2nww - Revision history

OCA at 10:24, 30 August 2023

OCA — Wed, 30 Aug 2023 10:24:35 GMT

←Older revision		Revision as of 10:24, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2nww' size='340' side='right'caption='[[2nww]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2nww' size='340' side='right'caption='[[2nww]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nww]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~'pyrococcus_shinkaii' 'pyrococcus shinkaii'~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NWW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nww]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NWW FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=TB1:(3S)~~-3~~-(BENZYLOXY)-L-ASPARTIC+ACID'>TB1</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1xhf\|1xhf]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TB1:(3S)-3-(BENZYLOXY)-L-ASPARTIC+ACID'>TB1</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nww OCA], [https://pdbe.org/2nww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nww RCSB], [https://www.ebi.ac.uk/pdbsum/2nww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nww ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nww OCA], [https://pdbe.org/2nww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nww RCSB], [https://www.ebi.ac.uk/pdbsum/2nww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nww ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GLT_PYRHO GLT_PYRHO] Sodium-dependent, high-affinity amino acid transporter that mediates aspartate uptake (PubMed:17435767, PubMed:19380583, PubMed:17230192, Ref.11). Has only very low glutamate transport activity (PubMed:19380583, PubMed:17230192). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions, resulting in electrogenic transport (PubMed:17435767, PubMed:19380583, Ref.11). Na(+) binding enhances the affinity for aspartate (PubMed:19380583, Ref.11). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:17435767). In contrast to mammalian homologs, transport does not depend on pH or K(+) ions (PubMed:19380583).<ref>PMID:17230192</ref> <ref>PMID:17435767</ref> <ref>PMID:19380583</ref> [PDB:4P19]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Pyrococcus shinkaii]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Boudker, O]]	+	[[Category: Pyrococcus horikoshii]]
-	[[Category: Gouaux, E]]	+	[[Category: Boudker O]]
-	[[Category: Ryan, R]]	+	[[Category: Gouaux E]]
-	[[Category: Shimamoto, K]]	+	[[Category: Ryan R]]
-	[[Category: Yernool, D]]	+	[[Category: Shimamoto K]]
-	~~[[Category: Amino acid transporter]]~~	+	[[Category: Yernool D]]
-	~~[[Category: Aspartate transporter]]~~	+
-	~~[[Category: Binding site]]~~	+
-	~~[[Category: Inhibitor binding binding]]~~	+
-	~~[[Category: Transmembrane transporter]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 18:10, 20 October 2021

OCA — Wed, 20 Oct 2021 18:10:27 GMT

←Older revision		Revision as of 18:10, 20 October 2021
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	<StructureSection load='2nww' size='340' side='right'caption='[[2nww]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2nww' size='340' side='right'caption='[[2nww]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nww]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/'pyrococcus_shinkaii' 'pyrococcus shinkaii']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NWW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2NWW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nww]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/'pyrococcus_shinkaii' 'pyrococcus shinkaii']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NWW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TB1:(3S)-3-(BENZYLOXY)-L-ASPARTIC+ACID'>TB1</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TB1:(3S)-3-(BENZYLOXY)-L-ASPARTIC+ACID'>TB1</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xhf\|1xhf]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xhf\|1xhf]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2nww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nww OCA], [~~http~~://pdbe.org/2nww PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2nww RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2nww PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2nww ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nww OCA], [https://pdbe.org/2nww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nww RCSB], [https://www.ebi.ac.uk/pdbsum/2nww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nww ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 06:36, 20 May 2020

OCA — Wed, 20 May 2020 06:36:15 GMT

←Older revision		Revision as of 06:36, 20 May 2020
Line 1:		Line 1:

	==Crystal structure of GltPh in complex with TBOA==		==Crystal structure of GltPh in complex with TBOA==
-	<StructureSection load='2nww' size='340' side='right' caption='[[2nww]], [[Resolution\|resolution]] 3.20Å' scene=''>	+	<StructureSection load='2nww' size='340' side='right'caption='[[2nww]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nww]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/'pyrococcus_shinkaii' 'pyrococcus shinkaii']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NWW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2NWW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nww]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/'pyrococcus_shinkaii' 'pyrococcus shinkaii']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NWW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2NWW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TB1:(3S)-3-(BENZYLOXY)-L-ASPARTIC+ACID'>TB1</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TB1:(3S)-3-(BENZYLOXY)-L-ASPARTIC+ACID'>TB1</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xhf\|1xhf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xhf\|1xhf]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2nww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nww OCA], [http://pdbe.org/2nww PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nww RCSB], [http://www.ebi.ac.uk/pdbsum/2nww PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2nww ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2nww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nww OCA], [http://pdbe.org/2nww PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nww RCSB], [http://www.ebi.ac.uk/pdbsum/2nww PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2nww ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Pyrococcus shinkaii]]		[[Category: Pyrococcus shinkaii]]
		+	[[Category: Large Structures]]
	[[Category: Boudker, O]]		[[Category: Boudker, O]]
	[[Category: Gouaux, E]]		[[Category: Gouaux, E]]

