2n12 - Revision history

OCA at 07:16, 9 August 2023

OCA — Wed, 09 Aug 2023 07:16:40 GMT

←Older revision		Revision as of 07:16, 9 August 2023
Line 1:		Line 1:

	==Solution structure of human Myosin VI isoform3 (1050-1131)==		==Solution structure of human Myosin VI isoform3 (1050-1131)==
-	<StructureSection load='2n12' size='340' side='right'caption='[[2n12~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2n12' size='340' side='right'caption='[[2n12]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2n12]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N12 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2n12]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N12 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2n0z\|2n0z]], [[2n10\|2n10]], [[2n11\|2n11]], [[2n13\|2n13]], [[6e5n\|6e5n]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MYO6, KIAA0389 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n12 OCA], [https://pdbe.org/2n12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n12 RCSB], [https://www.ebi.ac.uk/pdbsum/2n12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n12 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n12 OCA], [https://pdbe.org/2n12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n12 RCSB], [https://www.ebi.ac.uk/pdbsum/2n12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n12 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/MYO6_HUMAN MYO6_HUMAN]] Autosomal dominant non-syndromic sensorineural deafness type DFNA;Autosomal recessive non-syndromic sensorineural deafness type DFNB;Progressive sensorineural hearing loss - hypertrophic cardiomyopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/MYO6_HUMAN MYO6_HUMAN] Autosomal dominant non-syndromic sensorineural deafness type DFNA;Autosomal recessive non-syndromic sensorineural deafness type DFNB;Progressive sensorineural hearing loss - hypertrophic cardiomyopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MYO6_HUMAN MYO6_HUMAN]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).<ref>PMID:10519557</ref> <ref>PMID:11447109</ref> <ref>PMID:16507995</ref> <ref>PMID:16949370</ref>	+	[https://www.uniprot.org/uniprot/MYO6_HUMAN MYO6_HUMAN] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).<ref>PMID:10519557</ref> <ref>PMID:11447109</ref> <ref>PMID:16507995</ref> <ref>PMID:16949370</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: He, F]]	+	[[Category: He F]]
-	[[Category: Walters, K]]	+	[[Category: Walters K]]
-	~~[[Category: Motor protein]]~~	+
-	~~[[Category: Protein transport~~]]	+

OCA at 15:44, 3 November 2021

OCA — Wed, 03 Nov 2021 15:44:02 GMT

←Older revision		Revision as of 15:44, 3 November 2021
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2n12]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N12 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2n12]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N12 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2n0z\|2n0z]], [[2n10\|2n10]], [[2n11\|2n11]], [[2n13\|2n13]]</div></td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2n0z\|2n0z]], [[2n10\|2n10]], [[2n11\|2n11]], [[2n13\|2n13]], [[6e5n\|6e5n]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MYO6, KIAA0389 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MYO6, KIAA0389 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n12 OCA], [https://pdbe.org/2n12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n12 RCSB], [https://www.ebi.ac.uk/pdbsum/2n12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n12 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n12 OCA], [https://pdbe.org/2n12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n12 RCSB], [https://www.ebi.ac.uk/pdbsum/2n12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n12 ProSAT]</span></td></tr>

OCA at 15:24, 2 June 2021

OCA — Wed, 02 Jun 2021 15:24:58 GMT

←Older revision		Revision as of 15:24, 2 June 2021
Line 1:		Line 1:

