2o74 - Revision history

OCA at 08:56, 25 October 2023

OCA — Wed, 25 Oct 2023 08:56:37 GMT

←Older revision		Revision as of 08:56, 25 October 2023
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	<StructureSection load='2o74' size='340' side='right'caption='[[2o74]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2o74' size='340' side='right'caption='[[2o74]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2o74]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Brachidanio_rerio Brachidanio~~ rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O74 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O74 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2o74]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O74 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O74 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GUN:GUANINE'>GUN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[2o70\|2o70]], [[2o73\|2o73]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GUN:GUANINE'>GUN</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">zgc:158663 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o74 OCA], [https://pdbe.org/2o74 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o74 RCSB], [https://www.ebi.ac.uk/pdbsum/2o74 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o74 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o74 OCA], [https://pdbe.org/2o74 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o74 RCSB], [https://www.ebi.ac.uk/pdbsum/2o74 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o74 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/URAD_DANRE URAD_DANRE]] Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.	+	[https://www.uniprot.org/uniprot/URAD_DANRE URAD_DANRE] Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Brachidanio~~ rerio]]	+	[[Category: Danio rerio]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Berni, R]]	+	[[Category: Berni R]]
-	[[Category: Cendron, L]]	+	[[Category: Cendron L]]
-	[[Category: Folli, C]]	+	[[Category: Folli C]]
-	[[Category: Percudani, R]]	+	[[Category: Percudani R]]
-	[[Category: Ramazzina, I]]	+	[[Category: Ramazzina I]]
-	[[Category: Zanotti, G]]	+	[[Category: Zanotti G]]
-	~~[[Category: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline]]~~	+
-	~~[[Category: 5-hydroxyisourate]]~~	+
-	~~[[Category: Decarboxylation]]~~	+
-	~~[[Category: Hiu]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Ohcu~~]]	+

OCA at 16:01, 8 June 2021

OCA — Tue, 08 Jun 2021 16:01:56 GMT

←Older revision		Revision as of 16:01, 8 June 2021
Line 1:		Line 1:

	==Structure of OHCU decarboxylase in complex with guanine==		==Structure of OHCU decarboxylase in complex with guanine==
-	<StructureSection load='2o74' size='340' side='right' caption='[[2o74]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='2o74' size='340' side='right'caption='[[2o74]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2o74]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O74 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2O74 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2o74]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O74 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O74 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GUN:GUANINE'>GUN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GUN:GUANINE'>GUN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o70\|2o70]], [[2o73\|2o73]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2o70\|2o70]], [[2o73\|2o73]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">zgc:158663 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">zgc:158663 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2o74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o74 OCA], [~~http~~://pdbe.org/2o74 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2o74 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2o74 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2o74 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o74 OCA], [https://pdbe.org/2o74 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o74 RCSB], [https://www.ebi.ac.uk/pdbsum/2o74 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o74 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/URAD_DANRE URAD_DANRE]] Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.	+	[[https://www.uniprot.org/uniprot/URAD_DANRE URAD_DANRE]] Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Brachidanio rerio]]		[[Category: Brachidanio rerio]]
		+	[[Category: Large Structures]]
	[[Category: Berni, R]]		[[Category: Berni, R]]
	[[Category: Cendron, L]]		[[Category: Cendron, L]]

OCA at 07:24, 22 August 2018

OCA — Wed, 22 Aug 2018 07:24:52 GMT

←Older revision		Revision as of 07:24, 22 August 2018
Line 1:		Line 1:
		+
	==Structure of OHCU decarboxylase in complex with guanine==		==Structure of OHCU decarboxylase in complex with guanine==
	<StructureSection load='2o74' size='340' side='right' caption='[[2o74]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2o74' size='340' side='right' caption='[[2o74]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o70\|2o70]], [[2o73\|2o73]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o70\|2o70]], [[2o73\|2o73]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">zgc:158663 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">zgc:158663 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o74 OCA], [http://pdbe.org/2o74 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2o74 RCSB], [http://www.ebi.ac.uk/pdbsum/2o74 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o74 OCA], [http://pdbe.org/2o74 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2o74 RCSB], [http://www.ebi.ac.uk/pdbsum/2o74 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2o74 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o7/2o74_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o7/2o74_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 22:47, 9 February 2016