OCA at 16:53, 15 August 2018

OCA — Wed, 15 Aug 2018 16:53:10 GMT

←Older revision		Revision as of 16:53, 15 August 2018
Line 1:		Line 1:
		+
	==Crystal structure of GltPh in complex with TBOA==		==Crystal structure of GltPh in complex with TBOA==
	<StructureSection load='2nww' size='340' side='right' caption='[[2nww]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2nww' size='340' side='right' caption='[[2nww]], [[Resolution\|resolution]] 3.20Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TB1:(3S)-3-(BENZYLOXY)-L-ASPARTIC+ACID'>TB1</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TB1:(3S)-3-(BENZYLOXY)-L-ASPARTIC+ACID'>TB1</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xhf\|1xhf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xhf\|1xhf]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nww OCA], [http://pdbe.org/2nww PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nww RCSB], [http://www.ebi.ac.uk/pdbsum/2nww PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nww OCA], [http://pdbe.org/2nww PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nww RCSB], [http://www.ebi.ac.uk/pdbsum/2nww PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2nww ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nw/2nww_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nw/2nww_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nww ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:42, 11 September 2015

OCA — Fri, 11 Sep 2015 21:42:34 GMT

←Older revision		Revision as of 21:42, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2nww' size='340' side='right' caption='[[2nww]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2nww' size='340' side='right' caption='[[2nww]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nww]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pyrococcus_horikoshii Pyrococcus horikoshii~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NWW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NWW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nww]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/'pyrococcus_shinkaii' 'pyrococcus shinkaii']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NWW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NWW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TB1:(3S)-3-(BENZYLOXY)-L-ASPARTIC+ACID'>TB1</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TB1:(3S)-3-(BENZYLOXY)-L-ASPARTIC+ACID'>TB1</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xhf\|1xhf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xhf\|1xhf]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nww OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nww RCSB], [http://www.ebi.ac.uk/pdbsum/2nww PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nww OCA], [http://pdbe.org/2nww PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nww RCSB], [http://www.ebi.ac.uk/pdbsum/2nww PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2nww" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Pyrococcus ~~horikoshii~~]]	+	[[Category: Pyrococcus shinkaii]]
	[[Category: Boudker, O]]		[[Category: Boudker, O]]
	[[Category: Gouaux, E]]		[[Category: Gouaux, E]]

OCA at 16:14, 19 January 2015

OCA — Mon, 19 Jan 2015 16:14:49 GMT

←Older revision		Revision as of 16:14, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2nww]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NWW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NWW FirstGlance]. <br>		<table><tr><td colspan='2'>[[2nww]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NWW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NWW FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TB1:(3S)-3-(BENZYLOXY)-L-ASPARTIC+ACID'>TB1</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TB1:(3S)-3-(BENZYLOXY)-L-ASPARTIC+ACID'>TB1</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xhf\|1xhf]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xhf\|1xhf]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nww OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nww RCSB], [http://www.ebi.ac.uk/pdbsum/2nww PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nww OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nww RCSB], [http://www.ebi.ac.uk/pdbsum/2nww PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Pyrococcus horikoshii]]		[[Category: Pyrococcus horikoshii]]
-	[[Category: Boudker, O.]]	+	[[Category: Boudker, O]]
-	[[Category: Gouaux, E.]]	+	[[Category: Gouaux, E]]
-	[[Category: Ryan, R.]]	+	[[Category: Ryan, R]]
-	[[Category: Shimamoto, K.]]	+	[[Category: Shimamoto, K]]
-	[[Category: Yernool, D.]]	+	[[Category: Yernool, D]]
	[[Category: Amino acid transporter]]		[[Category: Amino acid transporter]]
	[[Category: Aspartate transporter]]		[[Category: Aspartate transporter]]

