2nsn - Revision history

OCA at 10:19, 30 August 2023

OCA — Wed, 30 Aug 2023 10:19:29 GMT

←Older revision		Revision as of 10:19, 30 August 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2nsn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NSN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NSN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2nsn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NSN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NSN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nsn OCA], [https://pdbe.org/2nsn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nsn RCSB], [https://www.ebi.ac.uk/pdbsum/2nsn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nsn ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nsn OCA], [https://pdbe.org/2nsn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nsn RCSB], [https://www.ebi.ac.uk/pdbsum/2nsn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nsn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 10:27, 15 March 2023

OCA — Wed, 15 Mar 2023 10:27:57 GMT

←Older revision		Revision as of 10:27, 15 March 2023
Line 3:		Line 3:
	<StructureSection load='2nsn' size='340' side='right'caption='[[2nsn]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2nsn' size='340' side='right'caption='[[2nsn]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nsn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NSN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NSN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nsn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NSN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NSN FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2b1w\|2b1w]], [[1cy5\|1cy5]], [[3ygs\|3ygs]], [[3crd\|3crd]], [[1dgn\|1dgn]]</div></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nsn OCA], [https://pdbe.org/2nsn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nsn RCSB], [https://www.ebi.ac.uk/pdbsum/2nsn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nsn ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CARD4, NOD1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nsn OCA], [https://pdbe.org/2nsn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nsn RCSB], [https://www.ebi.ac.uk/pdbsum/2nsn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nsn ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NOD1_HUMAN NOD1_HUMAN]] Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection.<ref>PMID:11058605</ref> <ref>PMID:19043560</ref> <ref>PMID:22672233</ref> <ref>PMID:17054981</ref>	+	[https://www.uniprot.org/uniprot/NOD1_HUMAN NOD1_HUMAN] Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection.<ref>PMID:11058605</ref> <ref>PMID:19043560</ref> <ref>PMID:22672233</ref> <ref>PMID:17054981</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Coussens~~, N P~~]]	+	[[Category: Coussens NP]]
-	[[Category: Ramaswamy, S]]	+	[[Category: Ramaswamy S]]
-	~~[[Category: Apoptosis]]~~	+
-	~~[[Category: Six helix greek key motif~~]]	+

OCA at 15:50, 8 June 2021

OCA — Tue, 08 Jun 2021 15:50:11 GMT

←Older revision		Revision as of 15:50, 8 June 2021
Line 1:		Line 1:

	==Crystal structure of Caspace Activation and Recruitment Domain (CARD) of NOD1==		==Crystal structure of Caspace Activation and Recruitment Domain (CARD) of NOD1==
-	<StructureSection load='2nsn' size='340' side='right' caption='[[2nsn]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='2nsn' size='340' side='right'caption='[[2nsn]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nsn]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NSN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2NSN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nsn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NSN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NSN FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2b1w\|2b1w]], [[1cy5\|1cy5]], [[3ygs\|3ygs]], [[3crd\|3crd]], [[1dgn\|1dgn]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2b1w\|2b1w]], [[1cy5\|1cy5]], [[3ygs\|3ygs]], [[3crd\|3crd]], [[1dgn\|1dgn]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CARD4, NOD1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CARD4, NOD1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2nsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nsn OCA], [~~http~~://pdbe.org/2nsn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2nsn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2nsn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2nsn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nsn OCA], [https://pdbe.org/2nsn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nsn RCSB], [https://www.ebi.ac.uk/pdbsum/2nsn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nsn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NOD1_HUMAN NOD1_HUMAN]] Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection.<ref>PMID:11058605</ref> <ref>PMID:19043560</ref> <ref>PMID:22672233</ref> <ref>PMID:17054981</ref>	+	[[https://www.uniprot.org/uniprot/NOD1_HUMAN NOD1_HUMAN]] Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection.<ref>PMID:11058605</ref> <ref>PMID:19043560</ref> <ref>PMID:22672233</ref> <ref>PMID:17054981</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Coussens, N P]]		[[Category: Coussens, N P]]
	[[Category: Ramaswamy, S]]		[[Category: Ramaswamy, S]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Six helix greek key motif]]		[[Category: Six helix greek key motif]]

