2onb - Revision history

OCA at 10:44, 30 August 2023

OCA — Wed, 30 Aug 2023 10:44:10 GMT

←Older revision		Revision as of 10:44, 30 August 2023
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	<StructureSection load='2onb' size='340' side='right'caption='[[2onb]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2onb' size='340' side='right'caption='[[2onb]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2onb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ONB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2onb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ONB FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=7PA:PROPANE~~-~~1,3-DIYLBIS(PHOSPHONIC+ACID)'>7PA</scene>, <scene name='pdbligand=EDO:1~~,2~~-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7PA:PROPANE-1,3-DIYLBIS(PHOSPHONIC+ACID)'>7PA</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td><~~td class~~=~~"sblockDat"><div style~~=~~'overflow~~: ~~auto; max-height: 3em;~~'>~~[[1ypv\|1ypv]]~~</~~div~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2onb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2onb OCA], [https://pdbe.org/2onb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2onb RCSB], [https://www.ebi.ac.uk/pdbsum/2onb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2onb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2onb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2onb OCA], [https://pdbe.org/2onb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2onb RCSB], [https://www.ebi.ac.uk/pdbsum/2onb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2onb ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TYSY_HUMAN TYSY_HUMAN] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.<ref>PMID:21876188</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gibson~~, L M~~]]	+	[[Category: Gibson LM]]
-	[[Category: Lebioda, L]]	+	[[Category: Lebioda L]]
-	[[Category: Lovelace~~, L L]]~~	+	[[Category: Lovelace LL]]
-	~~[[Category: Diphosphonic acid]]~~	+
-	~~[[Category: Fdump]]~~	+
-	~~[[Category: Heteroinhibition]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Zd9331~~]]	+

OCA at 13:00, 9 June 2021

OCA — Wed, 09 Jun 2021 13:00:40 GMT

←Older revision		Revision as of 13:00, 9 June 2021
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	<StructureSection load='2onb' size='340' side='right'caption='[[2onb]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2onb' size='340' side='right'caption='[[2onb]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2onb]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ONB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2onb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ONB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7PA:PROPANE-1,3-DIYLBIS(PHOSPHONIC+ACID)'>7PA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7PA:PROPANE-1,3-DIYLBIS(PHOSPHONIC+ACID)'>7PA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ypv\|1ypv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ypv\|1ypv]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2onb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2onb OCA], [~~http~~://pdbe.org/2onb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2onb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2onb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2onb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2onb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2onb OCA], [https://pdbe.org/2onb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2onb RCSB], [https://www.ebi.ac.uk/pdbsum/2onb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2onb ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Thymidylate synthase\|Thymidylate synthase]]	+	*[[Thymidylate synthase 3D structures\|Thymidylate synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:57, 31 July 2019

OCA — Wed, 31 Jul 2019 07:57:02 GMT

←Older revision		Revision as of 07:57, 31 July 2019
Line 1:		Line 1:

	==Human Thymidylate Synthase at low salt conditions with PDPA bound==		==Human Thymidylate Synthase at low salt conditions with PDPA bound==
-	<StructureSection load='2onb' size='340' side='right' caption='[[2onb]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='2onb' size='340' side='right'caption='[[2onb]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2onb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ONB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2onb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ONB FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/on/2onb_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/on/2onb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 2onb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2onb" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Thymidylate synthase\|Thymidylate synthase]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Gibson, L M]]		[[Category: Gibson, L M]]
	[[Category: Lebioda, L]]		[[Category: Lebioda, L]]

OCA at 09:04, 18 October 2017

OCA — Wed, 18 Oct 2017 09:04:24 GMT

←Older revision		Revision as of 09:04, 18 October 2017
Line 1:		Line 1:
		+
	==Human Thymidylate Synthase at low salt conditions with PDPA bound==		==Human Thymidylate Synthase at low salt conditions with PDPA bound==
	<StructureSection load='2onb' size='340' side='right' caption='[[2onb]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2onb' size='340' side='right' caption='[[2onb]], [[Resolution\|resolution]] 2.70Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ypv\|1ypv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ypv\|1ypv]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2onb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2onb OCA], [http://pdbe.org/2onb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2onb RCSB], [http://www.ebi.ac.uk/pdbsum/2onb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2onb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2onb OCA], [http://pdbe.org/2onb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2onb RCSB], [http://www.ebi.ac.uk/pdbsum/2onb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2onb ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2onb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 2onb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2onb" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Thymidylate synthase\|Thymidylate synthase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 01:03, 12 September 2015

OCA — Sat, 12 Sep 2015 01:03:41 GMT

←Older revision		Revision as of 01:03, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='2onb' size='340' side='right' caption='[[2onb]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2onb' size='340' side='right' caption='[[2onb]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2onb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ONB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2onb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ONB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7PA:PROPANE-1,3-DIYLBIS(PHOSPHONIC+ACID)'>7PA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7PA:PROPANE-1,3-DIYLBIS(PHOSPHONIC+ACID)'>7PA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ypv\|1ypv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ypv\|1ypv]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2onb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2onb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2onb RCSB], [http://www.ebi.ac.uk/pdbsum/2onb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2onb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2onb OCA], [http://pdbe.org/2onb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2onb RCSB], [http://www.ebi.ac.uk/pdbsum/2onb PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2onb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Gibson, L M]]		[[Category: Gibson, L M]]
	[[Category: Lebioda, L]]		[[Category: Lebioda, L]]