	==Solution structure of human Myosin VI isoform3 (1050-1131)==		==Solution structure of human Myosin VI isoform3 (1050-1131)==
-	<StructureSection load='2n12' size='340' side='right' caption='[[2n12]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2n12' size='340' side='right'caption='[[2n12]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2n12]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N12 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2N12 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2n12]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N12 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2n0z\|2n0z]], [[2n10\|2n10]], [[2n11\|2n11]], [[2n13\|2n13]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2n0z\|2n0z]], [[2n10\|2n10]], [[2n11\|2n11]], [[2n13\|2n13]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MYO6, KIAA0389 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MYO6, KIAA0389 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2n12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n12 OCA], [~~http~~://pdbe.org/2n12 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2n12 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2n12 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2n12 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n12 OCA], [https://pdbe.org/2n12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n12 RCSB], [https://www.ebi.ac.uk/pdbsum/2n12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n12 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/MYO6_HUMAN MYO6_HUMAN]] Autosomal dominant non-syndromic sensorineural deafness type DFNA;Autosomal recessive non-syndromic sensorineural deafness type DFNB;Progressive sensorineural hearing loss - hypertrophic cardiomyopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.	+	[[https://www.uniprot.org/uniprot/MYO6_HUMAN MYO6_HUMAN]] Autosomal dominant non-syndromic sensorineural deafness type DFNA;Autosomal recessive non-syndromic sensorineural deafness type DFNB;Progressive sensorineural hearing loss - hypertrophic cardiomyopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MYO6_HUMAN MYO6_HUMAN]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).<ref>PMID:10519557</ref> <ref>PMID:11447109</ref> <ref>PMID:16507995</ref> <ref>PMID:16949370</ref>	+	[[https://www.uniprot.org/uniprot/MYO6_HUMAN MYO6_HUMAN]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).<ref>PMID:10519557</ref> <ref>PMID:11447109</ref> <ref>PMID:16507995</ref> <ref>PMID:16949370</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: He, F]]		[[Category: He, F]]
	[[Category: Walters, K]]		[[Category: Walters, K]]
	[[Category: Motor protein]]		[[Category: Motor protein]]
	[[Category: Protein transport]]		[[Category: Protein transport]]

OCA at 17:13, 15 August 2018

OCA — Wed, 15 Aug 2018 17:13:22 GMT

←Older revision		Revision as of 17:13, 15 August 2018
Line 3:		Line 3:
	<StructureSection load='2n12' size='340' side='right' caption='[[2n12]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2n12' size='340' side='right' caption='[[2n12]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2n12]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N12 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2n12]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N12 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2n0z\|2n0z]], [[2n10\|2n10]], [[2n11\|2n11]], [[2n13\|2n13]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2n0z\|2n0z]], [[2n10\|2n10]], [[2n11\|2n11]], [[2n13\|2n13]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n12 OCA], [http://pdbe.org/2n12 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n12 RCSB], [http://www.ebi.ac.uk/pdbsum/2n12 PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MYO6, KIAA0389 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n12 OCA], [http://pdbe.org/2n12 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n12 RCSB], [http://www.ebi.ac.uk/pdbsum/2n12 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n12 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: He, F]]		[[Category: He, F]]
	[[Category: Walters, K]]		[[Category: Walters, K]]
	[[Category: Motor protein]]		[[Category: Motor protein]]
	[[Category: Protein transport]]		[[Category: Protein transport]]

OCA at 18:34, 10 May 2016

OCA — Tue, 10 May 2016 18:34:17 GMT

←Older revision		Revision as of 18:34, 10 May 2016
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/MYO6_HUMAN MYO6_HUMAN]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).<ref>PMID:10519557</ref> <ref>PMID:11447109</ref> <ref>PMID:16507995</ref> <ref>PMID:16949370</ref>		[[http://www.uniprot.org/uniprot/MYO6_HUMAN MYO6_HUMAN]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).<ref>PMID:10519557</ref> <ref>PMID:11447109</ref> <ref>PMID:16507995</ref> <ref>PMID:16949370</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Myosin VI functions in endocytosis and cell motility. Alternative splicing of myosin VI mRNA generates two distinct isoform types, myosin VIshort and myosin VIlong, which differ in the C-terminal region. Their physiological and pathological roles remain unknown. Here we identified an isoform-specific regulatory helix, named the alpha2-linker, that defines specific conformations and hence determines the target selectivity of human myosin VI. The presence of the alpha2-linker structurally defines a new clathrin-binding domain that is unique to myosin VIlong and masks the known RRL interaction motif. This finding is relevant to ovarian cancer, in which alternative myosin VI splicing is aberrantly regulated, and exon skipping dictates cell addiction to myosin VIshort in tumor-cell migration. The RRL interactor optineurin contributes to this process by selectively binding myosin VIshort. Thus, the alpha2-linker acts like a molecular switch that assigns myosin VI to distinct endocytic (myosin VIlong) or migratory (myosin VIshort) functional roles.
		+
		+	Diverse functions of myosin VI elucidated by an isoform-specific alpha-helix domain.,Wollscheid HP, Biancospino M, He F, Magistrati E, Molteni E, Lupia M, Soffientini P, Rottner K, Cavallaro U, Pozzoli U, Mapelli M, Walters KJ, Polo S Nat Struct Mol Biol. 2016 Apr;23(4):300-8. doi: 10.1038/nsmb.3187. Epub 2016 Mar , 7. PMID:26950368<ref>PMID:26950368</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 2n12" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:13, 2 March 2016

