2n3t - Revision history

OCA at 06:14, 15 May 2024

OCA — Wed, 15 May 2024 06:14:21 GMT

←Older revision		Revision as of 06:14, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2n3t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N3T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N3T FirstGlance]. <br>		<table><tr><td colspan='2'>[[2n3t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N3T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N3T FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n3t OCA], [https://pdbe.org/2n3t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n3t RCSB], [https://www.ebi.ac.uk/pdbsum/2n3t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n3t ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n3t OCA], [https://pdbe.org/2n3t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n3t RCSB], [https://www.ebi.ac.uk/pdbsum/2n3t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n3t ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:15, 8 March 2023

OCA — Wed, 08 Mar 2023 08:15:47 GMT

←Older revision		Revision as of 08:15, 8 March 2023
Line 1:		Line 1:

	==Solution structure of the Rpn1 substrate receptor site toroid 1 (T1)==		==Solution structure of the Rpn1 substrate receptor site toroid 1 (T1)==
-	<StructureSection load='2n3t' size='340' side='right'caption='[[2n3t~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='2n3t' size='340' side='right'caption='[[2n3t]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2n3t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Baker's_yeast Baker's yeast~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N3T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N3T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2n3t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N3T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N3T FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2n3u\|2n3u]], [[2n3v\|2n3v]], [[2n3w\|2n3w]]</div></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n3t OCA], [https://pdbe.org/2n3t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n3t RCSB], [https://www.ebi.ac.uk/pdbsum/2n3t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n3t ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RPN1, HRD2, NAS1, RPD1, YHR027C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n3t OCA], [https://pdbe.org/2n3t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n3t RCSB], [https://www.ebi.ac.uk/pdbsum/2n3t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n3t ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RPN1_YEAST RPN1_YEAST]] Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.<ref>PMID:9584156</ref>	+	[https://www.uniprot.org/uniprot/RPN1_YEAST RPN1_YEAST] Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.<ref>PMID:9584156</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Baker's yeast]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Chen, X~~]]	+	[[Category: Saccharomyces cerevisiae S288C]]
-	[[Category: ~~Walters, K J~~]]	+	[[Category: Chen X]]
-	[[Category: ~~Protein binding~~]]	+	[[Category: Walters KJ]]

OCA at 15:26, 2 June 2021

OCA — Wed, 02 Jun 2021 15:26:32 GMT

←Older revision		Revision as of 15:26, 2 June 2021
Line 1:		Line 1:

	==Solution structure of the Rpn1 substrate receptor site toroid 1 (T1)==		==Solution structure of the Rpn1 substrate receptor site toroid 1 (T1)==
-	<StructureSection load='2n3t' size='340' side='right' caption='[[2n3t]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='2n3t' size='340' side='right'caption='[[2n3t]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2n3t]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N3T OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2N3T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2n3t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N3T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N3T FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2n3u\|2n3u]], [[2n3v\|2n3v]], [[2n3w\|2n3w]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2n3u\|2n3u]], [[2n3v\|2n3v]], [[2n3w\|2n3w]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RPN1, HRD2, NAS1, RPD1, YHR027C ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RPN1, HRD2, NAS1, RPD1, YHR027C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2n3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n3t OCA], [~~http~~://pdbe.org/2n3t PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2n3t RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2n3t PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2n3t ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n3t OCA], [https://pdbe.org/2n3t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n3t RCSB], [https://www.ebi.ac.uk/pdbsum/2n3t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n3t ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RPN1_YEAST RPN1_YEAST]] Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.<ref>PMID:9584156</ref>	+	[[https://www.uniprot.org/uniprot/RPN1_YEAST RPN1_YEAST]] Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.<ref>PMID:9584156</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Baker's yeast]]		[[Category: Baker's yeast]]
		+	[[Category: Large Structures]]
	[[Category: Chen, X]]		[[Category: Chen, X]]
	[[Category: Walters, K J]]		[[Category: Walters, K J]]
	[[Category: Protein binding]]		[[Category: Protein binding]]

OCA at 16:55, 15 August 2018

OCA — Wed, 15 Aug 2018 16:55:06 GMT

←Older revision		Revision as of 16:55, 15 August 2018
Line 3:		Line 3:
	<StructureSection load='2n3t' size='340' side='right' caption='[[2n3t]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2n3t' size='340' side='right' caption='[[2n3t]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2n3t]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N3T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N3T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2n3t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N3T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N3T FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2n3u\|2n3u]], [[2n3v\|2n3v]], [[2n3w\|2n3w]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2n3u\|2n3u]], [[2n3v\|2n3v]], [[2n3w\|2n3w]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n3t OCA], [http://pdbe.org/2n3t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n3t RCSB], [http://www.ebi.ac.uk/pdbsum/2n3t PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RPN1, HRD2, NAS1, RPD1, YHR027C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n3t OCA], [http://pdbe.org/2n3t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n3t RCSB], [http://www.ebi.ac.uk/pdbsum/2n3t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n3t ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Baker's yeast]]
	[[Category: Chen, X]]		[[Category: Chen, X]]
	[[Category: Walters, K J]]		[[Category: Walters, K J]]
	[[Category: Protein binding]]		[[Category: Protein binding]]

