2o93 - Revision history

OCA at 10:33, 30 August 2023

OCA — Wed, 30 Aug 2023 10:33:26 GMT

←Older revision		Revision as of 10:33, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2o93' size='340' side='right'caption='[[2o93]], [[Resolution\|resolution]] 3.05Å' scene=''>		<StructureSection load='2o93' size='340' side='right'caption='[[2o93]], [[Resolution\|resolution]] 3.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2o93]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O93 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2o93]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O93 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1p7h\|1p7h]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.05Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">NFATC2, NFAT1, NFATP ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o93 OCA], [https://pdbe.org/2o93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o93 RCSB], [https://www.ebi.ac.uk/pdbsum/2o93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o93 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o93 OCA], [https://pdbe.org/2o93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o93 RCSB], [https://www.ebi.ac.uk/pdbsum/2o93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o93 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NFAC2_HUMAN NFAC2_HUMAN]] Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway.<ref>PMID:21871017</ref>	+	[https://www.uniprot.org/uniprot/NFAC2_HUMAN NFAC2_HUMAN] Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway.<ref>PMID:21871017</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bates~~, D L~~]]	+	[[Category: Bates DL]]
-	[[Category: Chen, L]]	+	[[Category: Chen L]]
-	~~[[Category: Double helix]]~~	+
-	~~[[Category: Ig domain]]~~	+
-	~~[[Category: Protein-dna complex]]~~	+
-	~~[[Category: Transcription-dna complex~~]]	+

OCA at 12:49, 9 June 2021

OCA — Wed, 09 Jun 2021 12:49:48 GMT

←Older revision		Revision as of 12:49, 9 June 2021
Line 1:		Line 1:

	==Crystal structure of NFAT bound to the HIV-1 LTR tandem kappaB enhancer element==		==Crystal structure of NFAT bound to the HIV-1 LTR tandem kappaB enhancer element==
-	<StructureSection load='2o93' size='340' side='right' caption='[[2o93]], [[Resolution\|resolution]] 3.05Å' scene=''>	+	<StructureSection load='2o93' size='340' side='right'caption='[[2o93]], [[Resolution\|resolution]] 3.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2o93]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O93 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2O93 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2o93]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O93 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p7h\|1p7h]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1p7h\|1p7h]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NFATC2, NFAT1, NFATP ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NFATC2, NFAT1, NFATP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2o93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o93 OCA], [~~http~~://pdbe.org/2o93 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2o93 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2o93 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2o93 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o93 OCA], [https://pdbe.org/2o93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o93 RCSB], [https://www.ebi.ac.uk/pdbsum/2o93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o93 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NFAC2_HUMAN NFAC2_HUMAN]] Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway.<ref>PMID:21871017</ref>	+	[[https://www.uniprot.org/uniprot/NFAC2_HUMAN NFAC2_HUMAN]] Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway.<ref>PMID:21871017</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o9/2o93_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o9/2o93_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bates, D L]]		[[Category: Bates, D L]]
	[[Category: Chen, L]]		[[Category: Chen, L]]

OCA at 08:54, 18 October 2017

OCA — Wed, 18 Oct 2017 08:54:25 GMT

←Older revision		Revision as of 08:54, 18 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of NFAT bound to the HIV-1 LTR tandem kappaB enhancer element==		==Crystal structure of NFAT bound to the HIV-1 LTR tandem kappaB enhancer element==
	<StructureSection load='2o93' size='340' side='right' caption='[[2o93]], [[Resolution\|resolution]] 3.05Å' scene=''>		<StructureSection load='2o93' size='340' side='right' caption='[[2o93]], [[Resolution\|resolution]] 3.05Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p7h\|1p7h]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p7h\|1p7h]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NFATC2, NFAT1, NFATP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NFATC2, NFAT1, NFATP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o93 OCA], [http://pdbe.org/2o93 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2o93 RCSB], [http://www.ebi.ac.uk/pdbsum/2o93 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o93 OCA], [http://pdbe.org/2o93 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2o93 RCSB], [http://www.ebi.ac.uk/pdbsum/2o93 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2o93 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 07:19, 8 February 2016

OCA — Mon, 08 Feb 2016 07:19:33 GMT

←Older revision		Revision as of 07:19, 8 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o93 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:11, 10 September 2015

OCA — Thu, 10 Sep 2015 09:11:52 GMT

←Older revision		Revision as of 09:11, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2o93' size='340' side='right' caption='[[2o93]], [[Resolution\|resolution]] 3.05Å' scene=''>		<StructureSection load='2o93' size='340' side='right' caption='[[2o93]], [[Resolution\|resolution]] 3.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2o93]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O93 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2o93]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O93 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p7h\|1p7h]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p7h\|1p7h]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NFATC2, NFAT1, NFATP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NFATC2, NFAT1, NFATP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o93 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2o93 RCSB], [http://www.ebi.ac.uk/pdbsum/2o93 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o93 OCA], [http://pdbe.org/2o93 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2o93 RCSB], [http://www.ebi.ac.uk/pdbsum/2o93 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2o93" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bates, D L]]		[[Category: Bates, D L]]
	[[Category: Chen, L]]		[[Category: Chen, L]]

