2ny8 - Revision history

OCA at 00:11, 28 December 2023

OCA — Thu, 28 Dec 2023 00:11:42 GMT

←Older revision		Revision as of 00:11, 28 December 2023
Line 1:		Line 1:

	==NMR structure of antibacterial defensin DEF-AAA from the insect anopheles gambiae==		==NMR structure of antibacterial defensin DEF-AAA from the insect anopheles gambiae==
-	<StructureSection load='2ny8' size='340' side='right'caption='[[2ny8~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='2ny8' size='340' side='right'caption='[[2ny8]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ny8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Anoga Anoga~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NY8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NY8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ny8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NY8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NY8 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2ny9\|2ny9]], [[2nz3\|2nz3]], [[2e3e\|2e3e]], [[2e3f\|2e3f]], [[2e3g\|2e3g]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DEF1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 ANOGA])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ny8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ny8 OCA], [https://pdbe.org/2ny8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ny8 RCSB], [https://www.ebi.ac.uk/pdbsum/2ny8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ny8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ny8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ny8 OCA], [https://pdbe.org/2ny8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ny8 RCSB], [https://www.ebi.ac.uk/pdbsum/2ny8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ny8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DEFI_ANOGA DEFI_ANOGA]] Responsible for the anti Gram-positive activity of immune hemolymph (By similarity).	+	[https://www.uniprot.org/uniprot/DEFI_ANOGA DEFI_ANOGA] Responsible for the anti Gram-positive activity of immune hemolymph (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Anoga~~]]	+	[[Category: Anopheles gambiae]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Barbault, F]]	+	[[Category: Barbault F]]
-	[[Category: Landon, C]]	+	[[Category: Landon C]]
-	[[Category: Vovelle, F]]	+	[[Category: Vovelle F]]
-	~~[[Category: Antibacterial]]~~	+
-	~~[[Category: Antimicrobial protein]]~~	+
-	~~[[Category: Csab motif]]~~	+
-	~~[[Category: Insect defensin~~]]	+

OCA at 15:54, 8 June 2021

OCA — Tue, 08 Jun 2021 15:54:52 GMT

←Older revision		Revision as of 15:54, 8 June 2021
Line 1:		Line 1:

	==NMR structure of antibacterial defensin DEF-AAA from the insect anopheles gambiae==		==NMR structure of antibacterial defensin DEF-AAA from the insect anopheles gambiae==
-	<StructureSection load='2ny8' size='340' side='right' caption='[[2ny8]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='2ny8' size='340' side='right'caption='[[2ny8]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ny8]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Anoga Anoga]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NY8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2NY8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ny8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Anoga Anoga]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NY8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NY8 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ny9\|2ny9]], [[2nz3\|2nz3]], [[2e3e\|2e3e]], [[2e3f\|2e3f]], [[2e3g\|2e3g]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ny9\|2ny9]], [[2nz3\|2nz3]], [[2e3e\|2e3e]], [[2e3f\|2e3f]], [[2e3g\|2e3g]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DEF1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 ANOGA])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DEF1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 ANOGA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ny8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ny8 OCA], [~~http~~://pdbe.org/2ny8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ny8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ny8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ny8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ny8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ny8 OCA], [https://pdbe.org/2ny8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ny8 RCSB], [https://www.ebi.ac.uk/pdbsum/2ny8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ny8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DEFI_ANOGA DEFI_ANOGA]] Responsible for the anti Gram-positive activity of immune hemolymph (By similarity).	+	[[https://www.uniprot.org/uniprot/DEFI_ANOGA DEFI_ANOGA]] Responsible for the anti Gram-positive activity of immune hemolymph (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Defensin\|Defensin]]	+	*[[Defensin 3D structures\|Defensin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Anoga]]		[[Category: Anoga]]
		+	[[Category: Large Structures]]
	[[Category: Barbault, F]]		[[Category: Barbault, F]]
	[[Category: Landon, C]]		[[Category: Landon, C]]

OCA at 16:50, 15 August 2018

OCA — Wed, 15 Aug 2018 16:50:17 GMT

←Older revision		Revision as of 16:50, 15 August 2018
Line 1:		Line 1:
		+
	==NMR structure of antibacterial defensin DEF-AAA from the insect anopheles gambiae==		==NMR structure of antibacterial defensin DEF-AAA from the insect anopheles gambiae==
	<StructureSection load='2ny8' size='340' side='right' caption='[[2ny8]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2ny8' size='340' side='right' caption='[[2ny8]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ny9\|2ny9]], [[2nz3\|2nz3]], [[2e3e\|2e3e]], [[2e3f\|2e3f]], [[2e3g\|2e3g]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ny9\|2ny9]], [[2nz3\|2nz3]], [[2e3e\|2e3e]], [[2e3f\|2e3f]], [[2e3g\|2e3g]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DEF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 ANOGA])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DEF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 ANOGA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ny8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ny8 OCA], [http://pdbe.org/2ny8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ny8 RCSB], [http://www.ebi.ac.uk/pdbsum/2ny8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ny8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ny8 OCA], [http://pdbe.org/2ny8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ny8 RCSB], [http://www.ebi.ac.uk/pdbsum/2ny8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ny8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ny/2ny8_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ny/2ny8_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ny8 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:50, 11 September 2015

