2ncn - Revision history

OCA at 10:00, 14 June 2023

OCA — Wed, 14 Jun 2023 10:00:58 GMT

←Older revision		Revision as of 10:00, 14 June 2023
Line 1:		Line 1:

	==Solution Structure of the Autophagy-Related Protein LC3C==		==Solution Structure of the Autophagy-Related Protein LC3C==
-	<StructureSection load='2ncn' size='340' side='right'caption='[[2ncn~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='2ncn' size='340' side='right'caption='[[2ncn]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ncn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NCN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NCN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ncn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NCN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NCN FirstGlance]. <br>
-	</td></tr>~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAP1LC3C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ncn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ncn OCA], [https://pdbe.org/2ncn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ncn RCSB], [https://www.ebi.ac.uk/pdbsum/2ncn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ncn ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ncn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ncn OCA], [https://pdbe.org/2ncn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ncn RCSB], [https://www.ebi.ac.uk/pdbsum/2ncn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ncn ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MLP3C_HUMAN MLP3C_HUMAN]] Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruites all ATG8 family members to infecting bacteria such as S.Typhimurium.<ref>PMID:23022382</ref>	+	[https://www.uniprot.org/uniprot/MLP3C_HUMAN MLP3C_HUMAN] Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruites all ATG8 family members to infecting bacteria such as S.Typhimurium.<ref>PMID:23022382</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Krichel, C]]	+	[[Category: Krichel C]]
-	[[Category: Neudecker, P]]	+	[[Category: Neudecker P]]
-	[[Category: Weiergraeber~~, O H~~]]	+	[[Category: Weiergraeber OH]]
-	[[Category: Willbold, D]]	+	[[Category: Willbold D]]
-	~~[[Category: Protein transport~~]]	+

OCA at 07:45, 29 June 2022

OCA — Wed, 29 Jun 2022 07:45:16 GMT

←Older revision		Revision as of 07:45, 29 June 2022
Line 3:		Line 3:
	<StructureSection load='2ncn' size='340' side='right'caption='[[2ncn]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2ncn' size='340' side='right'caption='[[2ncn]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ncn]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NCN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2NCN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ncn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NCN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NCN FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAP1LC3C ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAP1LC3C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2ncn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ncn OCA], [~~http~~://pdbe.org/2ncn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ncn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ncn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ncn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ncn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ncn OCA], [https://pdbe.org/2ncn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ncn RCSB], [https://www.ebi.ac.uk/pdbsum/2ncn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ncn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MLP3C_HUMAN MLP3C_HUMAN]] Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruites all ATG8 family members to infecting bacteria such as S.Typhimurium.<ref>PMID:23022382</ref>	+	[[https://www.uniprot.org/uniprot/MLP3C_HUMAN MLP3C_HUMAN]] Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruites all ATG8 family members to infecting bacteria such as S.Typhimurium.<ref>PMID:23022382</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:18, 23 September 2020

OCA — Wed, 23 Sep 2020 11:18:08 GMT

←Older revision		Revision as of 11:18, 23 September 2020
Line 1:		Line 1:

	==Solution Structure of the Autophagy-Related Protein LC3C==		==Solution Structure of the Autophagy-Related Protein LC3C==
-	<StructureSection load='2ncn' size='340' side='right' caption='[[2ncn]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='2ncn' size='340' side='right'caption='[[2ncn]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ncn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NCN OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2NCN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ncn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NCN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2NCN FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAP1LC3C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAP1LC3C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ncn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ncn OCA], [http://pdbe.org/2ncn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ncn RCSB], [http://www.ebi.ac.uk/pdbsum/2ncn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ncn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2ncn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ncn OCA], [http://pdbe.org/2ncn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ncn RCSB], [http://www.ebi.ac.uk/pdbsum/2ncn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ncn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/MLP3C_HUMAN MLP3C_HUMAN]] Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruites all ATG8 family members to infecting bacteria such as S.Typhimurium.<ref>PMID:23022382</ref>		[[http://www.uniprot.org/uniprot/MLP3C_HUMAN MLP3C_HUMAN]] Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruites all ATG8 family members to infecting bacteria such as S.Typhimurium.<ref>PMID:23022382</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	(Macro-)autophagy is a compartmental degradation pathway conserved from yeast to mammals. The yeast protein Atg8 mediates membrane tethering/hemifusion and cargo recruitment and is essential for autophagy. The human MAP1LC3/GABARAP family proteins show high sequence identity with Atg8, but MAP1LC3C is distinguished by a conspicuous amino-terminal extension with unknown functional significance. We have determined the high-resolution three-dimensional structure and measured the backbone dynamics of MAP1LC3C by NMR spectroscopy. From Ser18 to Ala120, MAP1LC3C forms an alpha-helix followed by the ubiquitin-like tertiary fold with two hydrophobic binding pockets used by MAP1LC3/GABARAP proteins to recognize targets presenting LC3-interacting regions (LIRs). Unlike other MAP1LC3/GABARAP proteins, the amino-terminal region of MAP1LC3C does not form a stable helix alpha1 but a "sticky arm" consisting of a polyproline II motif on a flexible linker. Ser18 at the interface between this linker and the structural core can be phosphorylated in vitro by protein kinase A, which causes additional conformational heterogeneity as monitored by NMR spectroscopy and molecular dynamics simulations, including changes in the LIR-binding interface. Based on these results we propose that the amino-terminal polyproline II motif mediates specific interactions with the microtubule cytoskeleton and that Ser18 phosphorylation modulates the interplay of MAP1LC3C with its various target proteins.
		+
		+	Solution structure of the autophagy-related protein LC3C reveals a polyproline II motif on a mobile tether with phosphorylation site.,Krichel C, Mockel C, Schillinger O, Huesgen PF, Sticht H, Strodel B, Weiergraber OH, Willbold D, Neudecker P Sci Rep. 2019 Oct 2;9(1):14167. doi: 10.1038/s41598-019-48155-8. PMID:31578424<ref>PMID:31578424</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 2ncn" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[Microtubule-associated protein\|Microtubule-associated protein]]	+	*[[Microtubule-associated protein 3D structures\|Microtubule-associated protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 17:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Krichel, C]]		[[Category: Krichel, C]]
	[[Category: Neudecker, P]]		[[Category: Neudecker, P]]

