2nqt - Revision history

OCA at 00:10, 28 December 2023

OCA — Thu, 28 Dec 2023 00:10:05 GMT

←Older revision		Revision as of 00:10, 28 December 2023
Line 3:		Line 3:
	<StructureSection load='2nqt' size='340' side='right'caption='[[2nqt]], [[Resolution\|resolution]] 1.58Å' scene=''>		<StructureSection load='2nqt' size='340' side='right'caption='[[2nqt]], [[Resolution\|resolution]] 1.58Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nqt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus~~ tuberculosis~~" (zopf 1883) klein 1884~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NQT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nqt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NQT FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.58Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;'>[[2i3a\|2i3a]]~~, [[~~2i3g~~\|~~2i3g~~]]~~</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>argC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1773~~ "~~Bacillus tuberculosis~~" ~~(Zopf 1883) Klein 1884])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.38 1.2.1.38]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nqt OCA], [https://pdbe.org/2nqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nqt RCSB], [https://www.ebi.ac.uk/pdbsum/2nqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nqt ProSAT], [https://www.topsan.org/Proteins/TBSGC/2nqt TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nqt OCA], [https://pdbe.org/2nqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nqt RCSB], [https://www.ebi.ac.uk/pdbsum/2nqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nqt ProSAT], [https://www.topsan.org/Proteins/TBSGC/2nqt TOPSAN]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ARGC_MYCTU ARGC_MYCTU]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Oxidoreductase~~]]	+	[[Category: Mycobacterium tuberculosis]]
-	[[Category: Cherney~~, L T~~]]	+	[[Category: Cherney LT]]
-	[[Category: Cherney~~, M M~~]]	+	[[Category: Cherney MM]]
-	[[Category: Garen~~, C R~~]]	+	[[Category: Garen CR]]
-	[[Category: James~~, M N.G~~]]	+	[[Category: James MNG]]
-	[[Category: Moraidin, F]]	+	[[Category: Moraidin F]]
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Apoprotein]]~~	+
-	~~[[Category: Dimer]]~~	+
-	~~[[Category: PSI, Protein structure initiative]]~~	+
-	~~[[Category: Rossmann fold]]~~	+
-	~~[[Category: Tbsgc~~]]	+

OCA at 15:48, 8 June 2021

OCA — Tue, 08 Jun 2021 15:48:51 GMT

←Older revision		Revision as of 15:48, 8 June 2021
Line 1:		Line 1:

	==Crystal structure of N-Acetyl-gamma-Glutamyl-Phosphate Reductase (Rv1652) from Mycobacterium tuberculosis at 1.58 A resolution==		==Crystal structure of N-Acetyl-gamma-Glutamyl-Phosphate Reductase (Rv1652) from Mycobacterium tuberculosis at 1.58 A resolution==
-	<StructureSection load='2nqt' size='340' side='right' caption='[[2nqt]], [[Resolution\|resolution]] 1.58Å' scene=''>	+	<StructureSection load='2nqt' size='340' side='right'caption='[[2nqt]], [[Resolution\|resolution]] 1.58Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nqt]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2NQT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nqt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NQT FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i3a\|2i3a]], [[2i3g\|2i3g]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2i3a\|2i3a]], [[2i3g\|2i3g]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">argC ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">argC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.38 1.2.1.38] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.38 1.2.1.38] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2nqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nqt OCA], [~~http~~://pdbe.org/2nqt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2nqt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2nqt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2nqt ProSAT], [~~http~~://www.topsan.org/Proteins/TBSGC/2nqt TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nqt OCA], [https://pdbe.org/2nqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nqt RCSB], [https://www.ebi.ac.uk/pdbsum/2nqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nqt ProSAT], [https://www.topsan.org/Proteins/TBSGC/2nqt TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Cherney, L T]]		[[Category: Cherney, L T]]