OCA — Fri, 11 Sep 2015 11:50:24 GMT

←Older revision		Revision as of 11:50, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2ny8' size='340' side='right' caption='[[2ny8]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2ny8' size='340' side='right' caption='[[2ny8]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ny8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Anopheles_gambiae Anopheles gambiae~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NY8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NY8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ny8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anoga Anoga]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NY8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NY8 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ny9\|2ny9]], [[2nz3\|2nz3]], [[2e3e\|2e3e]], [[2e3f\|2e3f]], [[2e3g\|2e3g]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ny9\|2ny9]], [[2nz3\|2nz3]], [[2e3e\|2e3e]], [[2e3f\|2e3f]], [[2e3g\|2e3g]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DEF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 ~~Anopheles gambiae~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DEF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 ANOGA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ny8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ny8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ny8 RCSB], [http://www.ebi.ac.uk/pdbsum/2ny8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ny8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ny8 OCA], [http://pdbe.org/2ny8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ny8 RCSB], [http://www.ebi.ac.uk/pdbsum/2ny8 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2ny8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Anopheles gambiae~~]]	+	[[Category: Anoga]]
	[[Category: Barbault, F]]		[[Category: Barbault, F]]
	[[Category: Landon, C]]		[[Category: Landon, C]]

OCA at 16:04, 25 December 2014

OCA — Thu, 25 Dec 2014 16:04:44 GMT

←Older revision		Revision as of 16:04, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ny8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NY8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NY8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ny8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NY8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NY8 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ny9\|2ny9]], [[2nz3\|2nz3]], [[2e3e\|2e3e]], [[2e3f\|2e3f]], [[2e3g\|2e3g]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ny9\|2ny9]], [[2nz3\|2nz3]], [[2e3e\|2e3e]], [[2e3f\|2e3f]], [[2e3g\|2e3g]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DEF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 Anopheles gambiae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DEF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 Anopheles gambiae])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ny8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ny8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ny8 RCSB], [http://www.ebi.ac.uk/pdbsum/2ny8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ny8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ny8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ny8 RCSB], [http://www.ebi.ac.uk/pdbsum/2ny8 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DEFI_ANOGA DEFI_ANOGA]] Responsible for the anti Gram-positive activity of immune hemolymph (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Anopheles gambiae]]		[[Category: Anopheles gambiae]]
-	[[Category: Barbault, F.]]	+	[[Category: Barbault, F]]
-	[[Category: Landon, C.]]	+	[[Category: Landon, C]]
-	[[Category: Vovelle, F.]]	+	[[Category: Vovelle, F]]
	[[Category: Antibacterial]]		[[Category: Antibacterial]]
	[[Category: Antimicrobial protein]]		[[Category: Antimicrobial protein]]
	[[Category: Csab motif]]		[[Category: Csab motif]]
	[[Category: Insect defensin]]		[[Category: Insect defensin]]

OCA at 19:11, 30 September 2014

OCA — Tue, 30 Sep 2014 19:11:24 GMT

←Older revision		Revision as of 19:11, 30 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2ny8\| PDB=2ny8 \| SCENE= }}~~	+	==NMR structure of antibacterial defensin DEF-AAA from the insect anopheles gambiae==
-	===NMR structure of antibacterial defensin DEF-AAA from the insect anopheles gambiae===	+	<StructureSection load='2ny8' size='340' side='right' caption='[[2ny8]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_18214975}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2ny8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NY8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NY8 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ny9\|2ny9]], [[2nz3\|2nz3]], [[2e3e\|2e3e]], [[2e3f\|2e3f]], [[2e3g\|2e3g]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DEF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 Anopheles gambiae])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ny8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ny8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ny8 RCSB], [http://www.ebi.ac.uk/pdbsum/2ny8 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ny/2ny8_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In an attempt to increase the antimicrobial activity of the insect defensin from Anopheles gambiae, which is active against Staphylococcus aureus at low concentration, hybrid defensins were designed by combining conserved sequence regions and variable regions of insect defensins. Their activity against S. aureus strains sensitive and resistant to conventional antibiotics was evaluated, and the toxicity of the most active molecules was tested. The three-dimensional structure of Anopheles gambiae defensin and five hybrids were determined by NMR and molecular modelling. This strategy led to the design of two chimeric defensins with increased activity compared with the native molecule, but one of them appears to be toxic to mice at a rather low concentration. The structure of the CS alphabeta motif, which is a characteristic of insect defensin, is sensitive to sequence modifications, in particular in the N-terminal loop. The existence of the CS alphabeta is most probably a prerequisite for the stability and the activity of the molecule, but is not sufficient by itself since the hybrid displaying the best defined structure is not active against the tested strains. The analysis of the structure, in relation with the activity and the toxicity data, underlines the importance of turns and of the N-terminal loop. Residues located in the turns contributing to the preservation of positive electrostatic areas at the surface of the molecules seem particularly important for the activity of the molecule, while residues involved in the N-terminal loop are both involved in the modulation of the activity and the toxicity of the molecule.

