2n88 - Revision history

OCA at 10:23, 15 March 2023

OCA — Wed, 15 Mar 2023 10:23:13 GMT

←Older revision		Revision as of 10:23, 15 March 2023
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	==Chromodomain 3 (CD3) of cpSRP43==		==Chromodomain 3 (CD3) of cpSRP43==
-	<StructureSection load='2n88' size='340' side='right'caption='[[2n88~~]], [[NMR_Ensembles_of_Models \| 9 NMR models~~]]' scene=''>	+	<StructureSection load='2n88' size='340' side='right'caption='[[2n88]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2n88]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Arath Arath~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N88 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N88 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2n88]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N88 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N88 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CAO, CPSRP43, At2g47450, T30B22.25 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n88 OCA], [https://pdbe.org/2n88 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n88 RCSB], [https://www.ebi.ac.uk/pdbsum/2n88 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n88 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n88 OCA], [https://pdbe.org/2n88 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n88 RCSB], [https://www.ebi.ac.uk/pdbsum/2n88 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n88 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SR43C_ARATH SR43C_ARATH]] Component of the chloroplast signal recognition particle pathway. Required for post-translational targeting of proteins into the tylakoid membrane but seems to be dispensable for co-translational targeting with a translating ribosome present. May be able to function independently of cpFTSY and FFC/cpSRP54 in targeting LHCPs to the thylakoids. Acts as a highly specific chaperone for LHCPs, preventing aggregation and being able to dissolve aggregates.<ref>PMID:9878634</ref> <ref>PMID:10480939</ref> <ref>PMID:15292240</ref> <ref>PMID:17513500</ref> <ref>PMID:20498370</ref>	+	[https://www.uniprot.org/uniprot/SR43C_ARATH SR43C_ARATH] Component of the chloroplast signal recognition particle pathway. Required for post-translational targeting of proteins into the tylakoid membrane but seems to be dispensable for co-translational targeting with a translating ribosome present. May be able to function independently of cpFTSY and FFC/cpSRP54 in targeting LHCPs to the thylakoids. Acts as a highly specific chaperone for LHCPs, preventing aggregation and being able to dissolve aggregates.<ref>PMID:9878634</ref> <ref>PMID:10480939</ref> <ref>PMID:15292240</ref> <ref>PMID:17513500</ref> <ref>PMID:20498370</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arath~~]]	+	[[Category: Arabidopsis thaliana]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hennig, J]]	+	[[Category: Hennig J]]
-	[[Category: Sattler, M]]	+	[[Category: Sattler M]]
-	~~[[Category: Chromodomain]]~~	+
-	~~[[Category: Cpsrp]]~~	+
-	~~[[Category: Membrane trafficking]]~~	+
-	~~[[Category: Plant signaling]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Srp~~]]	+

OCA at 15:41, 8 June 2021

OCA — Tue, 08 Jun 2021 15:41:50 GMT

←Older revision		Revision as of 15:41, 8 June 2021
Line 1:		Line 1:

