2n1v - Revision history

OCA at 06:13, 15 May 2024

OCA — Wed, 15 May 2024 06:13:34 GMT

←Older revision		Revision as of 06:13, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2n1v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N1V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N1V FirstGlance]. <br>		<table><tr><td colspan='2'>[[2n1v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N1V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N1V FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n1v OCA], [https://pdbe.org/2n1v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n1v RCSB], [https://www.ebi.ac.uk/pdbsum/2n1v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n1v ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n1v OCA], [https://pdbe.org/2n1v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n1v RCSB], [https://www.ebi.ac.uk/pdbsum/2n1v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n1v ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 08:14, 8 March 2023

OCA — Wed, 08 Mar 2023 08:14:03 GMT

←Older revision		Revision as of 08:14, 8 March 2023
Line 1:		Line 1:

	==Solution structure of human SUMO1==		==Solution structure of human SUMO1==
-	<StructureSection load='2n1v' size='340' side='right'caption='[[2n1v~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2n1v' size='340' side='right'caption='[[2n1v]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2n1v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N1V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N1V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2n1v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N1V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N1V FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1a5r\|1a5r]], [[2n1w\|2n1w]], [[2n1x\|2n1x]], [[2n1y\|2n1y]], [[2n1z\|2n1z]], [[2n20\|2n20]]</div></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n1v OCA], [https://pdbe.org/2n1v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n1v RCSB], [https://www.ebi.ac.uk/pdbsum/2n1v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n1v ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OK/SW-cl.43, SMT3C, SMT3H3, SUMO1, UBL1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n1v OCA], [https://pdbe.org/2n1v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n1v RCSB], [https://www.ebi.ac.uk/pdbsum/2n1v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n1v ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/SUMO1_HUMAN SUMO1_HUMAN]] Defects in SUMO1 are the cause of non-syndromic orofacial cleft type 10 (OFC10) [MIM:[https://omim.org/entry/613705 613705]]; also called non-syndromic cleft lip with or without cleft palate 10. OFC10 is a birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. Note=A chromosomal aberation involving SUMO1 is the cause of OFC10. Translocation t(2;8)(q33.1;q24.3). The breakpoint occurred in the SUMO1 gene and resulted in haploinsufficiency confirmed by protein assays.<ref>PMID:16990542</ref>	+	[https://www.uniprot.org/uniprot/SUMO1_HUMAN SUMO1_HUMAN] Defects in SUMO1 are the cause of non-syndromic orofacial cleft type 10 (OFC10) [MIM:[https://omim.org/entry/613705 613705]; also called non-syndromic cleft lip with or without cleft palate 10. OFC10 is a birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. Note=A chromosomal aberation involving SUMO1 is the cause of OFC10. Translocation t(2;8)(q33.1;q24.3). The breakpoint occurred in the SUMO1 gene and resulted in haploinsufficiency confirmed by protein assays.<ref>PMID:16990542</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SUMO1_HUMAN SUMO1_HUMAN]] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development.<ref>PMID:9019411</ref> <ref>PMID:9162015</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref>	+	[https://www.uniprot.org/uniprot/SUMO1_HUMAN SUMO1_HUMAN] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development.<ref>PMID:9019411</ref> <ref>PMID:9162015</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref>

	==See Also==		==See Also==
Line 19:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Huang, T]]	+	[[Category: Huang T]]
-	[[Category: Naik~~, M T~~]]	+	[[Category: Naik MT]]
-	[[Category: Naik, N]]	+	[[Category: Naik N]]
-	[[Category: Shih, H]]	+	[[Category: Shih H]]
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Ubiquitin-like protein~~]]	+

OCA at 15:25, 2 June 2021

OCA — Wed, 02 Jun 2021 15:25:31 GMT

←Older revision		Revision as of 15:25, 2 June 2021
Line 1:		Line 1:

