2mvs - Revision history

OCA at 06:11, 15 May 2024

OCA — Wed, 15 May 2024 06:11:08 GMT

←Older revision		Revision as of 06:11, 15 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mvs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MVS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mvs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MVS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mvs OCA], [https://pdbe.org/2mvs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mvs RCSB], [https://www.ebi.ac.uk/pdbsum/2mvs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mvs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mvs OCA], [https://pdbe.org/2mvs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mvs RCSB], [https://www.ebi.ac.uk/pdbsum/2mvs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mvs ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:08, 8 March 2023

OCA — Wed, 08 Mar 2023 08:08:30 GMT

←Older revision		Revision as of 08:08, 8 March 2023
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	==N6-Methyladenosine RNA==		==N6-Methyladenosine RNA==
-	<StructureSection load='2mvs' size='340' side='right'caption='[[2mvs~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>	+	<StructureSection load='2mvs' size='340' side='right'caption='[[2mvs]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mvs]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MVS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mvs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MVS FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4rlp\|4rlp]], [[2mvy\|2mvy]]</div~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mvs OCA], [https://pdbe.org/2mvs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mvs RCSB], [https://www.ebi.ac.uk/pdbsum/2mvs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mvs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mvs OCA], [https://pdbe.org/2mvs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mvs RCSB], [https://www.ebi.ac.uk/pdbsum/2mvs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mvs ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Kool, E~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Lynch, S R~~]]	+	[[Category: Kool E]]
-	[[Category: ~~N6-methyl adenosine]]~~	+	[[Category: Lynch SR]]
-	~~[[Category: Rna~~]]	+

OCA at 15:21, 2 June 2021

OCA — Wed, 02 Jun 2021 15:21:54 GMT

←Older revision		Revision as of 15:21, 2 June 2021
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	<StructureSection load='2mvs' size='340' side='right'caption='[[2mvs]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='2mvs' size='340' side='right'caption='[[2mvs]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mvs]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MVS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2MVS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mvs]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MVS FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rlp\|4rlp]], [[2mvy\|2mvy]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4rlp\|4rlp]], [[2mvy\|2mvy]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2mvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mvs OCA], [~~http~~://pdbe.org/2mvs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2mvs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2mvs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2mvs ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mvs OCA], [https://pdbe.org/2mvs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mvs RCSB], [https://www.ebi.ac.uk/pdbsum/2mvs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mvs ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:05, 21 August 2019

OCA — Wed, 21 Aug 2019 07:05:43 GMT

←Older revision		Revision as of 07:05, 21 August 2019
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	==N6-Methyladenosine RNA==		==N6-Methyladenosine RNA==
-	<StructureSection load='2mvs' size='340' side='right' caption='[[2mvs]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>	+	<StructureSection load='2mvs' size='340' side='right'caption='[[2mvs]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mvs]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MVS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MVS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mvs]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MVS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MVS FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Kool, E]]		[[Category: Kool, E]]
	[[Category: Lynch, S R]]		[[Category: Lynch, S R]]
	[[Category: N6-methyl adenosine]]		[[Category: N6-methyl adenosine]]
	[[Category: Rna]]		[[Category: Rna]]

OCA at 16:47, 16 November 2017

OCA — Thu, 16 Nov 2017 16:47:57 GMT

←Older revision		Revision as of 16:47, 16 November 2017
Line 1:		Line 1:
		+
	==N6-Methyladenosine RNA==		==N6-Methyladenosine RNA==
	<StructureSection load='2mvs' size='340' side='right' caption='[[2mvs]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='2mvs' size='340' side='right' caption='[[2mvs]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
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	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rlp\|4rlp]], [[2mvy\|2mvy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rlp\|4rlp]], [[2mvy\|2mvy]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mvs OCA], [http://pdbe.org/2mvs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mvs RCSB], [http://www.ebi.ac.uk/pdbsum/2mvs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mvs OCA], [http://pdbe.org/2mvs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mvs RCSB], [http://www.ebi.ac.uk/pdbsum/2mvs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mvs ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:12, 30 September 2015

