2n50 - Revision history

OCA at 06:15, 15 May 2024

OCA — Wed, 15 May 2024 06:15:09 GMT

←Older revision		Revision as of 06:15, 15 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2n50]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis_V583 Enterococcus faecalis V583]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N50 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2n50]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis_V583 Enterococcus faecalis V583]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N50 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n50 OCA], [https://pdbe.org/2n50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n50 RCSB], [https://www.ebi.ac.uk/pdbsum/2n50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n50 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n50 OCA], [https://pdbe.org/2n50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n50 RCSB], [https://www.ebi.ac.uk/pdbsum/2n50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n50 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 10:19, 15 March 2023

OCA — Wed, 15 Mar 2023 10:19:10 GMT

←Older revision		Revision as of 10:19, 15 March 2023
Line 1:		Line 1:

	==Novel Structural Components Contribute to the High Thermal Stability of Acyl Carrier Protein from Enterococcus faecalis==		==Novel Structural Components Contribute to the High Thermal Stability of Acyl Carrier Protein from Enterococcus faecalis==
-	<StructureSection load='2n50' size='340' side='right'caption='[[2n50~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2n50' size='340' side='right'caption='[[2n50]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2n50]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N50 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2n50]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis_V583 Enterococcus faecalis V583]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N50 FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2n4z\|2n4z]]</div></td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n50 OCA], [https://pdbe.org/2n50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n50 RCSB], [https://www.ebi.ac.uk/pdbsum/2n50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n50 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n50 OCA], [https://pdbe.org/2n50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n50 RCSB], [https://www.ebi.ac.uk/pdbsum/2n50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n50 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q82ZE9_ENTFA Q82ZE9_ENTFA]] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[RuleBase:RU003545]	+	[https://www.uniprot.org/uniprot/Q82ZE9_ENTFA Q82ZE9_ENTFA] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[RuleBase:RU003545]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Enterococcus faecalis V583]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Jeong, K]]	+	[[Category: Jeong K]]
-	[[Category: Jung, M]]	+	[[Category: Jung M]]
-	[[Category: Kim, Y]]	+	[[Category: Kim Y]]
-	[[Category: Park, Y]]	+	[[Category: Park Y]]
-	[[Category: Song, H]]	+	[[Category: Song H]]
-	~~[[Category: Acyl carrier protein]]~~	+
-	~~[[Category: Biosynthetic protein]]~~	+
-	~~[[Category: Enterococcus faecali]]~~	+
-	~~[[Category: Fatty acid synthase~~]]	+

OCA at 15:39, 8 June 2021

OCA — Tue, 08 Jun 2021 15:39:53 GMT

←Older revision		Revision as of 15:39, 8 June 2021
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	<StructureSection load='2n50' size='340' side='right'caption='[[2n50]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2n50' size='340' side='right'caption='[[2n50]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2n50]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N50 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2N50 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2n50]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N50 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2n4z\|2n4z]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2n4z\|2n4z]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2n50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n50 OCA], [~~http~~://pdbe.org/2n50 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2n50 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2n50 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2n50 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n50 OCA], [https://pdbe.org/2n50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n50 RCSB], [https://www.ebi.ac.uk/pdbsum/2n50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n50 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/Q82ZE9_ENTFA Q82ZE9_ENTFA]] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[RuleBase:RU003545]	+	[[https://www.uniprot.org/uniprot/Q82ZE9_ENTFA Q82ZE9_ENTFA]] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[RuleBase:RU003545]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:50, 21 August 2019

OCA — Wed, 21 Aug 2019 07:50:18 GMT

←Older revision		Revision as of 07:50, 21 August 2019
Line 1:		Line 1:

	==Novel Structural Components Contribute to the High Thermal Stability of Acyl Carrier Protein from Enterococcus faecalis==		==Novel Structural Components Contribute to the High Thermal Stability of Acyl Carrier Protein from Enterococcus faecalis==
-	<StructureSection load='2n50' size='340' side='right' caption='[[2n50]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2n50' size='340' side='right'caption='[[2n50]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2n50]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N50 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N50 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2n50]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N50 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N50 FirstGlance]. <br>
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 2n50" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2n50" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Acyl carrier protein 3D structures\|Acyl carrier protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Jeong, K]]		[[Category: Jeong, K]]
	[[Category: Jung, M]]		[[Category: Jung, M]]

OCA at 11:07, 16 November 2017

OCA — Thu, 16 Nov 2017 11:07:36 GMT

←Older revision		Revision as of 11:07, 16 November 2017
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 2n50" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2n50" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Acyl carrier protein\|Acyl carrier protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:58, 3 August 2017

