2oj6 - Revision history

OCA at 10:40, 30 August 2023

OCA — Wed, 30 Aug 2023 10:40:57 GMT

←Older revision		Revision as of 10:40, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2oj6' size='340' side='right'caption='[[2oj6]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='2oj6' size='340' side='right'caption='[[2oj6]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2oj6]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Reovirus ~~Reovirus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OJ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OJ6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2oj6]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Reovirus_sp. Reovirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OJ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OJ6 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[1kke\|1kke]], [[2oj5\|2oj5]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">S1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10891 Reovirus])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oj6 OCA], [https://pdbe.org/2oj6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oj6 RCSB], [https://www.ebi.ac.uk/pdbsum/2oj6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oj6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oj6 OCA], [https://pdbe.org/2oj6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oj6 RCSB], [https://www.ebi.ac.uk/pdbsum/2oj6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oj6 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SIGM1_REOVD SIGM1_REOVD] Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Reovirus]]	+	[[Category: Reovirus sp]]
-	[[Category: Dermody~~, T S~~]]	+	[[Category: Dermody TS]]
-	[[Category: Kirchner, E]]	+	[[Category: Kirchner E]]
-	[[Category: Stehle, T]]	+	[[Category: Stehle T]]
-	~~[[Category: Aspartic acid cluster]]~~	+
-	~~[[Category: Beta-barrel]]~~	+
-	~~[[Category: Beta-spiral repeat]]~~	+
-	~~[[Category: Greek key motif]]~~	+
-	~~[[Category: Trimer]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 12:57, 9 June 2021

OCA — Wed, 09 Jun 2021 12:57:58 GMT

←Older revision		Revision as of 12:57, 9 June 2021
Line 1:		Line 1:

	==Crystal Structure of Reovirus T3D Attachment Protein Sigma1 head domain D345N mutant==		==Crystal Structure of Reovirus T3D Attachment Protein Sigma1 head domain D345N mutant==
-	<StructureSection load='2oj6' size='340' side='right' caption='[[2oj6]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='2oj6' size='340' side='right'caption='[[2oj6]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2oj6]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Reovirus Reovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OJ6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2OJ6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2oj6]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Reovirus Reovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OJ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OJ6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kke\|1kke]], [[2oj5\|2oj5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1kke\|1kke]], [[2oj5\|2oj5]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10891 Reovirus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10891 Reovirus])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2oj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oj6 OCA], [~~http~~://pdbe.org/2oj6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2oj6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2oj6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2oj6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oj6 OCA], [https://pdbe.org/2oj6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oj6 RCSB], [https://www.ebi.ac.uk/pdbsum/2oj6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oj6 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oj/2oj6_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oj/2oj6_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 2oj6" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2oj6" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Reovirus]]		[[Category: Reovirus]]
	[[Category: Dermody, T S]]		[[Category: Dermody, T S]]

OCA at 09:02, 18 October 2017

OCA — Wed, 18 Oct 2017 09:02:05 GMT

←Older revision		Revision as of 09:02, 18 October 2017
Line 1:		Line 1:
		+
	==Crystal Structure of Reovirus T3D Attachment Protein Sigma1 head domain D345N mutant==		==Crystal Structure of Reovirus T3D Attachment Protein Sigma1 head domain D345N mutant==
	<StructureSection load='2oj6' size='340' side='right' caption='[[2oj6]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='2oj6' size='340' side='right' caption='[[2oj6]], [[Resolution\|resolution]] 1.85Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kke\|1kke]], [[2oj5\|2oj5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kke\|1kke]], [[2oj5\|2oj5]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10891 Reovirus])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10891 Reovirus])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oj6 OCA], [http://pdbe.org/2oj6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2oj6 RCSB], [http://www.ebi.ac.uk/pdbsum/2oj6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oj6 OCA], [http://pdbe.org/2oj6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2oj6 RCSB], [http://www.ebi.ac.uk/pdbsum/2oj6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2oj6 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oj6 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:16, 11 September 2015