OCA at 16:50, 15 August 2018

OCA — Wed, 15 Aug 2018 16:50:11 GMT

←Older revision		Revision as of 16:50, 15 August 2018
Line 1:		Line 1:
		+
	==Crystal structure of Caspace Activation and Recruitment Domain (CARD) of NOD1==		==Crystal structure of Caspace Activation and Recruitment Domain (CARD) of NOD1==
	<StructureSection load='2nsn' size='340' side='right' caption='[[2nsn]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2nsn' size='340' side='right' caption='[[2nsn]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2b1w\|2b1w]], [[1cy5\|1cy5]], [[3ygs\|3ygs]], [[3crd\|3crd]], [[1dgn\|1dgn]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2b1w\|2b1w]], [[1cy5\|1cy5]], [[3ygs\|3ygs]], [[3crd\|3crd]], [[1dgn\|1dgn]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CARD4, NOD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CARD4, NOD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nsn OCA], [http://pdbe.org/2nsn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nsn RCSB], [http://www.ebi.ac.uk/pdbsum/2nsn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nsn OCA], [http://pdbe.org/2nsn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nsn RCSB], [http://www.ebi.ac.uk/pdbsum/2nsn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2nsn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 14:16, 11 September 2015

OCA — Fri, 11 Sep 2015 14:16:41 GMT

←Older revision		Revision as of 14:16, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2nsn' size='340' side='right' caption='[[2nsn]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2nsn' size='340' side='right' caption='[[2nsn]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nsn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NSN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NSN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nsn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NSN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NSN FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2b1w\|2b1w]], [[1cy5\|1cy5]], [[3ygs\|3ygs]], [[3crd\|3crd]], [[1dgn\|1dgn]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2b1w\|2b1w]], [[1cy5\|1cy5]], [[3ygs\|3ygs]], [[3crd\|3crd]], [[1dgn\|1dgn]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CARD4, NOD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CARD4, NOD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nsn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nsn RCSB], [http://www.ebi.ac.uk/pdbsum/2nsn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nsn OCA], [http://pdbe.org/2nsn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nsn RCSB], [http://www.ebi.ac.uk/pdbsum/2nsn PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NOD1_HUMAN NOD1_HUMAN]] Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection.<ref>PMID:11058605</ref> <ref>PMID:19043560</ref> <ref>PMID:22672233</ref> <ref>PMID:17054981</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2nsn" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Coussens, N P]]		[[Category: Coussens, N P]]
	[[Category: Ramaswamy, S]]		[[Category: Ramaswamy, S]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Six helix greek key motif]]		[[Category: Six helix greek key motif]]

OCA at 22:31, 3 January 2015

OCA — Sat, 03 Jan 2015 22:31:06 GMT

←Older revision		Revision as of 22:31, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2nsn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NSN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NSN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2nsn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NSN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NSN FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2b1w\|2b1w]], [[1cy5\|1cy5]], [[3ygs\|3ygs]], [[3crd\|3crd]], [[1dgn\|1dgn]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2b1w\|2b1w]], [[1cy5\|1cy5]], [[3ygs\|3ygs]], [[3crd\|3crd]], [[1dgn\|1dgn]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CARD4, NOD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CARD4, NOD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nsn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nsn RCSB], [http://www.ebi.ac.uk/pdbsum/2nsn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nsn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nsn RCSB], [http://www.ebi.ac.uk/pdbsum/2nsn PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Coussens, N P.]]	+	[[Category: Coussens, N P]]
-	[[Category: Ramaswamy, S.]]	+	[[Category: Ramaswamy, S]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Six helix greek key motif]]		[[Category: Six helix greek key motif]]

OCA at 06:46, 9 June 2014

OCA — Mon, 09 Jun 2014 06:46:41 GMT

←Older revision		Revision as of 06:46, 9 June 2014
Line 1:		Line 1:
-	[[~~Image:~~2nsn.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of Caspace Activation and Recruitment Domain (CARD) of NOD1==
		+	<StructureSection load='2nsn' size='340' side='right' caption='[[2nsn]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2nsn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NSN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NSN FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2b1w\|2b1w]], [[1cy5\|1cy5]], [[3ygs\|3ygs]], [[3crd\|3crd]], [[1dgn\|1dgn]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CARD4, NOD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nsn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nsn RCSB], [http://www.ebi.ac.uk/pdbsum/2nsn PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Nod-like receptors (NLRs), Nod1 and Nod2 are cytosolic detectors of pathogen-associated molecular patterns (PAMPs). Nod1 is a three-domain protein, consisting of a caspase activation and recruitment domain (CARD), a nucleotide-binding oligomerization domain (NOD), and a leucine-rich repeat domain (LRR). The binding of PAMPs to the LRR results in the activation of signaling through homophilic CARD-CARD interactions. Several CARD structures have been determined, including a recent NMR structure of Nod1 CARD. In contrast to the reported NMR structure, the crystal structure reported here is a dimer, where the sixth helix is swapped between two monomers. While the overall structure is very similar to the known CARD structures, this is the first report of a homodimeric CARD structure. The ability of the CARD to exist in monomeric and dimeric forms suggests another level of regulation in the activation of NLR proteins.

