2n4h - Revision history

OCA at 06:14, 15 May 2024

OCA — Wed, 15 May 2024 06:14:48 GMT

←Older revision		Revision as of 06:14, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2n4h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N4H FirstGlance]. <br>		<table><tr><td colspan='2'>[[2n4h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N4H FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n4h OCA], [https://pdbe.org/2n4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n4h RCSB], [https://www.ebi.ac.uk/pdbsum/2n4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n4h ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n4h OCA], [https://pdbe.org/2n4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n4h RCSB], [https://www.ebi.ac.uk/pdbsum/2n4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n4h ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 10:18, 15 March 2023

OCA — Wed, 15 Mar 2023 10:18:34 GMT

←Older revision		Revision as of 10:18, 15 March 2023
Line 1:		Line 1:

	==Solution Structure of the Q343R Mutant of TDP-43 Amyloidogenic Core Region==		==Solution Structure of the Q343R Mutant of TDP-43 Amyloidogenic Core Region==
-	<StructureSection load='2n4h' size='340' side='right'caption='[[2n4h~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='2n4h' size='340' side='right'caption='[[2n4h]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2n4h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N4H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2n4h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N4H FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2n4g\|2n4g]], [[2n3x\|2n3x]]</div></td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n4h OCA], [https://pdbe.org/2n4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n4h RCSB], [https://www.ebi.ac.uk/pdbsum/2n4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n4h ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TARDBP, TDP43 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n4h OCA], [https://pdbe.org/2n4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n4h RCSB], [https://www.ebi.ac.uk/pdbsum/2n4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n4h ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/TADBP_HUMAN TADBP_HUMAN]] Defects in TARDBP are the cause of amyotrophic lateral sclerosis type 10 (ALS10) [MIM:[https://omim.org/entry/612069 612069]]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of ALS is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.<ref>PMID:20740007</ref> <ref>PMID:18288693</ref> <ref>PMID:18438952</ref> <ref>PMID:18396105</ref> <ref>PMID:18372902</ref> <ref>PMID:18309045</ref> <ref>PMID:19350673</ref> <ref>PMID:19224587</ref> <ref>PMID:19655382</ref> <ref>PMID:19695877</ref> <ref>PMID:21220647</ref> <ref>PMID:21418058</ref> <ref>PMID:22456481</ref>	+	[https://www.uniprot.org/uniprot/TADBP_HUMAN TADBP_HUMAN] Defects in TARDBP are the cause of amyotrophic lateral sclerosis type 10 (ALS10) [MIM:[https://omim.org/entry/612069 612069]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of ALS is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.<ref>PMID:20740007</ref> <ref>PMID:18288693</ref> <ref>PMID:18438952</ref> <ref>PMID:18396105</ref> <ref>PMID:18372902</ref> <ref>PMID:18309045</ref> <ref>PMID:19350673</ref> <ref>PMID:19224587</ref> <ref>PMID:19655382</ref> <ref>PMID:19695877</ref> <ref>PMID:21220647</ref> <ref>PMID:21418058</ref> <ref>PMID:22456481</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TADBP_HUMAN TADBP_HUMAN]] DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.<ref>PMID:17481916</ref> <ref>PMID:11285240</ref>	+	[https://www.uniprot.org/uniprot/TADBP_HUMAN TADBP_HUMAN] DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.<ref>PMID:17481916</ref> <ref>PMID:11285240</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hu, H]]	+	[[Category: Hu H]]
-	[[Category: Jiang, L]]	+	[[Category: Jiang L]]
-	[[Category: Zhao, J]]	+	[[Category: Zhao J]]
-	~~[[Category: Amyloidogenic core region]]~~	+
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Q343r]]~~	+
-	~~[[Category: Tdp-43~~]]	+

OCA at 15:39, 8 June 2021

OCA — Tue, 08 Jun 2021 15:39:31 GMT

←Older revision		Revision as of 15:39, 8 June 2021
Line 1:		Line 1:

