2nq0 - Revision history

OCA at 18:57, 29 November 2023

OCA — Wed, 29 Nov 2023 18:57:56 GMT

←Older revision		Revision as of 18:57, 29 November 2023
Line 1:		Line 1:

	==Solution Structures of a DNA Dodecamer Duplex with a Cisplatin 1,2-d(GG) Intrastrand Cross-Link==		==Solution Structures of a DNA Dodecamer Duplex with a Cisplatin 1,2-d(GG) Intrastrand Cross-Link==
-	<StructureSection load='2nq0' size='340' side='right'caption='[[2nq0~~]], [[NMR_Ensembles_of_Models \| 15 NMR models~~]]' scene=''>	+	<StructureSection load='2nq0' size='340' side='right'caption='[[2nq0]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2nq0]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NQ0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2nq0]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NQ0 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CPT:CISPLATIN'>CPT</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2npw\|2npw]], [[2nq1\|2nq1]], [[2nq4\|2nq4]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nq0 OCA], [https://pdbe.org/2nq0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nq0 RCSB], [https://www.ebi.ac.uk/pdbsum/2nq0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nq0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nq0 OCA], [https://pdbe.org/2nq0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nq0 RCSB], [https://www.ebi.ac.uk/pdbsum/2nq0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nq0 ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bhattacharyya, D]]	+	[[Category: Bhattacharyya D]]
-	[[Category: Campbell, S]]	+	[[Category: Campbell S]]
-	[[Category: Chaney, S]]	+	[[Category: Chaney S]]
-	[[Category: Wu, Y]]	+	[[Category: Wu Y]]
-	~~[[Category: Cisplatin]]~~	+
-	~~[[Category: Deoxyribonucleic acid]]~~	+
-	~~[[Category: Dna]]~~	+
-	~~[[Category: Dodecamer]]~~	+
-	~~[[Category: Duplex~~]]	+

OCA at 09:07, 23 February 2022

OCA — Wed, 23 Feb 2022 09:07:06 GMT

←Older revision		Revision as of 09:07, 23 February 2022
Line 3:		Line 3:
	<StructureSection load='2nq0' size='340' side='right'caption='[[2nq0]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='2nq0' size='340' side='right'caption='[[2nq0]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nq0]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQ0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2NQ0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nq0]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NQ0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2npw\|2npw]], [[2nq1\|2nq1]], [[2nq4\|2nq4]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2npw\|2npw]], [[2nq1\|2nq1]], [[2nq4\|2nq4]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2nq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nq0 OCA], [~~http~~://pdbe.org/2nq0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2nq0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2nq0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2nq0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nq0 OCA], [https://pdbe.org/2nq0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nq0 RCSB], [https://www.ebi.ac.uk/pdbsum/2nq0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nq0 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:34, 20 May 2020

OCA — Wed, 20 May 2020 06:34:14 GMT

←Older revision		Revision as of 06:34, 20 May 2020
Line 1:		Line 1:

	==Solution Structures of a DNA Dodecamer Duplex with a Cisplatin 1,2-d(GG) Intrastrand Cross-Link==		==Solution Structures of a DNA Dodecamer Duplex with a Cisplatin 1,2-d(GG) Intrastrand Cross-Link==
-	<StructureSection load='2nq0' size='340' side='right' caption='[[2nq0]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>	+	<StructureSection load='2nq0' size='340' side='right'caption='[[2nq0]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nq0]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQ0 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2NQ0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nq0]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQ0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2NQ0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2npw\|2npw]], [[2nq1\|2nq1]], [[2nq4\|2nq4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2npw\|2npw]], [[2nq1\|2nq1]], [[2nq4\|2nq4]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2nq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nq0 OCA], [http://pdbe.org/2nq0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nq0 RCSB], [http://www.ebi.ac.uk/pdbsum/2nq0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2nq0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2nq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nq0 OCA], [http://pdbe.org/2nq0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nq0 RCSB], [http://www.ebi.ac.uk/pdbsum/2nq0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2nq0 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Bhattacharyya, D]]		[[Category: Bhattacharyya, D]]
	[[Category: Campbell, S]]		[[Category: Campbell, S]]

