2nzy - Revision history

OCA at 08:56, 25 October 2023

OCA — Wed, 25 Oct 2023 08:56:05 GMT

←Older revision		Revision as of 08:56, 25 October 2023
Line 3:		Line 3:
	<StructureSection load='2nzy' size='340' side='right'caption='[[2nzy]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='2nzy' size='340' side='right'caption='[[2nzy]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nzy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_43504 Atcc 43504~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NZY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NZY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nzy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NZY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NZY FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FUC:ALPHA~~-~~L-FUCOSE'>FUC</scene>~~, ~~<scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2nzw\|2nzw]], [[2nzx\|2nzx]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b></td><td class="sblockDat">AF008596 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=~~5~~&id=210 ATCC 43504])</td~~></tr>	+
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>[https://en.wikipedia.org/wiki/4-galactosyl-N-acetylglucosaminide_3-alpha-L-fucosyltransferase 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.152 2.4.1.152] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nzy OCA], [https://pdbe.org/2nzy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nzy RCSB], [https://www.ebi.ac.uk/pdbsum/2nzy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nzy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nzy OCA], [https://pdbe.org/2nzy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nzy RCSB], [https://www.ebi.ac.uk/pdbsum/2nzy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nzy ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FUCT_HELPX FUCT_HELPX] Involved in the biosynthesis of the Lewis X (LeX) trisaccharide of the lipopolysaccharide (LPS) O-antigen. Catalyzes the addition of fucose in alpha 1-3 linkage to Gal-beta-1-4-GlcNAc-beta-O-R (LacNAc-R) type II acceptor.<ref>PMID:12676935</ref> <ref>PMID:16150700</ref> <ref>PMID:16800635</ref> <ref>PMID:17251184</ref> <ref>PMID:9261149</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase]]~~	+	[[Category: Helicobacter pylori]]
-	~~[[Category: Atcc 43504~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ko~~, T P~~]]	+	[[Category: Ko TP]]
-	[[Category: Sun~~, H Y]]~~	+	[[Category: Sun HY]]
-	~~[[Category: 3-fucosyltransferase]]~~	+
-	~~[[Category: Alpha1]]~~	+
-	~~[[Category: Fucosyltransferase]]~~	+
-	~~[[Category: Fuct]]~~	+
-	~~[[Category: Gt 10]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 15:56, 8 June 2021

OCA — Tue, 08 Jun 2021 15:56:21 GMT

←Older revision		Revision as of 15:56, 8 June 2021
Line 1:		Line 1:

	==Crystal Structure of alpha1,3-Fucosyltransferase with GDP-fucose==		==Crystal Structure of alpha1,3-Fucosyltransferase with GDP-fucose==
-	<StructureSection load='2nzy' size='340' side='right' caption='[[2nzy]], [[Resolution\|resolution]] 2.05Å' scene=''>	+	<StructureSection load='2nzy' size='340' side='right'caption='[[2nzy]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nzy]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NZY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2NZY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nzy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NZY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NZY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nzw\|2nzw]], [[2nzx\|2nzx]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2nzw\|2nzw]], [[2nzx\|2nzx]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AF008596 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 ATCC 43504])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AF008596 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 ATCC 43504])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/4-galactosyl-N-acetylglucosaminide_3-alpha-L-fucosyltransferase 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.152 2.4.1.152] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/4-galactosyl-N-acetylglucosaminide_3-alpha-L-fucosyltransferase 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.152 2.4.1.152] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2nzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nzy OCA], [~~http~~://pdbe.org/2nzy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2nzy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2nzy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2nzy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nzy OCA], [https://pdbe.org/2nzy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nzy RCSB], [https://www.ebi.ac.uk/pdbsum/2nzy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nzy ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nz/2nzy_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nz/2nzy_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 35:		Line 35:
	[[Category: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase]]		[[Category: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase]]
	[[Category: Atcc 43504]]		[[Category: Atcc 43504]]
		+	[[Category: Large Structures]]
	[[Category: Ko, T P]]		[[Category: Ko, T P]]
	[[Category: Sun, H Y]]		[[Category: Sun, H Y]]