	==Solution Structure of the Q343R Mutant of TDP-43 Amyloidogenic Core Region==		==Solution Structure of the Q343R Mutant of TDP-43 Amyloidogenic Core Region==
-	<StructureSection load='2n4h' size='340' side='right' caption='[[2n4h]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='2n4h' size='340' side='right'caption='[[2n4h]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2n4h]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N4H OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2N4H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2n4h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N4H FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2n4g\|2n4g]], [[2n3x\|2n3x]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2n4g\|2n4g]], [[2n3x\|2n3x]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TARDBP, TDP43 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TARDBP, TDP43 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2n4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n4h OCA], [~~http~~://pdbe.org/2n4h PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2n4h RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2n4h PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2n4h ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n4h OCA], [https://pdbe.org/2n4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n4h RCSB], [https://www.ebi.ac.uk/pdbsum/2n4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n4h ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/TADBP_HUMAN TADBP_HUMAN]] Defects in TARDBP are the cause of amyotrophic lateral sclerosis type 10 (ALS10) [MIM:[~~http~~://omim.org/entry/612069 612069]]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of ALS is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.<ref>PMID:20740007</ref> <ref>PMID:18288693</ref> <ref>PMID:18438952</ref> <ref>PMID:18396105</ref> <ref>PMID:18372902</ref> <ref>PMID:18309045</ref> <ref>PMID:19350673</ref> <ref>PMID:19224587</ref> <ref>PMID:19655382</ref> <ref>PMID:19695877</ref> <ref>PMID:21220647</ref> <ref>PMID:21418058</ref> <ref>PMID:22456481</ref>	+	[[https://www.uniprot.org/uniprot/TADBP_HUMAN TADBP_HUMAN]] Defects in TARDBP are the cause of amyotrophic lateral sclerosis type 10 (ALS10) [MIM:[https://omim.org/entry/612069 612069]]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of ALS is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.<ref>PMID:20740007</ref> <ref>PMID:18288693</ref> <ref>PMID:18438952</ref> <ref>PMID:18396105</ref> <ref>PMID:18372902</ref> <ref>PMID:18309045</ref> <ref>PMID:19350673</ref> <ref>PMID:19224587</ref> <ref>PMID:19655382</ref> <ref>PMID:19695877</ref> <ref>PMID:21220647</ref> <ref>PMID:21418058</ref> <ref>PMID:22456481</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TADBP_HUMAN TADBP_HUMAN]] DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.<ref>PMID:17481916</ref> <ref>PMID:11285240</ref>	+	[[https://www.uniprot.org/uniprot/TADBP_HUMAN TADBP_HUMAN]] DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.<ref>PMID:17481916</ref> <ref>PMID:11285240</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Hu, H]]		[[Category: Hu, H]]
	[[Category: Jiang, L]]		[[Category: Jiang, L]]

OCA at 12:23, 16 November 2017

OCA — Thu, 16 Nov 2017 12:23:29 GMT

←Older revision		Revision as of 12:23, 16 November 2017
Line 3:		Line 3:
	<StructureSection load='2n4h' size='340' side='right' caption='[[2n4h]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2n4h' size='340' side='right' caption='[[2n4h]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2n4h]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N4H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N4H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2n4h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N4H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N4H FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2n4g\|2n4g]], [[2n3x\|2n3x]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2n4g\|2n4g]], [[2n3x\|2n3x]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n4h OCA], [http://pdbe.org/2n4h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n4h RCSB], [http://www.ebi.ac.uk/pdbsum/2n4h PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TARDBP, TDP43 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n4h OCA], [http://pdbe.org/2n4h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n4h RCSB], [http://www.ebi.ac.uk/pdbsum/2n4h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n4h ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Hu, H]]		[[Category: Hu, H]]
	[[Category: Jiang, L]]		[[Category: Jiang, L]]

OCA at 18:37, 12 May 2016

OCA — Thu, 12 May 2016 18:37:13 GMT

←Older revision		Revision as of 18:37, 12 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 2n4h is ~~ON HOLD~~ ~~until Jun 18 2017~~	+	==Solution Structure of the Q343R Mutant of TDP-43 Amyloidogenic Core Region==
		+	<StructureSection load='2n4h' size='340' side='right' caption='[[2n4h]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2n4h]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N4H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N4H FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2n4g\|2n4g]], [[2n3x\|2n3x]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n4h OCA], [http://pdbe.org/2n4h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n4h RCSB], [http://www.ebi.ac.uk/pdbsum/2n4h PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/TADBP_HUMAN TADBP_HUMAN]] Defects in TARDBP are the cause of amyotrophic lateral sclerosis type 10 (ALS10) [MIM:[http://omim.org/entry/612069 612069]]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of ALS is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.<ref>PMID:20740007</ref> <ref>PMID:18288693</ref> <ref>PMID:18438952</ref> <ref>PMID:18396105</ref> <ref>PMID:18372902</ref> <ref>PMID:18309045</ref> <ref>PMID:19350673</ref> <ref>PMID:19224587</ref> <ref>PMID:19655382</ref> <ref>PMID:19695877</ref> <ref>PMID:21220647</ref> <ref>PMID:21418058</ref> <ref>PMID:22456481</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TADBP_HUMAN TADBP_HUMAN]] DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.<ref>PMID:17481916</ref> <ref>PMID:11285240</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	TDP-43 is a DNA/RNA binding protein associated with TDP-43 proteinopathies. Many mutations have been identified in the flexible C-terminal region, which is implicated in the disease pathology. We investigated four point mutations in the amyloidogenic core region (residues 311-360) of TDP-43 by biochemical and spectroscopic methods. We found that the G335D mutation enhances the aggregation and inclusion formation of TDP-43 and this mutant in TDP-35 (the C-terminal fragment of 35 kDa) exaggerates the antagonist effect on RNA processing by endogenous TDP-43; whereas Q343R gives an opposite effect. As a comparison, M337V and Q331K have very little impact on the aggregation and inclusion formation of TDP-43 or TDP-35. NMR structural analysis showed that the G335D mutant in the core region forms a loop linker between the two alpha-helices and promotes alpha-to-beta transition, but Q343R loses the second helix and consequently the structural transformation. Thus, the propensity of structural transformation in the amyloidogenic core of TDP-43 determines its aggregation and inclusion formation. This study may provide a molecular mechanism of the TDP-43 proteinopathies caused by genetic mutations.