OCA — Fri, 11 Sep 2015 15:16:09 GMT

←Older revision		Revision as of 15:16, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2oj6' size='340' side='right' caption='[[2oj6]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='2oj6' size='340' side='right' caption='[[2oj6]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2oj6]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Reovirus_sp.~~ Reovirus ~~sp.~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OJ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OJ6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2oj6]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Reovirus Reovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OJ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OJ6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kke\|1kke]], [[2oj5\|2oj5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kke\|1kke]], [[2oj5\|2oj5]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10891 Reovirus ~~sp.~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10891 Reovirus])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oj6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oj6 RCSB], [http://www.ebi.ac.uk/pdbsum/2oj6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oj6 OCA], [http://pdbe.org/2oj6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2oj6 RCSB], [http://www.ebi.ac.uk/pdbsum/2oj6 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2oj6" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Reovirus sp]]	+	[[Category: Reovirus]]
	[[Category: Dermody, T S]]		[[Category: Dermody, T S]]
	[[Category: Kirchner, E]]		[[Category: Kirchner, E]]

OCA at 16:39, 19 January 2015

OCA — Mon, 19 Jan 2015 16:39:42 GMT

←Older revision		Revision as of 16:39, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2oj6]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Reovirus_sp. Reovirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OJ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OJ6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2oj6]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Reovirus_sp. Reovirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OJ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OJ6 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kke\|1kke]], [[2oj5\|2oj5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kke\|1kke]], [[2oj5\|2oj5]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10891 Reovirus sp.])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10891 Reovirus sp.])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oj6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oj6 RCSB], [http://www.ebi.ac.uk/pdbsum/2oj6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oj6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oj6 RCSB], [http://www.ebi.ac.uk/pdbsum/2oj6 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Reovirus sp.]]	+	[[Category: Reovirus sp]]
-	[[Category: Dermody, T S.]]	+	[[Category: Dermody, T S]]
-	[[Category: Kirchner, E.]]	+	[[Category: Kirchner, E]]
-	[[Category: Stehle, T.]]	+	[[Category: Stehle, T]]
	[[Category: Aspartic acid cluster]]		[[Category: Aspartic acid cluster]]
	[[Category: Beta-barrel]]		[[Category: Beta-barrel]]

OCA at 19:23, 30 September 2014

OCA — Tue, 30 Sep 2014 19:23:00 GMT

←Older revision		Revision as of 19:23, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2oj6.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of Reovirus T3D Attachment Protein Sigma1 head domain D345N mutant==
		+	<StructureSection load='2oj6' size='340' side='right' caption='[[2oj6]], [[Resolution\|resolution]] 1.85Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2oj6]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Reovirus_sp. Reovirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OJ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OJ6 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kke\|1kke]], [[2oj5\|2oj5]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10891 Reovirus sp.])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oj6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oj6 RCSB], [http://www.ebi.ac.uk/pdbsum/2oj6 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oj/2oj6_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Reovirus attachment protein sigma1 mediates engagement of receptors on the surface of target cells and undergoes dramatic conformational rearrangements during viral disassembly in the endocytic pathway. The sigma1 protein is a filamentous, trimeric molecule with a globular beta-barrel head domain. An unusual cluster of aspartic acid residues sandwiched between hydrophobic tyrosines is located at the sigma1 subunit interface. A 1.75-A structure of the sigma1 head domain now reveals two water molecules at the subunit interface that are held strictly in position and interact with neighboring residues. Structural and biochemical analyses of mutants affecting the aspartic acid sandwich indicate that these residues and the corresponding chelated water molecules act as a plug to block the free flow of solvent and stabilize the trimer. This arrangement of residues at the sigma1 head trimer interface illustrates a new protein design motif that may confer conformational mobility during cell entry.

-	~~{{STRUCTURE_2oj6\| PDB=2oj6 \| SCENE= }}~~	+	The reovirus sigma1 aspartic acid sandwich: a trimerization motif poised for conformational change.,Schelling P, Guglielmi KM, Kirchner E, Paetzold B, Dermody TS, Stehle T J Biol Chem. 2007 Apr 13;282(15):11582-9. Epub 2007 Feb 15. PMID:17303562<ref>PMID:17303562</ref>

-	~~===Crystal Structure~~ of ~~Reovirus T3D Attachment Protein Sigma1 head domain D345N mutant===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17303562}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2oj6]] is a 6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Reovirus_sp~~. ~~Reovirus sp.]. Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2OJ6 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017303562<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Reovirus sp.]]		[[Category: Reovirus sp.]]
	[[Category: Dermody, T S.]]		[[Category: Dermody, T S.]]

