2n7o - Revision history

OCA at 10:22, 15 March 2023

OCA — Wed, 15 Mar 2023 10:22:51 GMT

←Older revision		Revision as of 10:22, 15 March 2023
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	==NMR Structure of Peptide PG-990 in DPC micelles==		==NMR Structure of Peptide PG-990 in DPC micelles==
-	<StructureSection load='2n7o' size='340' side='right'caption='[[2n7o~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='2n7o' size='340' side='right'caption='[[2n7o]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2n7o]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N7O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N7O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2n7o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N7O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N7O FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=4J2:(2R)-2-AMINO-3-(NAPHTHALEN-2-YL)PROPANOIC+ACID'>4J2</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4J2:(2R)-2-AMINO-3-(NAPHTHALEN-2-YL)PROPANOIC+ACID'>4J2</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2n7n\|2n7n]]</div~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n7o OCA], [https://pdbe.org/2n7o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n7o RCSB], [https://www.ebi.ac.uk/pdbsum/2n7o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n7o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n7o OCA], [https://pdbe.org/2n7o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n7o RCSB], [https://www.ebi.ac.uk/pdbsum/2n7o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n7o ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brancaccio, D]]	+	[[Category: Synthetic construct]]
-	[[Category: Carotenuto, A]]	+	[[Category: Brancaccio D]]
-	[[Category: Chai, M]]	+	[[Category: Carotenuto A]]
-	[[Category: Grieco, P]]	+	[[Category: Chai M]]
-	[[Category: Hruby, V]]	+	[[Category: Grieco P]]
-	[[Category: Merlino, F]]	+	[[Category: Hruby V]]
-	[[Category: Novellino, E]]	+	[[Category: Merlino F]]
-	[[Category: Yousif, A]]	+	[[Category: Novellino E]]
-	~~[[Category: De novo protein~~]]	+	[[Category: Yousif A]]

OCA at 15:41, 8 June 2021

OCA — Tue, 08 Jun 2021 15:41:35 GMT

←Older revision		Revision as of 15:41, 8 June 2021
Line 3:		Line 3:
	<StructureSection load='2n7o' size='340' side='right'caption='[[2n7o]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2n7o' size='340' side='right'caption='[[2n7o]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2n7o]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N7O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2N7O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2n7o]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N7O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N7O FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=4J2:(2R)-2-AMINO-3-(NAPHTHALEN-2-YL)PROPANOIC+ACID'>4J2</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=4J2:(2R)-2-AMINO-3-(NAPHTHALEN-2-YL)PROPANOIC+ACID'>4J2</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2n7n\|2n7n]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2n7n\|2n7n]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2n7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n7o OCA], [~~http~~://pdbe.org/2n7o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2n7o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2n7o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2n7o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n7o OCA], [https://pdbe.org/2n7o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n7o RCSB], [https://www.ebi.ac.uk/pdbsum/2n7o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n7o ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:32, 24 July 2019

OCA — Wed, 24 Jul 2019 09:32:04 GMT

←Older revision		Revision as of 09:32, 24 July 2019
Line 1:		Line 1:

	==NMR Structure of Peptide PG-990 in DPC micelles==		==NMR Structure of Peptide PG-990 in DPC micelles==
-	<StructureSection load='2n7o' size='340' side='right' caption='[[2n7o]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='2n7o' size='340' side='right'caption='[[2n7o]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2n7o]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N7O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N7O FirstGlance]. <br>		<table><tr><td colspan='2'>[[2n7o]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N7O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N7O FirstGlance]. <br>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Brancaccio, D]]		[[Category: Brancaccio, D]]
	[[Category: Carotenuto, A]]		[[Category: Carotenuto, A]]

OCA at 09:42, 12 October 2017

OCA — Thu, 12 Oct 2017 09:42:53 GMT

←Older revision		Revision as of 09:42, 12 October 2017
Line 1:		Line 1:
		+
	==NMR Structure of Peptide PG-990 in DPC micelles==		==NMR Structure of Peptide PG-990 in DPC micelles==
	<StructureSection load='2n7o' size='340' side='right' caption='[[2n7o]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2n7o' size='340' side='right' caption='[[2n7o]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=4J2:(2R)-2-AMINO-3-(NAPHTHALEN-2-YL)PROPANOIC+ACID'>4J2</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=4J2:(2R)-2-AMINO-3-(NAPHTHALEN-2-YL)PROPANOIC+ACID'>4J2</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2n7n\|2n7n]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2n7n\|2n7n]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n7o OCA], [http://pdbe.org/2n7o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n7o RCSB], [http://www.ebi.ac.uk/pdbsum/2n7o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n7o OCA], [http://pdbe.org/2n7o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n7o RCSB], [http://www.ebi.ac.uk/pdbsum/2n7o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n7o ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:46, 16 December 2015

