2o8w - Revision history

OCA at 00:15, 28 December 2023

OCA — Thu, 28 Dec 2023 00:15:49 GMT

←Older revision		Revision as of 00:15, 28 December 2023
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	<StructureSection load='2o8w' size='340' side='right'caption='[[2o8w]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='2o8w' size='340' side='right'caption='[[2o8w]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2o8w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O8W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O8W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2o8w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O8W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O8W FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>~~, ~~<scene name='pdbligand=PL0:~~1~~-PHENYLGUANIDINE'>PL0</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.86Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2o8t\|2o8t]], [[2o8u\|2o8u]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PL0:1-PHENYLGUANIDINE'>PL0</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o8w OCA], [https://pdbe.org/2o8w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o8w RCSB], [https://www.ebi.ac.uk/pdbsum/2o8w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o8w ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o8w OCA], [https://pdbe.org/2o8w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o8w RCSB], [https://www.ebi.ac.uk/pdbsum/2o8w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o8w ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[https://omim.org/entry/601709 601709]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Urokinase 3D Structures\|Urokinase 3D Structures]]		*[[Urokinase 3D Structures\|Urokinase 3D Structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: U-plasminogen activator]]~~	+	[[Category: Huang M]]
-	[[Category: Huang, M]]	+	[[Category: Huang Z]]
-	[[Category: Huang, Z]]	+	[[Category: Jiang L]]
-	[[Category: Jiang, L]]	+	[[Category: Yuan C]]
-	[[Category: Yuan, C]]	+	[[Category: Zhao G]]
-	[[Category: Zhao, G]]	+
-	~~[[Category: Benzamidine]]~~	+
-	~~[[Category: Contact area]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Phenylguanidine]]~~	+
-	~~[[Category: Urokinase-type plasminogen activator~~]]	+

OCA at 07:05, 10 November 2021

OCA — Wed, 10 Nov 2021 07:05:26 GMT

←Older revision		Revision as of 07:05, 10 November 2021
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	<StructureSection load='2o8w' size='340' side='right'caption='[[2o8w]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='2o8w' size='340' side='right'caption='[[2o8w]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2o8w]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O8W OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2O8W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2o8w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O8W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O8W FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PL0:1-PHENYLGUANIDINE'>PL0</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PL0:1-PHENYLGUANIDINE'>PL0</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o8t\|2o8t]], [[2o8u\|2o8u]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2o8t\|2o8t]], [[2o8u\|2o8u]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2o8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o8w OCA], [~~http~~://pdbe.org/2o8w PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2o8w RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2o8w PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2o8w ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o8w OCA], [https://pdbe.org/2o8w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o8w RCSB], [https://www.ebi.ac.uk/pdbsum/2o8w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o8w ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:58, 27 May 2020

OCA — Wed, 27 May 2020 07:58:57 GMT

←Older revision		Revision as of 07:58, 27 May 2020
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	==Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors==		==Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors==
-	<StructureSection load='2o8w' size='340' side='right' caption='[[2o8w]], [[Resolution\|resolution]] 1.86Å' scene=''>	+	<StructureSection load='2o8w' size='340' side='right'caption='[[2o8w]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2o8w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O8W OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2O8W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2o8w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O8W OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2O8W FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PL0:1-PHENYLGUANIDINE'>PL0</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PL0:1-PHENYLGUANIDINE'>PL0</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o8t\|2o8t]], [[2o8u\|2o8u]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o8t\|2o8t]], [[2o8u\|2o8u]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2o8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o8w OCA], [http://pdbe.org/2o8w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2o8w RCSB], [http://www.ebi.ac.uk/pdbsum/2o8w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2o8w ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2o8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o8w OCA], [http://pdbe.org/2o8w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2o8w RCSB], [http://www.ebi.ac.uk/pdbsum/2o8w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2o8w ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Urokinase\|Urokinase]]	+	*[[Urokinase 3D Structures\|Urokinase 3D Structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: U-plasminogen activator]]		[[Category: U-plasminogen activator]]
	[[Category: Huang, M]]		[[Category: Huang, M]]

OCA at 07:33, 22 August 2018

OCA — Wed, 22 Aug 2018 07:33:17 GMT

←Older revision		Revision as of 07:33, 22 August 2018
Line 1:		Line 1:
		+
	==Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors==		==Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors==
	<StructureSection load='2o8w' size='340' side='right' caption='[[2o8w]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='2o8w' size='340' side='right' caption='[[2o8w]], [[Resolution\|resolution]] 1.86Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o8t\|2o8t]], [[2o8u\|2o8u]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o8t\|2o8t]], [[2o8u\|2o8u]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o8w OCA], [http://pdbe.org/2o8w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2o8w RCSB], [http://www.ebi.ac.uk/pdbsum/2o8w PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o8w OCA], [http://pdbe.org/2o8w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2o8w RCSB], [http://www.ebi.ac.uk/pdbsum/2o8w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2o8w ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o8/2o8w_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o8/2o8w_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o8w ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