OCA at 16:58, 15 August 2018

OCA — Wed, 15 Aug 2018 16:58:37 GMT

←Older revision		Revision as of 16:58, 15 August 2018
Line 1:		Line 1:
		+
	==Crystal structure of N-Acetyl-gamma-Glutamyl-Phosphate Reductase (Rv1652) from Mycobacterium tuberculosis at 1.58 A resolution==		==Crystal structure of N-Acetyl-gamma-Glutamyl-Phosphate Reductase (Rv1652) from Mycobacterium tuberculosis at 1.58 A resolution==
	<StructureSection load='2nqt' size='340' side='right' caption='[[2nqt]], [[Resolution\|resolution]] 1.58Å' scene=''>		<StructureSection load='2nqt' size='340' side='right' caption='[[2nqt]], [[Resolution\|resolution]] 1.58Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">argC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">argC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.38 1.2.1.38] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.38 1.2.1.38] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nqt OCA], [http://pdbe.org/2nqt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nqt RCSB], [http://www.ebi.ac.uk/pdbsum/2nqt PDBsum], [http://www.topsan.org/Proteins/TBSGC/2nqt TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nqt OCA], [http://pdbe.org/2nqt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nqt RCSB], [http://www.ebi.ac.uk/pdbsum/2nqt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2nqt ProSAT], [http://www.topsan.org/Proteins/TBSGC/2nqt TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nq/2nqt_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nq/2nqt_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nqt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:54, 11 September 2015

OCA — Fri, 11 Sep 2015 15:54:28 GMT

←Older revision		Revision as of 15:54, 11 September 2015
Line 7:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">argC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">argC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.38 1.2.1.38] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.38 1.2.1.38] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nqt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nqt RCSB], [http://www.ebi.ac.uk/pdbsum/2nqt PDBsum], [http://www.topsan.org/Proteins/TBSGC/2nqt TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nqt OCA], [http://pdbe.org/2nqt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nqt RCSB], [http://www.ebi.ac.uk/pdbsum/2nqt PDBsum], [http://www.topsan.org/Proteins/TBSGC/2nqt TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2nqt" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:56, 25 January 2015

OCA — Sun, 25 Jan 2015 10:56:35 GMT

←Older revision		Revision as of 10:56, 25 January 2015
Line 2:		Line 2:
	<StructureSection load='2nqt' size='340' side='right' caption='[[2nqt]], [[Resolution\|resolution]] 1.58Å' scene=''>		<StructureSection load='2nqt' size='340' side='right' caption='[[2nqt]], [[Resolution\|resolution]] 1.58Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nqt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NQT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nqt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NQT FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i3a\|2i3a]], [[2i3g\|2i3g]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i3a\|2i3a]], [[2i3g\|2i3g]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">argC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.38 1.2.1.38] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.38 1.2.1.38] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nqt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nqt RCSB], [http://www.ebi.ac.uk/pdbsum/2nqt PDBsum], [http://www.topsan.org/Proteins/TBSGC/2nqt TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nqt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nqt RCSB], [http://www.ebi.ac.uk/pdbsum/2nqt PDBsum], [http://www.topsan.org/Proteins/TBSGC/2nqt TOPSAN]</span></td></tr>