OCA at 15:57, 19 January 2015

OCA — Mon, 19 Jan 2015 15:57:04 GMT

←Older revision		Revision as of 15:57, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2onb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ONB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2onb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ONB FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7PA:PROPANE-1,3-DIYLBIS(PHOSPHONIC+ACID)'>7PA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7PA:PROPANE-1,3-DIYLBIS(PHOSPHONIC+ACID)'>7PA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ypv\|1ypv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ypv\|1ypv]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2onb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2onb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2onb RCSB], [http://www.ebi.ac.uk/pdbsum/2onb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2onb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2onb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2onb RCSB], [http://www.ebi.ac.uk/pdbsum/2onb PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Gibson, L M.]]	+	[[Category: Gibson, L M]]
-	[[Category: Lebioda, L.]]	+	[[Category: Lebioda, L]]
-	[[Category: Lovelace, L L.]]	+	[[Category: Lovelace, L L]]
	[[Category: Diphosphonic acid]]		[[Category: Diphosphonic acid]]
	[[Category: Fdump]]		[[Category: Fdump]]

OCA at 08:07, 29 September 2014

OCA — Mon, 29 Sep 2014 08:07:07 GMT

←Older revision		Revision as of 08:07, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2onb.~~png~~\|~~left~~\|200px]]	+	==Human Thymidylate Synthase at low salt conditions with PDPA bound==
		+	<StructureSection load='2onb' size='340' side='right' caption='[[2onb]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2onb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ONB FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7PA:PROPANE-1,3-DIYLBIS(PHOSPHONIC+ACID)'>7PA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ypv\|1ypv]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2onb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2onb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2onb RCSB], [http://www.ebi.ac.uk/pdbsum/2onb PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/on/2onb_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Thymidylate synthase (TS) is a target in the chemotherapy of colorectal cancer and some other neoplasms. It catalyzes the transfer of a methyl group from methylenetetrahydrofolate to dUMP to form dTMP. On the basis of structural considerations, we have introduced 1,3-propanediphosphonic acid (PDPA) as an allosteric inhibitor of human TS (hTS); it is proposed that PDPA acts by stabilizing an inactive conformer of loop 181-197. Kinetic studies showed that PDPA is a mixed (noncompetitive) inhibitor versus dUMP. In contrast, versus methylenetrahydrofolate at concentrations lower than 0.25 microM, PDPA is an uncompetitive inhibitor, while at PDPA concentrations higher than 1 microM the inhibiton is noncompetive, as expected. At the concentrations corresponding to uncompetitive inhibition, PDPA shows positive cooperativity with an antifolate inhibitor, ZD9331, which binds to the active conformer. PDPA binding leads to the formation of hTS tetramers, but not higher oligomers. These data are consistent with a model in which hTS exists preferably as an asymmetric dimer with one subunit in the active conformation of loop 181-197 and the other in the inactive conformation.

-	~~{{STRUCTURE_2onb\| PDB=2onb \| SCENE= }}~~	+	Cooperative inhibition of human thymidylate synthase by mixtures of active site binding and allosteric inhibitors.,Lovelace LL, Gibson LM, Lebioda L Biochemistry. 2007 Mar 13;46(10):2823-30. Epub 2007 Feb 13. PMID:17297914<ref>PMID:17297914</ref>

-	~~===Human Thymidylate Synthase at low salt conditions with PDPA bound===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17297914}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2onb]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2ONB OCA].~~	+

	==See Also==		==See Also==
	*[[Thymidylate synthase\|Thymidylate synthase]]		*[[Thymidylate synthase\|Thymidylate synthase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017297914<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Gibson, L M.]]		[[Category: Gibson, L M.]]

OCA at 22:01, 20 October 2012

OCA — Sat, 20 Oct 2012 22:01:52 GMT

←Older revision		Revision as of 22:01, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2onb]] is a 1 chain structure ~~of [[Thymidylate synthase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONB OCA].	+	[[2onb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONB OCA].

	==See Also==		==See Also==

OCA: Protected "2onb" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 15:01:41 GMT

Protected "2onb" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:01, 27 July 2012

OCA at 15:01, 27 July 2012

OCA — Fri, 27 Jul 2012 15:01:40 GMT

←Older revision		Revision as of 15:01, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2onb.png\|left\|200px]]		[[Image:2onb.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2onb", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2onb\| PDB=2onb \| SCENE= }}		{{STRUCTURE_2onb\| PDB=2onb \| SCENE= }}

	===Human Thymidylate Synthase at low salt conditions with PDPA bound===		===Human Thymidylate Synthase at low salt conditions with PDPA bound===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17297914}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17297914 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17297914}}		{{ABSTRACT_PUBMED_17297914}}

	==About this Structure==		==About this Structure==
-	~~2ONB~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONB OCA].	+	[[2onb]] is a 1 chain structure of [[Thymidylate synthase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONB OCA].
		+
		+	==See Also==
		+	*[[Thymidylate synthase\|Thymidylate synthase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17297914~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017297914</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Gibson, L M.]]		[[Category: Gibson, L M.]]
Line 31:		Line 22:
	[[Category: Fdump]]		[[Category: Fdump]]
	[[Category: Heteroinhibition]]		[[Category: Heteroinhibition]]
		+	[[Category: Transferase]]
	[[Category: Zd9331]]		[[Category: Zd9331]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 08:51:37 2009''