OCA at 17:09, 15 August 2018

OCA — Wed, 15 Aug 2018 17:09:20 GMT

←Older revision		Revision as of 17:09, 15 August 2018
Line 1:		Line 1:
		+
	==Solution Structures of a DNA Dodecamer Duplex with a Cisplatin 1,2-d(GG) Intrastrand Cross-Link==		==Solution Structures of a DNA Dodecamer Duplex with a Cisplatin 1,2-d(GG) Intrastrand Cross-Link==
	<StructureSection load='2nq0' size='340' side='right' caption='[[2nq0]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='2nq0' size='340' side='right' caption='[[2nq0]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2npw\|2npw]], [[2nq1\|2nq1]], [[2nq4\|2nq4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2npw\|2npw]], [[2nq1\|2nq1]], [[2nq4\|2nq4]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nq0 OCA], [http://pdbe.org/2nq0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nq0 RCSB], [http://www.ebi.ac.uk/pdbsum/2nq0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nq0 OCA], [http://pdbe.org/2nq0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nq0 RCSB], [http://www.ebi.ac.uk/pdbsum/2nq0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2nq0 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:56, 11 September 2015

OCA — Fri, 11 Sep 2015 06:56:15 GMT

←Older revision		Revision as of 06:56, 11 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2npw\|2npw]], [[2nq1\|2nq1]], [[2nq4\|2nq4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2npw\|2npw]], [[2nq1\|2nq1]], [[2nq4\|2nq4]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nq0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nq0 RCSB], [http://www.ebi.ac.uk/pdbsum/2nq0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nq0 OCA], [http://pdbe.org/2nq0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nq0 RCSB], [http://www.ebi.ac.uk/pdbsum/2nq0 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2nq0" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:47, 22 January 2015

OCA — Thu, 22 Jan 2015 06:47:38 GMT

←Older revision		Revision as of 06:47, 22 January 2015
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bhattacharyya, D.]]	+	[[Category: Bhattacharyya, D]]
-	[[Category: Campbell, S.]]	+	[[Category: Campbell, S]]
-	[[Category: Chaney, S.]]	+	[[Category: Chaney, S]]
-	[[Category: Wu, Y.]]	+	[[Category: Wu, Y]]
	[[Category: Cisplatin]]		[[Category: Cisplatin]]
	[[Category: Deoxyribonucleic acid]]		[[Category: Deoxyribonucleic acid]]

OCA at 11:32, 20 October 2014

OCA — Mon, 20 Oct 2014 11:32:37 GMT

←Older revision		Revision as of 11:32, 20 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2nq0.~~png~~\|~~left~~\|~~200px~~]]	+	==Solution Structures of a DNA Dodecamer Duplex with a Cisplatin 1,2-d(GG) Intrastrand Cross-Link==
		+	<StructureSection load='2nq0' size='340' side='right' caption='[[2nq0]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2nq0]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NQ0 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2npw\|2npw]], [[2nq1\|2nq1]], [[2nq4\|2nq4]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nq0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nq0 RCSB], [http://www.ebi.ac.uk/pdbsum/2nq0 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Proteins that discriminate between cisplatin-DNA adducts and oxaliplatin-DNA adducts are thought to be responsible for the differences in tumor range, toxicity, and mutagenicity of these two important chemotherapeutic agents. However, the structural basis for differential protein recognition of these adducts has not been determined and could be important for the design of more effective platinum anticancer agents. We have determined high-resolution NMR structures for cisplatin-GG and undamaged DNA dodecamers in the AGGC sequence context and have compared these structures with the oxaliplatin-GG structure in the same sequence context determined previously in our laboratory. This structural study allows the first direct comparison of cisplatin-GG DNA and oxaliplatin-GG DNA solution structures referenced to undamaged DNA in the same sequence context. Non-hydrogen atom rmsds of 0.81 and 1.21 were determined for the 15 lowest-energy structures for cisplatin-GG DNA and undamaged DNA, respectively, indicating good structural convergence. The theoretical NOESY spectra obtained by back-calculation from the final average structures showed excellent agreement with the experimental data, indicating that the final structures are consistent with the NMR data. Several significant conformational differences were observed between the cisplatin-GG adduct and the oxaliplatin-GG adduct, including buckle at the 5' G6.C19 base pair, opening at the 3' G7.C18 base pair, twist at the A5G6.T20C19 base pair step, slide, twist, and roll at the G6G7.C19C18 base pair step, slide at the G7C8.C18G17 base pair step, G6G7 dihedral angle, and overall bend angle. We hypothesize that these conformational differences may be related to the ability of various DNA repair proteins, DNA binding proteins, and DNA polymerases to discriminate between cisplatin-GG and oxaliplatin-GG adducts.