	==Chromodomain 3 (CD3) of cpSRP43==		==Chromodomain 3 (CD3) of cpSRP43==
-	<StructureSection load='2n88' size='340' side='right' caption='[[2n88]], [[NMR_Ensembles_of_Models \| 9 NMR models]]' scene=''>	+	<StructureSection load='2n88' size='340' side='right'caption='[[2n88]], [[NMR_Ensembles_of_Models \| 9 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2n88]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Arath Arath]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N88 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2N88 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2n88]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arath Arath]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N88 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N88 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CAO, CPSRP43, At2g47450, T30B22.25 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CAO, CPSRP43, At2g47450, T30B22.25 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2n88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n88 OCA], [~~http~~://pdbe.org/2n88 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2n88 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2n88 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2n88 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n88 OCA], [https://pdbe.org/2n88 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n88 RCSB], [https://www.ebi.ac.uk/pdbsum/2n88 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n88 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SR43C_ARATH SR43C_ARATH]] Component of the chloroplast signal recognition particle pathway. Required for post-translational targeting of proteins into the tylakoid membrane but seems to be dispensable for co-translational targeting with a translating ribosome present. May be able to function independently of cpFTSY and FFC/cpSRP54 in targeting LHCPs to the thylakoids. Acts as a highly specific chaperone for LHCPs, preventing aggregation and being able to dissolve aggregates.<ref>PMID:9878634</ref> <ref>PMID:10480939</ref> <ref>PMID:15292240</ref> <ref>PMID:17513500</ref> <ref>PMID:20498370</ref>	+	[[https://www.uniprot.org/uniprot/SR43C_ARATH SR43C_ARATH]] Component of the chloroplast signal recognition particle pathway. Required for post-translational targeting of proteins into the tylakoid membrane but seems to be dispensable for co-translational targeting with a translating ribosome present. May be able to function independently of cpFTSY and FFC/cpSRP54 in targeting LHCPs to the thylakoids. Acts as a highly specific chaperone for LHCPs, preventing aggregation and being able to dissolve aggregates.<ref>PMID:9878634</ref> <ref>PMID:10480939</ref> <ref>PMID:15292240</ref> <ref>PMID:17513500</ref> <ref>PMID:20498370</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Arath]]		[[Category: Arath]]
		+	[[Category: Large Structures]]
	[[Category: Hennig, J]]		[[Category: Hennig, J]]
	[[Category: Sattler, M]]		[[Category: Sattler, M]]

OCA at 17:10, 15 August 2018

OCA — Wed, 15 Aug 2018 17:10:19 GMT

←Older revision		Revision as of 17:10, 15 August 2018
Line 1:		Line 1:
		+
	==Chromodomain 3 (CD3) of cpSRP43==		==Chromodomain 3 (CD3) of cpSRP43==
	<StructureSection load='2n88' size='340' side='right' caption='[[2n88]], [[NMR_Ensembles_of_Models \| 9 NMR models]]' scene=''>		<StructureSection load='2n88' size='340' side='right' caption='[[2n88]], [[NMR_Ensembles_of_Models \| 9 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2n88]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N88 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N88 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2n88]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N88 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N88 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n88 OCA], [http://pdbe.org/2n88 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n88 RCSB], [http://www.ebi.ac.uk/pdbsum/2n88 PDBsum]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CAO, CPSRP43, At2g47450, T30B22.25 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n88 OCA], [http://pdbe.org/2n88 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n88 RCSB], [http://www.ebi.ac.uk/pdbsum/2n88 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n88 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 20:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Arath]]
	[[Category: Hennig, J]]		[[Category: Hennig, J]]
	[[Category: Sattler, M]]		[[Category: Sattler, M]]