OCA at 07:19, 12 November 2014

OCA — Wed, 12 Nov 2014 07:19:01 GMT

←Older revision		Revision as of 07:19, 12 November 2014
Line 2:		Line 2:
	<StructureSection load='2nqt' size='340' side='right' caption='[[2nqt]], [[Resolution\|resolution]] 1.58Å' scene=''>		<StructureSection load='2nqt' size='340' side='right' caption='[[2nqt]], [[Resolution\|resolution]] 1.58Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nqt]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NQT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nqt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NQT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~CSW~~:~~CYSTEINE~~-~~S-DIOXIDE~~'>~~CSW~~</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i3a\|2i3a]], [[2i3g\|2i3g]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i3a\|2i3a]], [[2i3g\|2i3g]]</td></tr>
-	<tr~~><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">argC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1773 Mycobacterium tuberculosis])</td></tr>~~	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.38 1.2.1.38] </span></td></tr>
-	~~<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~N-acetyl-gamma-glutamyl-phosphate_reductase N-acetyl-gamma-glutamyl-phosphate reductase~~], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.38 1.2.1.38] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nqt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nqt RCSB], [http://www.ebi.ac.uk/pdbsum/2nqt PDBsum], [http://www.topsan.org/Proteins/TBSGC/2nqt TOPSAN]</span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nqt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nqt RCSB], [http://www.ebi.ac.uk/pdbsum/2nqt PDBsum], [http://www.topsan.org/Proteins/TBSGC/2nqt TOPSAN]</span></td></tr>	+	</table>
-	<table>	+
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mycobacterium tuberculosis]]~~	+	[[Category: Oxidoreductase]]
-	~~[[Category: N-acetyl-gamma-glutamyl-phosphate reductase~~]]	+	[[Category: Cherney, L T]]
-	[[Category: Cherney, L T.]]	+	[[Category: Cherney, M M]]
-	[[Category: Cherney, M M.]]	+	[[Category: Garen, C R]]
-	[[Category: Garen, C R.]]	+	[[Category: James, M N.G]]
-	[[Category: James, M N.G.]]	+	[[Category: Moraidin, F]]
-	[[Category: Moraidin, F.]]	+	[[Category: Structural genomic]]
-	[[Category: ~~TBSGC, TB~~ Structural ~~Genomics Consortium.~~]]	+
	[[Category: Apoprotein]]		[[Category: Apoprotein]]
	[[Category: Dimer]]		[[Category: Dimer]]
-	[[Category: ~~Oxidoreductase]]~~	+	[[Category: PSI, Protein structure initiative]]
-	~~[[Category:~~ Protein structure initiative]]	+
-	~~[[Category: Psi~~]]	+
	[[Category: Rossmann fold]]		[[Category: Rossmann fold]]
-	[[Category: Structural genomic]]
-	[[Category: Tb structural genomics consortium]]
	[[Category: Tbsgc]]		[[Category: Tbsgc]]

OCA at 19:57, 30 September 2014

OCA — Tue, 30 Sep 2014 19:57:19 GMT

←Older revision		Revision as of 19:57, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2nqt.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of N-Acetyl-gamma-Glutamyl-Phosphate Reductase (Rv1652) from Mycobacterium tuberculosis at 1.58 A resolution==
		+	<StructureSection load='2nqt' size='340' side='right' caption='[[2nqt]], [[Resolution\|resolution]] 1.58Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2nqt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NQT FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSW:CYSTEINE-S-DIOXIDE'>CSW</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i3a\|2i3a]], [[2i3g\|2i3g]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">argC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/N-acetyl-gamma-glutamyl-phosphate_reductase N-acetyl-gamma-glutamyl-phosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.38 1.2.1.38] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nqt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nqt RCSB], [http://www.ebi.ac.uk/pdbsum/2nqt PDBsum], [http://www.topsan.org/Proteins/TBSGC/2nqt TOPSAN]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nq/2nqt_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The enzyme N-acetyl-gamma-glutamyl-phosphate reductase (AGPR) catalyzes the nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reductive dephosphorylation of N-acetyl-gamma-glutamyl-phosphate to N-acetylglutamate-gamma-semialdehyde. This reaction is part of the arginine biosynthetic pathway that is essential for some microorganisms and plants, in particular, for Mycobacterium tuberculosis (Mtb). The structures of apo MtbAGPR in the space groups P2(1)2(1)2(1) and C2 and the structure of MtbAGPR bound to the cofactor NADP(+) have been solved and analyzed. Each MtbAGPR subunit consists of alpha/beta and alpha+beta domains; NADP(+) is bound in the cleft between them. The hydrogen bonds and hydrophobic contacts between the enzyme and cofactor have been examined. Comparison of the apo and the bound enzyme structures has revealed a conformational change in MtbAGPR upon NADP(+) binding. Namely, a loop (Leu88 to His92) moves more than 5 A to confine sterically the cofactor's adenine moiety in a hydrophobic pocket. To identify the catalytically important residues in MtbAGPR, a docking of the substrate to the enzyme has been performed using the present structure of the MtbAGPR/NADP(+) complex. It reveals that residues His217 and His219 could form hydrogen bonds with the docked substrate. In addition, an ion pair could form between the substrate phosphate group and the guanidinium group of Arg114. These interactions optimally place and orient the substrate for subsequent nucleophilic attack by Cys158 on the substrate gamma-carboxyl group. His219 is the most probable general base to accept a proton from Cys158 and an adjacent ion pair interaction with the side-chain carboxyl group of Glu222 could help to stabilize the resulting positive charge on His219. For this catalytic triad to function efficiently it requires a small conformational change of the order of 1 A in the loop containing His217 and His219; this could easily result from the substrate binding.