-	~~{{STRUCTURE_2nq0\| PDB=2nq0 \| SCENE= }}~~	+	Solution structures of a DNA dodecamer duplex with and without a cisplatin 1,2-d(GG) intrastrand cross-link: comparison with the same DNA duplex containing an oxaliplatin 1,2-d(GG) intrastrand cross-link.,Wu Y, Bhattacharyya D, King CL, Baskerville-Abraham I, Huh SH, Boysen G, Swenberg JA, Temple B, Campbell SL, Chaney SG Biochemistry. 2007 Jun 5;46(22):6477-87. Epub 2007 May 12. PMID:17497831<ref>PMID:17497831</ref>

-	~~===Solution Structures of a DNA Dodecamer Duplex with a Cisplatin 1~~,~~2-d(GG) Intrastrand Cross-Link===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17497831}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2nq0]] is~~ a ~~2 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2NQ0 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017497831<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Bhattacharyya, D.]]		[[Category: Bhattacharyya, D.]]
	[[Category: Campbell, S.]]		[[Category: Campbell, S.]]

OCA: Protected "2nq0" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 12:26:21 GMT

Protected "2nq0" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:26, 7 January 2013

OCA at 12:26, 7 January 2013

OCA — Mon, 07 Jan 2013 12:26:18 GMT

←Older revision		Revision as of 12:26, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2nq0.png\|left\|200px]]		[[Image:2nq0.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2nq0", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2nq0\| PDB=2nq0 \| SCENE= }}		{{STRUCTURE_2nq0\| PDB=2nq0 \| SCENE= }}

	===Solution Structures of a DNA Dodecamer Duplex with a Cisplatin 1,2-d(GG) Intrastrand Cross-Link===		===Solution Structures of a DNA Dodecamer Duplex with a Cisplatin 1,2-d(GG) Intrastrand Cross-Link===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17497831}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17497831 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17497831}}		{{ABSTRACT_PUBMED_17497831}}

	==About this Structure==		==About this Structure==
-	~~2NQ0~~ is a 2 ~~chains~~ structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQ0 OCA].	+	[[2nq0]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQ0 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17497831~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017497831</ref><references group="xtra"/>
	[[Category: Bhattacharyya, D.]]		[[Category: Bhattacharyya, D.]]
	[[Category: Campbell, S.]]		[[Category: Campbell, S.]]
Line 33:		Line 21:
	[[Category: Dodecamer]]		[[Category: Dodecamer]]
	[[Category: Duplex]]		[[Category: Duplex]]
-
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OCA at 04:29, 23 June 2010

OCA — Wed, 23 Jun 2010 04:29:55 GMT

←Older revision		Revision as of 04:29, 23 June 2010
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	==About this Structure==		==About this Structure==
-	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQ0 OCA].	+	2NQ0 is a 2 chains structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQ0 OCA].

	==Reference==		==Reference==
-	Solution structures of a DNA dodecamer duplex with and without a cisplatin 1,2-d(GG) intrastrand cross-link: comparison with the same DNA duplex containing an oxaliplatin 1,2-d(GG) intrastrand cross-link., Wu Y, Bhattacharyya D, King CL, Baskerville-Abraham I, Huh SH, Boysen G, Swenberg JA, Temple B, Campbell SL, Chaney SG, Biochemistry. 2007 Jun 5;46(22):6477-87. Epub 2007 May 12. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17497831 17497831]~~	+	<ref group="xtra">PMID:17497831</ref><references group="xtra"/>
	[[Category: Bhattacharyya, D.]]		[[Category: Bhattacharyya, D.]]
	[[Category: Campbell, S.]]		[[Category: Campbell, S.]]
Line 34:		Line 34:
	[[Category: Duplex]]		[[Category: Duplex]]

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