OCA at 13:43, 9 December 2015

OCA — Wed, 09 Dec 2015 13:43:05 GMT

←Older revision		Revision as of 13:43, 9 December 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Chromodomain 3 (CD3) of cpSRP43==
		+	<StructureSection load='2n88' size='340' side='right' caption='[[2n88]], [[NMR_Ensembles_of_Models \| 9 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2n88]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N88 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N88 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n88 OCA], [http://pdbe.org/2n88 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n88 RCSB], [http://www.ebi.ac.uk/pdbsum/2n88 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SR43C_ARATH SR43C_ARATH]] Component of the chloroplast signal recognition particle pathway. Required for post-translational targeting of proteins into the tylakoid membrane but seems to be dispensable for co-translational targeting with a translating ribosome present. May be able to function independently of cpFTSY and FFC/cpSRP54 in targeting LHCPs to the thylakoids. Acts as a highly specific chaperone for LHCPs, preventing aggregation and being able to dissolve aggregates.<ref>PMID:9878634</ref> <ref>PMID:10480939</ref> <ref>PMID:15292240</ref> <ref>PMID:17513500</ref> <ref>PMID:20498370</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Canonical membrane protein biogenesis requires co-translational delivery of ribosome-associated proteins to the Sec translocase and depends on the signal recognition particle (SRP) and its receptor (SR). In contrast, high-throughput delivery of abundant light-harvesting chlorophyll a,b-binding proteins (LHCPs) in chloroplasts to the Alb3 insertase occurs post-translationally via a soluble transit complex including the cpSRP43/cpSRP54 heterodimer (cpSRP). Here we describe the molecular mechanisms of tethering cpSRP to the Alb3 insertase by specific interaction of cpSRP43 chromodomain 3 with a linear motif in the Alb3 C-terminal tail. Combining NMR spectroscopy, X-ray crystallography and biochemical analyses, we dissect the structural basis for selectivity of chromodomains 2 and 3 for their respective ligands cpSRP54 and Alb3, respectively. Negative cooperativity in ligand binding can be explained by dynamics in the chromodomain interface. Our study provides a model for membrane recruitment of the transit complex and may serve as a prototype for a functional gain by the tandem arrangement of chromodomains.

-	~~The entry 2n88 is ON HOLD~~	+	Structural basis for cpSRP43 chromodomain selectivity and dynamics in Alb3 insertase interaction.,Horn A, Hennig J, Ahmed YL, Stier G, Wild K, Sattler M, Sinning I Nat Commun. 2015 Nov 16;6:8875. doi: 10.1038/ncomms9875. PMID:26568381<ref>PMID:26568381</ref>

-	~~Authors: Hennig~~, J.~~, Sattler, M~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Chromodomain 3 (CD3) of cpSRP43~~	+	<div class="pdbe-citations 2n88" style="background-color:#fffaf0;"></div>
-	~~[[Category: Unreleased Structures]]~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Hennig, J]]		[[Category: Hennig, J]]
	[[Category: Sattler, M]]		[[Category: Sattler, M]]
		+	[[Category: Chromodomain]]
		+	[[Category: Cpsrp]]
		+	[[Category: Membrane trafficking]]
		+	[[Category: Plant signaling]]
		+	[[Category: Protein binding]]
		+	[[Category: Srp]]

OCA at 22:33, 30 November 2015

OCA — Mon, 30 Nov 2015 22:33:23 GMT

←Older revision		Revision as of 22:33, 30 November 2015
Line 5:		Line 5:
	Authors: Hennig, J., Sattler, M.		Authors: Hennig, J., Sattler, M.

-	Description: ~~Chemical shift assignment, NMR constraints and PDB for chromodomain~~ 3 (CD3) of cpSRP43	+	Description: Chromodomain 3 (CD3) of cpSRP43
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Hennig, J]]		[[Category: Hennig, J]]
	[[Category: Sattler, M]]		[[Category: Sattler, M]]

OCA: Protected "2n88" [edit=sysop:move=sysop]

OCA — Thu, 15 Oct 2015 22:08:49 GMT

Protected "2n88" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:08, 15 October 2015

OCA: New page: '''Unreleased structure''' The entry 2n88 is ON HOLD Authors: Hennig, J., Sattler, M. Description: Chemical shift assignment, NMR constraints and PDB for chromodomain 3 (CD3) of cpSRP4...

OCA — Thu, 15 Oct 2015 22:08:48 GMT

New page: '''Unreleased structure''' The entry 2n88 is ON HOLD Authors: Hennig, J., Sattler, M. Description: Chemical shift assignment, NMR constraints and PDB for chromodomain 3 (CD3) of cpSRP4...

New page

'''Unreleased structure'''

The entry 2n88 is ON HOLD

Authors: Hennig, J., Sattler, M.

Description: Chemical shift assignment, NMR constraints and PDB for chromodomain 3 (CD3) of cpSRP43
[[Category: Unreleased Structures]]
[[Category: Hennig, J]]
[[Category: Sattler, M]]