OCA — Thu, 03 Aug 2017 09:58:43 GMT

←Older revision		Revision as of 09:58, 3 August 2017
Line 1:		Line 1:
		+
	==Novel Structural Components Contribute to the High Thermal Stability of Acyl Carrier Protein from Enterococcus faecalis==		==Novel Structural Components Contribute to the High Thermal Stability of Acyl Carrier Protein from Enterococcus faecalis==
	<StructureSection load='2n50' size='340' side='right' caption='[[2n50]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2n50' size='340' side='right' caption='[[2n50]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2n50]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N50 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N50 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2n50]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N50 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N50 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2n4z\|2n4z]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2n4z\|2n4z]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n50 OCA], [http://pdbe.org/2n50 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n50 RCSB], [http://www.ebi.ac.uk/pdbsum/2n50 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n50 OCA], [http://pdbe.org/2n50 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n50 RCSB], [http://www.ebi.ac.uk/pdbsum/2n50 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n50 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/Q82ZE9_ENTFA Q82ZE9_ENTFA]] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[RuleBase:RU003545]		[[http://www.uniprot.org/uniprot/Q82ZE9_ENTFA Q82ZE9_ENTFA]] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[RuleBase:RU003545]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Enterococcus faecalis is a Gram-positive, commensal bacterium that lives in the gastrointestinal tracts of humans and other mammals. It causes severe infections because of high antibiotic resistance. E. faecalis can endure extremes of temperature and pH. Acyl carrier protein (ACP) is a key element in the biosynthesis of fatty acids responsible for acyl group shuttling and delivery. In this study, to understand the origin of high thermal stabilities of E. faecalis ACP (Ef-ACP), its solution structure was investigated for the first time. CD experiments showed that the melting temperature of Ef-ACP is 78.8 degrees C, which is much higher than that of Escherichia coli ACP (67.2 degrees C). The overall structure of Ef-ACP shows the common ACP folding pattern consisting of four alpha-helices (helix I (residues 3-17), helix II (residues 39-53), helix III (residues 60-64), and helix IV (residues 68-78)) connected by three loops. Unique Ef-ACP structural features include a hydrophobic interaction between Phe(45) in helix II and Phe(18) in the alpha1alpha2 loop and a hydrogen bonding between Ser(15) in helix I and Ile(20) in the alpha1alpha2 loop, resulting in its high thermal stability. Phe(45)-mediated hydrophobic packing may block acyl chain binding subpocket II entry. Furthermore, Ser(58) in the alpha2alpha3 loop in Ef-ACP, which usually constitutes a proline in other ACPs, exhibited slow conformational exchanges, resulting in the movement of the helix III outside the structure to accommodate a longer acyl chain in the acyl binding cavity. These results might provide insights into the development of antibiotics against pathogenic drug-resistant E. faecalis strains.
		+
		+	Novel Structural Components Contribute to the High Thermal Stability of Acyl Carrier Protein from Enterococcus faecalis.,Park YG, Jung MC, Song H, Jeong KW, Bang E, Hwang GS, Kim Y J Biol Chem. 2016 Jan 22;291(4):1692-702. doi: 10.1074/jbc.M115.674408. Epub 2015, Dec 2. PMID:26631734<ref>PMID:26631734</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 2n50" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Acyl carrier protein\|Acyl carrier protein]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 13:45, 9 December 2015

OCA — Wed, 09 Dec 2015 13:45:13 GMT

←Older revision		Revision as of 13:45, 9 December 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Novel Structural Components Contribute to the High Thermal Stability of Acyl Carrier Protein from Enterococcus faecalis==
-		+	<StructureSection load='2n50' size='340' side='right' caption='[[2n50]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~The entry~~ 2n50 is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2n50]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N50 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N50 FirstGlance]. <br>
-	~~Authors~~: ~~Park, Y~~.~~, Jung, M~~., ~~Song~~, H., ~~Jeong, K~~., ~~Kim, Y~~.	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2n4z\|2n4z]]</td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n50 OCA], [http://pdbe.org/2n50 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n50 RCSB], [http://www.ebi.ac.uk/pdbsum/2n50 PDBsum]</span></td></tr>
-	~~Description~~: ~~Novel Structural Components Contribute to the High Thermal Stability of Acyl~~ Carrier ~~Protein from Enterococcus faecalis~~	+	</table>
-	[[Category: ~~Unreleased Structures~~]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q82ZE9_ENTFA Q82ZE9_ENTFA]] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[RuleBase:RU003545]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Jeong, K]]
	[[Category: Jung, M]]		[[Category: Jung, M]]
	[[Category: Kim, Y]]		[[Category: Kim, Y]]
-	[[Category: Song, H]]
	[[Category: Park, Y]]		[[Category: Park, Y]]
-	[[Category: ~~Jeong~~, K]]	+	[[Category: Song, H]]
		+	[[Category: Acyl carrier protein]]
		+	[[Category: Biosynthetic protein]]
		+	[[Category: Enterococcus faecali]]
		+	[[Category: Fatty acid synthase]]

OCA at 10:22, 2 December 2015

OCA — Wed, 02 Dec 2015 10:22:42 GMT

←Older revision		Revision as of 10:22, 2 December 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2n50 is ON HOLD	+	The entry 2n50 is ON HOLD until Paper Publication

	Authors: Park, Y., Jung, M., Song, H., Jeong, K., Kim, Y.		Authors: Park, Y., Jung, M., Song, H., Jeong, K., Kim, Y.

OCA: Protected "2n50" [edit=sysop:move=sysop]

OCA — Wed, 15 Jul 2015 08:10:57 GMT

Protected "2n50" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:10, 15 July 2015

OCA: New page: '''Unreleased structure''' The entry 2n50 is ON HOLD Authors: Park, Y., Jung, M., Song, H., Jeong, K., Kim, Y. Description: Novel Structural Components Contribute to the High Thermal S...

OCA — Wed, 15 Jul 2015 08:10:55 GMT

New page: '''Unreleased structure''' The entry 2n50 is ON HOLD Authors: Park, Y., Jung, M., Song, H., Jeong, K., Kim, Y. Description: Novel Structural Components Contribute to the High Thermal S...

New page

'''Unreleased structure'''

The entry 2n50 is ON HOLD

Authors: Park, Y., Jung, M., Song, H., Jeong, K., Kim, Y.

Description: Novel Structural Components Contribute to the High Thermal Stability of Acyl Carrier Protein from Enterococcus faecalis
[[Category: Unreleased Structures]]
[[Category: Jung, M]]
[[Category: Kim, Y]]
[[Category: Song, H]]
[[Category: Park, Y]]
[[Category: Jeong, K]]