OCA — Wed, 02 Mar 2016 15:13:03 GMT

←Older revision		Revision as of 15:13, 2 March 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 2n12 is ~~ON HOLD until Paper Publication~~	+	==Solution structure of human Myosin VI isoform3 (1050-1131)==
-		+	<StructureSection load='2n12' size='340' side='right' caption='[[2n12]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~Authors~~: He, F., ~~Walters~~, K.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2n12]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N12 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2n0z\|2n0z]], [[2n10\|2n10]], [[2n11\|2n11]], [[2n13\|2n13]]</td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n12 OCA], [http://pdbe.org/2n12 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n12 RCSB], [http://www.ebi.ac.uk/pdbsum/2n12 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/MYO6_HUMAN MYO6_HUMAN]] Autosomal dominant non-syndromic sensorineural deafness type DFNA;Autosomal recessive non-syndromic sensorineural deafness type DFNB;Progressive sensorineural hearing loss - hypertrophic cardiomyopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MYO6_HUMAN MYO6_HUMAN]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).<ref>PMID:10519557</ref> <ref>PMID:11447109</ref> <ref>PMID:16507995</ref> <ref>PMID:16949370</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: He, F]]		[[Category: He, F]]
	[[Category: Walters, K]]		[[Category: Walters, K]]
		+	[[Category: Motor protein]]
		+	[[Category: Protein transport]]

OCA at 07:42, 22 April 2015

OCA — Wed, 22 Apr 2015 07:42:52 GMT

←Older revision		Revision as of 07:42, 22 April 2015
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	Authors: He, F., Walters, K.		Authors: He, F., Walters, K.

-	Description: ~~Solution structure of human Myosin VI isoform3 (1050-1131)~~	+	Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: He, F]]		[[Category: He, F]]
	[[Category: Walters, K]]		[[Category: Walters, K]]

OCA at 07:24, 15 April 2015

OCA — Wed, 15 Apr 2015 07:24:00 GMT

←Older revision		Revision as of 07:24, 15 April 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2n12 is ON HOLD	+	The entry 2n12 is ON HOLD until Paper Publication

	Authors: He, F., Walters, K.		Authors: He, F., Walters, K.

OCA: Protected "2n12" [edit=sysop:move=sysop]

OCA — Wed, 01 Apr 2015 07:46:09 GMT

Protected "2n12" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:46, 1 April 2015

OCA: New page: '''Unreleased structure''' The entry 2n12 is ON HOLD Authors: He, F., Walters, K. Description: Solution structure of human Myosin VI isoform3 (1050-1131) [[Category: Unreleased Structu...

OCA — Wed, 01 Apr 2015 07:46:07 GMT

New page: '''Unreleased structure''' The entry 2n12 is ON HOLD Authors: He, F., Walters, K. Description: Solution structure of human Myosin VI isoform3 (1050-1131) [[Category: Unreleased Structu...

New page

'''Unreleased structure'''

The entry 2n12 is ON HOLD

Authors: He, F., Walters, K.

Description: Solution structure of human Myosin VI isoform3 (1050-1131)
[[Category: Unreleased Structures]]
[[Category: He, F]]
[[Category: Walters, K]]