OCA at 17:54, 10 May 2016

OCA — Tue, 10 May 2016 17:54:47 GMT

←Older revision		Revision as of 17:54, 10 May 2016
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/RPN1_YEAST RPN1_YEAST]] Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.<ref>PMID:9584156</ref>		[[http://www.uniprot.org/uniprot/RPN1_YEAST RPN1_YEAST]] Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.<ref>PMID:9584156</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hundreds of pathways for degradation converge at ubiquitin recognition by a proteasome. Here, we found that the five known proteasomal ubiquitin receptors in yeast are collectively nonessential for ubiquitin recognition and identified a sixth receptor, Rpn1. A site ( T1: ) in the Rpn1 toroid recognized ubiquitin and ubiquitin-like ( UBL: ) domains of substrate shuttling factors. T1 structures with monoubiquitin or lysine 48 diubiquitin show three neighboring outer helices engaging two ubiquitins. T1 contributes a distinct substrate-binding pathway with preference for lysine 48-linked chains. Proximal to T1 within the Rpn1 toroid is a second UBL-binding site ( T2: ) that assists in ubiquitin chain disassembly, by binding the UBL of deubiquitinating enzyme Ubp6. Thus, a two-site recognition domain intrinsic to the proteasome uses distinct ubiquitin-fold ligands to assemble substrates, shuttling factors, and a deubiquitinating enzyme.
		+
		+	Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome.,Shi Y, Chen X, Elsasser S, Stocks BB, Tian G, Lee BH, Shi Y, Zhang N, de Poot SA, Tuebing F, Sun S, Vannoy J, Tarasov SG, Engen JR, Finley D, Walters KJ Science. 2016 Feb 19;351(6275). pii: aad9421. doi: 10.1126/science.aad9421. PMID:26912900<ref>PMID:26912900</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 2n3t" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:13, 26 February 2016

OCA — Fri, 26 Feb 2016 18:13:34 GMT

←Older revision		Revision as of 18:13, 26 February 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 2n3t is ~~ON HOLD until Paper Publication~~	+	==Solution structure of the Rpn1 substrate receptor site toroid 1 (T1)==
-		+	<StructureSection load='2n3t' size='340' side='right' caption='[[2n3t]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
-	~~Authors~~: ~~Chen~~, X., ~~Walters~~, K.J.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2n3t]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N3T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N3T FirstGlance]. <br>
-	~~Description:~~	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2n3u\|2n3u]], [[2n3v\|2n3v]], [[2n3w\|2n3w]]</td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n3t OCA], [http://pdbe.org/2n3t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n3t RCSB], [http://www.ebi.ac.uk/pdbsum/2n3t PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RPN1_YEAST RPN1_YEAST]] Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.<ref>PMID:9584156</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Chen, X]]		[[Category: Chen, X]]
-	[[Category: Walters, K.J]]	+	[[Category: Walters, K J]]
		+	[[Category: Protein binding]]

OCA at 08:54, 29 July 2015

OCA — Wed, 29 Jul 2015 08:54:34 GMT

←Older revision		Revision as of 08:54, 29 July 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2n3t is ON HOLD	+	The entry 2n3t is ON HOLD until Paper Publication

-	Authors: Chen, X~~., Shi, Y., Elsasser, S., Vannoy, J., Finley, D., Tarasov, S.G~~., Walters, K.J.	+	Authors: Chen, X., Walters, K.J.

-	Description: ~~Proteasome protein fragment~~	+	Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Chen, X]]		[[Category: Chen, X]]
-	[[Category: Tarasov, S.G]]
-	[[Category: Vannoy, J]]
	[[Category: Walters, K.J]]		[[Category: Walters, K.J]]
-	[[Category: Finley, D]]
-	[[Category: Shi, Y]]
-	[[Category: Elsasser, S]]

OCA: Protected "2n3t" [edit=sysop:move=sysop]

OCA — Wed, 17 Jun 2015 09:27:14 GMT

Protected "2n3t" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:27, 17 June 2015

OCA: New page: '''Unreleased structure''' The entry 2n3t is ON HOLD Authors: Chen, X., Shi, Y., Elsasser, S., Vannoy, J., Finley, D., Tarasov, S.G., Walters, K.J. Description: Proteasome protein frag...

OCA — Wed, 17 Jun 2015 09:27:12 GMT

New page: '''Unreleased structure''' The entry 2n3t is ON HOLD Authors: Chen, X., Shi, Y., Elsasser, S., Vannoy, J., Finley, D., Tarasov, S.G., Walters, K.J. Description: Proteasome protein frag...

New page

'''Unreleased structure'''

The entry 2n3t is ON HOLD

Authors: Chen, X., Shi, Y., Elsasser, S., Vannoy, J., Finley, D., Tarasov, S.G., Walters, K.J.

Description: Proteasome protein fragment
[[Category: Unreleased Structures]]
[[Category: Chen, X]]
[[Category: Tarasov, S.G]]
[[Category: Vannoy, J]]
[[Category: Walters, K.J]]
[[Category: Finley, D]]
[[Category: Shi, Y]]
[[Category: Elsasser, S]]