OCA — Wed, 16 Dec 2015 13:46:37 GMT

←Older revision		Revision as of 13:46, 16 December 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==NMR Structure of Peptide PG-990 in DPC micelles==
		+	<StructureSection load='2n7o' size='340' side='right' caption='[[2n7o]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2n7o]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N7O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N7O FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=4J2:(2R)-2-AMINO-3-(NAPHTHALEN-2-YL)PROPANOIC+ACID'>4J2</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2n7n\|2n7n]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n7o OCA], [http://pdbe.org/2n7o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n7o RCSB], [http://www.ebi.ac.uk/pdbsum/2n7o PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The melanocortin receptors 3 and 4 control energy homeostasis, food-intake behavior, and correlated patho-physiological conditions. The melanocortin-4 receptor (MC4R) has been broadly investigated. In contrast, the knowledge related to physiological roles of the melanocortin-3 receptor (MC3R) is lacking because of the limited number of known MC3R selective lig-ands. Here, we report the design, synthesis, biological activity, conformational analysis and docking with receptors of two potent and selective agonists at the human MC3 receptor.

-	~~The entry 2n7o is ON HOLD~~	+	Discovery of Novel Potent and Selective Agonists at the Melanocortin3 Receptor.,Carotenuto A, Merlino F, Cai M, Brancaccio D, Yousif AM, Novellino E, Hruby VJ, Grieco P J Med Chem. 2015 Nov 24. PMID:26599352<ref>PMID:26599352</ref>

-	~~Authors: Carotenuto~~, A.~~, Merlino, F~~.~~, Chai, M., Brancaccio, D., Yousif, A., Novellino, E., Hruby, V., Grieco, P~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~NMR Structure of Peptide PG-990 in DPC micelles~~	+	<div class="pdbe-citations 2n7o" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
-	[[Category: ~~Novellino~~, E]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Brancaccio, D]]
		+	[[Category: Carotenuto, A]]
		+	[[Category: Chai, M]]
	[[Category: Grieco, P]]		[[Category: Grieco, P]]
-	[[Category: Brancaccio, D]]
	[[Category: Hruby, V]]		[[Category: Hruby, V]]
		+	[[Category: Merlino, F]]
		+	[[Category: Novellino, E]]
	[[Category: Yousif, A]]		[[Category: Yousif, A]]
-	[[Category: ~~Carotenuto, A]]~~	+	[[Category: De novo protein]]
-	~~[[Category: Merlino, F]]~~	+
-	~~[[Category: Chai, M~~]]	+

OCA: Protected "2n7o" [edit=sysop:move=sysop]

OCA — Wed, 30 Sep 2015 08:34:20 GMT

Protected "2n7o" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:34, 30 September 2015

OCA: New page: '''Unreleased structure''' The entry 2n7o is ON HOLD Authors: Carotenuto, A., Merlino, F., Chai, M., Brancaccio, D., Yousif, A., Novellino, E., Hruby, V., Grieco, P. Description: NMR S...

OCA — Wed, 30 Sep 2015 08:34:19 GMT

New page: '''Unreleased structure''' The entry 2n7o is ON HOLD Authors: Carotenuto, A., Merlino, F., Chai, M., Brancaccio, D., Yousif, A., Novellino, E., Hruby, V., Grieco, P. Description: NMR S...

New page

'''Unreleased structure'''

The entry 2n7o is ON HOLD

Authors: Carotenuto, A., Merlino, F., Chai, M., Brancaccio, D., Yousif, A., Novellino, E., Hruby, V., Grieco, P.

Description: NMR Structure of Peptide PG-990 in DPC micelles
[[Category: Unreleased Structures]]
[[Category: Novellino, E]]
[[Category: Grieco, P]]
[[Category: Brancaccio, D]]
[[Category: Hruby, V]]
[[Category: Yousif, A]]
[[Category: Carotenuto, A]]
[[Category: Merlino, F]]
[[Category: Chai, M]]