OCA at 12:36, 11 September 2015

OCA — Fri, 11 Sep 2015 12:36:06 GMT

←Older revision		Revision as of 12:36, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2o8w' size='340' side='right' caption='[[2o8w]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='2o8w' size='340' side='right' caption='[[2o8w]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2o8w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O8W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O8W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2o8w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O8W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O8W FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PL0:1-PHENYLGUANIDINE'>PL0</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PL0:1-PHENYLGUANIDINE'>PL0</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o8t\|2o8t]], [[2o8u\|2o8u]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o8t\|2o8t]], [[2o8u\|2o8u]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o8w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2o8w RCSB], [http://www.ebi.ac.uk/pdbsum/2o8w PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o8w OCA], [http://pdbe.org/2o8w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2o8w RCSB], [http://www.ebi.ac.uk/pdbsum/2o8w PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: U-plasminogen activator]]		[[Category: U-plasminogen activator]]
	[[Category: Huang, M]]		[[Category: Huang, M]]

OCA at 17:12, 19 January 2015

OCA — Mon, 19 Jan 2015 17:12:06 GMT

←Older revision		Revision as of 17:12, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2o8w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O8W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O8W FirstGlance]. <br>		<table><tr><td colspan='2'>[[2o8w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O8W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O8W FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PL0:1-PHENYLGUANIDINE'>PL0</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PL0:1-PHENYLGUANIDINE'>PL0</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o8t\|2o8t]], [[2o8u\|2o8u]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o8t\|2o8t]], [[2o8u\|2o8u]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o8w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2o8w RCSB], [http://www.ebi.ac.uk/pdbsum/2o8w PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o8w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2o8w RCSB], [http://www.ebi.ac.uk/pdbsum/2o8w PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 25:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: U-plasminogen activator]]		[[Category: U-plasminogen activator]]
-	[[Category: Huang, M.]]	+	[[Category: Huang, M]]
-	[[Category: Huang, Z.]]	+	[[Category: Huang, Z]]
-	[[Category: Jiang, L.]]	+	[[Category: Jiang, L]]
-	[[Category: Yuan, C.]]	+	[[Category: Yuan, C]]
-	[[Category: Zhao, G.]]	+	[[Category: Zhao, G]]
	[[Category: Benzamidine]]		[[Category: Benzamidine]]
	[[Category: Contact area]]		[[Category: Contact area]]

OCA at 19:44, 30 September 2014

OCA — Tue, 30 Sep 2014 19:44:10 GMT

←Older revision		Revision as of 19:44, 30 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2o8w\| PDB=2o8w \| SCENE= }}~~	+	==Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors==
-	===Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors===	+	<StructureSection load='2o8w' size='340' side='right' caption='[[2o8w]], [[Resolution\|resolution]] 1.86Å' scene=''>
-		+	== Structural highlights ==
-	==~~About this Structure~~==	+	<table><tr><td colspan='2'>[[2o8w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O8W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O8W FirstGlance]. <br>
-	[[2o8w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O8W OCA].	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PL0:1-PHENYLGUANIDINE'>PL0</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o8t\|2o8t]], [[2o8u\|2o8u]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o8w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2o8w RCSB], [http://www.ebi.ac.uk/pdbsum/2o8w PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o8/2o8w_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Urokinase\|Urokinase]]		*[[Urokinase\|Urokinase]]
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: U-plasminogen activator]]		[[Category: U-plasminogen activator]]

OCA at 16:55, 24 March 2013

OCA — Sun, 24 Mar 2013 16:55:09 GMT

←Older revision		Revision as of 16:55, 24 March 2013
Line 1:		Line 1:
-	[[Image:2o8w.png\|left\|200px]]
-
	{{STRUCTURE_2o8w\| PDB=2o8w \| SCENE= }}		{{STRUCTURE_2o8w\| PDB=2o8w \| SCENE= }}
-
	===Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors===		===Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors===
-

	==About this Structure==		==About this Structure==

OCA at 18:56, 20 October 2012

OCA — Sat, 20 Oct 2012 18:56:26 GMT

←Older revision		Revision as of 18:56, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[2o8w]] is a 1 chain structure ~~of [[Urokinase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O8W OCA].	+	[[2o8w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O8W OCA].

	==See Also==		==See Also==

OCA: Protected "2o8w" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 05:45:24 GMT

Protected "2o8w" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:45, 27 July 2012