OCA at 07:22, 16 November 2017

OCA — Thu, 16 Nov 2017 07:22:31 GMT

←Older revision		Revision as of 07:22, 16 November 2017
Line 1:		Line 1:
		+
	==Crystal Structure of alpha1,3-Fucosyltransferase with GDP-fucose==		==Crystal Structure of alpha1,3-Fucosyltransferase with GDP-fucose==
	<StructureSection load='2nzy' size='340' side='right' caption='[[2nzy]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='2nzy' size='340' side='right' caption='[[2nzy]], [[Resolution\|resolution]] 2.05Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AF008596 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 ATCC 43504])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AF008596 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 ATCC 43504])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-galactosyl-N-acetylglucosaminide_3-alpha-L-fucosyltransferase 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.152 2.4.1.152] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-galactosyl-N-acetylglucosaminide_3-alpha-L-fucosyltransferase 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.152 2.4.1.152] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nzy OCA], [http://pdbe.org/2nzy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nzy RCSB], [http://www.ebi.ac.uk/pdbsum/2nzy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nzy OCA], [http://pdbe.org/2nzy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nzy RCSB], [http://www.ebi.ac.uk/pdbsum/2nzy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2nzy ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nzy ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Helicobacter pylori alpha1,3-fucosyltransferase (FucT) is involved in catalysis to produce the Lewis x trisaccharide, the major component of the bacteria's lipopolysaccharides, which has been suggested to mimic the surface sugars in gastric epithelium to escape host immune surveillance. We report here three x-ray crystal structures of FucT, including the FucT.GDP-fucose and FucT.GDP complexes. The protein structure is typical of the glycosyltransferase-B family despite little sequence homology. We identified a number of catalytically important residues, including Glu-95, which serves as the general base, and Glu-249, which stabilizes the developing oxonium ion during catalysis. The residues Arg-195, Tyr-246, Glu-249, and Lys-250 serve to interact with the donor substrate, GDP-fucose. Variations in the protein and ligand conformations, as well as a possible FucT dimer, were also observed. We propose a catalytic mechanism and a model of polysaccharide binding not only to explain the observed variations in H. pylori lipopolysaccharides, but also to facilitate the development of potent inhibitors.
		+
		+	Structure and mechanism of Helicobacter pylori fucosyltransferase. A basis for lipopolysaccharide variation and inhibitor design.,Sun HY, Lin SW, Ko TP, Pan JF, Liu CL, Lin CN, Wang AH, Lin CH J Biol Chem. 2007 Mar 30;282(13):9973-82. Epub 2007 Jan 24. PMID:17251184<ref>PMID:17251184</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 2nzy" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:22, 11 September 2015

OCA — Fri, 11 Sep 2015 11:22:00 GMT

←Older revision		Revision as of 11:22, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2nzy' size='340' side='right' caption='[[2nzy]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='2nzy' size='340' side='right' caption='[[2nzy]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nzy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Helicobacter_pylori Helicobacter pylori~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NZY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NZY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nzy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NZY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NZY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nzw\|2nzw]], [[2nzx\|2nzx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nzw\|2nzw]], [[2nzx\|2nzx]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AF008596 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 ~~Helicobacter pylori~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AF008596 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 ATCC 43504])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-galactosyl-N-acetylglucosaminide_3-alpha-L-fucosyltransferase 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.152 2.4.1.152] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-galactosyl-N-acetylglucosaminide_3-alpha-L-fucosyltransferase 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.152 2.4.1.152] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nzy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nzy RCSB], [http://www.ebi.ac.uk/pdbsum/2nzy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nzy OCA], [http://pdbe.org/2nzy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nzy RCSB], [http://www.ebi.ac.uk/pdbsum/2nzy PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase]]		[[Category: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase]]
-	[[Category: ~~Helicobacter pylori~~]]	+	[[Category: Atcc 43504]]
	[[Category: Ko, T P]]		[[Category: Ko, T P]]
	[[Category: Sun, H Y]]		[[Category: Sun, H Y]]

