2osv - Revision history

OCA at 07:52, 2 March 2022

OCA — Wed, 02 Mar 2022 07:52:49 GMT

←Older revision		Revision as of 07:52, 2 March 2022
Line 3:		Line 3:
	<StructureSection load='2osv' size='340' side='right'caption='[[2osv]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='2osv' size='340' side='right'caption='[[2osv]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2osv]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2OSV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2osv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OSV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2osv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2osv OCA], [~~http~~://pdbe.org/2osv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2osv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2osv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2osv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2osv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2osv OCA], [https://pdbe.org/2osv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2osv RCSB], [https://www.ebi.ac.uk/pdbsum/2osv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2osv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ZNUA_ECOLI ZNUA_ECOLI]] Involved in the high-affinity zinc uptake transport system.	+	[[https://www.uniprot.org/uniprot/ZNUA_ECOLI ZNUA_ECOLI]] Involved in the high-affinity zinc uptake transport system.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:04, 27 May 2020

OCA — Wed, 27 May 2020 08:04:16 GMT

←Older revision		Revision as of 08:04, 27 May 2020
Line 1:		Line 1:

	==Crystal Structure of ZnuA from E. coli==		==Crystal Structure of ZnuA from E. coli==
-	<StructureSection load='2osv' size='340' side='right' caption='[[2osv]], [[Resolution\|resolution]] 1.75Å' scene=''>	+	<StructureSection load='2osv' size='340' side='right'caption='[[2osv]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2osv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSV OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2OSV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2osv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2OSV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2osv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2osv OCA], [http://pdbe.org/2osv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2osv RCSB], [http://www.ebi.ac.uk/pdbsum/2osv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2osv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2osv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2osv OCA], [http://pdbe.org/2osv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2osv RCSB], [http://www.ebi.ac.uk/pdbsum/2osv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2osv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
		+	[[Category: Large Structures]]
	[[Category: Jogl, G]]		[[Category: Jogl, G]]
	[[Category: Li, H]]		[[Category: Li, H]]
	[[Category: Metal transport]]		[[Category: Metal transport]]
	[[Category: Protein-zinc complex]]		[[Category: Protein-zinc complex]]

OCA at 06:51, 22 August 2018

OCA — Wed, 22 Aug 2018 06:51:34 GMT

←Older revision		Revision as of 06:51, 22 August 2018
Line 1:		Line 1:
		+
	==Crystal Structure of ZnuA from E. coli==		==Crystal Structure of ZnuA from E. coli==
	<StructureSection load='2osv' size='340' side='right' caption='[[2osv]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='2osv' size='340' side='right' caption='[[2osv]], [[Resolution\|resolution]] 1.75Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2osv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OSV FirstGlance]. <br>		<table><tr><td colspan='2'>[[2osv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OSV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2osv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2osv OCA], [http://pdbe.org/2osv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2osv RCSB], [http://www.ebi.ac.uk/pdbsum/2osv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2osv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2osv OCA], [http://pdbe.org/2osv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2osv RCSB], [http://www.ebi.ac.uk/pdbsum/2osv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2osv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/2osv_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/2osv_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2osv ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:45, 11 September 2015

OCA — Fri, 11 Sep 2015 12:45:12 GMT

←Older revision		Revision as of 12:45, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2osv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OSV FirstGlance]. <br>		<table><tr><td colspan='2'>[[2osv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OSV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2osv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2osv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2osv RCSB], [http://www.ebi.ac.uk/pdbsum/2osv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2osv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2osv OCA], [http://pdbe.org/2osv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2osv RCSB], [http://www.ebi.ac.uk/pdbsum/2osv PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2osv" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:38, 25 December 2014

OCA — Thu, 25 Dec 2014 16:38:01 GMT

←Older revision		Revision as of 16:38, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2osv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OSV FirstGlance]. <br>		<table><tr><td colspan='2'>[[2osv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OSV FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2osv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2osv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2osv RCSB], [http://www.ebi.ac.uk/pdbsum/2osv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2osv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2osv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2osv RCSB], [http://www.ebi.ac.uk/pdbsum/2osv PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ZNUA_ECOLI ZNUA_ECOLI]] Involved in the high-affinity zinc uptake transport system.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Jogl, G.]]	+	[[Category: Jogl, G]]
-	[[Category: Li, H.]]	+	[[Category: Li, H]]
	[[Category: Metal transport]]		[[Category: Metal transport]]
	[[Category: Protein-zinc complex]]		[[Category: Protein-zinc complex]]

OCA at 19:54, 30 September 2014

OCA — Tue, 30 Sep 2014 19:54:12 GMT

←Older revision		Revision as of 19:54, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2osv.~~png\|left~~\|200px]]	+	==Crystal Structure of ZnuA from E. coli==
		+	<StructureSection load='2osv' size='340' side='right' caption='[[2osv]], [[Resolution\|resolution]] 1.75Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2osv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OSV FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2osv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2osv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2osv RCSB], [http://www.ebi.ac.uk/pdbsum/2osv PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/2osv_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bacterial ATP-binding cassette transport systems for high-affinity uptake of zinc and manganese use a cluster 9 solute-binding protein. Structures of four cluster 9 transport proteins have been determined previously. However, the structural determinants for discrimination between zinc and manganese remain under discussion. To further investigate the variability of metal binding sites in bacterial transporters, we have determined the structure of the zinc-bound transport protein ZnuA from Escherichia coli to 1.75 A resolution. The overall structure of ZnuA is similar to other solute-binding transporters. A scaffolding alpha-helix forms the backbone for two structurally related globular domains. The metal-binding site is located at the domain interface. The bound zinc ion is coordinated by three histidine residues (His78, His161 and His225) and one glutamate residue (Glu77). The functional role of Glu77 for metal binding is unexpected, because this residue is not conserved in previously determined structures of zinc and manganese-specific transport proteins. The observed metal coordination by four protein residues differs significantly from the zinc-binding site in the ZnuA transporter from Synechocystis 6803, which binds zinc via three histidine residues. In addition, the E. coli ZnuA structure reveals the presence of a disulfide bond in the C-terminal globular domain that is not present in previously determined cluster 9 transport protein structures.