	==Solution structure of human SUMO1==		==Solution structure of human SUMO1==
-	<StructureSection load='2n1v' size='340' side='right' caption='[[2n1v]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2n1v' size='340' side='right'caption='[[2n1v]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2n1v]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N1V OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2N1V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2n1v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N1V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N1V FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a5r\|1a5r]], [[2n1w\|2n1w]], [[2n1x\|2n1x]], [[2n1y\|2n1y]], [[2n1z\|2n1z]], [[2n20\|2n20]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1a5r\|1a5r]], [[2n1w\|2n1w]], [[2n1x\|2n1x]], [[2n1y\|2n1y]], [[2n1z\|2n1z]], [[2n20\|2n20]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OK/SW-cl.43, SMT3C, SMT3H3, SUMO1, UBL1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OK/SW-cl.43, SMT3C, SMT3H3, SUMO1, UBL1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2n1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n1v OCA], [~~http~~://pdbe.org/2n1v PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2n1v RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2n1v PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2n1v ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n1v OCA], [https://pdbe.org/2n1v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n1v RCSB], [https://www.ebi.ac.uk/pdbsum/2n1v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n1v ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/SUMO1_HUMAN SUMO1_HUMAN]] Defects in SUMO1 are the cause of non-syndromic orofacial cleft type 10 (OFC10) [MIM:[~~http~~://omim.org/entry/613705 613705]]; also called non-syndromic cleft lip with or without cleft palate 10. OFC10 is a birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. Note=A chromosomal aberation involving SUMO1 is the cause of OFC10. Translocation t(2;8)(q33.1;q24.3). The breakpoint occurred in the SUMO1 gene and resulted in haploinsufficiency confirmed by protein assays.<ref>PMID:16990542</ref>	+	[[https://www.uniprot.org/uniprot/SUMO1_HUMAN SUMO1_HUMAN]] Defects in SUMO1 are the cause of non-syndromic orofacial cleft type 10 (OFC10) [MIM:[https://omim.org/entry/613705 613705]]; also called non-syndromic cleft lip with or without cleft palate 10. OFC10 is a birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. Note=A chromosomal aberation involving SUMO1 is the cause of OFC10. Translocation t(2;8)(q33.1;q24.3). The breakpoint occurred in the SUMO1 gene and resulted in haploinsufficiency confirmed by protein assays.<ref>PMID:16990542</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SUMO1_HUMAN SUMO1_HUMAN]] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development.<ref>PMID:9019411</ref> <ref>PMID:9162015</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref>	+	[[https://www.uniprot.org/uniprot/SUMO1_HUMAN SUMO1_HUMAN]] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development.<ref>PMID:9019411</ref> <ref>PMID:9162015</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref>
		+
		+	==See Also==
		+	*[[SUMO 3D Structures\|SUMO 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 17:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Huang, T]]		[[Category: Huang, T]]
	[[Category: Naik, M T]]		[[Category: Naik, M T]]

OCA at 12:22, 16 November 2017

OCA — Thu, 16 Nov 2017 12:22:51 GMT

←Older revision		Revision as of 12:22, 16 November 2017
Line 3:		Line 3:
	<StructureSection load='2n1v' size='340' side='right' caption='[[2n1v]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2n1v' size='340' side='right' caption='[[2n1v]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2n1v]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N1V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N1V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2n1v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N1V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N1V FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a5r\|1a5r]], [[2n1w\|2n1w]], [[2n1x\|2n1x]], [[2n1y\|2n1y]], [[2n1z\|2n1z]], [[2n20\|2n20]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a5r\|1a5r]], [[2n1w\|2n1w]], [[2n1x\|2n1x]], [[2n1y\|2n1y]], [[2n1z\|2n1z]], [[2n20\|2n20]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n1v OCA], [http://pdbe.org/2n1v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n1v RCSB], [http://www.ebi.ac.uk/pdbsum/2n1v PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OK/SW-cl.43, SMT3C, SMT3H3, SUMO1, UBL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n1v OCA], [http://pdbe.org/2n1v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n1v RCSB], [http://www.ebi.ac.uk/pdbsum/2n1v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n1v ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 15:		Line 16:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Huang, T]]		[[Category: Huang, T]]
	[[Category: Naik, M T]]		[[Category: Naik, M T]]