OCA at 10:17, 30 January 2019

OCA — Wed, 30 Jan 2019 10:17:28 GMT

←Older revision		Revision as of 10:17, 30 January 2019
Line 3:		Line 3:
	<StructureSection load='2ncn' size='340' side='right' caption='[[2ncn]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2ncn' size='340' side='right' caption='[[2ncn]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ncn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NCN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NCN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ncn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NCN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NCN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ncn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ncn OCA], [http://pdbe.org/2ncn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ncn RCSB], [http://www.ebi.ac.uk/pdbsum/2ncn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ncn ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAP1LC3C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ncn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ncn OCA], [http://pdbe.org/2ncn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ncn RCSB], [http://www.ebi.ac.uk/pdbsum/2ncn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ncn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/MLP3C_HUMAN MLP3C_HUMAN]] Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruites all ATG8 family members to infecting bacteria such as S.Typhimurium.<ref>PMID:23022382</ref>		[[http://www.uniprot.org/uniprot/MLP3C_HUMAN MLP3C_HUMAN]] Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruites all ATG8 family members to infecting bacteria such as S.Typhimurium.<ref>PMID:23022382</ref>
		+
		+	==See Also==
		+	*[[Microtubule-associated protein\|Microtubule-associated protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Krichel, C]]		[[Category: Krichel, C]]
	[[Category: Neudecker, P]]		[[Category: Neudecker, P]]

OCA at 12:55, 19 April 2017

OCA — Wed, 19 Apr 2017 12:55:51 GMT

←Older revision		Revision as of 12:55, 19 April 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 2ncn ~~is ON HOLD until Paper Publication~~	+	==Solution Structure of the Autophagy-Related Protein LC3C==
-		+	<StructureSection load='2ncn' size='340' side='right' caption='[[2ncn]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
-	~~Authors~~: ~~Krichel~~, C., ~~Weiergraeber~~, O.H., ~~Willbold, D~~., ~~Neudecker, P~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2ncn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NCN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NCN FirstGlance]. <br>
-	~~Description~~: ~~Solution Structure of the Autophagy~~-~~Related Protein LC3C~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ncn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ncn OCA], [http://pdbe.org/2ncn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ncn RCSB], [http://www.ebi.ac.uk/pdbsum/2ncn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ncn ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MLP3C_HUMAN MLP3C_HUMAN]] Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruites all ATG8 family members to infecting bacteria such as S.Typhimurium.<ref>PMID:23022382</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Krichel, C]]
		+	[[Category: Neudecker, P]]
		+	[[Category: Weiergraeber, O H]]
	[[Category: Willbold, D]]		[[Category: Willbold, D]]
-	[[Category: ~~Weiergraeber, O.H]]~~	+	[[Category: Protein transport]]
-	~~[[Category: Neudecker, P]]~~	+
-	~~[[Category: Krichel, C~~]]	+

OCA at 08:58, 10 August 2016

OCA — Wed, 10 Aug 2016 08:58:36 GMT

←Older revision		Revision as of 08:58, 10 August 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2ncn is ON HOLD	+	The entry 2ncn is ON HOLD until Paper Publication

	Authors: Krichel, C., Weiergraeber, O.H., Willbold, D., Neudecker, P.		Authors: Krichel, C., Weiergraeber, O.H., Willbold, D., Neudecker, P.

OCA: Protected "2ncn" [edit=sysop:move=sysop]

OCA — Tue, 10 May 2016 20:07:46 GMT

Protected "2ncn" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:07, 10 May 2016

OCA: New page: '''Unreleased structure''' The entry 2ncn is ON HOLD Authors: Krichel, C., Weiergraeber, O.H., Willbold, D., Neudecker, P. Description: Solution Structure of the Autophagy-Related Prot...

OCA — Tue, 10 May 2016 20:07:45 GMT

New page: '''Unreleased structure''' The entry 2ncn is ON HOLD Authors: Krichel, C., Weiergraeber, O.H., Willbold, D., Neudecker, P. Description: Solution Structure of the Autophagy-Related Prot...

New page

'''Unreleased structure'''

The entry 2ncn is ON HOLD

Authors: Krichel, C., Weiergraeber, O.H., Willbold, D., Neudecker, P.

Description: Solution Structure of the Autophagy-Related Protein LC3C
[[Category: Unreleased Structures]]
[[Category: Willbold, D]]
[[Category: Weiergraeber, O.H]]
[[Category: Neudecker, P]]
[[Category: Krichel, C]]