2orl - Revision history

OCA at 13:04, 9 June 2021

OCA — Wed, 09 Jun 2021 13:04:15 GMT

←Older revision		Revision as of 13:04, 9 June 2021
Line 1:		Line 1:

	==Solution structure of the cytochrome c- para-aminophenol adduct==		==Solution structure of the cytochrome c- para-aminophenol adduct==
-	<StructureSection load='2orl' size='340' side='right' caption='[[2orl]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>	+	<StructureSection load='2orl' size='340' side='right'caption='[[2orl]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2orl]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ORL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2orl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ORL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4NL:4-AMINOPHENOL'>4NL</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4NL:4-AMINOPHENOL'>4NL</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hv4\|2hv4]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2hv4\|2hv4]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYC1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYC1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2orl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2orl OCA], [~~http~~://pdbe.org/2orl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2orl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2orl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2orl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2orl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2orl OCA], [https://pdbe.org/2orl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2orl RCSB], [https://www.ebi.ac.uk/pdbsum/2orl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2orl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CYC1_YEAST CYC1_YEAST]] Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	+	[[https://www.uniprot.org/uniprot/CYC1_YEAST CYC1_YEAST]] Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Cytochrome c\|Cytochrome c]]	+	*[[Cytochrome C 3D structures\|Cytochrome C 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Assfalg, M]]		[[Category: Assfalg, M]]
	[[Category: Bertini, I]]		[[Category: Bertini, I]]

OCA at 07:11, 22 August 2018

OCA — Wed, 22 Aug 2018 07:11:05 GMT

←Older revision		Revision as of 07:11, 22 August 2018
Line 1:		Line 1:
		+
	==Solution structure of the cytochrome c- para-aminophenol adduct==		==Solution structure of the cytochrome c- para-aminophenol adduct==
	<StructureSection load='2orl' size='340' side='right' caption='[[2orl]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>		<StructureSection load='2orl' size='340' side='right' caption='[[2orl]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hv4\|2hv4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hv4\|2hv4]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2orl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2orl OCA], [http://pdbe.org/2orl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2orl RCSB], [http://www.ebi.ac.uk/pdbsum/2orl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2orl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2orl OCA], [http://pdbe.org/2orl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2orl RCSB], [http://www.ebi.ac.uk/pdbsum/2orl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2orl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/or/2orl_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/or/2orl_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2orl ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:52, 11 September 2015

OCA — Fri, 11 Sep 2015 16:52:39 GMT

←Older revision		Revision as of 16:52, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2orl' size='340' side='right' caption='[[2orl]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>		<StructureSection load='2orl' size='340' side='right' caption='[[2orl]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2orl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ORL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2orl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ORL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4NL:4-AMINOPHENOL'>4NL</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4NL:4-AMINOPHENOL'>4NL</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hv4\|2hv4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hv4\|2hv4]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2orl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2orl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2orl RCSB], [http://www.ebi.ac.uk/pdbsum/2orl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2orl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2orl OCA], [http://pdbe.org/2orl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2orl RCSB], [http://www.ebi.ac.uk/pdbsum/2orl PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2orl" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Assfalg, M]]		[[Category: Assfalg, M]]
	[[Category: Bertini, I]]		[[Category: Bertini, I]]

OCA at 19:15, 25 December 2014

OCA — Thu, 25 Dec 2014 19:15:33 GMT

←Older revision		Revision as of 19:15, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2orl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ORL FirstGlance]. <br>		<table><tr><td colspan='2'>[[2orl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ORL FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4NL:4-AMINOPHENOL'>4NL</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4NL:4-AMINOPHENOL'>4NL</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hv4\|2hv4]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hv4\|2hv4]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2orl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2orl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2orl RCSB], [http://www.ebi.ac.uk/pdbsum/2orl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2orl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2orl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2orl RCSB], [http://www.ebi.ac.uk/pdbsum/2orl PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CYC1_YEAST CYC1_YEAST]] Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Assfalg, M.]]	+	[[Category: Assfalg, M]]
-	[[Category: Bertini, I.]]	+	[[Category: Bertini, I]]
-	[[Category: Conte, R Del.]]	+	[[Category: Conte, R Del]]
-	[[Category: Giachetti, A.]]	+	[[Category: Giachetti, A]]
-	[[Category: Turano, P.]]	+	[[Category: Turano, P]]
	[[Category: Electron transport]]		[[Category: Electron transport]]
	[[Category: Protein-ligand adduct]]		[[Category: Protein-ligand adduct]]

OCA at 06:50, 29 September 2014

OCA — Mon, 29 Sep 2014 06:50:26 GMT

←Older revision		Revision as of 06:50, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2orl.~~png~~\|~~left~~\|200px]]	+	==Solution structure of the cytochrome c- para-aminophenol adduct==
		+	<StructureSection load='2orl' size='340' side='right' caption='[[2orl]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2orl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ORL FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4NL:4-AMINOPHENOL'>4NL</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hv4\|2hv4]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2orl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2orl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2orl RCSB], [http://www.ebi.ac.uk/pdbsum/2orl PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/or/2orl_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Protein-protein interactions are driven by specific properties of the molecular surfaces. Cytochrome c, a small electron transfer protein, is involved in a number of biologically relevant interactions with macromolecular partners. Small molecules may interfere with such interactions by binding to the surface of cytochrome c. Here we investigated the possibility of weak intermolecular interactions between reduced cytochrome c and a library of 325 small molecules, using WaterLOGSY NMR spectroscopy. Specific binding was found for p-aminophenol. The solution structure of the p-aminophenol-cytochrome c adduct was determined using a combination of in silico tools and NMR-based restraints. The ligand interacts in a specific binding site on the protein surface through a combination of stacking and H-bond interactions. Small but meaningful rearrangements of the solvent-exposed side chains are observed upon ligand binding and contribute to the stabilization of the complex.