OCA at 15:18, 19 January 2015

OCA — Mon, 19 Jan 2015 15:18:47 GMT

←Older revision		Revision as of 15:18, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2nzy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NZY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NZY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2nzy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NZY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NZY FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nzw\|2nzw]], [[2nzx\|2nzx]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nzw\|2nzw]], [[2nzx\|2nzx]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AF008596 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 Helicobacter pylori])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AF008596 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 Helicobacter pylori])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-galactosyl-N-acetylglucosaminide_3-alpha-L-fucosyltransferase 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.152 2.4.1.152] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-galactosyl-N-acetylglucosaminide_3-alpha-L-fucosyltransferase 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.152 2.4.1.152] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nzy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nzy RCSB], [http://www.ebi.ac.uk/pdbsum/2nzy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nzy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nzy RCSB], [http://www.ebi.ac.uk/pdbsum/2nzy PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 23:		Line 23:
	[[Category: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase]]		[[Category: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase]]
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]
-	[[Category: Ko, T P.]]	+	[[Category: Ko, T P]]
-	[[Category: Sun, H Y.]]	+	[[Category: Sun, H Y]]
	[[Category: 3-fucosyltransferase]]		[[Category: 3-fucosyltransferase]]
	[[Category: Alpha1]]		[[Category: Alpha1]]

OCA at 18:45, 30 September 2014

OCA — Tue, 30 Sep 2014 18:45:05 GMT

←Older revision		Revision as of 18:45, 30 September 2014
Line 1:		Line 1:
-	~~[[Image:2nzy.png\|left\|200px]]~~	+	==Crystal Structure of alpha1,3-Fucosyltransferase with GDP-fucose==
-		+	<StructureSection load='2nzy' size='340' side='right' caption='[[2nzy]], [[Resolution\|resolution]] 2.05Å' scene=''>
-	~~{{STRUCTURE_2nzy\| PDB=2nzy \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2nzy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NZY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NZY FirstGlance]. <br>
-	===Crystal Structure of alpha1,3-Fucosyltransferase with GDP-fucose===	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nzw\|2nzw]], [[2nzx\|2nzx]]</td></tr>
-	~~{{ABSTRACT_PUBMED_017251184}}~~	+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AF008596 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 Helicobacter pylori])</td></tr>
-		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-galactosyl-N-acetylglucosaminide_3-alpha-L-fucosyltransferase 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.152 2.4.1.152] </span></td></tr>
-	==~~About this Structure~~==	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nzy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nzy RCSB], [http://www.ebi.ac.uk/pdbsum/2nzy PDBsum]</span></td></tr>
-	[[2nzy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NZY OCA].	+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nz/2nzy_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	__TOC__
		+	</StructureSection>
	[[Category: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase]]		[[Category: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase]]
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]

OCA: Protected "2nzy" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 11:02:21 GMT

Protected "2nzy" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:02, 7 January 2013

OCA at 11:02, 7 January 2013

OCA — Mon, 07 Jan 2013 11:02:18 GMT

←Older revision		Revision as of 11:02, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2nzy.png\|left\|200px]]		[[Image:2nzy.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2nzy", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2nzy\| PDB=2nzy \| SCENE= }}		{{STRUCTURE_2nzy\| PDB=2nzy \| SCENE= }}

	===Crystal Structure of alpha1,3-Fucosyltransferase with GDP-fucose===		===Crystal Structure of alpha1,3-Fucosyltransferase with GDP-fucose===

		+	{{ABSTRACT_PUBMED_017251184}}

	==About this Structure==		==About this Structure==
-	~~2NZY~~ is a 3 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NZY OCA].	+	[[2nzy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NZY OCA].
	[[Category: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase]]		[[Category: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase]]
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]
	[[Category: Ko, T P.]]		[[Category: Ko, T P.]]
	[[Category: Sun, H Y.]]		[[Category: Sun, H Y.]]
-	[[Category: ~~Alpha1,~~3-fucosyltransferase]]	+	[[Category: 3-fucosyltransferase]]
		+	[[Category: Alpha1]]
	[[Category: Fucosyltransferase]]		[[Category: Fucosyltransferase]]
	[[Category: Fuct]]		[[Category: Fuct]]
	[[Category: Gt 10]]		[[Category: Gt 10]]
-		+	[[Category: Transferase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 20:51:04 2009''~~	+