-	~~Authors: Jiang, L~~., ~~Zhao~~, J., Hu, H.	+	Two mutations G335D and Q343R within the amyloidogenic core region of TDP-43 influence its aggregation and inclusion formation.,Jiang LL, Zhao J, Yin XF, He WT, Yang H, Che MX, Hu HY Sci Rep. 2016 Mar 31;6:23928. doi: 10.1038/srep23928. PMID:27030292<ref>PMID:27030292</ref>

-	~~Description: Solution Structure~~ of the ~~Q343R Mutant~~ of ~~TDP-43 Amyloidogenic Core Region~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Zhao, J]]~~	+	<div class="pdbe-citations 2n4h" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Hu, H]]		[[Category: Hu, H]]
	[[Category: Jiang, L]]		[[Category: Jiang, L]]
		+	[[Category: Zhao, J]]
		+	[[Category: Amyloidogenic core region]]
		+	[[Category: Dna binding protein]]
		+	[[Category: Q343r]]
		+	[[Category: Tdp-43]]

OCA at 06:35, 23 December 2015

OCA — Wed, 23 Dec 2015 06:35:04 GMT

←Older revision		Revision as of 06:35, 23 December 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2n4h is ON HOLD until ~~Dec~~ 18 ~~2016~~	+	The entry 2n4h is ON HOLD until Jun 18 2017

	Authors: Jiang, L., Zhao, J., Hu, H.		Authors: Jiang, L., Zhao, J., Hu, H.

OCA at 10:22, 2 December 2015

OCA — Wed, 02 Dec 2015 10:22:09 GMT

←Older revision		Revision as of 10:22, 2 December 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2n4h is ON HOLD until ~~Paper Publication~~	+	The entry 2n4h is ON HOLD until Dec 18 2016

	Authors: Jiang, L., Zhao, J., Hu, H.		Authors: Jiang, L., Zhao, J., Hu, H.

OCA at 08:44, 22 July 2015

OCA — Wed, 22 Jul 2015 08:44:58 GMT

←Older revision		Revision as of 08:44, 22 July 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2n4h is ON HOLD	+	The entry 2n4h is ON HOLD until Paper Publication

	Authors: Jiang, L., Zhao, J., Hu, H.		Authors: Jiang, L., Zhao, J., Hu, H.

OCA: Protected "2n4h" [edit=sysop:move=sysop]

OCA — Wed, 24 Jun 2015 07:22:06 GMT

Protected "2n4h" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:22, 24 June 2015

OCA: New page: '''Unreleased structure''' The entry 2n4h is ON HOLD Authors: Jiang, L., Zhao, J., Hu, H. Description: Solution Structure of the Q343R Mutant of TDP-43 Amyloidogenic Core Region [[Cate...

OCA — Wed, 24 Jun 2015 07:22:05 GMT

New page: '''Unreleased structure''' The entry 2n4h is ON HOLD Authors: Jiang, L., Zhao, J., Hu, H. Description: Solution Structure of the Q343R Mutant of TDP-43 Amyloidogenic Core Region [[Cate...

New page

'''Unreleased structure'''

The entry 2n4h is ON HOLD

Authors: Jiang, L., Zhao, J., Hu, H.

Description: Solution Structure of the Q343R Mutant of TDP-43 Amyloidogenic Core Region
[[Category: Unreleased Structures]]
[[Category: Zhao, J]]
[[Category: Hu, H]]
[[Category: Jiang, L]]