-	~~{{STRUCTURE_2nsn\| PDB=2nsn \| SCENE= }}~~	+	Crystal structure of the Nod1 caspase activation and recruitment domain.,Coussens NP, Mowers JC, McDonald C, Nunez G, Ramaswamy S Biochem Biophys Res Commun. 2007 Feb 2;353(1):1-5. Epub 2006 Dec 6. PMID:17173864<ref>PMID:17173864</ref>

-	~~===Crystal structure~~ of ~~Caspace Activation and Recruitment Domain (CARD) of NOD1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17173864}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2nsn]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2NSN OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017173864<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Coussens, N P.]]		[[Category: Coussens, N P.]]

OCA: Protected "2nsn" [edit=sysop:move=sysop]

OCA — Tue, 14 Aug 2012 17:16:25 GMT

Protected "2nsn" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:16, 14 August 2012

OCA at 17:16, 14 August 2012

OCA — Tue, 14 Aug 2012 17:16:24 GMT

←Older revision		Revision as of 17:16, 14 August 2012
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-	{{Seed}}
	[[Image:2nsn.png\|left\|200px]]		[[Image:2nsn.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2nsn", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2nsn\| PDB=2nsn \| SCENE= }}		{{STRUCTURE_2nsn\| PDB=2nsn \| SCENE= }}

	===Crystal structure of Caspace Activation and Recruitment Domain (CARD) of NOD1===		===Crystal structure of Caspace Activation and Recruitment Domain (CARD) of NOD1===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17173864}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17173864 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17173864}}		{{ABSTRACT_PUBMED_17173864}}

	==About this Structure==		==About this Structure==
-	~~2NSN is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NSN OCA].	+	[[2nsn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NSN OCA].

	==Reference==		==Reference==
-	~~Crystal structure of the Nod1 caspase activation and recruitment domain., Coussens NP, Mowers JC, McDonald C, Nunez G, Ramaswamy S, Biochem Biophys Res Commun. 2007 Feb 2;353(1):1-5. Epub 2006 Dec 6.~~ PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~17173864 17173864]~~	+	<ref group="xtra">PMID:017173864</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Coussens, N P.]]		[[Category: Coussens, N P.]]
	[[Category: Ramaswamy, S.]]		[[Category: Ramaswamy, S.]]
		+	[[Category: Apoptosis]]
	[[Category: Six helix greek key motif]]		[[Category: Six helix greek key motif]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:44:23 2008''

OCA at 04:44, 29 July 2008

OCA — Tue, 29 Jul 2008 04:44:25 GMT

←Older revision		Revision as of 04:44, 29 July 2008
Line 1:		Line 1:
-	[[Image:2nsn.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2nsn.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2nsn\| PDB=2nsn \| SCENE= }}		{{STRUCTURE_2nsn\| PDB=2nsn \| SCENE= }}

-	~~'''~~Crystal structure of Caspace Activation and Recruitment Domain (CARD) of NOD1~~'''~~	+	===Crystal structure of Caspace Activation and Recruitment Domain (CARD) of NOD1===


-	~~==Overview==~~	+	<!--
-	~~Nod~~-~~like receptors (NLRs), Nod1 and Nod2 are cytosolic detectors of pathogen~~-~~associated molecular patterns (PAMPs). Nod1 is a three-domain protein~~, ~~consisting of a caspase activation and recruitment domain (CARD)~~, ~~a nucleotide-binding oligomerization domain (NOD), and a leucine-rich repeat domain (LRR). The binding of PAMPs~~ to the ~~LRR results in the activation of signaling through homophilic CARD-CARD interactions~~. ~~Several CARD structures have been determined, including a recent NMR structure of Nod1 CARD~~. ~~In contrast to the reported NMR structure, the crystal structure reported here is a dimer~~, where ~~the sixth helix~~ is ~~swapped between two monomers. While~~ the overall structure is very similar to the known CARD structures, this is the first report of a homodimeric CARD structure. The ability of the CARD to exist in monomeric and dimeric forms suggests another level of regulation in the activation of NLR proteins.	+	The line below this paragraph, {{ABSTRACT_PUBMED_17173864}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17173864 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17173864}}

	==About this Structure==		==About this Structure==
Line 25:		Line 29:
	[[Category: Ramaswamy, S.]]		[[Category: Ramaswamy, S.]]
	[[Category: Six helix greek key motif]]		[[Category: Six helix greek key motif]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 09~~:51:49 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:44:23 2008''