OCA at 18:51, 17 February 2009

OCA — Tue, 17 Feb 2009 18:51:06 GMT

←Older revision		Revision as of 18:51, 17 February 2009
Line 1:		Line 1:
-	[[Image:2nzy.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2nzy.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2nzy\| PDB=2nzy \| SCENE= }}		{{STRUCTURE_2nzy\| PDB=2nzy \| SCENE= }}

-	~~'''~~Crystal Structure of alpha1,3-Fucosyltransferase with GDP-fucose~~'''~~	+	===Crystal Structure of alpha1,3-Fucosyltransferase with GDP-fucose===


	==About this Structure==		==About this Structure==
-	2NZY is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NZY OCA].	+	2NZY is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NZY OCA].
	[[Category: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase]]		[[Category: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase]]
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]
-	[[Category: Single protein]]
	[[Category: Ko, T P.]]		[[Category: Ko, T P.]]
	[[Category: Sun, H Y.]]		[[Category: Sun, H Y.]]
Line 23:		Line 23:
	[[Category: Fuct]]		[[Category: Fuct]]
	[[Category: Gt 10]]		[[Category: Gt 10]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 10~~:07:~~53 2008~~''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:51:04 2009''

OCA at 07:07, 4 May 2008

OCA — Sun, 04 May 2008 07:07:53 GMT

←Older revision		Revision as of 07:07, 4 May 2008
Line 1:		Line 1:
	[[Image:2nzy.gif\|left\|200px]]		[[Image:2nzy.gif\|left\|200px]]

-	~~{{Structure~~	+	<!--
-	~~\|PDB= 2nzy \|SIZE=350\|CAPTION=~~ <~~scene name='initialview01'>2nzy</scene>, resolution 2.05Å~~	+	The line below this paragraph, containing "STRUCTURE_2nzy", creates the "Structure Box" on the page.
-	~~\|SITE=~~	+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	~~\|LIGAND= <scene name='pdbligand=FUC:ALPHA~~-L-~~FUCOSE'>FUC</scene>~~, ~~<scene name='pdbligand=GDP:GUANOSINE-5'-DIPHOSPHATE'>GDP</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~	+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	~~\|ACTIVITY= <span class='plainlinks'>[http://en~~.wikipedia.org/wiki/4-galactosyl-N-acetylglucosaminide_3-alpha-L-fucosyltransferase 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.152 2.4.1.152] </span>	+	or leave the SCENE parameter empty for the default display.
-	~~\|GENE= AF008596~~ (~~[http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 Helicobacter pylori]~~)	+	-->
-	~~\|DOMAIN=~~	+	{{STRUCTURE_2nzy\| PDB=2nzy \| SCENE= }}
-	~~\|RELATEDENTRY=[[2nzw\|2NZW]]~~, ~~[[2nzx\|2NZX]]~~	+
-	~~\|RESOURCES=<span class='plainlinks'>[http://oca~~.~~weizmann.ac.il/oca~~-~~docs/fgij/fg.htm?mol=2nzy FirstGlance], [http://oca.weizmann.ac.il/oca~~-~~bin/ocaids?id~~=2nzy ~~OCA], [http://www.ebi.ac.uk/pdbsum/2nzy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId~~=~~2nzy RCSB]</span>~~	+
-	}}	+

	'''Crystal Structure of alpha1,3-Fucosyltransferase with GDP-fucose'''		'''Crystal Structure of alpha1,3-Fucosyltransferase with GDP-fucose'''
Line 22:		Line 19:
	[[Category: Ko, T P.]]		[[Category: Ko, T P.]]
	[[Category: Sun, H Y.]]		[[Category: Sun, H Y.]]
-	[[Category: ~~alpha1~~,3-fucosyltransferase]]	+	[[Category: Alpha1,3-fucosyltransferase]]
-	[[Category: ~~fucosyltransferase~~]]	+	[[Category: Fucosyltransferase]]
-	[[Category: ~~fuct~~]]	+	[[Category: Fuct]]
-	[[Category: gt 10]]	+	[[Category: Gt 10]]
-		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:07:53 2008''
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Mar 31 04:~~10:47 2008''	+