August 2018

OCA — Wed, 15 Aug 2018 17:16:41 GMT

←Older revision		Revision as of 17:16, 15 August 2018
Line 1:		Line 1:
		+
	==Solution Structure of the YTH Domain of YT521-B in complex with N6-Methyladenosine containing RNA==		==Solution Structure of the YTH Domain of YT521-B in complex with N6-Methyladenosine containing RNA==
	<StructureSection load='2mtv' size='340' side='right' caption='[[2mtv]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2mtv' size='340' side='right' caption='[[2mtv]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mtv]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MTV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mtv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MTV FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mtv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mtv OCA], [http://pdbe.org/2mtv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mtv RCSB], [http://www.ebi.ac.uk/pdbsum/2mtv PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ythdc1, Yt521 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mtv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mtv OCA], [http://pdbe.org/2mtv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mtv RCSB], [http://www.ebi.ac.uk/pdbsum/2mtv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mtv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
	[[Category: Allain, F H.T]]		[[Category: Allain, F H.T]]
	[[Category: Blatter, M]]		[[Category: Blatter, M]]

OCA at 18:43, 10 September 2015

OCA — Thu, 10 Sep 2015 18:43:31 GMT

←Older revision		Revision as of 18:43, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2mtv]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MTV FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mtv]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MTV FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mtv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mtv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mtv RCSB], [http://www.ebi.ac.uk/pdbsum/2mtv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mtv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mtv OCA], [http://pdbe.org/2mtv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mtv RCSB], [http://www.ebi.ac.uk/pdbsum/2mtv PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2mtv" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:30, 25 December 2014

OCA — Thu, 25 Dec 2014 04:30:01 GMT

←Older revision		Revision as of 04:30, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mtv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mtv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mtv RCSB], [http://www.ebi.ac.uk/pdbsum/2mtv PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mtv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mtv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mtv RCSB], [http://www.ebi.ac.uk/pdbsum/2mtv PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/YTDC1_RAT YTDC1_RAT]] RNA-binding protein that regulates alternative splice site selection.<ref>PMID:10564280</ref> <ref>PMID:9473574</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:51, 26 November 2014

OCA — Wed, 26 Nov 2014 07:51:42 GMT

←Older revision		Revision as of 07:51, 26 November 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Solution Structure of the YTH Domain of YT521-B in complex with N6-Methyladenosine containing RNA==
		+	<StructureSection load='2mtv' size='340' side='right' caption='[[2mtv]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2mtv]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MTV FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mtv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mtv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mtv RCSB], [http://www.ebi.ac.uk/pdbsum/2mtv PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	N6A methylation is the most abundant RNA modification occurring within messenger RNA. Impairment of methylase or demethylase functions are associated with severe phenotypes and diseases in several organisms. Beside writer and eraser enzymes of this dynamic RNA epigenetic modification, reader proteins that recognize this modification are involved in numerous cellular processes. Although the precise characterization of these reader proteins remains unknown, preliminary data showed that most potential reader proteins contained a conserved YT521-B homology (YTH) domain. Here we define the YTH domain of rat YT521-B as a N6-methylated adenosine reader domain and report its solution structure in complex with a N6-methylated RNA. The structure reveals a binding preference for NGANNN RNA hexamer and a deep hydrophobic cleft for m6A recognition. These findings establish a molecular function for YTH domains as m6A reader domains and should guide further studies into the biological functions of YTH-containing proteins in m6A recognition.

-	~~The entry 2mtv is ON HOLD~~	+	Solution structure of the YTH domain in complex with N6-methyladenosine RNA: a reader of methylated RNA.,Theler D, Dominguez C, Blatter M, Boudet J, Allain FH Nucleic Acids Res. 2014 Nov 11. pii: gku1116. PMID:25389274<ref>PMID:25389274</ref>

-	~~Authors: Theler~~, D.~~, Dominguez, C~~., Blatter, M., Boudet, J., ~~Allain~~, ~~F.H.-T.~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Solution Structure of the YTH Domain of YT521~~-~~B in~~ complex ~~with N6-Methyladenosine containing RNA~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Allain, F H.T]]
		+	[[Category: Blatter, M]]
		+	[[Category: Boudet, J]]
		+	[[Category: Dominguez, C]]
		+	[[Category: Theler, D]]
		+	[[Category: M6a]]
		+	[[Category: Rna binding protein-rna complex]]
		+	[[Category: Yth]]

OCA: Protected "2mtv" [edit=sysop:move=sysop]

OCA — Wed, 10 Sep 2014 07:42:10 GMT

Protected "2mtv" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:42, 10 September 2014

OCA: New page: '''Unreleased structure''' The entry 2mtv is ON HOLD Authors: Theler, D., Dominguez, C., Blatter, M., Boudet, J., Allain, F.H.-T. Description: Solution Structure of the YTH Domain of Y...

OCA — Wed, 10 Sep 2014 07:42:09 GMT

New page: '''Unreleased structure''' The entry 2mtv is ON HOLD Authors: Theler, D., Dominguez, C., Blatter, M., Boudet, J., Allain, F.H.-T. Description: Solution Structure of the YTH Domain of Y...

New page

'''Unreleased structure'''

The entry 2mtv is ON HOLD

Authors: Theler, D., Dominguez, C., Blatter, M., Boudet, J., Allain, F.H.-T.

Description: Solution Structure of the YTH Domain of YT521-B in complex with N6-Methyladenosine containing RNA