OCA — Wed, 30 Sep 2015 06:12:10 GMT

←Older revision		Revision as of 06:12, 30 September 2015
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-	'''~~Unreleased~~ structure'''	+	==N6-Methyladenosine RNA==
		+	<StructureSection load='2mvs' size='340' side='right' caption='[[2mvs]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2mvs]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MVS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MVS FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rlp\|4rlp]], [[2mvy\|2mvy]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mvs OCA], [http://pdbe.org/2mvs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mvs RCSB], [http://www.ebi.ac.uk/pdbsum/2mvs PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	N(6)-Methyladenosine (m(6)A) modification is hypothesized to control processes such as RNA degradation, localization, and splicing. However, the molecular mechanisms by which this occurs are unclear. Here, we measured structures of an RNA duplex containing m(6)A in the GGACU consensus, along with an unmodified RNA control, by 2D NMR. The data show that m(6)A-U pairing in the double-stranded context is accompanied by the methylamino group rotating from its energetically preferred syn geometry on the Watson-Crick face to the higher-energy anti conformation, positioning the methyl group in the major groove. Thermodynamic measurements of m(6)A in duplexes reveal that it is destabilizing by 0.5-1.7 kcal/mol. In contrast, we show that m(6)A in unpaired positions base stacks considerably more strongly than the unmodified base, adding substantial stabilization in single-stranded locations. Transcriptome-wide nuclease mapping of methylated RNA secondary structure from human cells reveals a structural transition at methylated adenosines, with a tendency to single-stranded structure adjacent to the modified base.

-	~~The entry 2mvs is ON HOLD until Paper Publication~~	+	Structure and thermodynamics of N6-methyladenosine in RNA: a spring-loaded base modification.,Roost C, Lynch SR, Batista PJ, Qu K, Chang HY, Kool ET J Am Chem Soc. 2015 Feb 11;137(5):2107-15. doi: 10.1021/ja513080v. Epub 2015 Feb , 2. PMID:25611135<ref>PMID:25611135</ref>

-	~~Authors: Lynch~~, S.~~R., Kool, E~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: N6~~-~~Methyladenosine RNA~~	+	<div class="pdbe-citations 2mvs" style="background-color:#fffaf0;"></div>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	== References ==
-	~~[[Category: Lynch, S.R]]~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Kool, E]]		[[Category: Kool, E]]
		+	[[Category: Lynch, S R]]
		+	[[Category: N6-methyl adenosine]]
		+	[[Category: Rna]]

OCA at 11:59, 21 January 2015

OCA — Wed, 21 Jan 2015 11:59:56 GMT

←Older revision		Revision as of 11:59, 21 January 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2mvs is ON HOLD	+	The entry 2mvs is ON HOLD until Paper Publication

	Authors: Lynch, S.R., Kool, E.		Authors: Lynch, S.R., Kool, E.

OCA at 12:30, 24 December 2014

OCA — Wed, 24 Dec 2014 12:30:25 GMT

←Older revision		Revision as of 12:30, 24 December 2014
Line 6:		Line 6:

	Description: N6-Methyladenosine RNA		Description: N6-Methyladenosine RNA
		+	[[Category: Unreleased Structures]]
		+	[[Category: Lynch, S.R]]
		+	[[Category: Kool, E]]

OCA: Protected "2mvs" [edit=sysop:move=sysop]

OCA — Wed, 22 Oct 2014 09:02:05 GMT

Protected "2mvs" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:02, 22 October 2014

OCA: New page: '''Unreleased structure''' The entry 2mvs is ON HOLD Authors: Lynch, S.R., Kool, E. Description: N6-Methyladenosine RNA

OCA — Wed, 22 Oct 2014 09:02:03 GMT

New page: '''Unreleased structure''' The entry 2mvs is ON HOLD Authors: Lynch, S.R., Kool, E. Description: N6-Methyladenosine RNA

New page

'''Unreleased structure'''

The entry 2mvs is ON HOLD

Authors: Lynch, S.R., Kool, E.

Description: N6-Methyladenosine RNA