OCA at 18:36, 12 May 2016

OCA — Thu, 12 May 2016 18:36:59 GMT

←Older revision		Revision as of 18:36, 12 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 2n1v ~~is ON HOLD until Apr 24 2017~~	+	==Solution structure of human SUMO1==
-		+	<StructureSection load='2n1v' size='340' side='right' caption='[[2n1v]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~Authors~~: ~~Naik, M~~.T., ~~Naik~~, N., ~~Shih~~, H., ~~Huang~~, T.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2n1v]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N1V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N1V FirstGlance]. <br>
-	~~Description~~: ~~Solution structure~~ of ~~human~~ SUMO1	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a5r\|1a5r]], [[2n1w\|2n1w]], [[2n1x\|2n1x]], [[2n1y\|2n1y]], [[2n1z\|2n1z]], [[2n20\|2n20]]</td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n1v OCA], [http://pdbe.org/2n1v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n1v RCSB], [http://www.ebi.ac.uk/pdbsum/2n1v PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/SUMO1_HUMAN SUMO1_HUMAN]] Defects in SUMO1 are the cause of non-syndromic orofacial cleft type 10 (OFC10) [MIM:[http://omim.org/entry/613705 613705]]; also called non-syndromic cleft lip with or without cleft palate 10. OFC10 is a birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. Note=A chromosomal aberation involving SUMO1 is the cause of OFC10. Translocation t(2;8)(q33.1;q24.3). The breakpoint occurred in the SUMO1 gene and resulted in haploinsufficiency confirmed by protein assays.<ref>PMID:16990542</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SUMO1_HUMAN SUMO1_HUMAN]] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development.<ref>PMID:9019411</ref> <ref>PMID:9162015</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Huang, T]]		[[Category: Huang, T]]
		+	[[Category: Naik, M T]]
		+	[[Category: Naik, N]]
	[[Category: Shih, H]]		[[Category: Shih, H]]
-	[[Category: ~~Naik, M.T~~]]	+	[[Category: Structural genomic]]
-	[[Category: ~~Naik, N~~]]	+	[[Category: Ubiquitin-like protein]]

OCA at 10:36, 27 May 2015

OCA — Wed, 27 May 2015 10:36:26 GMT

←Older revision		Revision as of 10:36, 27 May 2015
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2n1v is ON HOLD	+	The entry 2n1v is ON HOLD until Apr 24 2017

	Authors: Naik, M.T., Naik, N., Shih, H., Huang, T.		Authors: Naik, M.T., Naik, N., Shih, H., Huang, T.

OCA: Protected "2n1v" [edit=sysop:move=sysop]

OCA — Wed, 06 May 2015 07:52:34 GMT

Protected "2n1v" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:52, 6 May 2015

OCA: New page: '''Unreleased structure''' The entry 2n1v is ON HOLD Authors: Naik, M.T., Naik, N., Shih, H., Huang, T. Description: Solution structure of human SUMO1 [[Category: Unreleased Structures...

OCA — Wed, 06 May 2015 07:52:32 GMT

New page: '''Unreleased structure''' The entry 2n1v is ON HOLD Authors: Naik, M.T., Naik, N., Shih, H., Huang, T. Description: Solution structure of human SUMO1 [[Category: Unreleased Structures...

New page

'''Unreleased structure'''

The entry 2n1v is ON HOLD

Authors: Naik, M.T., Naik, N., Shih, H., Huang, T.

Description: Solution structure of human SUMO1
[[Category: Unreleased Structures]]
[[Category: Huang, T]]
[[Category: Shih, H]]
[[Category: Naik, M.T]]
[[Category: Naik, N]]