2n77 - Revision history

OCA at 04:31, 25 May 2023

OCA — Thu, 25 May 2023 04:31:20 GMT

←Older revision		Revision as of 04:31, 25 May 2023
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	==NMR solution structure of a complex of PEP-19 bound to the C-domain of apo calmodulin==		==NMR solution structure of a complex of PEP-19 bound to the C-domain of apo calmodulin==
-	<StructureSection load='2n77' size='340' side='right'caption='[[2n77~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2n77' size='340' side='right'caption='[[2n77]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2n77]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N77 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N77 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2n77]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N77 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N77 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), PCP4, PEP19 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n77 OCA], [https://pdbe.org/2n77 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n77 RCSB], [https://www.ebi.ac.uk/pdbsum/2n77 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n77 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n77 OCA], [https://pdbe.org/2n77 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n77 RCSB], [https://www.ebi.ac.uk/pdbsum/2n77 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n77 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~PCP4_HUMAN PCP4_HUMAN~~]~~] Probable regulator~~ of calmodulin ~~signaling~~.<ref>PMID:~~19106096~~</ref>	+	[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Putkey~~, J A~~]]	+	[[Category: Putkey JA]]
-	[[Category: Wang, X]]	+	[[Category: Wang X]]
-	~~[[Category: Intrinsically disordered]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Structural transition~~]]	+

OCA at 15:41, 8 June 2021

OCA — Tue, 08 Jun 2021 15:41:11 GMT

←Older revision		Revision as of 15:41, 8 June 2021
Line 1:		Line 1:

	==NMR solution structure of a complex of PEP-19 bound to the C-domain of apo calmodulin==		==NMR solution structure of a complex of PEP-19 bound to the C-domain of apo calmodulin==
-	<StructureSection load='2n77' size='340' side='right' caption='[[2n77]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2n77' size='340' side='right'caption='[[2n77]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2n77]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N77 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2N77 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2n77]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N77 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N77 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), PCP4, PEP19 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), PCP4, PEP19 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2n77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n77 OCA], [~~http~~://pdbe.org/2n77 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2n77 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2n77 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2n77 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n77 OCA], [https://pdbe.org/2n77 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n77 RCSB], [https://www.ebi.ac.uk/pdbsum/2n77 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n77 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PCP4_HUMAN PCP4_HUMAN]] Probable regulator of calmodulin signaling.<ref>PMID:19106096</ref>	+	[[https://www.uniprot.org/uniprot/PCP4_HUMAN PCP4_HUMAN]] Probable regulator of calmodulin signaling.<ref>PMID:19106096</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Putkey, J A]]		[[Category: Putkey, J A]]
	[[Category: Wang, X]]		[[Category: Wang, X]]

OCA at 08:18, 12 September 2018

OCA — Wed, 12 Sep 2018 08:18:07 GMT

←Older revision		Revision as of 08:18, 12 September 2018
Line 3:		Line 3:
	<StructureSection load='2n77' size='340' side='right' caption='[[2n77]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2n77' size='340' side='right' caption='[[2n77]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2n77]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N77 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N77 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2n77]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N77 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N77 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n77 OCA], [http://pdbe.org/2n77 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n77 RCSB], [http://www.ebi.ac.uk/pdbsum/2n77 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n77 ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), PCP4, PEP19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n77 OCA], [http://pdbe.org/2n77 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n77 RCSB], [http://www.ebi.ac.uk/pdbsum/2n77 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n77 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Putkey, J A]]		[[Category: Putkey, J A]]
	[[Category: Wang, X]]		[[Category: Wang, X]]

OCA at 19:40, 9 December 2016

OCA — Fri, 09 Dec 2016 19:40:24 GMT

←Older revision		Revision as of 19:40, 9 December 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 2n77 is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==NMR solution structure of a complex of PEP-19 bound to the C-domain of apo calmodulin==
		+	<StructureSection load='2n77' size='340' side='right' caption='[[2n77]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2n77]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N77 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N77 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n77 OCA], [http://pdbe.org/2n77 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n77 RCSB], [http://www.ebi.ac.uk/pdbsum/2n77 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n77 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PCP4_HUMAN PCP4_HUMAN]] Probable regulator of calmodulin signaling.<ref>PMID:19106096</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	PEP-19 is a small protein that increases the rates of Ca2+ binding to the C-domain of calmodulin (CaM) by an unknown mechanism. Although an IQ motif promotes binding to CaM, an acidic sequence in PEP-19 is required to modulate Ca2+ binding and to sensitize HeLa cells to ATP-induced Ca2+ release. Here, we report the NMR solution structure of a complex between PEP-19 and the C-domain of apo CaM. The acidic sequence of PEP-19 associates between helices E and F of CaM via hydrophobic interactions. This allows the acidic side chains in PEP-19 to extend toward the solvent and form a negatively charged surface that resembles a catcher's mitt near Ca2+ binding loop III of CaM. The topology and gradients of negative electrostatic surface potential support a mechanism by which PEP-19 increases the rate of Ca2+ binding to the C-domain of CaM by 'catching' and electrostatically steering Ca2+ to site III.

-	~~Authors: Wang~~, X., Putkey~~, J~~.A.	+	PEP-19 modulates calcium binding to calmodulin by electrostatic steering.,Wang X, Putkey JA Nat Commun. 2016 Nov 23;7:13583. doi: 10.1038/ncomms13583. PMID:27876793<ref>PMID:27876793</ref>

-	~~Description: NMR solution structure of~~ a ~~complex~~ of ~~PEP-19 bound to~~ the ~~C-domain~~ of ~~apo calmodulin~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: Putkey, J.A]]	+	<div class="pdbe-citations 2n77" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Putkey, J A]]
	[[Category: Wang, X]]		[[Category: Wang, X]]
		+	[[Category: Intrinsically disordered]]
		+	[[Category: Signaling protein]]
		+	[[Category: Structural transition]]

OCA at 08:34, 14 September 2016

OCA — Wed, 14 Sep 2016 08:34:35 GMT

←Older revision		Revision as of 08:34, 14 September 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2n77 is ON HOLD	+	The entry 2n77 is ON HOLD until Paper Publication

	Authors: Wang, X., Putkey, J.A.		Authors: Wang, X., Putkey, J.A.

OCA at 10:01, 9 September 2016

OCA — Fri, 09 Sep 2016 10:01:53 GMT

←Older revision		Revision as of 10:01, 9 September 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2n77 is ON HOLD ~~until Paper Publication~~	+	The entry 2n77 is ON HOLD

	Authors: Wang, X., Putkey, J.A.		Authors: Wang, X., Putkey, J.A.

OCA: Protected "2n77" [edit=sysop:move=sysop]

OCA — Wed, 30 Sep 2015 08:32:28 GMT

Protected "2n77" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:32, 30 September 2015

OCA: New page: '''Unreleased structure''' The entry 2n77 is ON HOLD until Paper Publication Authors: Wang, X., Putkey, J.A. Description: NMR solution structure of a complex of PEP-19 bound to the C-d...

OCA — Wed, 30 Sep 2015 08:32:26 GMT

New page: '''Unreleased structure''' The entry 2n77 is ON HOLD until Paper Publication Authors: Wang, X., Putkey, J.A. Description: NMR solution structure of a complex of PEP-19 bound to the C-d...

New page

'''Unreleased structure'''

The entry 2n77 is ON HOLD until Paper Publication

Authors: Wang, X., Putkey, J.A.

Description: NMR solution structure of a complex of PEP-19 bound to the C-domain of apo calmodulin
[[Category: Unreleased Structures]]
[[Category: Putkey, J.A]]
[[Category: Wang, X]]