OCA at 19:13, 30 September 2014

OCA — Tue, 30 Sep 2014 19:13:19 GMT

←Older revision		Revision as of 19:13, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2nww.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of GltPh in complex with TBOA==
		+	<StructureSection load='2nww' size='340' side='right' caption='[[2nww]], [[Resolution\|resolution]] 3.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2nww]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NWW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NWW FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TB1:(3S)-3-(BENZYLOXY)-L-ASPARTIC+ACID'>TB1</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xhf\|1xhf]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nww OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nww RCSB], [http://www.ebi.ac.uk/pdbsum/2nww PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nw/2nww_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Secondary transporters are integral membrane proteins that catalyse the movement of substrate molecules across the lipid bilayer by coupling substrate transport to one or more ion gradients, thereby providing a mechanism for the concentrative uptake of substrates. Here we describe crystallographic and thermodynamic studies of Glt(Ph), a sodium (Na+)-coupled aspartate transporter, defining sites for aspartate, two sodium ions and d,l-threo-beta-benzyloxyaspartate, an inhibitor. We further show that helical hairpin 2 is the extracellular gate that controls access of substrate and ions to the internal binding sites. At least two sodium ions bind in close proximity to the substrate and these sodium-binding sites, together with the sodium-binding sites in another sodium-coupled transporter, LeuT, define an unwound alpha-helix as the central element of the ion-binding motif, a motif well suited to the binding of sodium and to participation in conformational changes that accompany ion binding and unbinding during the transport cycle.

-	~~{{STRUCTURE_2nww\| PDB=2nww \| SCENE= }}~~	+	Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.,Boudker O, Ryan RM, Yernool D, Shimamoto K, Gouaux E Nature. 2007 Jan 25;445(7126):387-93. Epub 2007 Jan 17. PMID:17230192<ref>PMID:17230192</ref>

-	~~===Crystal structure~~ of ~~GltPh in complex with TBOA===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17230192}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2nww]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2NWW OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017230192<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Pyrococcus horikoshii]]		[[Category: Pyrococcus horikoshii]]
	[[Category: Boudker, O.]]		[[Category: Boudker, O.]]

OCA: Protected "2nww" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 11:31:25 GMT

Protected "2nww" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:31, 7 January 2013

OCA at 11:31, 7 January 2013

OCA — Mon, 07 Jan 2013 11:31:22 GMT

←Older revision		Revision as of 11:31, 7 January 2013
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-	{{Seed}}
	[[Image:2nww.png\|left\|200px]]		[[Image:2nww.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2nww", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2nww\| PDB=2nww \| SCENE= }}		{{STRUCTURE_2nww\| PDB=2nww \| SCENE= }}

	===Crystal structure of GltPh in complex with TBOA===		===Crystal structure of GltPh in complex with TBOA===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17230192}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17230192 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17230192}}		{{ABSTRACT_PUBMED_17230192}}

	==About this Structure==		==About this Structure==
-	~~2NWW~~ is a 3 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NWW OCA].	+	[[2nww]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NWW OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17230192~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017230192</ref><references group="xtra"/>
	[[Category: Pyrococcus horikoshii]]		[[Category: Pyrococcus horikoshii]]
	[[Category: Boudker, O.]]		[[Category: Boudker, O.]]
Line 35:		Line 23:
	[[Category: Inhibitor binding binding]]		[[Category: Inhibitor binding binding]]
	[[Category: Transmembrane transporter]]		[[Category: Transmembrane transporter]]
-		+	[[Category: Transport protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Feb 18 05:30:54 2009''~~	+

OCA at 03:30, 18 February 2009

OCA — Wed, 18 Feb 2009 03:30:55 GMT

←Older revision		Revision as of 03:30, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2NWW is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NWW OCA].	+	2NWW is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NWW OCA].

	==Reference==		==Reference==
-	Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter., Boudker O, Ryan RM, Yernool D, Shimamoto K, Gouaux E, Nature. 2007 Jan 25;445(7126):387-93. Epub 2007 Jan 17. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17230192 17230192]~~	+	<ref group="xtra">PMID:17230192</ref><references group="xtra"/>
	[[Category: Pyrococcus horikoshii]]		[[Category: Pyrococcus horikoshii]]
-	[[Category: Single protein]]
	[[Category: Boudker, O.]]		[[Category: Boudker, O.]]
	[[Category: Gouaux, E.]]		[[Category: Gouaux, E.]]
Line 37:		Line 36:
	[[Category: Transmembrane transporter]]		[[Category: Transmembrane transporter]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 12~~:12:~~44 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:30:54 2009''