-	~~{{STRUCTURE_2osv\| PDB=2osv \| SCENE= }}~~	+	Crystal structure of the zinc-binding transport protein ZnuA from Escherichia coli reveals an unexpected variation in metal coordination.,Li H, Jogl G J Mol Biol. 2007 May 18;368(5):1358-66. Epub 2007 Mar 15. PMID:17399739<ref>PMID:17399739</ref>

-	~~===Crystal Structure~~ of ~~ZnuA from E~~. ~~coli===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17399739}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2osv]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSV OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017399739<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Jogl, G.]]		[[Category: Jogl, G.]]

OCA: Protected "2osv" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 12:15:58 GMT

Protected "2osv" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:15, 7 January 2013

OCA at 12:15, 7 January 2013

OCA — Mon, 07 Jan 2013 12:15:54 GMT

←Older revision		Revision as of 12:15, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2osv.png\|left\|200px]]		[[Image:2osv.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2osv", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2osv\| PDB=2osv \| SCENE= }}		{{STRUCTURE_2osv\| PDB=2osv \| SCENE= }}

	===Crystal Structure of ZnuA from E. coli===		===Crystal Structure of ZnuA from E. coli===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17399739}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17399739 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17399739}}		{{ABSTRACT_PUBMED_17399739}}

	==About this Structure==		==About this Structure==
-	~~2OSV~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSV OCA].	+	[[2osv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSV OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17399739~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017399739</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Jogl, G.]]		[[Category: Jogl, G.]]
	[[Category: Li, H.]]		[[Category: Li, H.]]
		+	[[Category: Metal transport]]
	[[Category: Protein-zinc complex]]		[[Category: Protein-zinc complex]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:57:49 2009''

OCA at 19:57, 17 February 2009

OCA — Tue, 17 Feb 2009 19:57:50 GMT

←Older revision		Revision as of 19:57, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2OSV is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSV OCA].	+	2OSV is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSV OCA].

	==Reference==		==Reference==
-	Crystal structure of the zinc-binding transport protein ZnuA from Escherichia coli reveals an unexpected variation in metal coordination., Li H, Jogl G, J Mol Biol. 2007 May 18;368(5):1358-66. Epub 2007 Mar 15. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17399739 17399739]~~	+	<ref group="xtra">PMID:17399739</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Single protein]]
	[[Category: Jogl, G.]]		[[Category: Jogl, G.]]
	[[Category: Li, H.]]		[[Category: Li, H.]]
	[[Category: Protein-zinc complex]]		[[Category: Protein-zinc complex]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 06~~:10:~~56 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:57:49 2009''

OCA at 03:10, 29 July 2008

OCA — Tue, 29 Jul 2008 03:10:59 GMT

←Older revision		Revision as of 03:10, 29 July 2008
Line 1:		Line 1:
-	[[Image:2osv.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2osv.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2osv\| PDB=2osv \| SCENE= }}		{{STRUCTURE_2osv\| PDB=2osv \| SCENE= }}

-	~~'''~~Crystal Structure of ZnuA from E. coli~~'''~~	+	===Crystal Structure of ZnuA from E. coli===


-	~~==Overview==~~	+	<!--
-	~~Bacterial ATP~~-~~binding cassette transport systems for high~~-~~affinity uptake of zinc and manganese use a cluster 9 solute-binding protein. Structures of four cluster 9 transport proteins have been determined previously. However~~, ~~the structural determinants for discrimination between zinc and manganese remain under discussion. To further investigate the variability of metal binding sites in bacterial transporters~~, ~~we have determined~~ the ~~structure of the zinc-bound transport protein ZnuA from Escherichia coli~~ to ~~1.75 A resolution. The overall structure of ZnuA is similar to other solute-binding transporters. A scaffolding alpha-helix forms~~ the ~~backbone for two structurally related globular domains~~. ~~The metal-binding site is located at the domain interface~~. ~~The bound zinc ion is coordinated by three histidine residues (His78, His161 and His225~~) ~~and one glutamate residue (Glu77). The functional role of Glu77 for metal binding is unexpected~~, ~~because this residue~~ is ~~not conserved in previously determined structures of zinc and manganese-specific transport proteins. The observed metal coordination by four protein residues differs significantly from~~ the ~~zinc-binding site in the ZnuA transporter from Synechocystis 6803, which binds zinc via three histidine residues~~. ~~In addition, the E. coli ZnuA structure reveals the presence of a disulfide bond in the C~~-~~terminal globular domain that is not present in previously determined cluster 9 transport protein structures.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_17399739}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17399739 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17399739}}

	==About this Structure==		==About this Structure==
Line 25:		Line 29:
	[[Category: Li, H.]]		[[Category: Li, H.]]
	[[Category: Protein-zinc complex]]		[[Category: Protein-zinc complex]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 11~~:35:31 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:10:56 2008''