OCA at 21:36, 24 December 2014

OCA — Wed, 24 Dec 2014 21:36:40 GMT

←Older revision		Revision as of 21:36, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2o93]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O93 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2o93]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O93 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p7h\|1p7h]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p7h\|1p7h]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NFATC2, NFAT1, NFATP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NFATC2, NFAT1, NFATP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o93 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2o93 RCSB], [http://www.ebi.ac.uk/pdbsum/2o93 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o93 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2o93 RCSB], [http://www.ebi.ac.uk/pdbsum/2o93 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NFAC2_HUMAN NFAC2_HUMAN]] Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway.<ref>PMID:21871017</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bates, D L.]]	+	[[Category: Bates, D L]]
-	[[Category: Chen, L.]]	+	[[Category: Chen, L]]
	[[Category: Double helix]]		[[Category: Double helix]]
	[[Category: Ig domain]]		[[Category: Ig domain]]
	[[Category: Protein-dna complex]]		[[Category: Protein-dna complex]]
	[[Category: Transcription-dna complex]]		[[Category: Transcription-dna complex]]

OCA at 19:56, 30 September 2014

OCA — Tue, 30 Sep 2014 19:56:16 GMT

←Older revision		Revision as of 19:56, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2o93.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of NFAT bound to the HIV-1 LTR tandem kappaB enhancer element==
		+	<StructureSection load='2o93' size='340' side='right' caption='[[2o93]], [[Resolution\|resolution]] 3.05Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2o93]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O93 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p7h\|1p7h]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NFATC2, NFAT1, NFATP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o93 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2o93 RCSB], [http://www.ebi.ac.uk/pdbsum/2o93 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o9/2o93_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The host factor, nuclear factor of activated T-cells (NFAT), regulates the transcription and replication of HIV-1. Here, we have determined the crystal structure of the DNA binding domain of NFAT bound to the HIV-1 long terminal repeat (LTR) tandem kappaB enhancer element at 3.05 A resolution. NFAT binds as a dimer to the upstream kappaB site (Core II), but as a monomer to the 3' end of the downstream kappaB site (Core I). The DNA shows a significant bend near the 5' end of Core I, where a lysine residue from NFAT bound to the 3' end of Core II inserts into the minor groove and seems to cause DNA bases to flip out. Consistent with this structural feature, the 5' end of Core I become hypersensitive to dimethylsulfate in the in vivo footprinting upon transcriptional activation of the HIV-1 LTR. Our studies provide a basis for further investigating the functional mechanisms of NFAT in HIV-1 transcription and replication.

-	~~{{STRUCTURE_2o93\| PDB=2o93 \| SCENE= }}~~	+	Crystal structure of NFAT bound to the HIV-1 LTR tandem kappaB enhancer element.,Bates DL, Barthel KK, Wu Y, Kalhor R, Stroud JC, Giffin MJ, Chen L Structure. 2008 May;16(5):684-94. PMID:18462673<ref>PMID:18462673</ref>

-	~~===Crystal structure~~ of ~~NFAT bound to~~ the ~~HIV-1 LTR tandem kappaB enhancer element===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18462673}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2o93]] is a 5 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2O93 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018462673<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bates, D L.]]		[[Category: Bates, D L.]]

OCA: Protected "2o93" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 14:54:07 GMT

Protected "2o93" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:54, 7 January 2013

OCA at 14:54, 7 January 2013

OCA — Mon, 07 Jan 2013 14:54:03 GMT

←Older revision		Revision as of 14:54, 7 January 2013
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-	{{Seed}}
	[[Image:2o93.png\|left\|200px]]		[[Image:2o93.png\|left\|200px]]

-	<!--
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-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_2o93\| PDB=2o93 \| SCENE= }}		{{STRUCTURE_2o93\| PDB=2o93 \| SCENE= }}

	===Crystal structure of NFAT bound to the HIV-1 LTR tandem kappaB enhancer element===		===Crystal structure of NFAT bound to the HIV-1 LTR tandem kappaB enhancer element===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18462673}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18462673 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_18462673}}		{{ABSTRACT_PUBMED_18462673}}

	==About this Structure==		==About this Structure==
-	~~2O93~~ is a 5 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O93 OCA].	+	[[2o93]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O93 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18462673~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018462673</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bates, D L.]]		[[Category: Bates, D L.]]
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	[[Category: Ig domain]]		[[Category: Ig domain]]
	[[Category: Protein-dna complex]]		[[Category: Protein-dna complex]]
-	[[Category: Transcription/dna complex]]	+	[[Category: Transcription-dna complex]]
-		+
-	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:08:19 2009''~~	+

OCA at 18:08, 16 February 2009

OCA — Mon, 16 Feb 2009 18:08:20 GMT

←Older revision		Revision as of 18:08, 16 February 2009
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	==About this Structure==		==About this Structure==
-	2O93 is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O93 OCA].	+	2O93 is a 5 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O93 OCA].

	==Reference==		==Reference==
-	~~Crystal structure of NFAT bound to the HIV-1 LTR tandem kappaB enhancer element., Bates DL, Barthel KK, Wu Y, Kalhor R, Stroud JC, Giffin MJ, Chen L, Structure. 2008 May;16(5):684-94.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18462673 18462673]~~	+	<ref group="xtra">PMID:18462673</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Protein complex]]
	[[Category: Bates, D L.]]		[[Category: Bates, D L.]]
	[[Category: Chen, L.]]		[[Category: Chen, L.]]
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	[[Category: Transcription/dna complex]]		[[Category: Transcription/dna complex]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 23 10~~:12:~~59 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:08:19 2009''