-	~~==About this Structure==~~	+	Rational design of peptides active against the gram positive bacteria Staphylococcus aureus.,Landon C, Barbault F, Legrain M, Guenneugues M, Vovelle F Proteins. 2008 Jul;72(1):229-39. PMID:18214975<ref>PMID:18214975</ref>
-	~~[[2ny8]] is a~~ 1 ~~chain structure with sequence from [http~~:~~//en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]~~. ~~Full experimental information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2NY8 OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Defensin\|Defensin]]		*[[Defensin\|Defensin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018214975<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Anopheles gambiae]]		[[Category: Anopheles gambiae]]
	[[Category: Barbault, F.]]		[[Category: Barbault, F.]]

OCA at 10:14, 11 March 2013

OCA — Mon, 11 Mar 2013 10:14:25 GMT

←Older revision		Revision as of 10:14, 11 March 2013
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-	[[Image:2ny8.png\|left\|200px]]
-
	{{STRUCTURE_2ny8\| PDB=2ny8 \| SCENE= }}		{{STRUCTURE_2ny8\| PDB=2ny8 \| SCENE= }}
-
	===NMR structure of antibacterial defensin DEF-AAA from the insect anopheles gambiae===		===NMR structure of antibacterial defensin DEF-AAA from the insect anopheles gambiae===
-
	{{ABSTRACT_PUBMED_18214975}}		{{ABSTRACT_PUBMED_18214975}}

OCA: Protected "2ny8" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 11:29:01 GMT

Protected "2ny8" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:29, 7 January 2013

OCA at 11:28, 7 January 2013

OCA — Mon, 07 Jan 2013 11:28:58 GMT

←Older revision		Revision as of 11:28, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2ny8.png\|left\|200px]]		[[Image:2ny8.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2ny8", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2ny8\| PDB=2ny8 \| SCENE= }}		{{STRUCTURE_2ny8\| PDB=2ny8 \| SCENE= }}

	===NMR structure of antibacterial defensin DEF-AAA from the insect anopheles gambiae===		===NMR structure of antibacterial defensin DEF-AAA from the insect anopheles gambiae===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18214975}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18214975 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18214975}}		{{ABSTRACT_PUBMED_18214975}}

	==About this Structure==		==About this Structure==
-	~~2NY8~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NY8 OCA].	+	[[2ny8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NY8 OCA].
		+
		+	==See Also==
		+	*[[Defensin\|Defensin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18214975~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018214975</ref><references group="xtra"/>
	[[Category: Anopheles gambiae]]		[[Category: Anopheles gambiae]]
	[[Category: Barbault, F.]]		[[Category: Barbault, F.]]
Line 32:		Line 23:
	[[Category: Csab motif]]		[[Category: Csab motif]]
	[[Category: Insect defensin]]		[[Category: Insect defensin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:15:23 2009''

OCA at 19:15, 17 February 2009

OCA — Tue, 17 Feb 2009 19:15:24 GMT

←Older revision		Revision as of 19:15, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2NY8 is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NY8 OCA].	+	2NY8 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NY8 OCA].

	==Reference==		==Reference==
-	~~Rational design of peptides active against the gram positive bacteria Staphylococcus aureus., Landon C, Barbault F, Legrain M, Guenneugues M, Vovelle F, Proteins. 2008 Jul;72(1):229-39.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18214975 18214975]~~	+	<ref group="xtra">PMID:18214975</ref><references group="xtra"/>
	[[Category: Anopheles gambiae]]		[[Category: Anopheles gambiae]]
-	[[Category: Single protein]]
	[[Category: Barbault, F.]]		[[Category: Barbault, F.]]
	[[Category: Landon, C.]]		[[Category: Landon, C.]]
Line 34:		Line 33:
	[[Category: Insect defensin]]		[[Category: Insect defensin]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 23 10~~:05:~~50 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:15:23 2009''