OCA — Tue, 09 Feb 2016 22:47:10 GMT

←Older revision		Revision as of 22:47, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o74 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:48, 11 September 2015

OCA — Fri, 11 Sep 2015 02:48:26 GMT

←Older revision		Revision as of 02:48, 11 September 2015
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o70\|2o70]], [[2o73\|2o73]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o70\|2o70]], [[2o73\|2o73]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">zgc:158663 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">zgc:158663 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o74 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2o74 RCSB], [http://www.ebi.ac.uk/pdbsum/2o74 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o74 OCA], [http://pdbe.org/2o74 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2o74 RCSB], [http://www.ebi.ac.uk/pdbsum/2o74 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2o74" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:04, 25 December 2014

OCA — Thu, 25 Dec 2014 10:04:12 GMT

←Older revision		Revision as of 10:04, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2o74]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O74 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O74 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2o74]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O74 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O74 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GUN:GUANINE'>GUN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GUN:GUANINE'>GUN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o70\|2o70]], [[2o73\|2o73]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o70\|2o70]], [[2o73\|2o73]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">zgc:158663 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">zgc:158663 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o74 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2o74 RCSB], [http://www.ebi.ac.uk/pdbsum/2o74 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o74 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2o74 RCSB], [http://www.ebi.ac.uk/pdbsum/2o74 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/URAD_DANRE URAD_DANRE]] Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Brachidanio rerio]]		[[Category: Brachidanio rerio]]
-	[[Category: Berni, R.]]	+	[[Category: Berni, R]]
-	[[Category: Cendron, L.]]	+	[[Category: Cendron, L]]
-	[[Category: Folli, C.]]	+	[[Category: Folli, C]]
-	[[Category: Percudani, R.]]	+	[[Category: Percudani, R]]
-	[[Category: Ramazzina, I.]]	+	[[Category: Ramazzina, I]]
-	[[Category: Zanotti, G.]]	+	[[Category: Zanotti, G]]
	[[Category: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline]]		[[Category: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline]]
	[[Category: 5-hydroxyisourate]]		[[Category: 5-hydroxyisourate]]

OCA at 10:56, 3 October 2014

OCA — Fri, 03 Oct 2014 10:56:21 GMT

←Older revision		Revision as of 10:56, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2o74~~\| ~~PDB~~=2o74 \| ~~SCENE~~= }}	+	==Structure of OHCU decarboxylase in complex with guanine==
-	===~~Structure~~ of ~~OHCU~~ decarboxylase in complex with guanine~~===~~	+	<StructureSection load='2o74' size='340' side='right' caption='[[2o74]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_17428786}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2o74]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O74 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O74 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GUN:GUANINE'>GUN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o70\|2o70]], [[2o73\|2o73]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">zgc:158663 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o74 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2o74 RCSB], [http://www.ebi.ac.uk/pdbsum/2o74 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o7/2o74_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The complete degradation of uric acid to (S)-allantoin, as recently elucidated, involves three enzymatic reactions. Inactivation by pseudogenization of the genes of the pathway occurred during hominoid evolution, resulting in a high concentration of urate in the blood and susceptibility to gout. Here, we describe the 1.8A resolution crystal structure of the homodimeric 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase, which catalyzes the last step in the urate degradation pathway, for both ligand-free enzyme and enzyme in complex with the substrate analogs (R)-allantoin and guanine. Each monomer comprises ten alpha-helices, grouped into two domains and assembled in a novel fold. The structure and the mutational analysis of the active site have allowed us to identify some residues that are essential for catalysis, among which His-67 and Glu-87 appear to play a particularly significant role. Glu-87 may facilitate the exit of the carboxylate group because of electrostatic repulsion that destabilizes the ground state of the substrate, whereas His-67 is likely to be involved in a protonation step leading to the stereoselective formation of the (S)-allantoin enantiomer as reaction product. The structural and functional characterization of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase can provide useful information in view of the potential use of this enzyme in the enzymatic therapy of gout.