-	~~{{STRUCTURE_2nqt\| PDB=2nqt \| SCENE= }}~~	+	Crystal structure of N-acetyl-gamma-glutamyl-phosphate reductase from Mycobacterium tuberculosis in complex with NADP(+).,Cherney LT, Cherney MM, Garen CR, Niu C, Moradian F, James MN J Mol Biol. 2007 Apr 13;367(5):1357-69. Epub 2007 Jan 20. PMID:17316682<ref>PMID:17316682</ref>

-	~~===Crystal structure~~ of ~~N-Acetyl-gamma-Glutamyl-Phosphate Reductase (Rv1652) from Mycobacterium tuberculosis at 1~~.~~58 A resolution===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17316682}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2nqt]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQT OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017316682<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: N-acetyl-gamma-glutamyl-phosphate reductase]]		[[Category: N-acetyl-gamma-glutamyl-phosphate reductase]]

OCA: Protected "2nqt" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 14:56:03 GMT

Protected "2nqt" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:56, 7 January 2013

OCA at 14:56, 7 January 2013

OCA — Mon, 07 Jan 2013 14:56:01 GMT

←Older revision		Revision as of 14:56, 7 January 2013
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-	{{Seed}}
	[[Image:2nqt.png\|left\|200px]]		[[Image:2nqt.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2nqt", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2nqt\| PDB=2nqt \| SCENE= }}		{{STRUCTURE_2nqt\| PDB=2nqt \| SCENE= }}

	===Crystal structure of N-Acetyl-gamma-Glutamyl-Phosphate Reductase (Rv1652) from Mycobacterium tuberculosis at 1.58 A resolution===		===Crystal structure of N-Acetyl-gamma-Glutamyl-Phosphate Reductase (Rv1652) from Mycobacterium tuberculosis at 1.58 A resolution===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17316682}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17316682 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17316682}}		{{ABSTRACT_PUBMED_17316682}}

	==About this Structure==		==About this Structure==
-	~~2NQT~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQT OCA].	+	[[2nqt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQT OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17316682~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017316682</ref><references group="xtra"/>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: N-acetyl-gamma-glutamyl-phosphate reductase]]		[[Category: N-acetyl-gamma-glutamyl-phosphate reductase]]
Line 34:		Line 22:
	[[Category: Apoprotein]]		[[Category: Apoprotein]]
	[[Category: Dimer]]		[[Category: Dimer]]
		+	[[Category: Oxidoreductase]]
	[[Category: Protein structure initiative]]		[[Category: Protein structure initiative]]
	[[Category: Psi]]		[[Category: Psi]]
Line 40:		Line 29:
	[[Category: Tb structural genomics consortium]]		[[Category: Tb structural genomics consortium]]
	[[Category: Tbsgc]]		[[Category: Tbsgc]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:46:32 2009''

OCA at 00:46, 18 February 2009

OCA — Wed, 18 Feb 2009 00:46:34 GMT

←Older revision		Revision as of 00:46, 18 February 2009
Line 23:		Line 23:

	==Reference==		==Reference==
-	Crystal structure of N-acetyl-gamma-glutamyl-phosphate reductase from Mycobacterium tuberculosis in complex with NADP(+)., Cherney LT, Cherney MM, Garen CR, Niu C, Moradian F, James MN, J Mol Biol. 2007 Apr 13;367(5):1357-69. Epub 2007 Jan 20. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17316682 17316682]~~	+	<ref group="xtra">PMID:17316682</ref><references group="xtra"/>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: N-acetyl-gamma-glutamyl-phosphate reductase]]		[[Category: N-acetyl-gamma-glutamyl-phosphate reductase]]
Line 41:		Line 41:
	[[Category: Tbsgc]]		[[Category: Tbsgc]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Nov 16~~ 18:05:~~09 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:46:32 2009''