-	~~{{STRUCTURE_2orl\| PDB=2orl \| SCENE= }}~~	+	Cytochrome c and organic molecules: solution structure of the p-aminophenol adduct.,Assfalg M, Bertini I, Del Conte R, Giachetti A, Turano P Biochemistry. 2007 May 29;46(21):6232-8. Epub 2007 May 9. PMID:17488096<ref>PMID:17488096</ref>

-	~~===Solution structure~~ of the ~~cytochrome c- para-aminophenol adduct===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17488096}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2orl]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2ORL OCA].~~	+

	==See Also==		==See Also==
	*[[Cytochrome c\|Cytochrome c]]		*[[Cytochrome c\|Cytochrome c]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017488096<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Assfalg, M.]]		[[Category: Assfalg, M.]]

OCA at 20:26, 20 October 2012

OCA — Sat, 20 Oct 2012 20:26:40 GMT

←Older revision		Revision as of 20:26, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2orl]] is a 1 chain structure ~~of [[Cytochrome c]]~~ with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORL OCA].	+	[[2orl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORL OCA].

	==See Also==		==See Also==

OCA: Protected "2orl" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 10:30:33 GMT

Protected "2orl" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:30, 27 July 2012

OCA at 10:30, 27 July 2012

OCA — Fri, 27 Jul 2012 10:30:32 GMT

←Older revision		Revision as of 10:30, 27 July 2012
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-	{{Seed}}
	[[Image:2orl.png\|left\|200px]]		[[Image:2orl.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2orl\| PDB=2orl \| SCENE= }}		{{STRUCTURE_2orl\| PDB=2orl \| SCENE= }}

	===Solution structure of the cytochrome c- para-aminophenol adduct===		===Solution structure of the cytochrome c- para-aminophenol adduct===

-
-	<!--
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	{{ABSTRACT_PUBMED_17488096}}		{{ABSTRACT_PUBMED_17488096}}

	==About this Structure==		==About this Structure==
-	~~2ORL~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORL OCA].	+	[[2orl]] is a 1 chain structure of [[Cytochrome c]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORL OCA].
		+
		+	==See Also==
		+	*[[Cytochrome c\|Cytochrome c]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17488096~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017488096</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Assfalg, M.]]		[[Category: Assfalg, M.]]
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	[[Category: Giachetti, A.]]		[[Category: Giachetti, A.]]
	[[Category: Turano, P.]]		[[Category: Turano, P.]]
		+	[[Category: Electron transport]]
	[[Category: Protein-ligand adduct]]		[[Category: Protein-ligand adduct]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:12:04 2009''

OCA at 02:12, 18 February 2009

OCA — Wed, 18 Feb 2009 02:12:05 GMT

←Older revision		Revision as of 02:12, 18 February 2009
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	==About this Structure==		==About this Structure==
-	2ORL is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORL OCA].	+	2ORL is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORL OCA].

	==Reference==		==Reference==
-	~~Cytochrome c and organic molecules: solution structure of the p-aminophenol adduct., Assfalg M, Bertini I, Del Conte R, Giachetti A, Turano P, Biochemistry. 2007 May 29;46(21):6232-8. Epub 2007 May 9.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17488096 17488096]~~	+	<ref group="xtra">PMID:17488096</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Single protein]]
	[[Category: Assfalg, M.]]		[[Category: Assfalg, M.]]
	[[Category: Bertini, I.]]		[[Category: Bertini, I.]]
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	[[Category: Protein-ligand adduct]]		[[Category: Protein-ligand adduct]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 10~~:40:~~58 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:12:04 2009''

OCA at 07:41, 29 July 2008

OCA — Tue, 29 Jul 2008 07:41:11 GMT

←Older revision		Revision as of 07:41, 29 July 2008
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-	[[Image:2orl.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2orl.png\|left\|200px]]

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	{{STRUCTURE_2orl\| PDB=2orl \| SCENE= }}		{{STRUCTURE_2orl\| PDB=2orl \| SCENE= }}

-	~~'''~~Solution structure of the cytochrome c- para-aminophenol adduct~~'''~~	+	===Solution structure of the cytochrome c- para-aminophenol adduct===


-	~~==Overview==~~	+	<!--
-	~~Protein-protein interactions are driven by specific properties of the molecular surfaces. Cytochrome c~~, ~~a small electron transfer protein~~, ~~is involved in a number of biologically relevant interactions with macromolecular partners. Small molecules may interfere with such interactions by binding~~ to the ~~surface of cytochrome c~~. ~~Here we investigated the possibility of weak intermolecular interactions between reduced cytochrome c and a library of 325 small molecules~~, ~~using WaterLOGSY NMR spectroscopy. Specific binding was found for p-aminophenol. The solution structure of~~ the ~~p-aminophenol-cytochrome c adduct was determined using a combination of in silico tools and NMR-based restraints~~. ~~The ligand interacts in a specific binding site on the protein surface through a combination of stacking and H~~-~~bond interactions. Small but meaningful rearrangements of the solvent~~-~~exposed side chains are observed upon ligand binding and contribute to the stabilization of the complex.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_17488096}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17488096 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17488096}}

	==About this Structure==		==About this Structure==
-	2ORL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORL OCA].	+	2ORL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORL OCA].

	==Reference==		==Reference==
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	[[Category: Turano, P.]]		[[Category: Turano, P.]]
	[[Category: Protein-ligand adduct]]		[[Category: Protein-ligand adduct]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 11~~:31:28 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:40:58 2008''