-	~~==Function==~~	+	The structure of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase provides insights into the mechanism of uric acid degradation.,Cendron L, Berni R, Folli C, Ramazzina I, Percudani R, Zanotti G J Biol Chem. 2007 Jun 22;282(25):18182-9. Epub 2007 Apr 11. PMID:17428786<ref>PMID:17428786</ref>
-	~~[[http://www.uniprot.org/uniprot/URAD_DANRE URAD_DANRE]] Catalyzes the stereoselective decarboxylation~~ of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (~~OHCU) to (S~~)-~~allantoin~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2o74]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Brachidanio_rerio Brachidanio rerio]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2O74 OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:017428786</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Brachidanio rerio]]		[[Category: Brachidanio rerio]]
	[[Category: Berni, R.]]		[[Category: Berni, R.]]

OCA at 07:03, 2 April 2014

OCA — Wed, 02 Apr 2014 07:03:48 GMT

←Older revision		Revision as of 07:03, 2 April 2014
Line 1:		Line 1:
-	[[Image:2o74.png\|left\|200px]]
-
	{{STRUCTURE_2o74\| PDB=2o74 \| SCENE= }}		{{STRUCTURE_2o74\| PDB=2o74 \| SCENE= }}
-
	===Structure of OHCU decarboxylase in complex with guanine===		===Structure of OHCU decarboxylase in complex with guanine===
		+	{{ABSTRACT_PUBMED_17428786}}

-	~~{{ABSTRACT_PUBMED_017428786}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/URAD_DANRE URAD_DANRE]] Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.

	==About this Structure==		==About this Structure==
-	[[2o74]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Danio_rerio Danio~~ rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O74 OCA].	+	[[2o74]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O74 OCA].
-	[[Category: ~~Danio~~ rerio]]	+
		+	==Reference==
		+	<ref group="xtra">PMID:017428786</ref><references group="xtra"/><references/>
		+	[[Category: Brachidanio rerio]]
	[[Category: Berni, R.]]		[[Category: Berni, R.]]
	[[Category: Cendron, L.]]		[[Category: Cendron, L.]]

OCA: Protected "2o74" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 13:56:38 GMT

Protected "2o74" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:56, 7 January 2013

OCA at 13:56, 7 January 2013

OCA — Mon, 07 Jan 2013 13:56:33 GMT

←Older revision		Revision as of 13:56, 7 January 2013
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-	{{Seed}}
	[[Image:2o74.png\|left\|200px]]		[[Image:2o74.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2o74", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2o74\| PDB=2o74 \| SCENE= }}		{{STRUCTURE_2o74\| PDB=2o74 \| SCENE= }}

	===Structure of OHCU decarboxylase in complex with guanine===		===Structure of OHCU decarboxylase in complex with guanine===

		+	{{ABSTRACT_PUBMED_017428786}}

	==About this Structure==		==About this Structure==
-	~~2O74~~ is a 6 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O74 OCA].	+	[[2o74]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O74 OCA].
	[[Category: Danio rerio]]		[[Category: Danio rerio]]
	[[Category: Berni, R.]]		[[Category: Berni, R.]]
Line 26:		Line 20:
	[[Category: Decarboxylation]]		[[Category: Decarboxylation]]
	[[Category: Hiu]]		[[Category: Hiu]]
		+	[[Category: Lyase]]
	[[Category: Ohcu]]		[[Category: Ohcu]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 13:20:55 2009''