OCA: Protected "2oj6" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 14:22:03 GMT

Protected "2oj6" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:22, 7 January 2013

OCA at 14:22, 7 January 2013

OCA — Mon, 07 Jan 2013 14:22:00 GMT

←Older revision		Revision as of 14:22, 7 January 2013
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-	{{Seed}}
	[[Image:2oj6.png\|left\|200px]]		[[Image:2oj6.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2oj6", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2oj6\| PDB=2oj6 \| SCENE= }}		{{STRUCTURE_2oj6\| PDB=2oj6 \| SCENE= }}

	===Crystal Structure of Reovirus T3D Attachment Protein Sigma1 head domain D345N mutant===		===Crystal Structure of Reovirus T3D Attachment Protein Sigma1 head domain D345N mutant===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17303562}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17303562 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17303562}}		{{ABSTRACT_PUBMED_17303562}}

	==About this Structure==		==About this Structure==
-	~~2OJ6~~ is a 6 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Reovirus_sp. Reovirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OJ6 OCA].	+	[[2oj6]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Reovirus_sp. Reovirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OJ6 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17303562~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017303562</ref><references group="xtra"/>
	[[Category: Reovirus sp.]]		[[Category: Reovirus sp.]]
	[[Category: Dermody, T S.]]		[[Category: Dermody, T S.]]
Line 33:		Line 21:
	[[Category: Greek key motif]]		[[Category: Greek key motif]]
	[[Category: Trimer]]		[[Category: Trimer]]
-		+	[[Category: Viral protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Feb 18 01:50:57 2009''~~	+

OCA at 23:50, 17 February 2009

OCA — Tue, 17 Feb 2009 23:50:58 GMT

←Older revision		Revision as of 23:50, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2OJ6 is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Reovirus_sp. Reovirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OJ6 OCA].	+	2OJ6 is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Reovirus_sp. Reovirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OJ6 OCA].

	==Reference==		==Reference==
-	The reovirus sigma1 aspartic acid sandwich: a trimerization motif poised for conformational change., Schelling P, Guglielmi KM, Kirchner E, Paetzold B, Dermody TS, Stehle T, J Biol Chem. 2007 Apr 13;282(15):11582-9. Epub 2007 Feb 15. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17303562 17303562]~~	+	<ref group="xtra">PMID:17303562</ref><references group="xtra"/>
	[[Category: Reovirus sp.]]		[[Category: Reovirus sp.]]
-	[[Category: Single protein]]
	[[Category: Dermody, T S.]]		[[Category: Dermody, T S.]]
	[[Category: Kirchner, E.]]		[[Category: Kirchner, E.]]
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	[[Category: Trimer]]		[[Category: Trimer]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 08~~:44:~~03 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 01:50:57 2009''

OCA at 05:44, 29 July 2008

OCA — Tue, 29 Jul 2008 05:44:05 GMT

←Older revision		Revision as of 05:44, 29 July 2008
Line 1:		Line 1:
-	[[Image:2oj6.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2oj6.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2oj6\| PDB=2oj6 \| SCENE= }}		{{STRUCTURE_2oj6\| PDB=2oj6 \| SCENE= }}

-	~~'''~~Crystal Structure of Reovirus T3D Attachment Protein Sigma1 head domain D345N mutant~~'''~~	+	===Crystal Structure of Reovirus T3D Attachment Protein Sigma1 head domain D345N mutant===


-	~~==Overview==~~	+	<!--
-	Reovirus attachment protein sigma1 mediates engagement of receptors on the surface of target cells and undergoes dramatic conformational rearrangements during viral disassembly in the endocytic pathway. The ~~sigma1 protein is a filamentous~~, ~~trimeric molecule with a globular beta-barrel head domain. An unusual cluster of aspartic acid residues sandwiched between hydrophobic tyrosines is located at~~ the ~~sigma1 subunit interface. A 1.75-A structure of~~ the ~~sigma1 head domain now reveals two water molecules~~ at ~~the subunit interface that are held strictly in position and interact with neighboring residues~~. Structural and biochemical analyses of mutants affecting the aspartic acid sandwich indicate that these residues and the corresponding chelated water molecules act as a plug to block the free flow of solvent and stabilize the trimer. ~~This arrangement of residues at~~ the ~~sigma1 head trimer interface illustrates a new protein design motif that may confer conformational mobility during cell entry~~.	+	The line below this paragraph, {{ABSTRACT_PUBMED_17303562}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17303562 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17303562}}

	==About this Structure==		==About this Structure==
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	[[Category: Greek key motif]]		[[Category: Greek key motif]]
	[[Category: Trimer]]		[[Category: Trimer]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 11~~:01:42 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:44:03 2008''